phenylmethylsulfonyl fluoride has been researched along with Nervous System Disorders in 15 studies
Phenylmethylsulfonyl Fluoride: An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
phenylmethanesulfonyl fluoride : An acyl fluoride with phenylmethanesulfonyl as the acyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This kind of interaction among esterase inhibitors should be considered to study the potentiation/promotion phenomenon, which is observed when some esterase inhibitors enhance the severity of the OP induced neuropathy if they are dosed after a non neuropathic low dose of a neuropathy inducer." | 1.39 | Interactions of neuropathy inducers and potentiators/promoters with soluble esterases. ( Estévez, J; Mangas, I; Sogorb, MÁ; Vilanova, E, 2013) |
| "Phenylmethylsulfonyl fluoride (PMSF) is a protease and esterase inhibitor that causes protection or potentiation/promotion of organophosphorus delayed neuropathy (OPIDN) depending on whether it is dosed before or after an inducer of delayed neuropathy." | 1.38 | Phenylmethylsulfonyl fluoride, a potentiator of neuropathy, alters the interaction of organophosphorus compounds with soluble brain esterases. ( Estévez, J; Mangas, I; Vilanova, E, 2012) |
| " However, if PMSF is dosed after a low non-neuropathic dose of a neuropathic OP, its neurotoxicity is 'promoted', causing severe neuropathy." | 1.30 | Discrimination of carboxylesterases of chicken neural tissue by inhibition with a neuropathic, non-neuropathic organophosphorus compounds and neuropathy promoter. ( Barril, J; Céspedes, MV; Escudero, MA; Sogorb, MA; Vicedo, JL; Vilanova, E, 1997) |
| " Experiments were aimed to ascertain if neuropathy is caused by repeated dosing with a promoter not causing NTE inhibition and in the absence of deliberate injury to axons." | 1.30 | Repeated low doses of O-(2-chloro-2,3,3 trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) do not cause neuropathy in hens. ( Jokanovic, M; Lotti, M; Moretto, A, 1998) |
| " This is compatible with the fact that inhibited NTE is autopsy material from hens dosed with PPP can always be reactivated in vitro, presumably because no 'aging' reaction has occurred." | 1.29 | Prophylaxis against and promotion of organophosphate-induced delayed neuropathy by phenyl di-n-pentylphosphinate. ( Johnson, MK; Read, DJ, 1993) |
| " PFK activity decreased in sciatic nerve 15 days after dosing with TOCP or TOCP + PMSF." | 1.28 | Decrease of phosphofructokinase activity in relation to the pathogenesis of triorthocresyl-phosphate-induced delayed neuropathy. ( Hernández, AF; Pla, A; Villanueva, E, 1992) |
| " Prior administration of phenylmethylsulfonyl fluoride (PMSF) reduced the incidence of damage to the peripheral nerve of animals dosed with TPP, but did not prevent toxic effects on the cell bodies in the spinal cord or the clinical effects." | 1.27 | Histopathological assessment of triphenyl phosphite neurotoxicity in the hen. ( Abou-Donia, MB; Brown, HR; Carrington, CD, 1988) |
| " Conversely, another group of rats, pretreated with Mipafox, was dosed with PMSF when NTE inhibition was 90." | 1.27 | Phenylmethylsulfonyl fluoride protects rats from Mipafox-induced delayed neuropathy. ( Padilla, S; Veronesi, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mangas, I | 2 |
| Vilanova, E | 3 |
| Estévez, J | 2 |
| Sogorb, MÁ | 2 |
| Caroldi, S | 2 |
| Lotti, M | 5 |
| Masutti, A | 1 |
| Drakontides, AB | 1 |
| Baker, T | 1 |
| Johnson, MK | 1 |
| Read, DJ | 1 |
| Fioroni, F | 1 |
| Moretto, A | 4 |
| Milatovic, D | 1 |
| Osman, KA | 1 |
| Céspedes, MV | 1 |
| Escudero, MA | 1 |
| Barril, J | 1 |
| Vicedo, JL | 1 |
| Jokanovic, M | 1 |
| Massicotte, C | 1 |
| Inzana, KD | 1 |
| Ehrich, M | 1 |
| Jortner, BS | 1 |
| Hernández, AF | 1 |
| Pla, A | 1 |
| Villanueva, E | 1 |
| Pope, CN | 1 |
| Padilla, S | 2 |
| Capodicasa, E | 1 |
| Carrington, CD | 1 |
| Brown, HR | 1 |
| Abou-Donia, MB | 1 |
| Veronesi, B | 1 |
15 other studies available for phenylmethylsulfonyl fluoride and Nervous System Disorders
| Article | Year |
|---|---|
Phenylmethylsulfonyl fluoride, a potentiator of neuropathy, alters the interaction of organophosphorus compounds with soluble brain esterases.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Enzyme Inhibitors; Hydrolysis; Nervous System | 2012 |
Interactions of neuropathy inducers and potentiators/promoters with soluble esterases.
Topics: Animals; Brain; Catalytic Domain; Chickens; Enzyme Inhibitors; Esterases; Isoflurophate; Kinetics; N | 2013 |
Intra-arterial injection of diisopropylfluorophosphate or phenylmethanesulphonyl fluoride produces unilateral neuropathy or protection, respectively, in hens.
Topics: Animals; Carboxylic Ester Hydrolases; Chickens; Female; Injections, Intra-Arterial; Isoflurophate; N | 1984 |
An electrophysiologic and ultrastructural study of the phenylmethanesulfonyl fluoride protection against a delayed organophosphorus neuropathy.
Topics: Animals; Cats; Drug Evaluation, Preclinical; Evoked Potentials; Female; Gait; Isoflurophate; Male; M | 1983 |
Prophylaxis against and promotion of organophosphate-induced delayed neuropathy by phenyl di-n-pentylphosphinate.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Dose-Response Relationship, Drug; Drug Synerg | 1993 |
Triphenylphosphite neuropathy in hens.
Topics: Animals; Axonal Transport; Brain; Carboxylic Ester Hydrolases; Chickens; Nerve Tissue; Nervous Syste | 1995 |
Phenyl valerate esterases other than neuropathy target esterase and the promotion of organophosphate polyneuropathy.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Enzyme Inhibitors; Female; Isoflurophate; Kin | 1997 |
Discrimination of carboxylesterases of chicken neural tissue by inhibition with a neuropathic, non-neuropathic organophosphorus compounds and neuropathy promoter.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Central Nervous System; Chickens; Cholinesterase Inhibi | 1997 |
Repeated low doses of O-(2-chloro-2,3,3 trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) do not cause neuropathy in hens.
Topics: Acetylcholinesterase; Animals; Axons; Brain; Carboxylic Ester Hydrolases; Chickens; Cholinesterase I | 1998 |
Neuropathologic effects of phenylmethylsulfonyl fluoride (PMSF)-induced promotion and protection in organophosphorus ester-induced delayed neuropathy (OPIDN) in hens.
Topics: Animals; Brain; Chickens; Female; Nerve Degeneration; Nerve Fibers; Nervous System Diseases; Organop | 1999 |
Decrease of phosphofructokinase activity in relation to the pathogenesis of triorthocresyl-phosphate-induced delayed neuropathy.
Topics: Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Carboxylic Ester Hydrolases; Chickens; | 1992 |
Promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride.
Topics: Animals; Drug Synergism; Nervous System Diseases; Organophosphorus Compounds; Phenylmethylsulfonyl F | 1991 |
Promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride.
Topics: Animals; Carbamates; Carboxylic Ester Hydrolases; Chickens; Dose-Response Relationship, Drug; Drug S | 1991 |
Histopathological assessment of triphenyl phosphite neurotoxicity in the hen.
Topics: Animals; Chickens; Female; Injections, Subcutaneous; Isoflurophate; Nervous System Diseases; Organop | 1988 |
Phenylmethylsulfonyl fluoride protects rats from Mipafox-induced delayed neuropathy.
Topics: Animals; Brain; Injections, Intraperitoneal; Injections, Subcutaneous; Isoflurophate; Male; Nervous | 1985 |