phenylephrine-hydrochloride and Stomach-Ulcer

Apnea in the neonatal period frequently is associated with prematurity. Full-term infants who develop apnea usually have associated clinical conditions such as infection, shock, metabolic disorders, neonatal abstinence syndrome, intracranial pathology, and gastroesophageal reflux. Gastric ulcer also is a rare phenomenon in the neonatal period. We describe a full-term infant presenting with apnea. Upon investigation, a 6-channel pneumocardiogram revealed central apnea and multiple episodes of low esophageal pH (< 4), which is suggestive of gastroesophageal reflux. This was confirmed by an upper gastrointestinal series. A small antral ulcer crater also was demonstrated. When assessing the etiology of apnea in a full-term infant, gastroesophageal reflux and gastric ulcer should be considered.

Topics: Anti-Ulcer Agents; Apnea; Cisapride; Esophagus; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Male; Nose; Oxygen; Piperidines; Pulmonary Ventilation; Pulse; Ranitidine; Respiration; Stomach Ulcer

The incidence of upper gastrointestinal (UGI) bleeding and the effect of nutritional support was studied retrospectively in 166 spinal cord injured patients. Sixty six patients included in group 1 were started on oral diet when 'clinically ready' which resulted in a haphazard manner for provision of nutrition. One hundred patients in group 2 were treated according to an organised nutrition protocol. The protocol initiates total parental nutrition (TPN) if the patient is not tolerating an oral diet by day 5. All group 2 patients met their total energy requirements (TER) within 48 hours after initiating caloric supplementation. The overall incidence of acute acid peptic ulceration leading to significant bleeding or perforation was 4%. Five of the 66 group 1 patients (7.5%) and 2 of the 100 group 2 patients (2%) developed acute ulcerations. While the exact mechanism remains unclear, this significant (p less than 0.05) reduction indicates that a nutritional regimen that meets a patients TER decreases the likelihood of acid peptic complications after spinal cord injury.

Topics: Adult; Female; Gastric Acid; Gastrointestinal Hemorrhage; Humans; Male; Nose; Parenteral Nutrition, Total; Spinal Cord Injuries; Stomach Ulcer; Stress, Physiological; Suction

Topics: Gastroscopes; Gastroscopy; Humans; Intubation, Gastrointestinal; Nose; Stomach Ulcer

Topics: Anti-Allergic Agents; Histamine H1 Antagonists; Mice; Nasal Decongestants; Nose; Phenylephrine; Research; Stomach Ulcer; Toxicology; Vasoconstrictor Agents