phenylthiourea and Epilepsy

The study was based on the data of a sample of 400 epileptic patients (200 idiopathic and 200 symptomatic) and 100 normal healthy individuals serving as controls. The PTC threshold distribution was bimodal. The number of non-tasters among idiopathic epileptics (35.5%) and symptomatic epileptics (32.5%) was significantly higher than controls (20%). The relative incidence of non-tasters in idiopathic and symptomatic epilepsies was 2.20 and 1.93 respectively. There is evidence that non-tasters tend to ingest a greater quantity of bitter tasting goitrogenic substances present naturally in edible plants which in turn exert greater thyroid stress in non-tasters or less sensitive tasters. Such a stress during intrauterine or early childhood growth and development might have affected neurological maturation which in turn made them more susceptible to epilepsy than tasters, who faced lesser stress.

Topics: Adolescent; Adult; Case-Control Studies; Epilepsy; Female; Humans; Male; Phenylthiourea; Sensory Thresholds; Taste

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Eye; Female; Functional Laterality; Genetics, Population; Hair; Hand; Humans; Infant; Infant, Newborn; Male; Middle Aged; Pedigree; Phenylthiourea; Pigmentation; Schizophrenia; Sex Ratio; Tajikistan; Taste

Topics: Alcoholism; Bipolar Disorder; Black or African American; Chromosome Mapping; Epilepsy; Female; Genes; Genetics, Medical; Humans; Intellectual Disability; Male; Mental Disorders; Phenylthiourea; Schizophrenia; Sex Factors; Taste; White People