phenytoin has been researched along with Acute Liver Injury, Drug-Induced in 128 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 7.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "Agranulocytosis is a rare side effect of phenytoin treatment." | 7.68 | Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction? ( McClune, GL; Sharafuddin, MJ; Spanheimer, RG, 1991) |
| "We report a life-threatening case of phenytoin hypersensitivity syndrome, a rare reaction primarily characterized by fever, skin eruptions, lymphadenopathy, eosinophilia, and hepatotoxicity." | 7.68 | Phenytoin hypersensitivity syndrome: a case report. ( Dunn, MI; Engen, PL; Howard, PA, 1991) |
| "Five cases of the phenytoin syndrome are reviewed here." | 7.66 | The phenytoin syndrome. ( Tomsick, RS, 1983) |
| "Liver biopsy was performed and showed chronic persistent hepatitis." | 5.29 | Phenytoin-induced chronic hepatitis. ( Levine, RA; Mahoney, HC; Roy, AK, 1993) |
| " One hundred thirty-two patients at high risk for seizures were assigned to receive a 1-week course of phenytoin, 120 were assigned to receive a 1-month course of valproate, and 127 were assigned to receive a 6-month course of valproate." | 5.09 | Valproate therapy for prevention of posttraumatic seizures: a randomized trial. ( Anderson, GD; Awan, A; Cohen, W; Dikmen, SS; Holmes, MD; Nelson, P; Newell, DW; Temkin, NR; Wilensky, AJ; Winn, HR, 1999) |
| "Phenytoin, one of the most common antiepileptic drugs, is a major cause of antiepileptic drug hypersensitivity syndrome (AHS), which is a rare but potentially fatal complication." | 3.75 | Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ( Imai, K; Ito, S; Oguni, H; Osawa, M; Sasaki, K; Shioda, M, 2009) |
| "Agranulocytosis is a rare side effect of phenytoin treatment." | 3.68 | Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction? ( McClune, GL; Sharafuddin, MJ; Spanheimer, RG, 1991) |
| "We report a life-threatening case of phenytoin hypersensitivity syndrome, a rare reaction primarily characterized by fever, skin eruptions, lymphadenopathy, eosinophilia, and hepatotoxicity." | 3.68 | Phenytoin hypersensitivity syndrome: a case report. ( Dunn, MI; Engen, PL; Howard, PA, 1991) |
| "Five cases of the phenytoin syndrome are reviewed here." | 3.66 | The phenytoin syndrome. ( Tomsick, RS, 1983) |
| " Idiosyncratic DILI is most often unrelated to pharmacological effects or the dosing amount of a drug." | 2.58 | Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries. ( Sasaki, E; Yokoi, T, 2018) |
| "Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression." | 2.38 | Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991) |
| " The severity of this adverse effect ranges from self-limiting to fatal." | 2.38 | Phenytoin hepatotoxicity: a review of the literature. ( Smythe, MA; Umstead, GS, 1989) |
| "6 million adverse event reports made to the FDA Adverse Event Reporting System (FAERS) database between July 1, 2018 and March 31, 2020 for DILI due to ASMs commonly used in clinical practice." | 1.62 | Drug-induced liver injury associated with antiseizure medications from the FDA Adverse Event Reporting System (FAERS). ( Catalano, C; Gupta, K; Kamitaki, BK; Minacapelli, CD; Rustgi, V; Wachuku, C; Zhang, P, 2021) |
| "Phenytoin has a narrow therapeutic window, and when managing cases of toxicity, clinicians are very wary of this fact." | 1.40 | Free phenytoin toxicity. ( Gambhir, H; Imam, SH; John, D; Kaul, V; Kloss, B; Landry, K, 2014) |
| "Phenytoin (DPH) is an anticonvulsant drug that is widely used for the treatment of epilepsy." | 1.39 | A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism. ( Fukami, T; Iida, A; Matsuo, K; Nakajima, M; Sasaki, E; Tsuneyama, K; Yokoi, T, 2013) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Phenytoin is a highly effective and widely prescribed anticonvulsant agent, but it can be associated with dose-related side effects and hypersensitivity reactions." | 1.32 | Phenytoin-induced toxic cholestatic hepatitis in a patient with skin lesions: case report. ( Altuntaş, Y; Erdem, L; Günes, G; Karul, S; Oztürk, B; Sengül, A; Uçak, S, 2003) |
| " So, the toxicogenomics through this technology may be very powerful for understanding the effect of unknown toxic mechanisms in biological system." | 1.32 | Gene expression analysis of peroxisome proliferators- and phenytoin-induced hepatotoxicity using cDNA microarray. ( Hwang, JW; Hwang, SY; Jeon, KS; Jung, JW; Kang, JS; Kang, KS; Kim, YS; Lee, GJ; Lee, WS; Lee, YS; Li, P; Oh, MJ; Park, JE; Park, JS; Song, BS; Um, CH; Yeo, CD; Youn, JP, 2004) |
| "Liver biopsy was performed and showed chronic persistent hepatitis." | 1.29 | Phenytoin-induced chronic hepatitis. ( Levine, RA; Mahoney, HC; Roy, AK, 1993) |
| " Other features of this adverse drug reaction were unremitting fever, leukocytosis with eosinophilia and atypical lymphocytosis, and proteinuria." | 1.28 | Phenobarbital hepatotoxicity in an 8-month-old infant. ( Goldbach, M; Phillips, MJ; Roberts, EA; Spielberg, SP, 1990) |
| "The laboratory findings revealed leukocytosis with atypical lymphocytes, eosinophilia and altered liver function." | 1.27 | [Hypersensitivity syndrome caused by phenytoins and phenobarbital]. ( Azulay, DR; Azulay, RD; Fonseca, JC; Rozembau, I, 1984) |
| " However, whereas toxic reactions following phenytoin and carbamazepine are characterised by a rather short duration of exposure before symptoms occur with accompanying clinical features of hypersensitivity, valproate-induced hepatic toxicity exhibits no signs of hypersensitivity and often occurs following prolonged exposure, speaking in favor of a metabolic aberration as the underlying cause." | 1.27 | Hepatic toxicity of antiepileptic drugs: a review. ( Bentsen, KD; Gram, L, 1983) |
| "Phenytoin therapy was discontinued again, with complete resolution of the hepatic abnormalities." | 1.27 | Cholestatic liver dysfunction after long-term phenytoin therapy. ( Mitros, FA; Murphy, MJ; Stein, MN; Taylor, JW, 1984) |
| " Frequency and extent of increased activity of gamma-GT were highly related to daily dosage in both preparations." | 1.27 | The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. ( Aldenhövel, HG, 1988) |
| "Phenytoin was discontinued after admission; however, phenytoin 1 g i." | 1.27 | Phenytoin-induced hypersensitivity reactions. ( Lander, RD; Prosser, TR, 1987) |
| "Phenytoin alone was not toxic to cells." | 1.26 | Predisposition to phenytoin hepatotoxicity assessed in vitro. ( Blake, DA; Goldstein, DA; Gordon, GB; Herlong, HF; Spielberg, SP, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (60.94) | 18.7374 |
| 1990's | 18 (14.06) | 18.2507 |
| 2000's | 11 (8.59) | 29.6817 |
| 2010's | 18 (14.06) | 24.3611 |
| 2020's | 3 (2.34) | 2.80 |
| Authors | Studies |
|---|---|
| Yogeeswari, P | 1 |
| Sriram, D | 1 |
| Thirumurugan, R | 1 |
| Raghavendran, JV | 1 |
| Sudhan, K | 1 |
| Pavana, RK | 1 |
| Stables, J | 1 |
| Rana, A | 1 |
| Siddiqui, N | 1 |
| Khan, SA | 1 |
| Ehtaishamul Haque, S | 1 |
| Bhat, MA | 1 |
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Chalasani, N | 1 |
| Bonkovsky, HL | 1 |
| Stine, JG | 1 |
| Gu, J | 1 |
| Barnhart, H | 1 |
| Jacobsen, E | 1 |
| Björnsson, E | 1 |
| Fontana, RJ | 2 |
| Kleiner, DE | 1 |
| Hoofnagle, JH | 2 |
| Azzam, SM | 1 |
| Abdel Khalek, MR | 1 |
| Abdel Rahman, AAS | 1 |
| Osman, AA | 1 |
| Selim, HMRM | 1 |
| Sharif, AF | 1 |
| El-Khattib, YA | 1 |
| Rabea, S | 1 |
| Ali, SK | 1 |
| Darwish, A | 1 |
| Kamitaki, BK | 1 |
| Minacapelli, CD | 1 |
| Zhang, P | 2 |
| Wachuku, C | 1 |
| Gupta, K | 1 |
| Catalano, C | 1 |
| Rustgi, V | 1 |
| Sasaki, E | 3 |
| Yokoi, T | 3 |
| Keel, BR | 1 |
| Payne, CL | 1 |
| Velasco, MJ | 1 |
| McDermott, J | 1 |
| Matsuo, K | 1 |
| Iida, A | 1 |
| Tsuneyama, K | 2 |
| Fukami, T | 2 |
| Nakajima, M | 2 |
| Imam, SH | 1 |
| Landry, K | 1 |
| Kaul, V | 1 |
| Gambhir, H | 1 |
| John, D | 1 |
| Kloss, B | 1 |
| Mattes, W | 1 |
| Davis, K | 1 |
| Fabian, E | 1 |
| Greenhaw, J | 1 |
| Herold, M | 1 |
| Looser, R | 1 |
| Mellert, W | 1 |
| Groeters, S | 1 |
| Marxfeld, H | 1 |
| Moeller, N | 1 |
| Montoya-Parra, G | 1 |
| Prokoudine, A | 1 |
| van Ravenzwaay, B | 1 |
| Strauss, V | 1 |
| Walk, T | 1 |
| Kamp, H | 1 |
| Owoeye, O | 1 |
| Adedara, IA | 1 |
| Adeyemo, OA | 1 |
| Bakare, OS | 1 |
| Egun, C | 1 |
| Farombi, EO | 1 |
| Iwamura, A | 1 |
| Kume, T | 1 |
| Mohammadi, F | 1 |
| MacLasco, A | 1 |
| Paloucek, FP | 1 |
| Ekaidem, IS | 1 |
| Usoh, IF | 1 |
| Akpanabiatu, MI | 1 |
| Uboh, FE | 1 |
| Akpan, HD | 1 |
| Jiang, XF | 1 |
| Nie, X | 1 |
| Huang, Y | 1 |
| Zeng, F | 1 |
| Xia, X | 1 |
| Wu, S | 1 |
| Ito, S | 1 |
| Shioda, M | 1 |
| Sasaki, K | 1 |
| Imai, K | 1 |
| Oguni, H | 1 |
| Osawa, M | 1 |
| Crespo Pérez, L | 1 |
| Moreira Vicente, V | 1 |
| Cano Ruiz, A | 1 |
| Gobernado Serrano, JM | 1 |
| Cobo Ibañez, N | 1 |
| Milicua Salamero, JM | 1 |
| Altuntaş, Y | 1 |
| Oztürk, B | 1 |
| Erdem, L | 1 |
| Günes, G | 1 |
| Karul, S | 1 |
| Uçak, S | 1 |
| Sengül, A | 1 |
| Citerio, G | 1 |
| Nobili, A | 1 |
| Airoldi, L | 1 |
| Pastorelli, R | 1 |
| Patruno, A | 1 |
| HARVEY, P | 1 |
| RODGERS, JB | 1 |
| MALLORY, GK | 1 |
| DAVIDSON, DS | 1 |
| STEIN, S | 1 |
| PEMBROOK, RC | 1 |
| Jung, JW | 1 |
| Park, JS | 1 |
| Hwang, JW | 1 |
| Kang, KS | 1 |
| Lee, YS | 1 |
| Song, BS | 1 |
| Lee, GJ | 1 |
| Yeo, CD | 1 |
| Kang, JS | 1 |
| Lee, WS | 1 |
| Jeon, KS | 1 |
| Um, CH | 1 |
| Kim, YS | 1 |
| Oh, MJ | 1 |
| Youn, JP | 1 |
| Li, P | 1 |
| Park, JE | 1 |
| Hwang, SY | 1 |
| Jinjuvadia, K | 1 |
| Kwan, W | 1 |
| Delima, SI | 1 |
| Walsh, LE | 1 |
| Golomb, MR | 1 |
| Berkovic, SF | 1 |
| Bladin, PF | 1 |
| Jones, DB | 1 |
| Smallwood, RA | 1 |
| Vajda, FJ | 1 |
| Dostert, P | 1 |
| Benedetti, MS | 1 |
| Ting, S | 1 |
| Dunsky, EH | 1 |
| Tomsick, RS | 1 |
| Fonseca, JC | 1 |
| Azulay, DR | 1 |
| Rozembau, I | 1 |
| Azulay, RD | 1 |
| Gram, L | 1 |
| Bentsen, KD | 1 |
| Palm, R | 1 |
| Silseth, C | 1 |
| Alván, G | 1 |
| Kahn, HD | 1 |
| Faguet, GB | 1 |
| Agee, JF | 1 |
| Middleton, HM | 1 |
| Jezequel, AM | 1 |
| Librari, ML | 1 |
| Mosca, P | 1 |
| Novelli, G | 1 |
| Lorenzini, I | 1 |
| Orlandi, F | 1 |
| Egerton-Vernon, JM | 1 |
| Fisk, MJ | 1 |
| Snell, AP | 1 |
| Martí Massó, JF | 1 |
| Carrera, N | 1 |
| Zabalza, R | 1 |
| García Bengoechea, M | 1 |
| Smith, DA | 1 |
| Burgdorf, WH | 1 |
| Taylor, JW | 1 |
| Stein, MN | 1 |
| Murphy, MJ | 1 |
| Mitros, FA | 1 |
| Pineda, JA | 1 |
| Leal, M | 1 |
| Lissén, E | 1 |
| Sánchez Quijano, A | 1 |
| Lozano, F | 1 |
| Andreu Kern, F | 1 |
| Keown, PA | 1 |
| Stiller, CR | 1 |
| Laupacis, AL | 1 |
| Howson, W | 1 |
| Coles, R | 1 |
| Stawecki, M | 1 |
| Koegler, J | 1 |
| Carruthers, G | 1 |
| McKenzie, N | 1 |
| Sinclair, NR | 1 |
| Spielberg, SP | 3 |
| Gordon, GB | 1 |
| Blake, DA | 1 |
| Goldstein, DA | 1 |
| Herlong, HF | 1 |
| Höjer, B | 1 |
| Rane, A | 1 |
| Cook, IF | 1 |
| Shilkin, KB | 1 |
| Reed, WD | 1 |
| Maddrey, WC | 1 |
| Valerdiz Casasola, S | 1 |
| Linares Rodríguez, A | 1 |
| Recarte Alvarez, J | 1 |
| Rodrigo Sáez, L | 1 |
| Mullick, FG | 1 |
| Ishak, KG | 1 |
| Shapiro, PA | 1 |
| Antonioli, DA | 1 |
| Peppercorn, MA | 1 |
| Callaghan, N | 1 |
| Majeed, T | 1 |
| O'Connell, A | 1 |
| Oliveira, DB | 2 |
| Ranek, L | 1 |
| Dalhoff, K | 1 |
| Poulsen, HE | 1 |
| Brøsen, K | 1 |
| Flachs, H | 1 |
| Loft, S | 1 |
| Wantzin, P | 1 |
| Chandra, RS | 1 |
| Dalvi, SS | 1 |
| Powar, HS | 1 |
| Karnad, PD | 1 |
| Kshirsagar, NA | 1 |
| Roy, AK | 1 |
| Mahoney, HC | 1 |
| Levine, RA | 1 |
| de la Serna Higuera, C | 1 |
| Gil Grande, LA | 1 |
| Bárcena Marugán, R | 1 |
| Conger, LA | 1 |
| Grabski, WJ | 1 |
| Sugimoto, T | 1 |
| Muro, H | 1 |
| Woo, M | 1 |
| Nishida, N | 1 |
| Murakami, K | 1 |
| Watanabe, K | 1 |
| Tanaka, Y | 1 |
| Takemura, T | 1 |
| Naitoh, M | 1 |
| Hata, Y | 1 |
| Kino, K | 1 |
| Tsuru, M | 1 |
| Fukazawa, T | 1 |
| Sawabe, M | 1 |
| Meythaler, JM | 1 |
| Hazlewood, J | 1 |
| DeVivo, MJ | 1 |
| Rosner, M | 1 |
| Temkin, NR | 1 |
| Dikmen, SS | 1 |
| Anderson, GD | 1 |
| Wilensky, AJ | 1 |
| Holmes, MD | 1 |
| Cohen, W | 1 |
| Newell, DW | 1 |
| Nelson, P | 1 |
| Awan, A | 1 |
| Winn, HR | 1 |
| Kakar, A | 1 |
| Byotra, SP | 1 |
| Manzano ALonso, ML | 1 |
| Muñoz Gómez, R | 1 |
| Fernández Vázquez, I | 1 |
| Castellano Tortajada, G | 1 |
| Solis Herruzo, JA | 1 |
| Rumack, BH | 1 |
| Ziegler, HK | 1 |
| Sinazadeh, M | 1 |
| Weedon, AP | 2 |
| Addington, WW | 1 |
| Parker, WA | 1 |
| Shearer, CA | 1 |
| Lee, TJ | 1 |
| Carney, CN | 1 |
| Lapis, JL | 1 |
| Higgins, T | 1 |
| Fallon, HJ | 1 |
| Campbell, CB | 1 |
| McGuffie, C | 1 |
| Powell, LW | 1 |
| Cammann, R | 1 |
| Wiechert, P | 1 |
| Nash, AS | 1 |
| Thompson, H | 1 |
| Bogan, JA | 1 |
| Schwartz, IL | 1 |
| Moult, PJ | 1 |
| Sherlock, S | 1 |
| Ni, YH | 1 |
| Chang, MH | 1 |
| Wu, MZ | 1 |
| Wyllie, E | 1 |
| Wyllie, R | 1 |
| Sharafuddin, MJ | 1 |
| Spanheimer, RG | 1 |
| McClune, GL | 1 |
| Yew, WW | 1 |
| Lau, KS | 1 |
| Ling, MH | 1 |
| Foster, GR | 1 |
| Goldin, RD | 1 |
| Freeth, CJ | 1 |
| Nieman, E | 1 |
| Howard, PA | 1 |
| Engen, PL | 1 |
| Dunn, MI | 1 |
| Roberts, EA | 1 |
| Goldbach, M | 1 |
| Phillips, MJ | 1 |
| Smythe, MA | 1 |
| Umstead, GS | 1 |
| Lisker-Melman, M | 1 |
| Korman, LB | 1 |
| Olson, MJ | 1 |
| Carro, JA | 1 |
| Senior, J | 1 |
| Rubio, CE | 1 |
| Torres, EA | 1 |
| Aldenhövel, HG | 1 |
| Ramsay, RE | 1 |
| Powers, NG | 1 |
| Carson, SH | 1 |
| Himelman, RB | 1 |
| Brown, M | 1 |
| Schubert, T | 1 |
| Crawford, P | 1 |
| Chadwick, D | 1 |
| Itoh, T | 1 |
| Sawada, Y | 1 |
| Lin, TH | 1 |
| Iga, T | 1 |
| Hanano, M | 1 |
| Olsson, R | 1 |
| Zettergren, L | 1 |
| Plumber, ST | 1 |
| Pipalia, DH | 1 |
| Karpurkar, AP | 1 |
| Naik, SR | 1 |
| Prosser, TR | 1 |
| Lander, RD | 1 |
| Dill, RE | 1 |
| Jones, RG | 1 |
| Davis, WL | 1 |
| Bunch, SE | 1 |
| Conway, MB | 1 |
| Center, SA | 1 |
| Castleman, WL | 1 |
| Baldwin, BH | 1 |
| Hornbuckle, WE | 1 |
| Tennant, BC | 1 |
| Sherertz, EF | 1 |
| Jegasothy, BV | 1 |
| Lazarus, GS | 1 |
| Aaron, JS | 1 |
| Bank, S | 1 |
| Ackert, G | 1 |
| Tucker, MS | 1 |
| Fitzharris, JW | 1 |
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| Murray, M | 1 |
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13 reviews available for phenytoin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries.
Topics: Animals; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En | 2018 |
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine; | 2009 |
[Biochemical mechanisms of the hepatotoxicity of psychotropic drugs].
Topics: Acute Disease; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic | 1984 |
Drug-related acute and chronic hepatitis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersen | 1980 |
[Toxic cholestatic hepatitis due to phenytoin].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle Aged; Phe | 1995 |
Dilantin hypersensitivity reaction.
Topics: Adult; Anti-Arrhythmia Agents; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Eruptio | 1996 |
Diphenylhydantoin-induced hepatic necrosis. A case study.
Topics: Adult; Autopsy; Chemical and Drug Induced Liver Injury; Epilepsy, Tonic-Clonic; Female; Hepatic Ence | 1976 |
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit | 1991 |
Phenytoin hepatotoxicity: a review of the literature.
Topics: Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Lymphocyte Activation; Phenytoin | 1989 |
Use of phenytoin and carbamazepine in treatment of epilepsy.
Topics: Anemia, Aplastic; Carbamazepine; Cerebellar Ataxia; Chemical and Drug Induced Liver Injury; Cognitio | 1986 |
Toxic hepatic porphyrias.
Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyc | 1968 |
Halothane anesthesia and hepatitis in a high-risk population.
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Diazepam; Enzyme Induction; Halothane; Human | 1973 |
4 trials available for phenytoin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Valproate therapy for prevention of posttraumatic seizures: a randomized trial.
Topics: Adult; Anticonvulsants; Blood Coagulation Disorders; Brain Injuries; Chemical and Drug Induced Liver | 1999 |
A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug | 1986 |
Sequential biochemical tests in persons taking PH phenytoin.
Topics: Alkaline Phosphatase; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury | 1972 |
Effects of diphenylhydantoin on disruptive behavior. Study of male delinquents.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child, Institutionalized; Clinical Trials as Top | 1969 |
111 other studies available for phenytoin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver | 2005 |
N-{[(6-substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: synthesis and pharmacological evaluation.
Topics: Animals; Anticonvulsants; Benzamides; Benzothiazoles; Central Nervous System Depressants; Chemical a | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study.
Topics: Adult; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Chemical and Drug Ind | 2022 |
Revealing how phenytoin triggers liver damage and the potential protective effects of Balanites Aegyptiaca fruit extracts: Exploring Nrf2/MAPK/ Beclin-1 signaling pathways.
Topics: Animals; Balanites; Beclin-1; Chemical and Drug Induced Liver Injury; Fruit; Liver; Male; MAP Kinase | 2023 |
Drug-induced liver injury associated with antiseizure medications from the FDA Adverse Event Reporting System (FAERS).
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Humans; Lamotrigine; Levetiracetam; Phenyto | 2021 |
Anticonvulsant hypersensitivity syndrome (AHS): a case report.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Exanthema; Fe | 2013 |
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome and hepatitis induced by phenytoin.
Topics: Acute Kidney Injury; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensi | 2014 |
A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inh | 2013 |
Free phenytoin toxicity.
Topics: Aged; Anticonvulsants; Chemical and Drug Induced Liver Injury; Gait Disorders, Neurologic; Humans; H | 2014 |
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma.
Topics: Animals; Atropine; Captopril; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Dr | 2014 |
Modulatory role of kolaviron in phenytoin-induced hepatic and testicular dysfunctions in Wistar rats.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Flavonoids | 2015 |
Role of cytochrome P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury.
Topics: Acetylcysteine; Activation, Metabolic; Alanine Transaminase; Animals; Anticonvulsants; Bile; Chemica | 2015 |
Inappropriate utilization of the Sheiner-Tozer equation to determine phenytoin toxicity.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Gait Disorders, Neurologic; Humans; Hypoalb | 2015 |
Urate synthesis and oxidative stress in phenytoin hepatotoxicity: the role of antioxidant vitamins.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotec | 2014 |
A two-photon fluorescent sensor revealing drug-induced liver injury via tracking γ-glutamyltranspeptidase (GGT) level in vivo.
Topics: Animals; Cell Line; Chemical and Drug Induced Liver Injury; Female; Fluorescent Dyes; gamma-Glutamyl | 2016 |
Agranulocytosis following phenytoin-induced hypersensitivity syndrome.
Topics: Agranulocytosis; Anti-Bacterial Agents; Anticonvulsants; Cefepime; Cephalosporins; Chemical and Drug | 2009 |
Phenytoin-induced toxic cholestatic hepatitis in a patient with skin lesions: case report.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis; Dermatitis, Exfoliative; Femal | 2003 |
Severe intoxication after phenytoin infusion: a preventable pharmacogenetic adverse reaction.
Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chemical and Drug Induced Li | 2003 |
DRUG REACTIONS INVOLVING THE ALIMENTARY TRACT.
Topics: Anticoagulants; Bismuth; Chemical and Drug Induced Liver Injury; Chlorothiazide; Drug Therapy; Esoph | 1964 |
MASSIVE LIVER CELL NECROSIS; A RETROSPECTIVE STUDY.
Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Halothane; Hepatitis; Hepatitis A; Isoniazid; M | 1964 |
CROSS-SENSITIVITY TO DILANTIN (DIPHENYLBYDANTOIN) AND CELONTIN (METHSUXIMIDE).
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Clinical Laboratory Techniques; Derm | 1965 |
Gene expression analysis of peroxisome proliferators- and phenytoin-induced hepatotoxicity using cDNA microarray.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Clofibrate; Dose-Response Relation | 2004 |
Searching for a needle in a haystack: use of ICD-9-CM codes in drug-induced liver injury.
Topics: Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Li | 2007 |
Simultaneous toxicities in a child on multiple anticonvulsants.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, P | 2008 |
Hepatotoxicity of sodium valproate.
Topics: Adolescent; Adult; Aged; Carbamazepine; Chemical and Drug Induced Liver Injury; Child; Fibrinogen; g | 1983 |
Diphenylhydantoin-induced hepatitis.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Drug Hypersensitivity; | 1982 |
The phenytoin syndrome.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Drug Eruptions; Female; Fever; Humans; Lymphatic | 1983 |
[Hypersensitivity syndrome caused by phenytoins and phenobarbital].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; | 1984 |
Hepatic toxicity of antiepileptic drugs: a review.
Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Energy Metabolism; Epilepsy; | 1983 |
Phenytoin intoxication as the first symptom of fatal liver damage induced by sodium valproate.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsies, Partial; Femal | 1984 |
Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Cross Reactions; Drug Hypersensitivity; Female; | 1984 |
Changes induced in human liver by long-term anticonvulsant therapy. Functional and ultrastructural data.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Endoplasm | 1984 |
Phenytoin-induced hepatotoxicity.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Phenytoin | 1983 |
[Hepatotoxicity caused by diphenylhydantoin].
Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Phenytoin | 1983 |
Universal cutaneous depigmentation following phenytoin-induced toxic epidermal necrolysis.
Topics: Chemical and Drug Induced Liver Injury; Child; Female; Humans; Melanocytes; Nephritis, Interstitial; | 1984 |
Cholestatic liver dysfunction after long-term phenytoin therapy.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle Aged; Phenytoin | 1984 |
[Hepatitis caused by diphenylhydantoin].
Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Phenytoin | 1984 |
The effects and side effects of cyclosporine: relationship to drug pharmacokinetics.
Topics: Administration, Oral; Biological Availability; Chemical and Drug Induced Liver Injury; Cyclosporins; | 1982 |
Case for diagnosis: toxic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Male; Phenytoin | 1980 |
Predisposition to phenytoin hepatotoxicity assessed in vitro.
Topics: Adult; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Drug Hypersensitivity; Epoxid | 1981 |
Fatal hepatic failure in a child treated with phenytoin and valproic acid.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Interactions; Drug Therapy, Combinati | 1982 |
Phenytoin induced granulomatous hepatitis.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Granuloma; Humans | 1981 |
[Hepatitis caused by drugs. 4].
Topics: Adult; Aminosalicylic Acid; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Halothane | 1982 |
Hepatic injury associated with diphenylhydantoin therapy. A clinicopathologic study of 20 cases.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Mi | 1980 |
Barbiturate-induced submassive hepatic necrosis. Report of a case and review of the literature.
Topics: Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Necrosis; Phenytoin; Se | 1980 |
A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Chemical a | 1994 |
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis.
Topics: Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Complement C3; Female; Halothane; H | 1993 |
Phenytoin toxicity due to rifampicin induced hepatic dysfunction.
Topics: Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Epilepsy; Female; Humans; Isoniazi | 1993 |
Phenytoin-induced chronic hepatitis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Dia | 1993 |
Valproate metabolites in high-dose valproate plus phenytoin therapy.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injur | 1996 |
[A case of anticonvulsive drug-induced liver injury accompanied by a transient appearance of antimitochondrial antibody, M2].
Topics: Aged; Anticonvulsants; Autoantibodies; Chemical and Drug Induced Liver Injury; Female; Humans; Liver | 1998 |
Elevated liver enzymes after nontraumatic intracranial hemorrhages.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antico | 1998 |
Phenytoin induced severe agranulocytosis and hepatitis.
Topics: Agranulocytosis; Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; Humans; Middle Age | 1999 |
[Chronic hepatotoxicity due to phenytoin].
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Humans; Male; Phenytoin | 2001 |
Acetaminophen hepatotoxicity: the first 35 years.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Anticonvulsants; Aspa | 2002 |
[Anticonvulsant drugs and liver damage (Author's transl)].
Topics: Adult; Anticonvulsants; Antitubercular Agents; Autopsy; Chemical and Drug Induced Liver Injury; Chol | 1975 |
Diphenylhydantoin sensitivity. a syndrome resembling infectious mononucleosis with a morbilliform rash and cholestatic hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Child; Cholestasis; Diagnosis, Differential; Drug Eruptions; | 1975 |
Medical Staff Conference. Drug-induced liver disease.
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Drug Therapy; Female; Humans; Isoniazi | 1979 |
The side effects and interactions of antituberculosis drugs.
Topics: Adult; Aminosalicylic Acid; Antitubercular Agents; Central Nervous System Diseases; Chemical and Dru | 1979 |
Phenytoin hepatotoxicity: a case report and review.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Hu | 1979 |
Clinicopathological Conference. Diagnostic difficulties in a case of polypharmacy. Demonstrated at the Royal College of Physicians of London.
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Vir | 1977 |
Cholestatic liver disease associated with diphenylhydantoin therapy. Possible pathogenic importance of altered bile salt metabolism.
Topics: Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Humans; Hyperlipid | 1977 |
[Liver damage after long-term administration of phenylethylbarbituric acid and diphenylhydantoin].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Leucy | 1977 |
Phenytoin toxicity: a fatal case in a dog with hepatitis and jaundice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Jaundice; Liver; Male; Phenytoi | 1977 |
Letter: Question on diphenylhydantoin dosage.
Topics: Chemical and Drug Induced Liver Injury; Epilepsy, Temporal Lobe; Humans; Liver; Phenytoin | 1975 |
Halothane-related hepatitis. A clinical study of twenty-six cases.
Topics: Adult; Aged; Anesthesia, General; Bilirubin; Chemical and Drug Induced Liver Injury; Diagnosis, Diff | 1975 |
Mononucleosis and hepatic failure associated with diphenylhydantoin treatment in an infant.
Topics: Chemical and Drug Induced Liver Injury; Fatigue Syndrome, Chronic; Humans; Infant; Infectious Mononu | 1991 |
Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction?
Topics: Agranulocytosis; Brain Neoplasms; Carcinoma, Squamous Cell; Chemical and Drug Induced Liver Injury; | 1991 |
Phenytoin toxicity in a patient with isoniazid-induced hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Interactions; Epilepsy; Female; Humans; Isoniazi | 1991 |
Liver damage in long-term anticonvulsant therapy: a serological and histological study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Combinatio | 1991 |
Phenytoin hypersensitivity syndrome: a case report.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity; Heart | 1991 |
Phenobarbital hepatotoxicity in an 8-month-old infant.
Topics: Carbamazepine; Cell Survival; Chemical and Drug Induced Liver Injury; Humans; Infant; Lymphocytes; M | 1990 |
Phenytoin hepatotoxicity masked by corticosteroids.
Topics: Brain Edema; Chemical and Drug Induced Liver Injury; Dexamethasone; Drug Hypersensitivity; Humans; L | 1989 |
Phenytoin-induced hepatitis, rhabdomyolysis, and renal dysfunction.
Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Kidney Function Tests; Male; | 1989 |
Phenytoin induced fatal hepatic injury.
Topics: Brain Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Meningioma; Middle Aged; Ph | 1989 |
The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carbamazepine; Chemi | 1988 |
Idiosyncratic reactions to phenytoin.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Eruptions; | 1987 |
Fulminant hepatic failure six weeks postpartum.
Topics: Adult; Ascites; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; Phenytoin; P | 1986 |
Phenytoin hypersensitivity hepatitis and mononucleosis syndrome.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Fema | 1986 |
Kinetic analysis of phenytoin disposition in rats with experimental renal and hepatic diseases.
Topics: Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Male; Models, B | 1988 |
Anticonvulsant-induced liver damage.
Topics: Adult; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Clonazepam; Humans; L | 1988 |
Phenytoin induced hepatotoxicity.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Phenytoin | 1986 |
Phenytoin-induced hypersensitivity reactions.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Lymphatic Dise | 1987 |
In vitro analysis of idiosyncratic drug reactions.
Topics: Animals; Anticonvulsants; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Humans; In V | 1986 |
Phenytoin-induced connective tissue growth in the rat.
Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Connective Tissue; Dose-Response Rel | 1986 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |
Phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Report of a patient treated with corticosteroid "pulse therapy".
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Male; Methylprednisolone; Mid | 1985 |
Diphenylhydantoin-induced hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Liver; Middle Aged; P | 1985 |
Dilantin-induced erythema multiforme major: report of a case with liver and kidney involvement.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Nephritis, Interstitial; Phenytoin; S | 1985 |
Halothane hepatitis. Detection of a constitutional susceptibility factor.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Drug Evaluation, Precli | 1985 |
Halothane hepatitis revisited.
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Halothane; Humans; In Vitro Technique | 1985 |
Diphenylhydantoin--induced hepatic necrosis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epilepsy, Tonic-Clonic; Female | 1974 |
[Cholestatic hepatosis induced by diphenylhydantoin].
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Diagnosis, Differential; Drug Eruptions; | 1972 |
Proceedings: Studies on the interference of 14C-pentobarbital, 14C-diphenylhydantoin and 3H-digitoxin with ethanol in the isolated perfused guinea-pig liver.
Topics: Animals; Bile; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1974 |
Diphenylhydantoin.
Topics: Affective Symptoms; Arrhythmias, Cardiac; Ataxia; Carbamazepine; Central Nervous System Diseases; Ch | 1971 |
Massive hepatic necrosis after fluroxene anesthesia--a case of drug interaction?
Topics: Aged; Anesthesia, Inhalation; Anesthetics; Autopsy; Chemical and Drug Induced Liver Injury; Drug Int | 1972 |
[Accidents of diphenylhydantoin induced by antituberculous treatments].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Antagonism; Ethambutol; Humans; Isoniazid; Male; | 1971 |
[Febrile toxic hepatitis with eosinophilia, lymphadenopathy and exanthema during phenytoin therapy].
Topics: Adult; Chemical and Drug Induced Liver Injury; Eosinophilia; Exanthema; Fever; Humans; Liver Functio | 1971 |
Anicteric hepatitis induced by diphenylhydantoin.
Topics: Adult; Chemical and Drug Induced Liver Injury; Fever; Humans; Male; Phenytoin; Skin Manifestations | 1970 |
Diphenylhydantoin fatal hepatic necrosis (a review of literature and report of a case treated with exchange transfusion).
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Exchange Tran | 1970 |
[Toxic hepatitis during phenytoin therapy].
Topics: Aneurysm; Chemical and Drug Induced Liver Injury; Female; Humans; Middle Aged; Phenytoin; Time Facto | 1967 |
Diphenylhydantoin sodium hepatitis.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Humans; L | 1968 |
[Acute hepatic cell damage by simultaneous administration of isonicotinic acid hydrazide and antiepileptic agents in humans, (diphenylhydantoin or carbamazepin)].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Dibenzaze | 1969 |
Use of diphenylhydantoin in epilepsy treatment.
Topics: Ataxia; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; Necrosis; Nervous System Diseases; | 1969 |
Hypersensitivity to diphenylhydantoin (Dilantin): a case report with toxic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Hypersensitivity; Liver; Male; Phenytoin | 1966 |