phenylthiourea and Body-Weight

One of the critical factors that determines individual differences in dietary behavior and nutritional status is the sensory-affecting quality of food, in particular its taste. Variation of one bitter taste receptor gene, TAS2R38, which is associated with the differential sensitivity to phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP), has been demonstrated to affect the dietary intake pattern. A case study was performed to examine the association of the TAS2R38 genotypes/haplotypes with the body size (height, weight and BMI) and with the food and nutrient intake. Eighty-four college students, all females, with an age range of 18-21 y were recruited from the University of Shizuoka. The genotypes of two common single nucleotide polymorphisms in TAS2R38 (A49P and I296V) were determined by PCR-restriction fragment length polymorphism (RFLP) method. The height, weight and body mass index (BMI), and (in a subgroup of 47 subjects) food and nutrition intake estimated from 3 d of food recording, were compared between homozygotes for the PTC/PROP-nontaster haplotype (AI haplotype) and carriers with the PTC/PROP-taster haplotype (PV haplotype). The results show that the homozygotes with AI haplotype were taller and heavier than the carriers of PV haplotype, while BMI values were similar between them. The former group also had higher energy and carbohydrate intakes than the latter group. Neither vegetable nor dairy product intake was different between the homozygotes with AI haplotype and the carriers of PV haplotype. In conclusion, the PTC/PROP-nontaster TAS2R38 genotype/haplotype was associated with height and weight but not with BMI, which may in turn have influenced the energy and carbohydrate intakes.

Topics: Adolescent; Adult; Body Height; Body Mass Index; Body Weight; Diet; Dietary Carbohydrates; Dysgeusia; Eating; Energy Intake; Female; Genotype; Humans; Phenylthiourea; Polymorphism, Single Nucleotide; Propylthiouracil; Students; Taste; Universities; Young Adult

Topics: Acetylcholine; Analgesia; Animals; Behavior, Animal; Body Weight; Brain; Choline; Chromatography, Gas; Copper; Dopamine; Dopamine beta-Hydroxylase; Drug Synergism; Drug Tolerance; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Norepinephrine; Phenylthiourea; Serotonin; Substance Withdrawal Syndrome; Time Factors

Topics: Adrenocorticotropic Hormone; Animals; Body Height; Body Weight; Carbon Radioisotopes; Carotenoids; Cyprinidae; Lutein; Phenylthiourea; Pigmentation; Time Factors; Xanthines

Topics: Adipose Tissue; Adolescent; Adult; Anthropometry; Body Height; Body Weight; Child; Color Perception; Ethnicity; Eye; Female; Genetics, Population; Hair; Humans; Israel; Male; Middle Aged; Phenylthiourea; Taste

Topics: Age Factors; Animals; Blood Glucose; Body Weight; Cysteine; Drug Tolerance; Glutathione; Injections, Intraperitoneal; Liver; Liver Glycogen; Lung; Male; Methionine; Phenylthiourea; Pulmonary Edema; Rats; Sulfur

Topics: Administration, Oral; Animals; Body Weight; Drug Combinations; Ethambutol; Ethionamide; Guinea Pigs; Isoniazid; Lung; Mycobacterium; Mycobacterium Infections; Phenylthiourea; Pneumoconiosis; Radiography; Time Factors; Tuberculosis, Pulmonary

Topics: Black or African American; Body Height; Body Weight; Child; Growth; Humans; Phenylthiourea; Skeleton; Taste; United States

Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Biomedical Research; Blood Sedimentation; Body Temperature; Body Weight; Carbanilides; Drug Resistance; Drug Resistance, Microbial; Gastric Lavage; Isoniazid; Phenylthiourea; Sputum; Statistics as Topic; Toxicology; Tuberculosis; Tuberculosis, Pulmonary