phenylthiourea and Glaucoma

Topics: Alcohol Oxidoreductases; Catalase; Cholinesterases; Dicumarol; Diseases in Twins; Drug Hypersensitivity; Drug Resistance; Drug-Related Side Effects and Adverse Reactions; Environment; Female; Genetic Diseases, Inborn; Glaucoma; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Infant, Newborn; Intraocular Pressure; Isoniazid; Malignant Hyperthermia; Mutation; Pharmaceutical Preparations; Pharmacogenetics; Phenylthiourea; Phenytoin; Pregnancy; Protein Binding; Racial Groups; Warfarin

Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Clinical Trials as Topic; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Glaucoma; Humans; Hydrocortisone; Intraocular Pressure; Phenotype; Phenylthiourea; Pituitary-Adrenal Function Tests; Taste; Thyroid Function Tests

A series of 474 mixed cases of glaucoma was assessed to determine whether there were any genetic differences between different types of glaucoma. A careful distinction was made between chronic open angle glaucoma (COAG), acute and chronic angle closure glaucoma, ocular hypertension, low tension glaucoma, patients with large cup disc ratios, and various types of secondary glaucoma including pseudoexfoliation of the lens capsule, uveitic and traumatic glaucoma. Using ABO blood groups, Rhesus groups, ABH secretion or non-secretion, and phenylthiourea tasting we identified certain differences. The differences from normal were significant decrease in Rh-negative patients in chronic closed angle glaucoma (p less than 0.05), a decrease in ABH secretors in ocular hypertension (p less than 0.01), and fewer HB secretors in patients with COAG (p less than 0.02). There was a significant decrease in AH secretors and increase in HB secretors in both pseudoexfoliation with raised intraocular pressure compared with COAG (p less than 0.01) and in secondary glaucomas as a group compared with COAG (p less than 0.01). Tasters of phenylthiourea were more common in traumatic and uveitic glaucoma than in normal controls (p less than 0.05). These results suggest that secondary glaucoma develops in different subjects from COAG, while patients who develop a rise in intraocular pressure proceed to cupping and field loss if they have a certain genetic constitution. The groups of patients are too small for the differences to be of great prognostic value.

Topics: Blood Group Antigens; Genetic Markers; Glaucoma; Humans; Phenylthiourea; Rh-Hr Blood-Group System; Taste Threshold

Topics: ABO Blood-Group System; Glaucoma; Humans; Phenylthiourea; Polymorphism, Genetic; Taste

Topics: Female; Glaucoma; Humans; Male; Pedigree; Phenylthiourea; Taste; Thyroid Function Tests; Thyroid Gland; Time Factors

Topics: Aged; Cataract; Female; Glaucoma; Humans; Male; Phenylthiourea; Taste

Topics: Adolescent; Adrenocortical Hyperfunction; Adult; Glaucoma; Humans; Middle Aged; Phenylthiourea; Taste; Taste Buds

Topics: Adolescent; Adult; Aged; Astigmatism; Child; Glaucoma; Humans; Middle Aged; Phenylthiourea; Refractive Errors; Solutions; Taste

Topics: Female; Glaucoma; Humans; Intraocular Pressure; Male; Phenylthiourea; Taste

Topics: ABO Blood-Group System; Blood Pressure Determination; Czechoslovakia; Factor Analysis, Statistical; Glaucoma; Humans; Intraocular Pressure; Phenylthiourea; Taste; Tonometry, Ocular

Topics: Adolescent; Adult; Aged; Anterior Chamber; Child; Eye; Female; Gene Frequency; Genes, Recessive; Genetics, Population; Glaucoma; Greenland; Humans; Inuit; Male; Middle Aged; Phenylthiourea; Taste

Topics: Adult; Aged; Black People; Dexamethasone; Genes; Glaucoma; Glucose Tolerance Test; Homozygote; Humans; Hydrocortisone; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Phenylthiourea; Prisons; Stimulation, Chemical; Taste; Thyroid Function Tests; White People

Topics: Administration, Topical; Adult; Anterior Chamber; Circadian Rhythm; Dexamethasone; Glaucoma; Glucose Tolerance Test; Homozygote; Humans; Hydrocortisone; Intraocular Pressure; Optic Nerve; Phenotype; Phenylthiourea; Taste; Thyroid Function Tests; Tonometry, Ocular; Water

Topics: Adult; Aged; Anterior Chamber; Female; Glaucoma; Gonioscopy; Greenland; Humans; Inuit; Male; Mass Screening; Middle Aged; Phenylthiourea; Tonometry, Ocular

Topics: Age Factors; Dexamethasone; Glaucoma; Glucose Tolerance Test; Humans; Hydrocortisone; Indians, North American; Intraocular Pressure; Missouri; Phenylthiourea; Taste; Tonometry, Ocular

Topics: Dexamethasone; Glaucoma; Humans; Intraocular Pressure; Phenylthiourea; Taste; Thyroid Function Tests; White People

Topics: Adolescent; Child, Preschool; Eye Diseases; Female; Glaucoma; Humans; Hyperopia; Keratoconus; Male; Myopia; Phenylthiourea; Taste

Topics: Adrenal Cortex Hormones; Adult; Betamethasone; Diseases in Twins; Female; Glaucoma; Homozygote; Humans; Intraocular Pressure; Male; Middle Aged; Myopia; Pedigree; Phenotype; Phenylthiourea

Topics: Adult; Female; Genetics, Medical; Glaucoma; Goiter; Gonioscopy; Humans; Hyperthyroidism; Hypothyroidism; Intraocular Pressure; Male; Middle Aged; Phenylthiourea; Taste; Thyroid Diseases; Thyroid Function Tests; Tonometry, Ocular

Topics: Female; Glaucoma; Humans; Male; Phenylthiourea; Taste

Topics: Antibodies; Glaucoma; Humans; Iodine Radioisotopes; Phenylthiourea; Thyroglobulin; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland

In a series of Caucasian patients over the age of 40 years, the number of individuals unable to recognize the bitter taste of phenylthiourea (8.1 mg/100 ml) was found to be 28 percent in a "normal" eye clinic population (446 individuals), 17 percent in a series of 155 patients with angleclosure glaucoma, and 53 percent in 211 patients with primary open-angle glaucoma.

Topics: Biomedical Research; Diagnosis; Geriatrics; Glaucoma; Glaucoma, Open-Angle; Humans; Middle Aged; Phenylthiourea; Taste; Thiourea; White People

Topics: Black People; Genetics, Medical; Glaucoma; Humans; Phenylthiourea; Taste; White People

Topics: Diagnosis; Glaucoma; Humans; Phenylthiourea; Taste