Compounds > phenytoin
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phenytoin and Abnormalities, Multiple

phenytoin has been researched along with Abnormalities, Multiple in 42 studies

Abnormalities, Multiple: Congenital abnormalities that affect more than one organ or body structure.

Research Excerpts

ExcerptRelevanceReference
"An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back."3.72Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism? ( Holmes, LB; Huang, T; Lyon, HM, 2003)
"Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities."3.66Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978)
"A second case of severe limb malformations was observed following maternal use of haloperidol early in the first trimester of pregnancy."3.65Limb malformations following maternal use of haloperidol. ( Heggeness, L; McCullar, FW, 1975)
"Valproic acid is an anticonvulsant that has been associated with open neural tube defects."2.38Valproic acid prenatal exposure. Association with lipomyelomeningocele. ( Carter, BS; Stewart, JM, 1989)
"She had growth retardation, mental deficiency, craniofacial dysmorphism and iris colomobata specific to FHS."1.30Polydactyly and fetal hydantoin syndrome: an additional component of the syndrome? ( Cenani, A; Somay, G; Tüysüz, B; Yalçinkaya, C, 1997)
"The fetal hydantoin syndrome is a variable pattern of altered growth (pre and postnatal), mental deficiency, unusual facies, distal phalangeal hypoplasia, and other defects occurring in some infants exposed in utero to hydantoins."1.26[The fetal hydantoin syndrome (author's transl)]. ( Cabezuelo-Huerta, G; Frontera-Izquierdo, P; Mulas, F, 1981)
"A case is presented of fetal teratogenic damage from an unusually high maternal dosage of diphenylhydantoin, 600 mg daily, to a 40-kg woman throughout pregnancy."1.26Diphenylhydantoin teratogenicity in man. ( Chang, MJ; Chi, CC; Tsai, CJ; Yang, TS, 1978)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199034 (80.95)18.7374
1990's4 (9.52)18.2507
2000's3 (7.14)29.6817
2010's1 (2.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hegde, A1
Kaur, A1
Sood, A1
Dhanorkar, M1
Varma, HT1
Singh, G1
Saini, AG1
Kumar, P1
Murki, S1
Dutta, S1
Mahesha, V1
Harvey, EA2
Coull, BA1
Holmes, LB3
Lyon, HM1
Huang, T1
Chitayat, D1
Keisar, N1
Legum, C1
Silver, L1
Finnell, RH1
Chernoff, GF1
El-Sayed, MG1
Aly, AE1
Kadri, M1
Moustafa, AM1
Krzelj, F1
Rumboldt, Z1
Jurica, A1
Besker, M1
Bartoshesky, LE1
Bhan, I1
Nagpaul, K1
Pashayan, H1
Wilker, R1
Nathenson, G1
Kousseff, BG1
Frontera-Izquierdo, P1
Cabezuelo-Huerta, G1
Mulas, F1
Allen, RW1
Ogden, B1
Bentley, FL1
Jung, AL1
McClain, RM1
Langhoff, L1
Yalçinkaya, C1
Tüysüz, B1
Somay, G1
Cenani, A1
Corcoran, R1
Rizk, MW1
Sherman, S1
Roizen, N1
Pinto, W1
Gardner, LI1
Rosenbaum, P1
Wood, BP1
Young, LW1
Bustamante, SA1
Stumpff, LC1
Yang, TS1
Chi, CC1
Tsai, CJ1
Chang, MJ1
Goodman, RM1
Katznelson, MB1
Hertz, M1
Katznelson, D1
Rotem, Y1
Waziri, M1
Ionasescu, V1
Zellweger, H1
Hirschberger, M1
Kleinberg, F1
Biale, Y1
Lewenthal, H1
Aderet, NB1
McCullar, FW1
Heggeness, L1
Satpathy, R1
Bhuyan, BK1
Das, DB1
Pant, KC1
Sarangi, J1
Pani, S1
Martínez Orgado, J1
García Aparicio, J1
Cabanillas Vilaplana, L1
Sáez Pérez, E1
Carter, BS1
Stewart, JM1
Nanda, A1
Kanwar, A1
Kaur, S1
Strickler, SM1
Dansky, LV1
Miller, MA1
Seni, MH1
Andermann, E1
Spielberg, SP1
Durá, T1
Moya, M1
Muñoz, M1
Juste, M1
Castaño, C1
Trice, JE1
Ambler, M1
Loughnan, PM1
Gold, H1
Vance, JC1
Lewin, PK1
Barry, JE1
Danks, DM1
Ho, NK1
Loo, DS1
Shapiro, IuL1
Vaĭntrub, MIa1
Grinberg, KN1
Zhurkov, VS1
Wu, NF1
Kushnick, T1
Elshove, J1
van Eck, JH1

Reviews

3 reviews available for phenytoin and Abnormalities, Multiple

ArticleYear
[Choreoathetosis induced by diphenylhydantoin in and infant with CHARGE syndrome].
    Anales espanoles de pediatria, 1990, Volume: 33, Issue:4

    Topics: Abnormalities, Multiple; Athetosis; Chorea; Humans; Infant, Newborn; Male; Phenytoin; Seizures; Synd

1990
Valproic acid prenatal exposure. Association with lipomyelomeningocele.
    Clinical pediatrics, 1989, Volume: 28, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Cleft Palate; Female;

1989
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1972, Volume: 72, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent

1972

Other Studies

39 other studies available for phenytoin and Abnormalities, Multiple

ArticleYear
Fetal Hydantoin Syndrome.
    The Journal of pediatrics, 2017, Volume: 188

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Administration, Oral; Epilepsy; Female; Humans

2017
Truncus arteriosus in fetal hydantoin syndrome - a new association?
    Indian pediatrics, 2003, Volume: 40, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Fatal Outcom

2003
Anticonvulsant teratogenesis 5: observer bias in a cohort study.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Boston; Cohort Studies

2003
Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:12

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Female; Gest

2003
[Fetal phenytoin syndrome].
    Harefuah, 1982, Apr-01, Volume: 102, Issue:7

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Brain; Developmental Disabilities; Electroence

1982
Hand abnormalities in the fetal hydantoin syndrome.
    The Journal of hand surgery, 1981, Volume: 6, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Fingers; Humans; Infant; Infant, Newbo

1981
Variable patterns of malformation in the mouse fetal hydantoin syndrome.
    American journal of medical genetics, 1984, Volume: 19, Issue:3

    Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female;

1984
Comparative study on the teratogenicity of some antiepileptics in the rat.
    East African medical journal, 1983, Volume: 60, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Carbamazepine; Ethos

1983
[Teratogenic effects of anticonvulsants with the development of multiple congenital anomalies - report on 3 patients].
    Lijecnicki vjesnik, 1983, Volume: 105, Issue:5

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child, Preschool; Female; Hum

1983
Severe cardiac and ophthalmologic malformations in an infant exposed to diphenylhydantoin in utero.
    Pediatrics, 1982, Volume: 69, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Eye Diseases; Female; Heart Defects, Co

1982
Combined fetal alcohol and hydantoin syndromes.
    Clinical pediatrics, 1982, Volume: 21, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Alcoholism; Epilepsy; Female; Fetal Alc

1982
Subcutaneous vascular abnormalities in fetal hydantoin syndrome.
    Birth defects original article series, 1982, Volume: 18, Issue:3 Pt A

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Blood Vessels; Child, Preschool; Female; Human

1982
[The fetal hydantoin syndrome (author's transl)].
    Anales espanoles de pediatria, 1981, Volume: 14, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Facial Expression; Female; Growth Disorders; H

1981
Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate.
    JAMA, 1980, Sep-26, Volume: 244, Issue:13

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Humans; Hydantoins; Infant,

1980
Teratogenicity of diphenylhydantoin in the New Zealand white rabbit.
    Teratology, 1980, Volume: 21, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Dose-Response Relationship, Drug; Fem

1980
Holoprosencephaly and the teratogenicity of anticonvulsants.
    Teratology, 1994, Volume: 49, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Finge

1994
Polydactyly and fetal hydantoin syndrome: an additional component of the syndrome?
    Clinical genetics, 1997, Volume: 51, Issue:5

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Craniofacial Abnormalities;

1997
VACTERL congenital malformation and phenytoin therapy.
    Lancet (London, England), 1976, Oct-30, Volume: 2, Issue:7992

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Epilepsy; Female; Humans; Infant,

1976
Fetal hydantoin syndrome and neuroblastoma.
    Lancet (London, England), 1976, Sep-04, Volume: 1, Issue:7984

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adrenal Gland Neoplasms; Child, Preschool; Fem

1976
Abnormal genitalia as a presenting sign in two male infants with hydantoin embryopathy syndrome.
    American journal of diseases of children (1960), 1977, Volume: 131, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Epilepsy, Tonic-Clonic; Fem

1977
Pseudohyperphalangism in fetal Dilantin syndrome.
    Radiology, 1979, Volume: 131, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Female; Fetus; Finger

1979
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
    American journal of diseases of children (1960), 1978, Volume: 132, Issue:10

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder

1978
Diphenylhydantoin teratogenicity in man.
    Obstetrics and gynecology, 1978, Volume: 52, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Fingers; Humans; Infant; Infant

1978
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil

1976
Teratogenic effect of anticonvulsant drugs.
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:9

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child,

1976
Maternal phenytoin ingestion and congenital abnormalities: report of a case.
    American journal of diseases of children (1960), 1975, Volume: 129, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anus, Imperforate; Bladder Exstrophy; E

1975
Congenital malformations due to anticonvulsive drugs.
    Obstetrics and gynecology, 1975, Volume: 45, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord

1975
Limb malformations following maternal use of haloperidol.
    JAMA, 1975, Jan-06, Volume: 231, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Therapy, Combination; Female; Fetus; Halo

1975
Foetal hydantoin syndrome.
    Journal of the Indian Medical Association, 1990, Volume: 88, Issue:6

    Topics: Abnormalities, Multiple; Clubfoot; Epilepsy; Facial Bones; Female; Humans; Infant, Newborn; Phenytoi

1990
Fetal hydantoin syndrome?
    Pediatric dermatology, 1989, Volume: 6, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Infant, Newborn; Phenytoin; Pr

1989
Genetic predisposition to phenytoin-induced birth defects.
    Lancet (London, England), 1985, Oct-05, Volume: 2, Issue:8458

    Topics: Abnormalities, Multiple; Child; Epilepsy; Female; Humans; Phenytoin; Pregnancy

1985
[Combination of hydantoins and valproate. Evidence of its teratogenic effect in 4 consecutive gestations].
    Anales espanoles de pediatria, 1986, Volume: 25, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Drug Therapy, Combina

1986
Multiple cerebral defects in an infant exposed in utero to anticonvulsants.
    Archives of pathology & laboratory medicine, 1985, Volume: 109, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Brain; Cerebral Ventricles; E

1985
Phenytoin teratogenicity in man.
    Lancet (London, England), 1973, Jan-13, Volume: 1, Issue:7794

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Dose-Response Relationship, D

1973
Phenytoin-associated congenital defects with Y-chromosome variant.
    Lancet (London, England), 1973, Mar-10, Volume: 1, Issue:7802

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Chromosome Aberrations; Female; Humans;

1973
Letter: Anticonvulsants and congenital abnormalities.
    Lancet (London, England), 1974, Jul-06, Volume: 2, Issue:7871

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fingers; He

1974
Sympodia.
    American journal of diseases of children (1960), 1974, Volume: 128, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile

1974
The Beckwith-Wiedemann syndrome. The exomphalos-macroglossia-gigantism syndrome.
    Clinical pediatrics, 1974, Volume: 13, Issue:5

    Topics: Abnormalities, Multiple; Blood Glucose; Brain Damage, Chronic; Congenital Hypothyroidism; Diagnosis,

1974
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
    Nederlands tijdschrift voor geneeskunde, 1971, Aug-14, Volume: 115, Issue:33

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema

1971