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Page last updated: 2024-10-21

phenytoin and Acute Post-operative Pain

phenytoin has been researched along with Acute Post-operative Pain in 5 studies

Research Excerpts

ExcerptRelevanceReference
"Gabapentin is an anticonvulsant drug that has analgesic properties for acute postoperative pain."2.74The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. ( Aykac, B; Bingol, CA; Karlikaya, G; Sayin, M; Türe, H; Türe, U, 2009)
"Phenytoin pretreatment significantly reduced myalgia from 45% (nine patients) in the control group to 10% (two patients) (p less than 0."2.67Phenytoin reduces suxamethonium-induced myalgia. ( Hatta, V; Kaul, HL; Saxena, A, 1992)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Iturri, F1
Valencia, L1
Honorato, C1
Martínez, A1
Valero, R1
Fàbregas, N1
Lavaf, M1
Simbar, M1
Mojab, F1
Alavi Majd, H1
Samimi, M1
Türe, H1
Sayin, M1
Karlikaya, G1
Bingol, CA1
Aykac, B1
Türe, U1
Gottschalk, A1
Hatta, V1
Saxena, A1
Kaul, HL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]Phase 477 participants (Actual)Interventional2018-05-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

Interventionscore on 10-point scale (Mean)
Standard of Care2.26
Postoperative Gabapentin Regimen2.46

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care3.84
Postoperative Gabapentin Regimen3.54

"VAS Score 3: How Well Are You Sleeping?"

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care5.73
Postoperative Gabapentin Regimen6.38

"VAS Score 4: How Bad is Your Nausea?"

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care0.36
Postoperative Gabapentin Regimen0.17

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care7.83
Postoperative Gabapentin Regimen8.48

Days Taking Opioids

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventiondays (Mean)
Standard of Care14.8
Postoperative Gabapentin Regimen18.7

Opioid Consumption

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Interventionmorphine equivalents (Mean)
Standard of Care287.0
Postoperative Gabapentin Regimen281.1

Reviews

1 review available for phenytoin and Acute Post-operative Pain

ArticleYear
Narrative review of acute post-craniotomy pain. Concept and strategies for prevention and treatment of pain.
    Revista espanola de anestesiologia y reanimacion, 2020, Volume: 67, Issue:2

    Topics: Acupuncture Analgesia; Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory A

2020

Trials

3 trials available for phenytoin and Acute Post-operative Pain

ArticleYear
Comparison of honey and phenytoin (PHT) cream effects on intensity of pain and episiotomy wound healing in nulliparous women.
    Journal of complementary & integrative medicine, 2017, Oct-05, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Episiotomy; Female; Honey; Humans; Pain, Postoperative; Phenytoin; Pregnancy; Wou

2017
The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:5

    Topics: Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid;

2009
Phenytoin reduces suxamethonium-induced myalgia.
    Anaesthesia, 1992, Volume: 47, Issue:8

    Topics: Adult; Female; Humans; Male; Muscles; Pain, Postoperative; Phenytoin; Potassium; Prospective Studies

1992

Other Studies

1 other study available for phenytoin and Acute Post-operative Pain

ArticleYear
Craniotomy pain: trying to do better.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:5

    Topics: Administration, Oral; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anticon

2009