phenytoin has been researched along with Abnormality, Heart in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 5.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| "Mexiletine therapy was terminated for side effects in only five patients (12%)." | 5.27 | Mexiletine: an effective antiarrhythmic drug for treatment of ventricular arrhythmias in congenital heart disease. ( Garson, A; Moak, JP; Smith, RT, 1987) |
| "During treatment with phenytoin, the arrhythmia was decreased in all 19 patients and was completely suppressed in 15; the four remaining patients had only uniform VPCs on repeat ambulatory ECG." | 5.26 | Phenytoin therapy for ventricular arrhythmias occurring late after surgery for congenital heart disease. ( Blackman, MS; Kavey, RE; Sondheimer, HM, 1982) |
| "Phenytoin is one of the most well established and most effective antiepileptic medications for the treatment of focal seizures." | 3.83 | Phenytoin toxicity in two-month-old Thai infant with CYP2C9 gene polymorphism--A case report. ( Jaroonvanichkul, V; Netbaramee, W; Phaisarn, P; Uyathanarat, T; Veeravigrom, M, 2016) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "Phenytoin (PHT) is an antiepileptic drug known to have teratogenic effects." | 1.32 | Effect of prenatal phenytoin administration on the fine structure of rat myocardium and aorta. ( Dubovický, M; Guller, L; Mach, M; Okruhlicová, L; Sotníková, R; Tribulová, N; Ujházy, E, 2003) |
| " Embryonic heart rate was also recorded on individual days after dosing days 9-16." | 1.31 | Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. ( Azarbayjani, F; Danielsson, BR, 2001) |
| "Mexiletine therapy was terminated for side effects in only five patients (12%)." | 1.27 | Mexiletine: an effective antiarrhythmic drug for treatment of ventricular arrhythmias in congenital heart disease. ( Garson, A; Moak, JP; Smith, RT, 1987) |
| "During treatment with phenytoin, the arrhythmia was decreased in all 19 patients and was completely suppressed in 15; the four remaining patients had only uniform VPCs on repeat ambulatory ECG." | 1.26 | Phenytoin therapy for ventricular arrhythmias occurring late after surgery for congenital heart disease. ( Blackman, MS; Kavey, RE; Sondheimer, HM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (71.43) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Veeravigrom, M | 1 |
| Jaroonvanichkul, V | 1 |
| Netbaramee, W | 1 |
| Phaisarn, P | 1 |
| Uyathanarat, T | 1 |
| Okruhlicová, L | 1 |
| Ujházy, E | 1 |
| Mach, M | 1 |
| Sotníková, R | 1 |
| Tribulová, N | 1 |
| Guller, L | 1 |
| Dubovický, M | 1 |
| Harned, HS | 1 |
| Mallow, DW | 1 |
| Herrick, MK | 1 |
| Gathman, G | 1 |
| Pai, GS | 1 |
| Bartoshesky, LE | 1 |
| Bhan, I | 1 |
| Nagpaul, K | 1 |
| Pashayan, H | 1 |
| Kavey, RE | 1 |
| Blackman, MS | 1 |
| Sondheimer, HM | 1 |
| Rocchini, AP | 1 |
| Chun, PO | 1 |
| Dick, M | 1 |
| Hartsfield, JK | 1 |
| Holmes, LB | 1 |
| Morel, JG | 1 |
| Azarbayjani, F | 1 |
| Danielsson, BR | 1 |
| Singh, M | 1 |
| Shah, GL | 1 |
| Singh, KP | 1 |
| Annegers, JF | 3 |
| Hauser, WA | 3 |
| Elveback, LR | 3 |
| Anderson, VE | 1 |
| Kurland, LI | 1 |
| Anderson, RC | 1 |
| Kurland, LT | 2 |
| Tanaka, H | 1 |
| Takeda, A | 1 |
| Izumi, M | 1 |
| Okada, H | 1 |
| Ishikawa, S | 1 |
| Clapper, ML | 1 |
| Clark, ME | 1 |
| Klein, NW | 1 |
| Kurtz, PJ | 1 |
| Carlton, BD | 1 |
| Chhabra, RS | 1 |
| Moak, JP | 1 |
| Smith, RT | 1 |
| Garson, A | 1 |
| Shapiro, IuL | 1 |
| Vaĭntrub, MIa | 1 |
| Grinberg, KN | 1 |
| Zhurkov, VS | 1 |
| Viles, PH | 1 |
| Manning, JA | 1 |
| Marshall, CE | 1 |
| Shappell, SD | 1 |
3 reviews available for phenytoin and Abnormality, Heart
| Article | Year |
|---|---|
Cardiovascular problems of the newborn and their etiologies.
Topics: Amphetamines; Animals; Cardiovascular Diseases; Estrogens; Ethanol; Female; Fetal Hypoxia; Heart Def | 1983 |
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
Recent advances in the treatment of congenital heart disease.
Topics: Age Factors; Arrhythmias, Cardiac; Child; Child, Preschool; Chlorothiazide; Diet, Sodium-Restricted; | 1974 |
18 other studies available for phenytoin and Abnormality, Heart
| Article | Year |
|---|---|
Phenytoin toxicity in two-month-old Thai infant with CYP2C9 gene polymorphism--A case report.
Topics: Anal Canal; Anticonvulsants; Cytochrome P-450 CYP2C9; Esophagus; Heart Defects, Congenital; Humans; | 2016 |
Effect of prenatal phenytoin administration on the fine structure of rat myocardium and aorta.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anticonvulsants; Aorta, Thoracic; Female | 2003 |
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E | 1980 |
Cardiac and ophthalmic malformations and in utero exposure to dilantin.
Topics: Abnormalities, Drug-Induced; Child; Eye Abnormalities; Heart Defects, Congenital; Humans; Phenytoin | 1982 |
Severe cardiac and ophthalmologic malformations in an infant exposed to diphenylhydantoin in utero.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Eye Diseases; Female; Heart Defects, Co | 1982 |
Phenytoin therapy for ventricular arrhythmias occurring late after surgery for congenital heart disease.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Child; Heart Defects, Congenital; Heart Ventricles; Humans; | 1982 |
Ventricular tachycardia in children.
Topics: Adolescent; Adult; Child; Child, Preschool; Echocardiography; Electrocardiography; Exercise Test; He | 1981 |
Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice.
Topics: Animals; Anticonvulsants; Body Weight; Drug Interactions; Enzyme Inhibitors; Epoxide Hydrolases; Fem | 1995 |
Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bradycardia; Cleft Palate; Delayed Rectifier | 2001 |
Teratogenic effects of dilantin on thoraco-abdominal organs of developing chick embryos.
Topics: Animals; Anticonvulsants; Chick Embryo; Heart; Heart Defects, Congenital; Kidney; Liver; Phenytoin; | 2000 |
Congenital malformations and seizure disorders in the offspring of parents with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Barbiturates; Child; Child, Preschool; Congenital Ab | 1978 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Cardiovascular defects in rat embryos cultured on serum from rats chronically exposed to phenytoin.
Topics: Animals; Drug Administration Schedule; Ectogenesis; Embryo, Mammalian; Female; Heart; Heart Defects, | 1986 |
Mexiletine: an effective antiarrhythmic drug for treatment of ventricular arrhythmias in congenital heart disease.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Electrocardiography; Heart Defects | 1987 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
Sudden death and the ballooning posterior leaflet syndrome. Detailed anatomic and histochemical investigation.
Topics: Adult; Aorta; Autopsy; Coronary Vessels; Death, Sudden; Electrocardiography; Female; Heart Auscultat | 1974 |