phenylephrine-hydrochloride and Soft-Tissue-Neoplasms

The bilobed transposition flap has earned its reputation as a reliable and predictable flap, offering aesthetically appealing reconstructive results on difficult nasal defects. Several modifications to the bilobed technique have been made in recent years and there is a tendency towards bigger flaps executed at non-nasal locations. This review describes the development since Esser's original design, and summarizes present knowledge on bilobed flap repair. Furthermore, insight is offered into the latest indications for non-nasal reconstructions.

Topics: Carcinoma; Carcinoma, Basal Cell; Face; Facial Neoplasms; Forearm; History, 20th Century; Humans; Nose; Nose Neoplasms; Plastic Surgery Procedures; Skin Neoplasms; Soft Tissue Neoplasms; Surgery, Plastic; Surgical Flaps

When a sarcomatous neoplasm is identified in the breast, distinguishing metaplastic carcinoma, malignant phyllodes tumor (MPT), and primary sarcoma is a diagnostic challenge, especially on small biopsies, as all these tumors may have overlapping morphological features, thoroughly grossing with histological examination and immunohistochemical staining being the standard approach to aid in classifying these lesions. Recently, we identified a highly sensitive and specific breast carcinoma marker TRPS1 with high expression in metaplastic breast carcinoma. In the current study, we tested TRPS1 in MPTs and primary sarcoma of the breast. We found TRPS1 was highly expressed (95%) within spindle cell, chondro-osseous, and/or liposarcomatous components of MPTs, in all breast primary chondrosarcomas and extraskeletal osteosarcomas, but not in other sarcomas of the breast. In extramammary sarcomas, TRPS1 was expressed in 28% of conventional chondrosarcomas and 56% of osteosarcomas of bone, but rarely in undifferentiated pleomorphic sarcomas (UPSs), liposarcomas, and angiosarcomas. In summary, MPTs may share similar genetic background with metaplastic carcinoma exhibiting TRPS1 expression, and TRPS1 may play a role in chondro-osseous differentiation because of its expression in chondro-osseous sarcomas from both breast and extramammary sites. Our findings suggest TRPS1 may be clinically useful in distinguishing MPT and metaplastic carcinoma from primary breast sarcoma except for tumors with chondro-osseous differentiation.

Topics: Bone Neoplasms; Breast Neoplasms; Carcinoma; Chondrosarcoma; Female; Fingers; Hair Diseases; Humans; Langer-Giedion Syndrome; Nose; Osteosarcoma; Phyllodes Tumor; Repressor Proteins; Sarcoma; Soft Tissue Neoplasms

A nasoalveolar cyst is a rare, non-odontogenic soft tissue cyst encountered in the anterior maxillary labial sulcus as an asymptomatic soft tissue swelling. Often, patients with these cysts report them to the dental clinic where they are mistaken for odontogenic lesions by the dental surgeon, especially if concomitant dental problems are present. They cannot be detected by routine conventional dental radiography as they are peripheral, lying within the mucosa thereby posing a diagnostic challenge. We document a case of a 47-year-old woman with a nasoalveolar cyst.

Topics: Cysts; Dentistry; Dentists; Female; Humans; Jaw Cysts; Maxilla; Maxillary Diseases; Middle Aged; Mouth Diseases; Nose; Nose Neoplasms; Odontogenic Cysts; Soft Tissue Neoplasms; Tooth Socket

Myopericytoma is a rare, recently described tumor demonstrating a hemangiopericytoma-like vascular pattern. We present two cases of myopericytoma associated with trauma: a 64-year-old man who developed several nodules on his nose four months after sustaining multiple abrasions to his forehead and nose, and a 72-year-old woman with a solitary growth in the alveolar ridge of unknown duration. Biopsy specimens of the lesions in both cases demonstrated a striking concentric perivascular proliferation of bland spindle-shaped pericytic cells characteristic of myopericytoma. Despite sharing morphologic features with angioleiomyoma, myofibroma and glomus tumor, myopericytoma is thought to represent a distinct perivascular myoid neoplasm of skin and soft tissues. The tumor is characterized by a radial and perivascular arrangement of ovoid, spindled to round neoplastic cells that are immunoreactive to alpha-smooth muscle actin, often for h-caldesmon as well as smooth muscle myosin-heavy chain, and usually negative for desmin antibodies. Most cases of myopericytoma are benign, however, local recurrence and malignancy have recently been reported, Myopericytoma can be multifocal involving a single or multiple anatomic regions, and tends to occur in dermal and superficial soft tissues of adults primarily on the extremities. Our cases are unusual examples of myopericytoma manifesting as multiple nodules on the nose, and a solitary growth on the buccal mucosa after trauma.

Topics: Actins; Aged; Biomarkers, Tumor; Calcium-Binding Proteins; Calponins; Female; Hemangiopericytoma; Humans; Male; Microfilament Proteins; Middle Aged; Mouth Mucosa; Myosin Heavy Chains; Nose; Skin Neoplasms; Soft Tissue Neoplasms; Treatment Outcome; Wounds and Injuries

We report 2 cases of nasolabial cyst and a case of schwannoma beneath the alar base that required a differential diagnosis because of clinical features and MR images that resembled the nasolabial cyst. The morphologic analysis on MR images revealed the characteristic appearance of the nasolabial cyst, and the sagittal MR image may be most helpful for diagnosing this rare disease.

Topics: Adolescent; Connective Tissue; Cysts; Female; Humans; Lip; Lip Neoplasms; Male; Middle Aged; Neurilemmoma; Nose; Nose Neoplasms; Soft Tissue Neoplasms

Topics: Adult; Diagnosis, Differential; Humans; Immunohistochemistry; Leiomyoma; Male; Nose; Soft Tissue Neoplasms

We report 3 patients with isolated cleft or coloboma of the nose--an extremely rare occurrence. This entity belongs to no. 1 of Tessier's classification of craniofacial clefts. Excessive separation of the medial and lateral nasal processes of the frontonasal process may be the genesis of this condition. Management should address two points: the cleft and the associated malformations of the cartilaginous nasal framework.

Topics: Adult; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Lipoma; Male; Nose; Reoperation; Rhinoplasty; Soft Tissue Neoplasms; Surgical Flaps

Juvenile hyaline fibromatosis (JHF) is a rare disease of autosomal recessive heredity characterized by multiple subcutaneous nodules, hypertrophy of the gingiva, and flexural contracture of the joints including those of the cervical vertebrae and the mandibula. It has been pointed out that the clinical features render tracheal intubation profoundly difficult. We present a case of 6-year-old girl diagnosed as JHF and anesthetized for tumor resection and reconstruction of the naso-oral region. She was significantly small for her age weight 12.3 kg and lived on a wheel-chair because of flexion contracture of the extremities. However, the cervical spinal joints were not involved and the neck could be extended in our case. With extreme care and preparation, anesthetic induction and tracheal intubation were smoothly done although a tooth was damaged by the surgeon when gauze-packing was attempted into the pharynx before the operation. Anesthesia was maintained uneventfully and satisfactorily during the surgery under anesthesia with nitrous oxide, oxygen, sevoflurane, fentanyl and vecuronium. There was no prolongation of nor abnormal reaction to the effect of vecuronium observed in this patient.

Topics: Anesthesia, Inhalation; Child; Female; Fibroma; Humans; Mouth; Nose; Soft Tissue Neoplasms