phenytoin has been researched along with Abnormalities, Autosome in 30 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients receiving phenytoin (PHT) may develop pseudolymphoma or, rare ly, malignant lymphoma." | 7.69 | Phenytoin-induced pseudolymphoma: reevaluation using modern molecular biology techniques. ( Jeng, YM; Su, IJ; Tien, HF, 1996) |
| "Patients receiving phenytoin (PHT) may develop pseudolymphoma or, rare ly, malignant lymphoma." | 3.69 | Phenytoin-induced pseudolymphoma: reevaluation using modern molecular biology techniques. ( Jeng, YM; Su, IJ; Tien, HF, 1996) |
| " Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE." | 3.69 | Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. ( Diomedi, M; Gigli, GL; Masala, C; Placidi, F; Pomponi, MG; Scalise, A; Silvestri, G, 1996) |
| "Chromosome studies were carried out on the peripheral blood of 26 epilepsy patients treated with phenobarbital and/or diphenylhydantoin, on ten healthy controls and on eight untreated epileptic controls." | 3.67 | Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin. ( Ambani, LM; Kulkarni, PS; Mondkar, VP; Sonawalla, AB, 1984) |
| " The treatment of status epilepticus with intravenous phenytoin is effective." | 3.66 | Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979) |
| "Phenytoin has probably mutagenic potential effect on human sperm cells." | 1.31 | [Effects of phenytoin on structural aberration of human sperm chromosomes in vitro]. ( Cui, X; Gao, X; Li, D; Meng, H; Wang, X; Wang, Z; Zhang, F, 2001) |
| "The rate of chromosomal aberrations induced by the 3 anticonvulsants was significantly increased from the first concentration analyzed, similar to half the therapeutic serum concentration." | 1.27 | Effect of anticonvulsants on human chromosomes. 2. In vitro studies. ( García Sagredo, JM, 1988) |
| " The long-term administration of anticonvulsant drugs was monitored by measurement of the serum concentrations of phenytoin and primidone, by seizure anamnesis, and by repeated EEG investigations." | 1.26 | Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone. ( Esser, KJ; Habedank, M; Kotlarek, F; Mühler, E; Mühler, U, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (80.00) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 2 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, UN | 3 |
| Rao, KP | 3 |
| Beckman, DA | 1 |
| Brent, RL | 1 |
| Riedel, L | 1 |
| Obe, G | 2 |
| Kulkarni, PS | 1 |
| Mondkar, VP | 1 |
| Sonawalla, AB | 1 |
| Ambani, LM | 1 |
| Ramadevi, G | 2 |
| Rao, MS | 2 |
| Nakane, Y | 1 |
| Esser, KJ | 1 |
| Kotlarek, F | 1 |
| Habedank, M | 1 |
| Mühler, U | 1 |
| Mühler, E | 1 |
| Jeng, YM | 1 |
| Tien, HF | 1 |
| Su, IJ | 1 |
| Gigli, GL | 1 |
| Scalise, A | 1 |
| Silvestri, G | 1 |
| Diomedi, M | 1 |
| Placidi, F | 1 |
| Pomponi, MG | 1 |
| Masala, C | 1 |
| Meng, H | 1 |
| Zhang, F | 1 |
| Gao, X | 1 |
| Wang, X | 1 |
| Li, D | 1 |
| Cui, X | 1 |
| Wang, Z | 1 |
| Knuutila, S | 1 |
| Siimes, M | 1 |
| Simell, O | 1 |
| Tammisto, P | 1 |
| Weber, T | 1 |
| Bruni, J | 1 |
| Willmore, LJ | 1 |
| Rodríguez Rivera, L | 1 |
| Flores García, R | 1 |
| Gutiérrez Calzado, C | 1 |
| Betancourt Rovira, A | 1 |
| Sánchez Castillo, A | 1 |
| Gebhart, E | 1 |
| Alving, J | 1 |
| Krogh Jensen, M | 1 |
| Meyer, H | 1 |
| Herha, J | 1 |
| Bishun, NP | 1 |
| Smith, NS | 1 |
| Williams, DC | 1 |
| Kindig, D | 1 |
| Garriott, ML | 1 |
| Parton, JW | 1 |
| Brunny, JD | 1 |
| Beyers, JE | 1 |
| McFee, AF | 1 |
| Tice, RR | 1 |
| Shelby, MD | 1 |
| Krieg, T | 1 |
| Schurig, V | 1 |
| Braun-Falco, O | 1 |
| García Sagredo, JM | 1 |
| De Oliveira, AR | 1 |
| Machado-Santelli, GM | 1 |
| Maurya, AK | 1 |
| Goyle, S | 1 |
| Lewin, PK | 1 |
| Shapiro, IuL | 1 |
| Vaĭntrub, MIa | 1 |
| Grinberg, KN | 1 |
| Zhurkov, VS | 1 |
| Zellweger, H | 1 |
| Roman, IC | 1 |
| Caratzali, A | 1 |
| Stenchever, MA | 1 |
| Jarvis, JA | 1 |
| Ortiz-Neu, C | 1 |
| LeRoy, EC | 1 |
3 reviews available for phenytoin and Abnormalities, Autosome
| Article | Year |
|---|---|
Mechanisms of teratogenesis.
Topics: Aminopterin; Androgens; Animals; Antithyroid Agents; Chromosome Aberrations; Coumarins; Diethylstilb | 1984 |
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
Anticonvulsants during pregnancy: a danger to the developing fetus?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome | 1974 |
1 trial available for phenytoin and Abnormalities, Autosome
| Article | Year |
|---|---|
Long-term use of phenytoin: effects on bone-marrow chromosomes in man.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Child; Child, Preschool; Chromosome Aberrations; | 1977 |
26 other studies available for phenytoin and Abnormalities, Autosome
| Article | Year |
|---|---|
Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice.
Topics: Alprostadil; Animals; Benzo(a)pyrene; Bone Marrow Cells; Chromosome Aberrations; Erythroblasts; Gamm | 2006 |
Mutagenicity of antiepileptic drugs. II. Phenytoin, primidone and phenobarbital.
Topics: Animals; Biotransformation; Cells, Cultured; Chromosome Aberrations; Cricetinae; Female; Mutation; O | 1984 |
Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin.
Topics: Adult; Animals; Chromosome Aberrations; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; M | 1984 |
Prostaglandins and mutagenesis: modification of phenytoin induced genetic damage by prostaglandins in lymphocyte cultures.
Topics: Cells, Cultured; Chromosome Aberrations; Humans; Lymphocytes; Mutation; Phenytoin; Prostaglandins | 1984 |
The teratological problem of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Anticonvulsants; Chromosome Aberrations; Cleft Lip; Cle | 1980 |
Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone.
Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; Ep | 1981 |
Phenytoin-induced pseudolymphoma: reevaluation using modern molecular biology techniques.
Topics: Adolescent; Biopsy; Blotting, Southern; Chromosome Aberrations; Diagnosis, Differential; Epilepsy, T | 1996 |
Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1996 |
[Effects of phenytoin on structural aberration of human sperm chromosomes in vitro].
Topics: Adult; Anticonvulsants; Chromosome Aberrations; Chromosomes, Human; Humans; Karyotyping; Male; Pheny | 2001 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C | 1979 |
[Chromosomal in study patients treated with anticonvulsant drugs].
Topics: Adolescent; Adult; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human | 1977 |
[Problems of mutagenic side effects of psychotropic substances. 1. Psychotropic drugs, narcotics, anticonvulsants].
Topics: Animals; Anticonvulsants; Barbiturates; Chromosome Aberrations; Humans; Hypnotics and Sedatives; Lym | 1979 |
Diphenylhydantoin and chromosome morphology in man and rat. A negative report.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chromosome Aberrations; Chromosomes; Human | 1976 |
Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.
Topics: Adolescent; Adult; Carbamazepine; Chromosome Aberrations; Chromosomes; Epilepsy; Female; Humans; Mal | 1976 |
Chromosomes and anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cells, Cultured; Chromatids; Chromosome Aberrations; C | 1975 |
Diphenylhydantoin is not genotoxic in a battery of short-term cytogenetic assays.
Topics: Animals; Biotransformation; CHO Cells; Chromosome Aberrations; Cricetinae; Female; Liver; Male; Mate | 1992 |
In vivo cytogenetic activity of diphenylhydantoin in mice.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Dose-Response Relationship, Drug; Erythrocytes; Male; | 1992 |
Prostaglandins can modify gamma-radiation and chemical induced cytotoxicity and genetic damage in vitro and in vivo.
Topics: Alprostadil; Animals; Benzo(a)pyrene; Bone Marrow; Chromosome Aberrations; Dinoprost; Dinoprostone; | 1989 |
[Hereditary bullous epidermolyses. Recent aspects of diagnosis and therapy].
Topics: Antibodies, Monoclonal; Antibody Specificity; Autoantigens; Basement Membrane; Carrier Proteins; Chr | 1986 |
Effect of anticonvulsants on human chromosomes. 2. In vitro studies.
Topics: Anticonvulsants; Chromosome Aberrations; Chromosomes, Human; Ethosuximide; Humans; In Vitro Techniqu | 1988 |
Diphenylhydantoin and mitotic spindle abnormalities in cultured mouse and human cells.
Topics: Aneuploidy; Animals; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Huma | 1987 |
Mutagenic potential of anticonvulsant diphyenylhydantoin (DPH) on human lymphocytes in vitro.
Topics: Cells, Cultured; Chromosome Aberrations; Female; Humans; Lymphocytes; Mutagens; Phenytoin; Sister Ch | 1985 |
Phenytoin-associated congenital defects with Y-chromosome variant.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Chromosome Aberrations; Female; Humans; | 1973 |
Effects of anticonvulsant drugs on chromosomes.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Embryo, Mammalian; Female; Fertilit | 1971 |
Diphenylhydantoin: effect on the chromosomes of human leukocytes.
Topics: Abnormalities, Drug-Induced; Adult; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cultu | 1971 |
The coincidence of Klinefelter's syndrome and systemic lupus erythematosus.
Topics: Adult; Anemia, Hemolytic; Autoimmune Diseases; Chromosome Aberrations; Chromosome Disorders; Gonadal | 1969 |