phenytoin and Abdominal Epilepsy studies

Research Excerpts

Excerpt	Relevance	Reference
"To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy."	9.08	Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998)
"A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described."	9.05	A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. ( Engler, C; English, JR; Fry, DE; Gawel, MJ; Gibberd, FB; Page, NG; Park, DM; Rose, FC; Scott, G, 1982)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures."	8.98	Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018)
"To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)."	8.93	Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures."	8.90	Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014)
"To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types."	8.89	Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013)
"To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types."	8.89	Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013)
"To review the best evidence comparing oxcarbazepine and phenytoin when used as monotherapy in patients with epilepsy."	8.83	Oxcarbazepine versus phenytoin monotherapy for epilepsy. ( Marson, AG; Muller, M; Williamson, PR, 2006)
"To review the effects of phenobarbitone compared to phenytoin when used as monotherapy in patients with partial onset seizures or generalized tonic-clonic seizures with or without other generalized seizure types."	8.81	Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Taylor, S; Tudur Smith, C; Williamson, PR, 2001)
"To review the best evidence comparing phenytoin and valproate when used as monotherapy in subjects with partial onset seizures, or generalized onset tonic-clonic seizures with or without other generalized seizure types."	8.81	Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Tudur Smith, C; Williamson, PR, 2001)
"To evaluate whether the occurrence or severity of gingival hyperplasia is associated with liver function test results or phenytoin metabolism."	7.74	Association of galactose single-point test levels and phenytoin metabolic polymorphisms with gingival hyperplasia in patients receiving long-term phenytoin therapy. ( Hsiong, CH; Hu, OY; Hung, CC; Lin, CJ; Lin, MS; Liou, HH; Yen, MF, 2008)
"INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH)."	7.69	A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report. ( Tigaran, S, 1994)
"Nine cases of childhood epilepsy manifesting motor convulsions uncontrolled despite high levels of phenytoin (PHT) were studied clinically and electroencephalographically."	7.66	Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study. ( Iinuma, K; Onuma, A; Tada, K; Takamatsu, N, 1979)
"Twenty-two patients with partial status epilepticus were treated with phenytoin (DPH) intravenously (mean daily dose: 18,6 +/- 7,3 mg/kg)."	7.66	[Use of intravenous phenytoin in treatment of partial status epilepticus (author's transl)]. ( Chauplannaz, G; Courjon, J; Ferry, S; Mauguière, F, 1981)
" Dosing of phenytoin remains a challenge for all clinicians which increase the need for such reports."	5.62	Phenytoin-Induced Paradoxical Seizures and Blood Dyscrasias in a Patient Receiving Rapid Intravenous Infusion: A Case Report. ( Radhakrishnan, A; Sudarsan, P; Suresh, A; Varghese, R, 2021)
"Adenosine is an inhibitor of neuronal activity in the brain."	5.31	Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. ( Aebischer, P; Boison, D; Déglon, N; Huber, A; Möhler, H; Padrun, V, 2001)
"Phenytoin has been considered a possible cause of cerebellar degeneration, especially after clinical intoxication."	5.29	[Cerebellar atrophy and phenytoin poisoning. An MR study]. ( Aichner, F; Bauer, G; Birbamer, G; Felber, S; Luef, G; Marosi, M, 1993)
"To compare the effectiveness of monotherapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy."	5.08	Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. ( , 1998)
"A group of 51 patients with chronic cryptogenic or symptomatic localized epilepsy refractory to therapy with barbiturates underwent progressive substitution with phenytoin or carbamazepine, in standardized and randomized fashion."	5.07	Carbamazepine and phenytoin in epilepsies refractory to barbiturates: efficacy, toxicity and mental function. ( Antoniuk, SA; Bigarella, MM; Bittencourt, PR; da Costa, JC; Doro, MP; Ferreira, AS; Fonseca, LC; Gonçalves e Silva, GE; Gorz, AM; Marcourakis, T, 1993)
" All the patients had epilepsy that had previously been untreated, and had been randomly assigned to receive carbamazepine, phenytoin, or sodium valproate."	5.06	Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study. ( Callaghan, N; Garrett, A; Goggin, T, 1988)
"A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described."	5.05	A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. ( Engler, C; English, JR; Fry, DE; Gawel, MJ; Gibberd, FB; Page, NG; Park, DM; Rose, FC; Scott, G, 1982)
"Eighty-eight patients with the onset of epilepsy in adult life were randomly allocated to treatment with sodium valproate (600 mg/day), or phenytoin (300 mg/day), and followed up for at least 12 months."	5.05	A comparison of phenytoin and valproate in previously untreated adult epileptic patients. ( Chadwick, DW; Rawlins, MD; Turnbull, DM; Weightman, D, 1982)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset focal or generalized seizures."	4.98	Clobazam monotherapy for focal or generalized seizures. ( Anand, V; Arya, R; Garg, SK; Giridharan, N, 2018)
"To review the time to treatment failure, remission and first seizure of sodium valproate compared to phenytoin when used as monotherapy in people with focal onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)."	4.98	Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C; Weston, J, 2018)
"To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)."	4.93	Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016)
"To evaluate the efficacy, effectiveness, tolerability and safety of clobazam as monotherapy in people with new-onset partial or generalized seizures."	4.90	Clobazam monotherapy for partial-onset or generalized-onset seizures. ( Anand, V; Arya, R; Garg, SK; Michael, BD, 2014)
"To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types."	4.89	Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013)
"To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types."	4.89	Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."	4.87	Epilepsy (partial). ( Maguire, M; Marson, AG; Ramaratnam, S, 2011)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."	4.86	Epilepsy (partial). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010)
"To review the best evidence comparing oxcarbazepine and phenytoin when used as monotherapy in patients with epilepsy."	4.83	Oxcarbazepine versus phenytoin monotherapy for epilepsy. ( Marson, AG; Muller, M; Williamson, PR, 2006)
"To review the best evidence comparing phenytoin and valproate when used as monotherapy in subjects with partial onset seizures, or generalized onset tonic-clonic seizures with or without other generalized seizure types."	4.81	Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Tudur Smith, C; Williamson, PR, 2001)
"To review the effects of phenobarbitone compared to phenytoin when used as monotherapy in patients with partial onset seizures or generalized tonic-clonic seizures with or without other generalized seizure types."	4.81	Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Taylor, S; Tudur Smith, C; Williamson, PR, 2001)
"We present the case of a 77 year old man who had been treated for twenty years with phenytoin for partial crises secondary to a left frontal hematoma."	4.80	[Acute phenytoin poisoning secondary to an interaction with ticlopidine]. ( López-Ariztegui, N; Martín, M; Nevado, C; Ochoà, M; Sánchez-Migallón, MJ, 1998)
"To evaluate whether the occurrence or severity of gingival hyperplasia is associated with liver function test results or phenytoin metabolism."	3.74	Association of galactose single-point test levels and phenytoin metabolic polymorphisms with gingival hyperplasia in patients receiving long-term phenytoin therapy. ( Hsiong, CH; Hu, OY; Hung, CC; Lin, CJ; Lin, MS; Liou, HH; Yen, MF, 2008)
"From 100 consecutive epilepsy patients we selected those with phenytoin use for more than 2 months and with MRI scan available for volumetric studies."	3.72	Cerebellar volume and long-term use of phenytoin. ( Cendes, F; De Marcos, FA; Ghizoni, E; Kobayashi, E; Li, LM, 2003)
" The second patient complained of impotence after a rash while taking phenytoin and carbamazepine."	3.70	Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000)
"INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH)."	3.69	A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report. ( Tigaran, S, 1994)
"39 adult patients with intractable epilepsy were successfully treated with high-dose monotherapy, using carbamazepine or phenytoin."	3.68	[High-dose monotherapy in intractable epilepsy]. ( Peng, SM; Wu, JZ, 1990)
"Twenty-two patients with partial status epilepticus were treated with phenytoin (DPH) intravenously (mean daily dose: 18,6 +/- 7,3 mg/kg)."	3.66	[Use of intravenous phenytoin in treatment of partial status epilepticus (author's transl)]. ( Chauplannaz, G; Courjon, J; Ferry, S; Mauguière, F, 1981)
"Nine cases of childhood epilepsy manifesting motor convulsions uncontrolled despite high levels of phenytoin (PHT) were studied clinically and electroencephalographically."	3.66	Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study. ( Iinuma, K; Onuma, A; Tada, K; Takamatsu, N, 1979)
"The case of a 19-year-old patient is reported who during treatment with phenytoin (5,5-dephenylhydantoin) developed a Stevens-Johnson syndrome."	3.65	[Stevens-Johnson syndrome as an early allergic reaction to diphenylhydantoin]. ( Marg, E, 1976)
"Phenytoin is a prototypic drug prescribed for the treatment of a variety of seizure disorders."	3.01	Cutaneous Hypersensitivity Reaction After Phenytoin Therapy in a Neonate: A Case Report and Review of Literature Elucidating the Potential Pharmacological Plausibility and Preventive Strategies. ( Prabath, I; Rajendran, P; Rani, J, 2023)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."	2.82	Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Cividini, S; Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C, 2022)
"Gabapentin was started at 400 mg/day and was individually titrated to effective tolerable dose up to 2400 mg/day."	2.69	Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice. ( Bruni, J, 1998)
"Carbamazepine or phenytoin was withdrawn over the next 4 weeks; then patients entered a 12-week monotherapy period."	2.69	An active-control trial of lamotrigine monotherapy for partial seizures. ( Chang, GY; Gilliam, F; Messenheimer, J; Nyberg, J; Risner, ME; Rudd, GD; Sackellares, JC; Vazquez, B, 1998)
"The gabapentin dosage was titrated to effective tolerated dose up to 2400 mg/day."	2.69	Gabapentin as adjunctive therapy for partial seizures. ( Bruni, J, 1999)
" After 1-month observation, the patients entered a 7-month treatment period that involved administration of placebo for 1 month followed by VGB at the initial dosage of 40 mg/kg/day, to be increased to 60 and 80 mg/kg/day at 2-month intervals if seizures persisted."	2.68	Efficacy and tolerability of vigabatrin in children with refractory partial seizures: a single-blind dose-increasing study. ( Buti, D; Cianchetti, C; Dalla Bernardina, B; Fontana, E; Fusco, L; Galeone, D; Gnanasakthy, A; Iudice, A; Torelli, D; Vigevano, F, 1995)
"A 62-year-old woman, who frequently had numbness seizures in the right half of her body, is reported."	2.67	Pure sensory seizures. ( Fukunishi, I; Hosokawa, K; Kohira, I; Kugoh, T; Okudaira, A; Yamamoto, M, 1993)
"Felbamate was statistically superior to placebo in seizure reduction, percent seizure reduction, and truncated percent seizure reduction."	2.67	Felbamate for partial seizures: results of a controlled clinical trial. ( Bertram, E; Cereghino, JJ; Dreifuss, FE; Drury, I; Graves, NM; Jacobs, MP; Leppik, IE; Pledger, GW; Santilli, N; Tsay, JY, 1991)
"Ninety four patients of generalised and partial epilepsy were randomly assigned to treatment with sodium valproate (49 cases) or phenytoin (45 cases)."	2.67	Comparison of sodium valproate and phenytoin as single drug treatment in generalised and partial epilepsy. ( Agarwala, RK; Mehrotra, TN; Rastogi, P; Singh, VS, 1991)
"Decreased libido and impotence were more common in patients given primidone."	2.66	Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. ( Browne, TR; Collins, JF; Cramer, JA; Delgado-Escueta, AV; Mattson, RH; McCutchen, CB; McNamara, JO; Smith, DB; Treiman, DM; Williamson, PD, 1985)
"Carbamazepine was compared with phenytoin in a double-blind study."	2.65	A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults. ( Berger, JR; Bruni, J; Ramsay, RE; Wilder, BJ, 1983)
"Carbamazepine is a current first-line treatment for partial onset seizures in the USA and Europe."	2.55	Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C; Weston, J, 2017)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."	2.55	Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."	2.55	Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
"Carbamazepine is a current first line treatment for partial onset seizures in the USA and Europe."	2.52	Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2015)
"We review the various forms of partial epilepsy that appear in childhood and adolescence, emphasizing the most common forms."	2.39	[The diagnosis and treatment of partial epilepsy in childhood and adolescence]. ( Martínez Bermejo, Z; Pascual-Castroviejo, I, 1996)
"Neocortical focal seizures are characterized by motor jerks in one limb (Jacksonian type), head turning (adversive attack), or localized sensory manifestations, and limbic or psychomotor attacks by brief impairment of consciousness and often by motor automatisms."	2.37	[Therapy of brain-related minor seizures]. ( Hess, CW, 1988)
" The latter must be compensated for by planned dosage increases to maintain therapeutic plasma steady-state levels during the first 2 or 3 months of treatment."	2.37	Carbamazepine efficacy in adults with partial and generalized tonic-clonic seizures. ( Rangel, R; Wilder, BJ, 1987)
"Valproic acid is a new antiepileptic drug."	2.36	Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979)
"Drug treatment of status epilepticus is reviewed."	2.36	Drug therapy reviews: drug therapy of status epilepticus. ( Browne, TR, 1978)
" Dosing of phenytoin remains a challenge for all clinicians which increase the need for such reports."	1.62	Phenytoin-Induced Paradoxical Seizures and Blood Dyscrasias in a Patient Receiving Rapid Intravenous Infusion: A Case Report. ( Radhakrishnan, A; Sudarsan, P; Suresh, A; Varghese, R, 2021)
"Perampanel (PER) is a new antiepileptic drug (AED) with a novel mechanism of action."	1.51	Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. ( Ishikawa, N; Kobayashi, M; Kobayashi, Y; Tani, H; Tateishi, Y, 2019)
"Topiramate was more likely prescribed for those with comorbid headache or migraine (incident: 335 of 1251 [26."	1.51	Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. ( Faught, E; Fishman, J; Kalilani, L; Kim, H; Thurman, DJ, 2019)
"Among those with Idiopathic Generalized Epilepsy (46%), generalized tonic clonic seizure was encountered in 74% and absence seizure was observed in 13%."	1.39	Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital. ( Chowdhury, AH; Chowdhury, RN; Ghose, SK; Habib, M; Haque, B; Hasan, AT; Hoque, A; Khan, SU; Mohammad, QD; Mondal, BA; Rahman, KM, 2013)
"Epilepsy was confirmed in 58 cases."	1.37	[Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011)
" The observed cerebellar ataxia might be due to long-term administration of phenytoin."	1.35	[Case of juvenile myoclonic epilepsy misdiagnosed as simple partial seizure for more than 60 years]. ( Komori, T; Mizoi, Y; Shimazu, K; Sumita, N; Tamura, N; Yamamoto, T, 2009)
"Chronic focal epilepsy was induced by injecting 25-50 ng of tetanus toxin or vehicle alone (controls) into the motor neocortex of rats."	1.33	Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat. ( Cock, HR; Nilsen, KE; Walker, MC, 2005)
"We report a case of a patient with presyncope and prosthetic mitral valve dysfunction with intermittent flow obstruction."	1.33	[Mitral prosthetic valve and presyncope]. ( Aguilera Saborido, A; Arana Rueda, E; Florián Sanz, F; Gómez Navarro, C; López Pardo, F; Nevado Portero, J, 2005)
" Likewise, PGB steady-state pharmacokinetic parameter values were similar among patients receiving CBZ, PHT, LTG, or VPA and, in general, were similar to those observed historically in healthy subjects receiving PGB alone."	1.33	Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy. ( Alvey, CW; Bockbrader, HN; Brodie, MJ; Bron, NJ; Gibson, GL; Hounslow, NJ; Posvar, EL; Randinitis, EJ; Wesche, DL; Wilson, EA, 2005)
"Adenosine is an inhibitor of neuronal activity in the brain."	1.31	Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. ( Aebischer, P; Boison, D; Déglon, N; Huber, A; Möhler, H; Padrun, V, 2001)
"Epilepsy is a relatively common problem in children, adults and the elderly."	1.30	Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998)
" Pharmacokinetic data and occurrence of AE were compared between the two groups at the time of the single-dose kinetic study, at the completion of the switchover to CBZ, and 4 weeks after discontinuation of the previous AED."	1.30	Rapid switchover to carbamazepine using pharmacokinetic parameters. ( Bourgeois, BF; Hasegawa, H; Hutson, P; Kanner, AM, 1998)
"Idiopathic generalized epilepsy (IGE) was diagnosed in 12 cases and partial epilepsy (PE) in 23 cases."	1.29	Sex hormones, gonadotropins and prolactin in male epileptic subjects in remission: role of the epileptic syndrome and of antiepileptic drugs. ( Costelli, P; Fonzi, S; Galimberti, CA; Manni, R; Murialdo, G; Parodi, C; Polleri, A; Solinas, GP; Tartara, A; Torre, F, 1994)
"Treatment of phenytoin responders and nonresponders with other primary antiepileptic drugs showed that valproate and phenobarbital induced much smaller increases in focal seizure threshold in phenytoin nonresponders than in responders, whereas carbamazepine induced about the same threshold increase in both groups."	1.29	Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy. ( Hönack, D; Löscher, W; Rundfeldt, C, 1993)
"Authors report about a boy with Rasmussen syndrome."	1.29	[Rasmussen syndrome]. ( Lombay, B; Velkey, I, 1993)
"Phenytoin has been considered a possible cause of cerebellar degeneration, especially after clinical intoxication."	1.29	[Cerebellar atrophy and phenytoin poisoning. An MR study]. ( Aichner, F; Bauer, G; Birbamer, G; Felber, S; Luef, G; Marosi, M, 1993)
"Carbamazepine has no effect on the EEG, in epilepsies with atypical course (atypical benign partial epilepsy, Landau-Kleffner syndrome, epilepsy with continuous spikes and waves during slow sleep [CSWS]) carbamazepine usually has no effect either on the seizures or on the EEG, on the contrary, in some cases both may even get worse."	1.29	Treatment of "benign" partial epilepsies of childhood, including atypical forms. ( Gross-Selbeck, G, 1995)
"We report an additional patient with cardiac arrest during a mesiobasal left temporal lobe seizure discharge."	1.28	Cardiac arrest due to partial epileptic seizures. ( Gudjonsson, O; Liedholm, LJ, 1992)
" Its pharmacokinetic features and optimal dosage show great individual variability, larger than that of other drugs and, in cases of combined drug regimens, interactions may more frequently be expected."	1.28	Place of phenytoin in treatment of resistant epilepsy. ( Rajna, P; Veres, J; Vitray, J, 1991)
"Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety."	1.27	Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983)
"Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given."	1.27	[Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983)
"The optimal dosage of phenytoin can be accurately determined by a pharmacokinetic method."	1.26	Rapid metabolism of phenytoin: a method of calculating proper dosage. ( Allen, JP; Hawkins, DW; Hoffman, SF; Ludden, TM, 1979)
"Carbamazepine levels were also slightly greater in white matter."	1.26	Distribution of anticonvulsant drugs in gray and white matter of human brain. ( Harvey, CD; Sherwin, AL; Van Der Kleijn, E, 1977)
"Analysis of the recurrence of seizures suggested that the first year of treatment may be crucial in determining the long-term prognosis."	1.26	Early prognosis of epilepsy. ( Reynolds, EH; Shorvon, SD, 1982)
" The dosage received by this group was from 4."	1.26	Plasma levels of diphenylhydantoin and the control of adult epileptic seizures: a Chilean experience. ( Aguilera, LI; Concha, GL; Droguett, PA; Galdames, DG; Morales, ER; Ortiz, MA; Saavedra, IN; Valenzuela, AL, 1980)
" (3) Use of well-standardized, yet simplified, mental performance tests in combination with changes in the dosage of medication can help in reaching a compromise between acceptable seizure control and avoidance of excessive slowing of mental activity."	1.25	Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. ( Dekaban, AS; Lehman, EJ, 1975)
"Benign focal epilepsy of childhood is an entity that includes characteristic clinical and electroencephalographic manifestations."	1.25	Benign focal epilepsy of childhood. A follow-up study of 100 recovered patients. ( Kivity, S; Lerman, P, 1975)
"Glycine content was markedly elevated in two of 16 epileptogenic foci."	1.25	Amino acids in human epileptogenic foci. ( Hansen, S; Kennedy, J; Perry, TL; Thompson, GB; Wada, JA, 1975)

Research

Studies (202)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

Timeframe	Studies, this research(%)	All Research%
pre-1990	100 (49.50)	18.7374
1990's	50 (24.75)	18.2507
2000's	24 (11.88)	29.6817
2010's	25 (12.38)	24.3611
2020's	3 (1.49)	2.80

Authors	Studies
Nevitt, SJ	6
Sudell, M	3
Cividini, S	1
Marson, AG	16
Tudur Smith, C	13
Rajendran, P	1
Prabath, I	1
Rani, J	1
Sudarsan, P	1
Varghese, R	1
Suresh, A	1
Radhakrishnan, A	1
Weston, J	6
Arya, R	2
Giridharan, N	1
Anand, V	2
Garg, SK	2
Ishikawa, N	1
Tateishi, Y	1
Tani, H	1
Kobayashi, Y	1
Kobayashi, M	1
Kim, H	1
Faught, E	1
Thurman, DJ	1
Fishman, J	1
Kalilani, L	1
Nolan, SJ	5
Pulman, J	2
Rubio-Nazabal, E	1
Alvarez-Pérez, P	1
Lema-Facal, T	1
López-Facal, S	1
Muller, M	2
Tanaka, S	1
Tanaka, T	1
Habib, M	1
Khan, SU	1
Hoque, A	1
Mondal, BA	1
Hasan, AT	1
Chowdhury, RN	1
Haque, B	1
Rahman, KM	1
Chowdhury, AH	1
Ghose, SK	1
Mohammad, QD	1
Michael, BD	1
Janszky, J	1
Horvath, R	1
Komoly, S	1
Mintzer, S	2
Miller, R	1
Shah, K	1
Chervoneva, I	1
Nei, M	1
Skidmore, C	1
Sperling, MR	1
Mizoi, Y	1
Sumita, N	1
Yamamoto, T	1
Komori, T	1
Tamura, N	1
Shimazu, K	1
Bernášková, K	1
Mareš, P	3
Mattson, RT	1
Maguire, M	2
Ramaratnam, S	2
Kotov, AS	1
Rudakova, IG	1
Baulac, S	1
Ishida, S	1
Mashimo, T	1
Boillot, M	1
Fumoto, N	1
Kuwamura, M	1
Ohno, Y	1
Takizawa, A	1
Aoto, T	1
Ueda, M	1
Ikeda, A	2
LeGuern, E	1
Takahashi, R	1
Serikawa, T	1
Fernández-de Orueta, L	1
Esteban-Fernández, J	1
Aichner, HF	1
Casillas-Villamor, A	1
Rodríguez-Álvarez, S	1
De Marcos, FA	1
Ghizoni, E	1
Kobayashi, E	1
Li, LM	1
Cendes, F	1
PRESTON, DN	1
ATACK, EA	1
Cramer, JA	3
Hammer, AE	1
Kustra, RP	1
Herzog, AG	2
Drislane, FW	2
Schomer, DL	2
Pennell, PB	2
Bromfield, EB	2
Kelly, KM	1
Farina, EL	2
Frye, CA	2
Margari, L	1
Lucia, M	1
Presicci, A	1
Anna, P	1
Ventura, P	1
Patrizia, V	1
Buttiglione, M	1
Maura, B	1
Andreula, C	1
Cosma, A	1
Perniola, T	1
Tommaso, P	1
Nilsen, KE	1
Walker, MC	1
Cock, HR	1
Arana Rueda, E	1
Florián Sanz, F	1
Gómez Navarro, C	1
Nevado Portero, J	1
Aguilera Saborido, A	1
López Pardo, F	1
Brodie, MJ	2
Wilson, EA	1
Wesche, DL	1
Alvey, CW	1
Randinitis, EJ	1
Posvar, EL	1
Hounslow, NJ	1
Bron, NJ	1
Gibson, GL	1
Bockbrader, HN	1
Williamson, PR	3
Itomi, S	1
Okumura, A	2
Ikuta, T	2
Negoro, T	2
Watanabe, K	2
Dworetzky, BA	1
Gilbert, TH	1
Teskey, GC	1
Tsuge, I	1
Kubota, T	1
Kurahashi, H	1
Natsume, J	1
Lin, CJ	1
Yen, MF	1
Hu, OY	1
Lin, MS	1
Hsiong, CH	1
Hung, CC	1
Liou, HH	1
Wilensky, AJ	3
Ojemann, LM	3
Temkin, NR	1
Troupin, AS	2
Dodrill, CB	2
Strejcková, A	1
Maresová, D	1
Smejkalová, V	1
Rowan, AJ	1
Ramsay, RE	1
Wilder, BJ	3
Berger, JR	1
Bruni, J	4
Friel, PN	1
Almes, MJ	1
Levy, RH	2
Dreifuss, FE	2
McGowan, ME	1
Hinge, HH	1
Schmidt, D	1
Turnbull, DM	3
Rawlins, MD	3
Weightman, D	2
Chadwick, DW	3
Palm, R	1
Silseth, C	1
Alván, G	1
Wolf, P	1
Röder-Wanner, UU	1
Brede, M	1
D'Alessandro, R	1
Cortelli, P	1
Gallassi, R	1
Ghisoli, E	1
Montanaro, N	1
Zoni, E	1
Baruzzi, A	1
Pratt, JA	1
Jenner, P	1
Johnson, AL	4
Shorvon, SD	3
Reynolds, EH	5
Mauguière, F	2
Fischer, C	1
Ferry, S	2
Courjon, J	2
Davies, SM	1
Rothner, AD	1
Erenberg, G	1
Galdames, DG	1
Saavedra, IN	1
Ortiz, MA	1
Aguilera, LI	1
Valenzuela, AL	1
Concha, GL	1
Droguett, PA	1
Morales, ER	1
Chauplannaz, G	1
Petrone, F	1
Cavalcanti, S	1
Turchiaro, GG	1
Rolando, G	1
Browne, TR	3
Habedank, M	1
Esser, KJ	1
Brüll, D	1
Kotlarek, F	1
Stumpf, C	1
Gibberd, FB	3
Park, DM	1
Scott, G	1
Gawel, MJ	1
Fry, DE	1
Page, NG	1
Engler, C	1
English, JR	1
Rose, FC	1
Dalla Bernardina, B	1
Fontana, E	1
Vigevano, F	1
Fusco, L	1
Torelli, D	1
Galeone, D	1
Buti, D	1
Cianchetti, C	1
Gnanasakthy, A	1
Iudice, A	1
Gross-Selbeck, G	1
Heller, AJ	1
Chesterman, P	1
Elwes, RD	1
Crawford, P	1
Chadwick, D	1
Tigaran, S	1
Callaghan, N	4
Majeed, T	1
O'Connell, A	1
Oliveira, DB	1
Murialdo, G	1
Galimberti, CA	1
Fonzi, S	1
Manni, R	1
Costelli, P	1
Parodi, C	1
Torre, F	1
Solinas, GP	1
Polleri, A	1
Tartara, A	1
Yamamoto, M	1
Okudaira, A	1
Kohira, I	1
Kugoh, T	1
Fukunishi, I	1
Hosokawa, K	1
Löscher, W	4
Rundfeldt, C	2
Hönack, D	1
Velkey, I	1
Lombay, B	1
Bittencourt, PR	1
Antoniuk, SA	2
Bigarella, MM	1
da Costa, JC	1
Doro, MP	1
Ferreira, AS	1
Fonseca, LC	1
Gorz, AM	1
Gonçalves e Silva, GE	1
Marcourakis, T	1
Tsuji, M	1
Hori, S	1
Asai, N	1
Hamanaka, T	1
Ishikawa, T	1
Hiyoshi, T	1
Mochizuki, H	1
Bauer, TM	1
Brühwiler, J	1
Aschwanden, M	1
Wagner, S	1
Schwander, J	1
Luef, G	1
Marosi, M	1
Felber, S	1
Birbamer, G	1
Aichner, F	1
Bauer, G	1
Riley, RJ	1
Smith, G	2
Wolf, CR	1
Cook, VA	1
Leeder, JS	1
Jibiki, I	1
Kido, H	1
Matsuda, H	1
Yamaguchi, N	1
Hisada, K	1
de Silva, M	1
MacArdle, B	1
McGowan, M	1
Hughes, E	1
Stewart, J	1
Neville, BG	2
Privitera, M	1
Fincham, R	1
Penry, J	1
Reife, R	1
Kramer, L	1
Pledger, G	1
Karim, R	1
Martínez Bermejo, Z	1
Pascual-Castroviejo, I	1
Kato, H	1
Kishikawa, H	1
Emura, S	1
Takashima, T	1
Ohmori, K	1
Fujita, H	1
Bill, PA	1
Vigonius, U	2
Pohlmann, H	2
Guerreiro, CA	1
Kochen, S	1
Saffer, D	1
Moore, A	2
Guerreiro, MM	1
de Manreza, ML	1
Fejerman, N	1
Pal, DK	1
Das, T	1
Chaudhury, G	1
Kennedy, BT	1
Haller, JS	1
Kanner, AM	1
Bourgeois, BF	1
Hasegawa, H	1
Hutson, P	1
López-Ariztegui, N	1
Ochoà, M	1
Sánchez-Migallón, MJ	1
Nevado, C	1
Martín, M	1
Gilliam, F	1
Vazquez, B	1
Sackellares, JC	1
Chang, GY	1
Messenheimer, J	1
Nyberg, J	1
Risner, ME	1
Rudd, GD	1
Hattori, H	1
Odani, A	1
Kimura, J	1
Shibasaki, H	1
Ebert, U	3
Lehmann, H	1
Scholz, J	1
Vieregge, P	1
Moser, A	1
Contin, M	1
Riva, R	1
Albani, F	1
Baruzzi, AA	1
Brückner, C	1
Heinemann, U	1
Husain, AM	1
Carwile, ST	1
Miller, PP	1
Radtke, RA	1
Reissmüller, E	1
McBride, MC	1
Laroia, N	1
Guillet, R	1
Kmieć, T	1
Jóźwiak, S	1
Kuczyński, D	1
Karkowska, B	1
Bachański, M	1
Huber, A	1
Padrun, V	1
Déglon, N	1
Aebischer, P	1
Möhler, H	1
Boison, D	1
Bauer, J	1
Burr, W	1
Taylor, S	1
Friel, P	2
Morretti-Ojemann, L	1
Feigl, P	2
Janz, D	1
Kosteljanetz, M	2
Christiansen, J	3
Dam, AM	2
Hansen, BS	2
Lyon, BB	2
Pedersen, H	2
Dam, M	3
Hawkins, DW	1
Ludden, TM	1
Hoffman, SF	1
Allen, JP	1
Iinuma, K	1
Takamatsu, N	1
Onuma, A	1
Tada, K	1
Ward, AA	1
Harvey, CD	1
Sherwin, AL	2
Van Der Kleijn, E	1
Ito, T	1
Hori, M	1
Yoshida, K	1
Shimizu, M	1
Troupin, A	1
Halpern, L	1
Dodrill, C	1
Wilkus, R	1
Kristensen, CB	1
Gartside, IB	1
McNaughton, FL	1
Rasmussen, T	1
Lerman, P	2
Kivity, S	1
Perry, TL	1
Hansen, S	1
Kennedy, J	1
Wada, JA	1
Thompson, GB	1
Mikkelsen, B	1
Birket-Smith, E	1
Holm, P	1
Lund, M	1
Vestermark, S	1
Olsen, PZ	1
Sutton, G	1
Kupferberg, HJ	1
Dekaban, AS	1
Lehman, EJ	1
Mygind, KI	1
Marg, E	1
Hassan, MN	1
Laljee, HC	1
Parsonage, MJ	1
Thomas, JA	1
Knotts, GR	1
Moses, PD	1
Kirubakaran, C	1
Chacko, DS	1
McKee, PJ	1
Percy-Robb, I	1
Liedholm, LJ	1
Gudjonsson, O	1
Guillaume, D	1
Grisar, T	1
Delgado-Escueta, AV	2
Laschet, J	1
Bureau-Heeren, M	1
Bardy, AH	1
Fujikawa, Y	1
Kubota, H	1
Matsuda, K	1
Fujiwara, T	1
Yagi, K	1
Seino, M	1
Rastogi, P	1
Mehrotra, TN	1
Agarwala, RK	1
Singh, VS	1
al-Rubeaan, K	1
Ryan, EA	1
Rajna, P	1
Veres, J	1
Vitray, J	1
Leppik, IE	1
Pledger, GW	1
Graves, NM	1
Santilli, N	1
Drury, I	1
Tsay, JY	1
Jacobs, MP	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
PLA General Hospital[NCT05920512]	Phase 1/Phase 2	10 participants (Anticipated)	Interventional	2022-04-01	Recruiting
Efficacy and Tolerability of Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy (STANDLOW). A Multicenter, Randomized, Single-blind, Parallel-group Trial[NCT03689114]	Phase 4	374 participants (Anticipated)	Interventional	2020-01-07	Not yet recruiting
Antiseizure Medication-Induced Elevation of Serum Estradiol and Reproductive Dysfunction in Men With Epilepsy[NCT00179426]		175 participants	Observational	1999-10-31	Completed
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]	Phase 2	2 participants (Actual)	Interventional	2012-04-30	Completed
An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418]	Phase 4	122 participants (Actual)	Interventional	2006-02-28	Terminated (stopped due to Insufficient enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

Intervention	Abscence seizures (Number)
Week 8 Baseline	165
Week 12 Verapamil 4mg/kg/Day	101

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

Intervention	General tonic-clonic seizures (Number)
Week 8 Baseline	39
Week 12 Verapamil 4mg/kg/Day	14

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Change From Baseline in Adverse Event Profile (AEP) Score

Intervention	Myoclonic seizures (Number)
Week 8 Baseline	116
Week 12 Verapamil 4mg/kg/Day	175

Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months

Change From Baseline in Center for Epidemiologic Studies Depression Scale (CES-D) Score

Intervention	Units on a scale (Mean)
VNS Therapy	-6.0
Best Medical Practice	-3.2

The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months

Change From Baseline in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score

Intervention	Units on a Scale (Mean)
VNS Therapy	-2.2
Best Medical Practice	0.5

The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months

Changes in Anti-epileptic Drugs (AEDs)

Intervention	Units on a Scale (Mean)
VNS Therapy	-1.0
Best Medical Practice	-0.2

Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months

Mean Change From Beginning of Intervention Clinical Global Impression-Improvement Scale (CGI-I) Score at 12 Months

Intervention	Number of AEDs Taken (Median)
VNS Therapy	0
Best Medical Practice	0

The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months

Mean Percent Change in Seizure Frequency

Intervention	Units on a Scale (Mean)
VNS Therapy	-0.8
Best Medical Practice	-0.3

Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months

Overall Quality of Life in Epilepsy-89 (QOLIE-89) Score in Patients With Baseline & at Least One Post-baseline QOLIE Assessment

Intervention	Percent Change (Mean)
VNS Therapy	-19.1
Best Medical Practice	-1.0

QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months

Response Rate

Intervention	units on a scale (Mean)
VNS Therapy	5.5
Best Medical Practice	1.2

Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score < 40

Intervention	participants (Number)
VNS Therapy	10
Best Medical Practice	7

QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months

Change From Baseline in QOLIE-89 Measures: Subgroup Analysis of Population With Baseline Adverse Event Profile Score >= 40

Article	Year
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. The Cochrane database of systematic reviews, 2022, 04-01, Volume: 4 Topics: Adult; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Humans; Network Meta-Analysis; Phenyto	2022
Cutaneous Hypersensitivity Reaction After Phenytoin Therapy in a Neonate: A Case Report and Review of Literature Elucidating the Potential Pharmacological Plausibility and Preventive Strategies. Current drug safety, 2023, Volume: 18, Issue:4 Topics: Anticonvulsants; Child; Drug Hypersensitivity; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized;	2023
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. The Cochrane database of systematic reviews, 2017, 06-29, Volume: 6 Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti	2017
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. The Cochrane database of systematic reviews, 2017, 12-15, Volume: 12 Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti	2017
Clobazam monotherapy for focal or generalized seizures. The Cochrane database of systematic reviews, 2018, 07-11, Volume: 7 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par	2018
Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. The Cochrane database of systematic reviews, 2018, 08-09, Volume: 8 Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenytoin; Randomized Controlle	2018
Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. The Cochrane database of systematic reviews, 2018, 10-23, Volume: 10 Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Induction Chemotherapy; Oxcarb	2018
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. The Cochrane database of systematic reviews, 2013, Jan-31, Issue:1 Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; I	2013
Oxcarbazepine versus phenytoin monotherapy for epilepsy. The Cochrane database of systematic reviews, 2013, May-31, Issue:5 Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Induction Chemotherapy; Oxcar	2013
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. The Cochrane database of systematic reviews, 2013, Aug-23, Issue:8 Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto	2013
Clobazam monotherapy for partial-onset or generalized-onset seizures. The Cochrane database of systematic reviews, 2014, Oct-04, Issue:10 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsies, Par	2014
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Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. The Cochrane database of systematic reviews, 2016, Apr-28, Volume: 4 Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto	2016
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Probable cerebellar abnormality on 123I-IMP SPECT scans in epileptic patients with long-term high-dose phenytoin therapy. Based on observation of multiple cases. Acta neurologica, 1993, Volume: 15, Issue:1 Topics: Adult; Amphetamines; Cerebellar Diseases; Cerebellum; Epilepsies, Partial; Female; Frontal Lobe; Fun	1993
[The diagnosis and treatment of partial epilepsy in childhood and adolescence]. Neurologia (Barcelona, Spain), 1996, Volume: 11 Suppl 4 Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epile	1996
[Acute phenytoin poisoning secondary to an interaction with ticlopidine]. Revista de neurologia, 1998, Volume: 26, Issue:154 Topics: Acute Disease; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Ataxia; Cerebrovascular Disorde	1998
Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. The Cochrane database of systematic reviews, 2001, Issue:4 Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenytoin; Randomized Controlle	2001
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. The Cochrane database of systematic reviews, 2001, Issue:4 Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenobarbital; Phenytoin; Rando	2001
Valproic acid. Review of a new antiepileptic drug. Archives of neurology, 1979, Volume: 36, Issue:7 Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha	1979
Drug therapy reviews: drug therapy of status epilepticus. American journal of hospital pharmacy, 1978, Volume: 35, Issue:8 Topics: Anesthesia, General; Diazepam; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil	1978
Theoretical basis for surgical therapy of epilepsy. Advances in neurology, 1975, Volume: 8 Topics: Animals; Cerebellum; Cerebral Cortex; Epilepsies, Partial; Haplorhini; Humans; Memory; Microelectrod	1975
Mechanisms of anticonvulsant drug action. I. Drugs primarily used for generalized tonic-clonic and partial epilepsies. European journal of pediatrics, 1987, Volume: 146, Issue:1 Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Kinetics; Phenobarbital; Phen	1987
Carbamazepine efficacy in adults with partial and generalized tonic-clonic seizures. Epilepsia, 1987, Volume: 28 Suppl 3 Topics: Adult; Carbamazepine; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Phenytoin	1987
[Therapy of brain-related minor seizures]. Schweizerische medizinische Wochenschrift, 1988, Dec-17, Volume: 118, Issue:50 Topics: Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial;	1988
Anticonvulsants, folic acid, and epilepsy. Lancet (London, England), 1973, Jun-16, Volume: 1, Issue:7816 Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Ep	1973
Diagnosis and treatment of epilepsy: overview and general principles. Pediatrics, 1974, Volume: 53, Issue:4 Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination;	1974
Current drug therapy--antiepilepsy agents. American journal of hospital pharmacy, 1974, Volume: 31, Issue:12 Topics: Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Drug Interactions; Epilepsies, Partial	1974
Anticonvulsant drugs. II. Clinical pharmacological and therapeutic aspects. Drugs, 1972, Volume: 4, Issue:3 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Cerebellum; Drug Interact	1972

Article	Year
Quality of life improvement with conversion to lamotrigine monotherapy. Epilepsy & behavior : E&B, 2004, Volume: 5, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Electroencephalography	2004
Clorazepate and phenobarbital as antiepileptic drugs: a double-blind study. Neurology, 1981, Volume: 31, Issue:10 Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Clinical Trials as Topic; Clorazepate Dipotassium; Doub	1981
A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults. Neurology, 1983, Volume: 33, Issue:7 Topics: Adolescent; Adult; Aged; Carbamazepine; Double-Blind Method; Epilepsies, Partial; Epilepsy, Tonic-Cl	1983
Cinromide in epilepsy: a pilot study. Epilepsia, 1983, Volume: 24, Issue:4 Topics: Adult; Carbamazepine; Cinnamates; Clinical Trials as Topic; Epilepsies, Partial; Female; Humans; Mal	1983
Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy. Epilepsia, 1984, Volume: 25, Issue:4 Topics: Adolescent; Adult; Aged; Drug Interactions; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Mid	1984
A comparison of phenytoin and valproate in previously untreated adult epileptic patients. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:1 Topics: Adolescent; Adult; Age Factors; Aged; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans	1982
A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:12 Topics: Adolescent; Adult; Aged; Anticonvulsants; Clinical Trials as Topic; Double-Blind Method; Epilepsies,	1982
Efficacy and tolerability of vigabatrin in children with refractory partial seizures: a single-blind dose-increasing study. Epilepsia, 1995, Volume: 36, Issue:7 Topics: Anticonvulsants; Child; Child, Preschool; Data Interpretation, Statistical; Epilepsies, Partial; Fem	1995
Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial. Journal of neurology, neurosurgery, and psychiatry, 1995, Volume: 58, Issue:1 Topics: Adolescent; Adult; Aged; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female;	1995
Pure sensory seizures. Seizure, 1993, Volume: 2, Issue:1 Topics: Carbamazepine; Cerebral Infarction; Electroencephalography; Epilepsies, Partial; Female; Functional	1993
Carbamazepine and phenytoin in epilepsies refractory to barbiturates: efficacy, toxicity and mental function. Epilepsy research, 1993, Volume: 16, Issue:2 Topics: Adolescent; Adult; Affect; Carbamazepine; Child; Cognition; Epilepsies, Partial; Epilepsy; Female; H	1993
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy. Lancet (London, England), 1996, Mar-16, Volume: 347, Issue:9003 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy;	1996
Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages. Topiramate YE Study Group. Neurology, 1996, Volume: 46, Issue:6 Topics: Adolescent; Adult; Aged; Anticonvulsants; Carboplatin; Dose-Response Relationship, Drug; Double-Blin	1996
A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in adults with previously untreated epilepsy. Epilepsy research, 1997, Volume: 27, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Double-Blind Method; Epi	1997
A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in children and adolescents with epilepsy. Epilepsy research, 1997, Volume: 27, Issue:3 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Double-Blind Method; Epilepsies	1997
Randomised controlled trial to assess acceptability of phenobarbital for childhood epilepsy in rural India. Lancet (London, England), 1998, Jan-03, Volume: 351, Issue:9095 Topics: Adolescent; Anticonvulsants; Child; Child Behavior Disorders; Child, Preschool; Developing Countries	1998
Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1998, Volume: 25, Issue:2 Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anti-Anxiety Agents; Anticonvulsants;	1998
Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy. Epilepsia, 1998, Volume: 39, Issue:9 Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; C	1998
An active-control trial of lamotrigine monotherapy for partial seizures. Neurology, 1998, Volume: 51, Issue:4 Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsies, Partial; E	1998
Gabapentin as adjunctive therapy for partial seizures. Epilepsia, 1999, Volume: 40 Suppl 6 Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dizziness; Dru	1999
Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy. Therapeutic drug monitoring, 1999, Volume: 21, Issue:6 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Chil	1999
Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology, 2000, Aug-22, Volume: 55, Issue:4 Topics: Anticonvulsants; Asphyxia Neonatorum; Demography; Developmental Disabilities; Electroencephalography	2000
[Gabitril as an additive drug in therapy of intractable epileptic seizures in children]. Neurologia i neurochirurgia polska, 2000, Volume: 34 Suppl 7 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi	2000
Evaluation of clorazepate (Tranxene) as an anticonvulsant--a pilot study. Neurology, 1979, Volume: 29, Issue:4 Topics: Adolescent; Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Clorazepate Dipotassium; Dose-Resp	1979
Carbamazepine vs phenytoin. A controlled clinical trial in focal motor and generalized epilepsy. Archives of neurology, 1979, Volume: 36, Issue:1 Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P	1979
[Carbamazepine (Tegretol) or phenytoin in the treatment of focal motor epilepsy or generalized epilepsy? A controlled clinical trial]. Ugeskrift for laeger, 1979, Apr-09, Volume: 141, Issue:15 Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Evaluati	1979
Carbamazepine--a double-blind comparison with phenytoin. Neurology, 1977, Volume: 27, Issue:6 Topics: Adult; Ataxia; Carbamazepine; Clinical Trials as Topic; Drug Evaluation; Epilepsies, Partial; Hemato	1977
A controlled trial on clonazepam INN (Ro 5-4023, Rivotril (R)) in the treatment of focal epilepsy and secondary generalized grand mal epilepsy. Acta neurologica Scandinavica. Supplementum, 1975, Volume: 60 Topics: Adolescent; Adult; Aged; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clona	1975
Comparison of sodium valproate and phenytoin as single drug treatment in generalised and partial epilepsy. The Journal of the Association of Physicians of India, 1991, Volume: 39, Issue:8 Topics: Adolescent; Adult; Child; Epilepsies, Partial; Epilepsy, Generalized; Female; Humans; Male; Middle A	1991
Felbamate for partial seizures: results of a controlled clinical trial. Neurology, 1991, Volume: 41, Issue:11 Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Therapy, Combination; Epilepsies, P	1991
Post-operative epilepsy and the efficacy of anticonvulsant therapy. Acta neurochirurgica. Supplementum, 1990, Volume: 50 Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Epilepsies, Partial; Follow-Up Studies; Glioma; Hum	1990
Serum levels of sodium valproate, phenytoin and carbamazepine and seizure control in epilepsy. Irish medical journal, 1986, Volume: 79, Issue:6 Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Fema	1986
Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study. The New England journal of medicine, 1988, Apr-14, Volume: 318, Issue:15 Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Par	1988
Aspects of compliance: taking drugs and keeping clinic appointments. Epilepsy research. Supplement, 1988, Volume: 1 Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Clinical Trials as To	1988
Which drug for the adult epileptic patient: phenytoin or valproate? British medical journal (Clinical research ed.), 1985, Mar-16, Volume: 290, Issue:6471 Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Femal	1985
The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin. Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:4 Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination;	1985
Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P	1985
A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy. Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:7 Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Child, Preschool; Clinical Trials as Topic; Dose-Resp	1985
Evaluation of albutoin as an antiepileptic drug. Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:4 Topics: Adolescent; Adult; Allyl Compounds; Analysis of Variance; Anticonvulsants; Appetite; Biopharmaceutic	1974
Diphenylhydantoin as an anticonvulsant: evaluation of treatment in forty mentally subnormal epileptics. Journal of mental deficiency research, 1969, Volume: 13, Issue:3 Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Electroencephalography; Epilepsies, Par	1969

Article	Year
Phenytoin-Induced Paradoxical Seizures and Blood Dyscrasias in a Patient Receiving Rapid Intravenous Infusion: A Case Report. Journal of pharmacy practice, 2021, Volume: 34, Issue:2 Topics: Anticonvulsants; Epilepsies, Partial; Humans; Infusions, Intravenous; Middle Aged; Phenytoin; Seizur	2021
Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy. Epilepsy & behavior : E&B, 2019, Volume: 94 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dizziness; Drug Resistant Epile	2019
Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. JAMA neurology, 2019, 07-01, Volume: 76, Issue:7 Topics: Adolescent; Adult; Anticonvulsants; Anxiety Disorders; Comorbidity; Dissociative Disorders; Epilepsi	2019
[Othello syndrome secondary to zonisamide]. Medicina clinica, 2014, Feb-04, Volume: 142, Issue:3 Topics: Adult; Anticonvulsants; Brain Diseases; Cysts; Delusions; Drug Substitution; Drug Therapy, Combinati	2014
Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy. Epileptic disorders : international epilepsy journal with videotape, 2013, Volume: 15, Issue:2 Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Drug Therapy, Combination; Epilepsies, Partial; E	2013
Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital. BMC research notes, 2013, Nov-18, Volume: 6 Topics: Adolescent; Adult; Anticonvulsants; Bangladesh; Carbamazepine; Child; Drug Combinations; Epilepsies,	2013
Long-term effect of antiepileptic drug switch on serum lipids and C-reactive protein. Epilepsy & behavior : E&B, 2016, Volume: 58 Topics: Anticonvulsants; Biomarkers; C-Reactive Protein; Carbamazepine; Drug Substitution; Drug Therapy, Com	2016
[Case of juvenile myoclonic epilepsy misdiagnosed as simple partial seizure for more than 60 years]. Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:1 Topics: Aged; Cerebellar Ataxia; Diagnostic Errors; Electroencephalography; Electromyography; Epilepsies, Pa	2009
Similar effects of lamotrigine and phenytoin against cortical epileptic foci in immature rats. Physiological research, 2010, Volume: 59, Issue:1 Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Dose-Response Relations	2010
[Epilepsy in elderly]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:7 Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies,	2011
A rat model for LGI1-related epilepsies. Human molecular genetics, 2012, Aug-15, Volume: 21, Issue:16 Topics: Amino Acid Sequence; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Chlorocebus ae	2012
Topiramate-induced metabolic acidosis: a case study. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2012, May-14, Volume: 32, Issue:3 Topics: Acidosis; Acidosis, Renal Tubular; Aged; Anticonvulsants; Cerebral Hemorrhage, Traumatic; Comorbidit	2012
Cerebellar volume and long-term use of phenytoin. Seizure, 2003, Volume: 12, Issue:5 Topics: Adolescent; Adult; Aged; Anticonvulsants; Cerebellum; Child; Child, Preschool; Dose-Response Relatio	2003
TEMPORAL LOBE EPILEPSY: A CLINICAL STUDY OF 47 CASES. Canadian Medical Association journal, 1964, Dec-12, Volume: 91 Topics: Adolescent; Biomedical Research; Birth Injuries; Depression; Depressive Disorder; Diagnosis, Differe	1964
Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia, 2004, Volume: 45, Issue:7 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Estradiol; Humans; Lamotrigi	2004
Congenital bilateral perisylvian syndrome with partial epilepsy. Case report with long-term follow-up. Brain & development, 2005, Volume: 27, Issue:1 Topics: Adolescent; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Female; Follow-Up Studies;	2005
Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat. Epilepsia, 2005, Volume: 46, Issue:2 Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Electroencephal	2005
[Mitral prosthetic valve and presyncope]. Anales de medicina interna (Madrid, Spain : 1984), 2005, Volume: 22, Issue:5 Topics: Anticoagulants; Anticonvulsants; Atrial Fibrillation; Diagnostic Errors; Electroencephalography; Epi	2005
Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy. Epilepsia, 2005, Volume: 46, Issue:9 Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combinatio	2005
Phenytoin desensitization in a child with symptomatic localization-related epilepsy. Brain & development, 2007, Volume: 29, Issue:2 Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Partial; Humans; Male; Phenytoin; Pri	2007
Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy. Epilepsia, 2006, Volume: 47, Issue:11 Topics: Adolescent; Adult; Androgens; Androstanes; Anticonvulsants; Biological Availability; Carbamazepine;	2006
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration. Experimental brain research, 2007, Volume: 178, Issue:1 Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal;	2007
Phenytoin desensitization monitored by antigen specific T cell response using carboxyfluorescein succinimidyl ester dilution assay. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2007, Volume: 11, Issue:6 Topics: Anticonvulsants; CD4-Positive T-Lymphocytes; Child; Desensitization, Immunologic; Dose-Response Rela	2007
Association of galactose single-point test levels and phenytoin metabolic polymorphisms with gingival hyperplasia in patients receiving long-term phenytoin therapy. Pharmacotherapy, 2008, Volume: 28, Issue:1 Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pr	2008
Effect of diphenylhydantoin on unit activity in a cortical epileptogenic focus in the rat. Neuropharmacology, 1983, Volume: 22, Issue:3 Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Male; Penicillins; Phenytoin;	1983
Effect of diphenylhydantion on cortical epileptogenic foci in the rat. Physiologia Bohemoslovaca, 1983, Volume: 32, Issue:1 Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Male; Penicillins; Phenytoin;	1983
Treatment of the nonconvulsive epilepsies. Epilepsia, 1983, Volume: 24 Suppl 1 Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi	1983
[Status epilepticus following lumbar myelography with metrizamide (Amipaque)]. Ugeskrift for laeger, 1983, Sep-12, Volume: 145, Issue:37 Topics: Clonazepam; Epilepsies, Partial; Female; Humans; Metrizamide; Middle Aged; Myelography; Phenytoin	1983
[Pharmacotherapy of epilepsy--current problems and controversies]. Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:11 Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy,	1983
"Therapeutic" serum concentration of phenytoin: the influence of seizure type. Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:3 Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Epilepsies, Partial; Female; Humans; Male	1984
Phenytoin intoxication as the first symptom of fatal liver damage induced by sodium valproate. British journal of clinical pharmacology, 1984, Volume: 17, Issue:5 Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsies, Partial; Femal	1984
Phenytoin-induced increase in growth hormone response to levodopa in adult males. Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:7 Topics: Adult; Epilepsies, Partial; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Levodopa; Male;	1984
Anticonvulsant drugs alter plasma tryptophan concentrations in epileptic patients: implications for antiepileptic action and mental function. Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:10 Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsies, Myoclon	1984
[Treatment of partial motor status epilepticus in adults with intravenous diphenylhydantoin (DPH). Prospective study of 50 cases]. Revue d'electroencephalographie et de neurophysiologie clinique, 1984, Volume: 14, Issue:3 Topics: Adult; Epilepsies, Partial; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Ph	1984
Epilepsy in children. Family practice, 1984, Volume: 1, Issue:3 Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Electroencephalogr	1984
Status epilepticus. Pediatric clinics of North America, 1980, Volume: 27, Issue:3 Topics: Anesthesia, General; Child; Child, Preschool; Diazepam; Epilepsies, Myoclonic; Epilepsies, Partial;	1980
Plasma levels of diphenylhydantoin and the control of adult epileptic seizures: a Chilean experience. Epilepsia, 1980, Volume: 21, Issue:5 Topics: Adolescent; Adult; Aged; Chile; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Phenytoin	1980
[Use of intravenous phenytoin in treatment of partial status epilepticus (author's transl)]. La Nouvelle presse medicale, 1981, Mar-21, Volume: 10, Issue:13 Topics: Adult; Epilepsies, Partial; Female; Humans; Injections, Intravenous; Male; Middle Aged; Phenytoin; S	1981
[Polytherapy and monotherapy in the treatment of patients with epilepsy]. Acta neurologica. Quaderni, 1981, Volume: 42 Topics: Adult; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy,	1981
Therapy of status epilepticus. Comprehensive therapy, 1982, Volume: 8, Issue:5 Topics: Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Paraldehy	1982
Increased sister chromatid exchanges in epileptic children during long-term therapy with phenytoin. Human genetics, 1982, Volume: 61, Issue:1 Topics: Adolescent; Cells, Cultured; Child; Chromosomes, Human; Crossing Over, Genetic; Epilepsies, Partial;	1982
Early prognosis of epilepsy. British medical journal (Clinical research ed.), 1982, Dec-11, Volume: 285, Issue:6356 Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Female; Humans; Male;	1982
Treatment of "benign" partial epilepsies of childhood, including atypical forms. Neuropediatrics, 1995, Volume: 26, Issue:1 Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinone	1995
A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report. Acta neurologica Scandinavica, 1994, Volume: 90, Issue:5 Topics: Adult; Carbamazepine; Cerebral Infarction; Dose-Response Relationship, Drug; Epilepsies, Partial; Fe	1994
A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients. Acta neurologica Scandinavica, 1994, Volume: 89, Issue:4 Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Chemical a	1994
Sex hormones, gonadotropins and prolactin in male epileptic subjects in remission: role of the epileptic syndrome and of antiepileptic drugs. Neuropsychobiology, 1994, Volume: 30, Issue:1 Topics: Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dihydrotestosterone; Epilepsies, Partial; Ep	1994
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy. Epilepsy research, 1993, Volume: 15, Issue:3 Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Carbamazepine; Disease Models, Anim	1993
[Rasmussen syndrome]. Orvosi hetilap, 1993, Nov-28, Volume: 134, Issue:48 Topics: Acyclovir; Carbamazepine; Child, Preschool; Electroencephalography; Encephalitis; Epilepsies, Partia	1993
Two epileptics showing antiepileptic drug-induced psychoses. The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2 Topics: Adolescent; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroenc	1993
[Neurocysticercosis]. Deutsche medizinische Wochenschrift (1946), 1994, Feb-11, Volume: 119, Issue:6 Topics: Albendazole; Animals; Antibodies, Helminth; Brain; Brain Diseases; Croatia; Cysticercosis; Diagnosis	1994
[Cerebellar atrophy and phenytoin poisoning. An MR study]. Der Nervenarzt, 1993, Volume: 64, Issue:8 Topics: Adult; Anticonvulsants; Atrophy; Cerebellar Ataxia; Cerebellum; Dose-Response Relationship, Drug; Dr	1993
Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s) Biochemical and biophysical research communications, 1993, Feb-26, Volume: 191, Issue:1 Topics: Adult; Animals; Anticonvulsants; Autoantibodies; Autoantigens; Carbamazepine; Cell Line; Cross React	1993
Treatment of focal status epilepticus with lignocaine. Journal of accident & emergency medicine, 1997, Volume: 14, Issue:3 Topics: Aged; Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Generalized; Humans; Lidocaine; Male	1997
Treatment of the epileptic patient in the dental office. The New York state dental journal, 1998, Volume: 64, Issue:2 Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep	1998
Rapid switchover to carbamazepine using pharmacokinetic parameters. Epilepsia, 1998, Volume: 39, Issue:2 Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedul	1998
Gynaecomastia in association with phenytoin and zonisamide in a patient having a CYP2C subfamily mutation. Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 65, Issue:5 Topics: Adult; Anticonvulsants; Epilepsies, Partial; Gynecomastia; Humans; Isoxazoles; Male; Metabolism, Inb	1998
Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of experimental and environmental factors. Epilepsy research, 1999, Volume: 33, Issue:2-3 Topics: Animals; Anticonvulsants; Atmospheric Pressure; Differential Threshold; Disease Models, Animal; Drug	1999
Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of genetic factors. Epilepsy research, 1999, Volume: 33, Issue:2-3 Topics: Animals; Anticonvulsants; Differential Threshold; Disease Models, Animal; Drug Resistance; Electroph	1999
Central pain as a manifestation of partial epileptic seizures. Pain, 1999, Volume: 80, Issue:1-2 Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Female; Humans; Magnetic Resona	1999
Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices. Brain research, 2000, Mar-17, Volume: 859, Issue:1 Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbamazepine; Entorhinal Cortex; Epilepsies, Partial; Fe	2000
Improved sexual function in three men taking lamotrigine for epilepsy. Southern medical journal, 2000, Volume: 93, Issue:3 Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial;	2000
The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats. Neuropharmacology, 2000, Jul-24, Volume: 39, Issue:10 Topics: Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Resistance; Electric Stim	2000
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proceedings of the National Academy of Sciences of the United States of America, 2001, Jun-19, Volume: 98, Issue:13 Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aggression; Animals; Brain; Cell Line; Cell Transp	2001
Course of chronic focal epilepsy resistant to anticonvulsant treatment. Seizure, 2001, Volume: 10, Issue:4 Topics: Adult; Anticonvulsants; Carbamazepine; Cluster Analysis; Disease Progression; Documentation; Drug Ad	2001
[Drug resistance in epilepsy therapy]. Deutsche medizinische Wochenschrift (1946), 1978, Oct-13, Volume: 103, Issue:41 Topics: Anticonvulsants; Contraceptives, Oral; Drug Resistance; Drug Therapy, Combination; Electroencephalog	1978
Rapid metabolism of phenytoin: a method of calculating proper dosage. Archives of neurology, 1979, Volume: 36, Issue:2 Topics: Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Tonic-Cl	1979
Childhood epilepsy uncontrolled by phenytoin: clinical and electroencephalographic study. Brain & development, 1979, Volume: 1, Issue:1 Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy	1979
Distribution of anticonvulsant drugs in gray and white matter of human brain. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1977, Volume: 4, Issue:2 Topics: Anticonvulsants; Brain; Carbamazepine; Epilepsies, Partial; Humans; Mesencephalon; Nervous System; P	1977
Effect of anticonvulsants on cortical focal seizure in cats. Epilepsia, 1977, Volume: 18, Issue:1 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epileps	1977
One-sided gingival hyperplasia after treatment with diphenylhydantoin. Acta neurologica Scandinavica, 1977, Volume: 56, Issue:4 Topics: Adult; Epilepsies, Partial; Female; Gingival Hyperplasia; Humans; Phenytoin; Pregnancy; Pregnancy Co	1977
The actions of diazepam and phenytoin on a low dose penicillin epileptiform focus in the anaesthetised rat. British journal of pharmacology, 1978, Volume: 62, Issue:2 Topics: Animals; Diazepam; Electroencephalography; Epilepsies, Partial; Penicillin G; Phenytoin; Rats	1978
Criteria for selection of patients for neurosurgical treatment. Advances in neurology, 1975, Volume: 8 Topics: Adolescent; Age Factors; Child; Electroencephalography; Encephalitis; Epilepsies, Partial; Epilepsy;	1975
Benign focal epilepsy of childhood. A follow-up study of 100 recovered patients. Archives of neurology, 1975, Volume: 32, Issue:4 Topics: Adolescent; Child; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Female; F	1975
Amino acids in human epileptogenic foci. Archives of neurology, 1975, Volume: 32, Issue:11 Topics: Adolescent; Adult; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Child; Cystathionine; Epile	1975
Diseases of the central nervous system: Epilepsy. British medical journal, 1975, Nov-01, Volume: 4, Issue:5991 Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth	1975
Isoniazid as an inhibitor of primidone metabolism. Neurology, 1975, Volume: 25, Issue:12 Topics: Depression, Chemical; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Isoniazid; Mid	1975
Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. Acta neurologica Scandinavica, 1975, Volume: 52, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Child; Chronic Disease; Dose-Response Relationship, Drug; Epilep	1975
Phenytoin and phenobarbitone plasma clearance during pregnancy. Acta neurologica Scandinavica, 1976, Volume: 54, Issue:2 Topics: Adult; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Human	1976
[Stevens-Johnson syndrome as an early allergic reaction to diphenylhydantoin]. Psychiatrie, Neurologie, und medizinische Psychologie, 1976, Volume: 28, Issue:7 Topics: Adult; Drug Hypersensitivity; Epilepsies, Partial; Humans; Male; Phenytoin; Stevens-Johnson Syndrome	1976
Sodium valproate in the treatment of resistant epilepsy. Acta neurologica Scandinavica, 1976, Volume: 54, Issue:3 Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies,	1976
Epilepsy and other seizure disorders in children: drug management. The Journal of school health, 1976, Volume: 46, Issue:8 Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T	1976
Disappearing CT lesions in focal seizures. Annals of tropical paediatrics, 1992, Volume: 12, Issue:3 Topics: Brain Diseases; Child; Cysticercosis; Epilepsies, Partial; Female; Humans; Phenytoin; Praziquantel;	1992
Therapeutic drug monitoring improves seizure control and reduces anticonvulsant side-effects in patients with refractory epilepsy. Seizure, 1992, Volume: 1, Issue:4 Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Electroencephalog	1992
Cardiac arrest due to partial epileptic seizures. Neurology, 1992, Volume: 42, Issue:4 Topics: Adult; Electrocardiography; Electroencephalography; Epilepsies, Partial; Female; Heart Arrest; Human	1992
Phosphorylation of brain (Na+,K+)-ATPase alpha catalytic subunits in normal and epileptic cerebral cortex: II. Partial seizures in human epilepsy. Journal of neuroscience research, 1991, Volume: 29, Issue:2 Topics: Brain; Catalysis; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Epilepsies, Partial; Epileps	1991
[Diagnosis of petit mal attack]. Duodecim; laaketieteellinen aikakauskirja, 1990, Volume: 106, Issue:16 Topics: Adult; Diagnosis, Differential; Epilepsies, Partial; Epilepsy, Absence; Humans; Phenytoin	1990
Reversal of MRI lesion with relapse and remission of partial motor seizures in epilepsia partialis continua. The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:2 Topics: Adolescent; Anticonvulsants; Cerebral Cortex; Drug Therapy, Combination; Electroencephalography; Epi	1991
Phenytoin-induced insulin insensitivity. Diabetic medicine : a journal of the British Diabetic Association, 1991, Volume: 8, Issue:10 Topics: Aged; Aged, 80 and over; C-Peptide; Coronary Artery Bypass; Coronary Disease; Epilepsies, Partial; H	1991
Place of phenytoin in treatment of resistant epilepsy. Therapia Hungarica (English edition), 1991, Volume: 39, Issue:1 Topics: Adolescent; Adult; Aged; Epilepsies, Partial; Female; Follow-Up Studies; Humans; Male; Middle Aged;	1991
Possible roles for frequent salivary antiepileptic drug monitoring in the management of epilepsy. Epilepsy research, 1990, Volume: 6, Issue:2 Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Menstrua	1990
Focal seizure in non-ketotic hyperglycaemia. Annals of the Academy of Medicine, Singapore, 1990, Volume: 19, Issue:4 Topics: Aged; Blood Glucose; Brain Diseases; Diabetes Mellitus, Type 2; Epilepsies, Partial; Female; Humans;	1990
[High-dose monotherapy in intractable epilepsy]. Zhonghua nei ke za zhi, 1990, Volume: 29, Issue:4 Topics: Adolescent; Adult; Carbamazepine; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Female; Huma	1990
Evoked potentials of self-interrupted Jacksonian epilepsy. The Tokushima journal of experimental medicine, 1990, Volume: 37, Issue:3-4 Topics: Aged; Electroencephalography; Epilepsies, Partial; Evoked Potentials, Auditory; Evoked Potentials, S	1990
Epilepsy following neurosurgical intervention. Acta neurochirurgica. Supplementum, 1990, Volume: 50 Topics: Anticonvulsants; Craniotomy; Epilepsies, Partial; Humans; Intracranial Aneurysm; Phenytoin; Postoper	1990
Organic mania induced by phenytoin: a case report. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1989, Volume: 34, Issue:8 Topics: Aged; Bipolar Disorder; Cerebral Infarction; Epilepsies, Partial; Female; Humans; Mental Status Sche	1989
[Insulinoma, complex partial seizures and diphenylhydantoin]. Revista clinica espanola, 1987, Volume: 181, Issue:1 Topics: Adenoma, Islet Cell; Electroencephalography; Epilepsies, Partial; Female; Humans; Insulinoma; Middle	1987
Carbamazepine, phenytoin and phenobarbital in drug-resistant partial epilepsies. Italian journal of neurological sciences, 1986, Volume: 7, Issue:1 Topics: Adolescent; Adult; Carbamazepine; Drug Evaluation; Drug Resistance; Epilepsies, Partial; Epilepsy, T	1986
Adult onset stuttering and seizures. Clinical EEG (electroencephalography), 1986, Volume: 17, Issue:3 Topics: Adult; Combined Modality Therapy; Electroencephalography; Epilepsies, Partial; Female; Humans; Pheny	1986
[Clinical application of the measurement of serum phenytoin sodium (DPH) concentrations]. Zhonghua nei ke za zhi, 1986, Volume: 25, Issue:9 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Femal	1986
Phenytoin encephalopathy. The Journal of the Association of Physicians of India, 1986, Volume: 34, Issue:11 Topics: Child; Encephalitis; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Male; Phenytoin	1986
[Rolandi epilepsy--a frequent seizure disorder in childhood. Symptomatology, electroencephalography, etiology, therapy, prognosis]. Der Nervenarzt, 1988, Volume: 59, Issue:1 Topics: Adolescent; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsies, Par	1988
Adrenal cortex hormones in male epileptic patients before and during a 2-year phenytoin treatment. Journal of neurology, neurosurgery, and psychiatry, 1988, Volume: 51, Issue:3 Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adult; Epilepsies, Partial; Epil	1988
Phenytoin interaction with rifampicin. BMJ (Clinical research ed.), 1988, Oct-22, Volume: 297, Issue:6655 Topics: Aged; Aged, 80 and over; Drug Interactions; Epilepsies, Partial; Humans; Male; Phenytoin; Rifampin;	1988
Postictal pulmonary edema in children. Neurology, 1985, Volume: 35, Issue:3 Topics: Carbamazepine; Child; Epilepsies, Partial; Furosemide; Humans; Intubation, Intratracheal; Male; Oxyg	1985
Diphenylhydantoin encephalopathy. A case report. Acta neurologica, 1985, Volume: 7, Issue:1 Topics: Adult; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies, Partial; Evoked Potenti	1985
[Single daily dose of diphenylhydantoin in treating epilepsy]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1985, Volume: 18, Issue:3 Topics: Adolescent; Adult; Child; Drug Administration Schedule; Epilepsies, Partial; Epilepsy, Tonic-Clonic;	1985
[Antiepileptic monotherapy and combination therapy of simple focal seizures]. Fortschritte der Neurologie-Psychiatrie, 1985, Volume: 53, Issue:12 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Ele	1985
Where, why, and what type of therapy. Pediatric annals, 1985, Volume: 14, Issue:11 Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Hum	1985
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports. Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53 Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec	1973
Anticonvulsant drugs in human epileptogenic brain. Correlation of phenobarbital and diphenylhydantoin levels with plasma. Archives of neurology, 1973, Volume: 29, Issue:2 Topics: Adolescent; Adult; Aged; Animals; Biopsy; Cerebral Cortex; Child; Electroencephalography; Epilepsies	1973
[Undesirable effect of antiepileptic therapy in a patient with epilepsy and maturational focal discharges]. Arquivos de neuro-psiquiatria, 1973, Volume: 31, Issue:3 Topics: Cerebral Cortex; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy, Absence; H	1973
The pattern of epilepsy in Uganda. Tropical and geographical medicine, 1973, Volume: 25, Issue:3 Topics: Adolescent; Adult; Age Factors; Black People; Child; Child, Preschool; Electroencephalography; Epile	1973
Effect of diphenylhydantoin on insulin response in the oral glucose tolerance test in children and adolescents. Helvetica paediatrica acta, 1973, Volume: 28, Issue:6 Topics: Administration, Oral; Adolescent; Age Factors; Child; Epilepsies, Partial; Epilepsy, Tonic-Clonic; F	1973
Epilepsy in cerebral hydatidosis. Epilepsia, 1974, Volume: 15, Issue:1 Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Dominance, Cerebral; Echinococcosis; Ele	1974
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat. Experimental neurology, 1974, Volume: 45, Issue:2 Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence	1974
Syndromes of Sturge-Weber and Klippel-Weber in the same patient. Fukushima journal of medical science, 1974, Volume: 20, Issue:3-4 Topics: Adolescent; Angiomatosis; Bone Diseases; Electromyography; Epilepsies, Partial; Humans; Leukocyte Co	1974
Epilepsy in the elderly. Age and ageing, 1974, Volume: 3, Issue:4 Topics: Age Factors; Aged; Angiography; Brain Neoplasms; Cerebrovascular Disorders; Dementia; Electroencepha	1974
[Outpatient therapy of epilepsy]. Zeitschrift fur arztliche Fortbildung, 1970, Jul-15, Volume: 64, Issue:14 Topics: Anticonvulsants; Barbiturates; Depression, Chemical; Drug Eruptions; Drug Hypersensitivity; Epilepsi	1970
Epilepsy. British medical journal, 1969, Nov-01, Volume: 4, Issue:5678 Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T	1969
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects. Drugs, 1972, Volume: 4, Issue:3 Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog	1972
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats. Epilepsia, 1972, Volume: 13, Issue:3 Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography;	1972
Megaloblastic anemia after anticonvulsive therapy. The New England journal of medicine, 1972, Nov-09, Volume: 287, Issue:19 Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Epilepsies, Partial; Humans; Male; Phenobarbital; Phenyt	1972
Suppressant effects of diphenylhydantoin on the cortical epileptogenic focus. Neurology, 1973, Volume: 23, Issue:3 Topics: Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Electroencephalography	1973
Prolonged unconsciousness following electroconvulsive therapy. The American journal of psychiatry, 1967, Volume: 124, Issue:1 Topics: Adult; Aged; Coma; Craniocerebral Trauma; Depression; Electroconvulsive Therapy; Epilepsies, Partial	1967
[Results of treatment of epilepsy in children up to 14 years of age]. Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3 Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc	1971
Epilepsia partialis continua. Epilepsia, 1971, Volume: 12, Issue:3 Topics: Adult; Brain Diseases; Brain Stem; Electroencephalography; Epilepsies, Partial; Epilepsy; Hematoma,	1971

phenytoin and Abdominal Epilepsy