phenylthiourea and Hyperthyroidism

Gustatory differences in Phenylthiocarbamide (PTC) tasters and non-tasters were studied in hypothyroid and hyperthyroid subjects. After presenting for PTC sensitivity, gustatory responses to 7 dilutions of test solutions for glucose (sweet), sodium chloride (salt), citric acid (sour) and quinine sulphate (bitter) were studied in PTC tasters and non-tasters. The intensity and pleasantness responses for 4 basic tastes were measured on a 7-point and 6-point category scale respectively. Sixty percent of subjects of hyperthyroid and 40% of hypothyroid subjects were tasters. Hypothyroid subjects showed more gustatory differences as compared to hyperthyroids. The diminished intensity perception for sweet and bitter taste was much more prominent in non-tasters than tasters hypothyroids. The greater hedonic value for salt was largely observed among hypothyroid tasters.

Topics: Citrates; Citric Acid; Humans; Hyperthyroidism; Hypothyroidism; Phenylthiourea; Quinine; Sodium Chloride; Taste

In vivo saturation studies of thyroidectomized, propyl thiouracil, and L-triiodothyronine treated animals indicate that the hepatic nuclear binding capacity is not significantly influenced by the thyroidal status of the tissues. The constancy of the nuclear binding capacity for L-triiodothyronine facilitated an analysis of the relationship between nuclear occupancy and hepatic response to an intravenous injection of a triiodothyronine pulse. The activity of the mitochondrial enzyme alpha-glycerophosphate dehydrogenase was used as an index of tissue response to the administered triiodothyronine. Results were compatible with the following model. Saturation of nuclear sites is rapidly followed by a maximal rate of enzyme synthesis. When the sites are saturated, the activity of alpha-glycerophosphate dehydrogenase appeared to be independent of the dose administered. Higher doses of triiodothyronine achieve greater effects simply by occupying nuclear sites for a longer period. The apparent ability of nuclear sites to constrain tissue response to hormone administration provides additional supporting data for the physiological relevance of these sites in the initiation of hormonal action.

Topics: Animals; Binding Sites; Cell Nucleus; Glycerolphosphate Dehydrogenase; Hyperthyroidism; Hypothyroidism; Liver; Male; Mitochondria, Liver; Phenylthiourea; Protein Binding; Rats; Receptors, Cell Surface; Triiodothyronine

Topics: Animals; Antithyroid Agents; Child; Goiter; Graves Disease; Humans; Hyperthyroidism; Methimazole; Phenylthiourea; Propylthiouracil; Rats; Sulfaguanidine; Thioglycosides; Thyroid Gland; Vegetables

Topics: Adult; Female; Genetics, Medical; Glaucoma; Goiter; Gonioscopy; Humans; Hyperthyroidism; Hypothyroidism; Intraocular Pressure; Male; Middle Aged; Phenylthiourea; Taste; Thyroid Diseases; Thyroid Function Tests; Tonometry, Ocular

Topics: Genetics, Medical; Goiter; Humans; Hyperthyroidism; Hypothyroidism; Japan; Nuclear Warfare; Phenylthiourea; Taste; Thiourea; Thyroid Neoplasms; Thyroiditis