phenylephrine-hydrochloride and Sneezing

The review discusses the physiological and pathophysiological mechanisms associated with the symptoms of acute and chronic rhinosinusitis. An understanding of symptom mechanisms is important for the clinical diagnosis of rhinosinusitis and is important in assessing the efficacy of surgical and medical treatments for rhinosinusitis. The review will discuss the four primary symptoms used to diagnose rhinosinusitis: nasal obstruction, nasal discharge, facial pain and loss of sense of smell; and the secondary symptoms, cough, sneezing, sore throat and voice changes, epiphora, fever, and psychological effects and fatigue. The review will highlight that our understanding of a key diagnostic symptoms facial pain is limited, and that the incidence of pain with rhinosinusitis is controversial. Sneezing is a common symptom of acute rhinosinusitis with allergy but is not normally described as symptom in chronic rhinosinusitis and this anomaly is in need of more research. The mechanism of unilateral nasal obstruction with rhinosinusitis is discussed.

Topics: Chronic Disease; Humans; Nasal Obstruction; Nose; Olfaction Disorders; Pharyngitis; Rhinitis; Sinusitis; Sneezing; Tomography, X-Ray Computed

The incidence of rhinitis is on the increase, especially in towns and cities with high levels of pollution from motor traffic and industry. There is a growing body of evidence which links this increased incidence of rhinitis to chronic nasal irritation from industrial pollution. Studies on the mechanisms of nasal inflammation and the nasal immune response are now providing insights into the etiology of rhinitis. This knowledge will help in the development of therapies aimed at alleviating the symptoms of rhinitis and controlling the development of rhinitis in susceptible individuals. This review discusses some of the factors that may explain the increased incidence of rhinitis and examines basic mechanisms involved in the nasal response to infection and allergy.

Topics: Air Pollution; Bronchial Hyperreactivity; Humans; Nose; Nose Diseases; Respiratory Hypersensitivity; Rhinitis; Sneezing

The nose, as an organ initiating reflexes affecting itself and the rest of the body, and as a target organ of control, is highly complex. Its innervation includes parasympathetic, sympathetic, sensory/afferent, and somatic motor nerves, which combine in a variety of morphologic pathways. The vasculature of the nose contains capacitance vessels such as sinusoids and distensible venules, as well as arteriovenous anastomoses, arterioles, capillaries, and venules. The secretory tissue of the nose includes epithelial cells, submucosal glands, and relatively large anterior or lateral serous glands; in addition, some species have specialized secretory glands. The nose is the source of many powerful reflexes, including the diving response, sneeze and sniff reflexes, and reflexes affecting autonomic nervous function to the cardiovascular system, airways in the lungs, the larynx, and other organs. Axon reflex control of the nasal vasculature is also important. The nasal vasculature can be shown to be under parasympathetic and sympathetic control, but there is little precise information concerning the effect of nerves on different types of blood vessels. Pharmacologic experiments show that vascular resistance and vascular volume can be separately influenced by nerves and mediators, and that vascular resistance and airway resistance are not necessarily inversely related. Nasal secretion is also under the influence of both parasympathetic and sympathetic nerves, and can be induced by a wide range of neurotransmitters and mediators. In general, the concentrations needed to promote secretion are considerably higher than those that affect vascular resistance, at least with regard to the lateral nasal gland of the dog. In humans, nasal patency is affected by several nervous inputs, presumably acting via vascular beds. The nasal cycle is the alternation of resistances between the two sides of the nose, on which other changes are superimposed. In exercise and hyperpnea, nasal airflow resistance decreases, presumably with vascular decongestion. Recent studies of the crutch reflex (the ipsilateral nasal congestion caused by stimulation of the axilla) show that some of the reflex inputs to the nose can be unilateral.

Topics: Airway Resistance; Apnea; Axilla; Diving; Humans; Nasal Mucosa; Nervous System Physiological Phenomena; Nose; Physical Exertion; Pulmonary Ventilation; Reflex; Regional Blood Flow; Respiration Disorders; Sneezing; Thorax

Topics: Airway Obstruction; Anesthetics, Local; Headache; Hearing Disorders; Histamine H1 Antagonists; Humans; Imidazoles; Mucus; Nasal Decongestants; Nose; Nose Diseases; Phenethylamines; Sneezing

Topics: Antigens; Bacterial Infections; Bronchi; Cilia; Cough; Environmental Pollutants; Environmental Pollution; Genes; Histocompatibility; Humans; Immunity, Cellular; Immunoglobulin E; Lung; Lymphatic System; Lymphocytes; Mucus; Neutralization Tests; Nose; Pulmonary Alveoli; Reflex; Respiratory Tract Diseases; Respiratory Tract Infections; Sensory Receptor Cells; Sneezing; Virus Diseases

Topics: Aerosols; Air Microbiology; Animals; Bacteria; Cell Count; Child; Cough; Guinea Pigs; Humans; Infant; Infections; Mycobacterium tuberculosis; Nose; Respiratory System; Saliva; Schools; Sneezing; Speech; Staphylococcus; Streptococcus; Tuberculosis; Virus Diseases; Viruses

Exposure to bright light such as sunlight elicits a sneeze or prickling sensation in about one of every four individuals. This study presents the first scientific examination of this phenomenon, called 'the photic sneeze reflex'.. In the present experiment, 'photic sneezers' and controls were exposed to a standard checkerboard stimulus (block 1) and bright flashing lights (block 2) while their EEG (electro-encephalogram) was recorded. Remarkably, we found a generally enhanced excitability of the visual cortex (mainly in the cuneus) to visual stimuli in 'photic sneezers' compared with control subjects. In addition, a stronger prickling sensation in the nose of photic sneezers was found to be associated with activation in the insula and stronger activation in the secondary somatosensory cortex.. We propose that the photic sneeze phenomenon might be the consequence of higher sensitivity to visual stimuli in the visual cortex and of co-activation of somatosensory areas. The 'photic sneeze reflex' is therefore not a classical reflex that occurs only at a brainstem or spinal cord level but, in stark contrast to many theories, involves also specific cortical areas.

Topics: Adult; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Light; Male; Nose; Photic Stimulation; Reflex; Sneezing; Somatosensory Cortex; Sunlight; Visual Cortex; Visual Perception; Young Adult

The aim of this study is pursue the effect of herbal point-patch treatment on allergic rhinitis patients by investigation of the changes of serum total IgE (T-IgE) and eosinophile cationic protein (ECP) levels and through assessment of the results of SF-36 and rhinitis severity questionnaires. A prospective, randomized, single-blind, parallel, controlled study was used. Forty- three eligible participants were selected from outpatients of the Dept. of Ear, Nose, and Throat and Chinese medicine clinic, and 33 eligible participants completed the treatment satisfactorily. Participants used a Chinese herbal point-patch or a placebo patch once a week, for three hours at a time, after being randomly assigned to a control or an experimental group. Each treatment course was three weeks in duration, and each participant underwent two courses of treatment. Before and after each course, participants evaluated the effectiveness of the treatment by completing a questionnaire, and blood samples were collected for T-IgE and ECP analysis. The data revealed that the acupoint herbal patch is a valuable treatment for allergic rhinitis, especially in the symptoms of sneezing, running and itchy nose. The results of the SF-36 indicate a distinct improvement in GH (general health) and VT (vitality) in patients treated with acupoint herbal patches. This study supports the belief that the acupoint herbal patch is an effective treatment for allergic rhinitis and can significantly improve general health, social life and vitality in quality of life.

Topics: Acupuncture Points; Administration, Cutaneous; Adolescent; Adult; Child; Drugs, Chinese Herbal; Eosinophil Cationic Protein; Female; Humans; Immunoglobulin E; Magnoliopsida; Male; Nasal Mucosa; Nose; Phytotherapy; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Single-Blind Method; Sneezing; Surveys and Questionnaires; Treatment Outcome; Young Adult

To study the response of the maxillary sinus to histamine provocation, we performed a double-blind, randomized, crossover trial during which nonallergic subjects without symptoms of rhinitis (n = 25) received either 10 mg loratadine or placebo once daily for a week and then underwent nasal challenge with histamine (3, 10, and 30 mg/ml) followed, 24 h later, by a maxillary sinus challenge while still receiving the medication. Nasal challenge with histamine led to significant increases in vascular permeability, reflex nasal secretions, sneezing, and other nasal symptoms. Sinus challenge resulted in significant increases in vascular permeability within the sinus cavity (P < 0.01) and some nasal symptoms but no significant change in reflex nasal secretions. The response of the sinus mucosa to histamine was lower in magnitude than that of the nose. Treatment with loratadine resulted in a significant inhibition of the histamine-induced changes in both nasal and sinus cavities. Our data suggest the lack of a sinonasal reflex response to histamine provocation of the maxillary sinus of nonallergic individuals.

Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Maxillary Sinus; Nose; Pilot Projects; Reflex; Serum Albumin; Sneezing

Topical sodium cromoglycate is used to treat allergic diseases of the upper and lower airways. To investigate its mechanisms of action, intranasal histamine challenge was used in nine subjects with perennial allergic rhinitis. After a preliminary day where subjects' reactivity thresholds (D100) for histamine were determined, intranasal sodium cromoglycate was administered in a double-blind, placebo-controlled fashion. Graded (D100/3, D100, D100X3), sequential challenges were performed on days 1 and 21 of each course, and responses measured by changes in nasal airway resistance, sneezes, secretion volume and secretion content: total protein, lysozyme and mucin. After a single dose of sodium cromoglycate, there was no change in resistance, but secretion volumes fell significantly (3.12 ml/5 min c.i. 2.83-3.4; placebo 3.61, c.i. 3.32-3.90: P = 0.026). After a 3-week-course, there was a significant fall in resistance (4.29 cm H2O/l/s, c.i. 3.85-4.72; placebo 5.45, c.i. 5.01-5.88: P < 0.0001). No change in other parameters was observed. Thus, in perennial allergic rhinitis, intranasal sodium cromoglycate has both short- and long-term effects on nasal reactivity to histamine challenge. Acutely, there is a reduction in nasal lavage fluid volume which may be the result of reduced irritant receptor activity. After a 3-week course, there is a reduction in nasal resistance responses, a possible anti-inflammatory effect.

Topics: Administration, Intranasal; Adult; Aged; Airway Resistance; Anti-Inflammatory Agents; Cromolyn Sodium; Double-Blind Method; Female; Histamine; Humans; Male; Middle Aged; Mucins; Muramidase; Nasal Lavage Fluid; Nasal Mucosa; Nasal Provocation Tests; Nose; Placebos; Proteins; Rhinitis, Allergic, Perennial; Sneezing

The aim of the study was to compare the efficacy and side-effects of oral antihistamine and nasal glucocorticoid therapy in seasonal allergic rhinitis. In a double-blind, double-dummy, group-comparative study, 60 birch and grass pollen allergic patients were treated with either loratadine (10 mg daily) or beclomethasone dipropionate (BDP) (100 micrograms in each nostril twice daily) during a 3 weeks' study period. Grading of 4 nasal and 3 non-nasal symptoms was performed at 4 weekly visits, and patients recorded daily symptoms and possible adverse experiences in a diary. Patients treated with BDP showed significantly less nasal blockage than those receiving loratadine (P less than 0.05), but there was no difference (P greater than 0.05) in other nasal symptoms (sneezing, itching and discharge). Patients treated with loratadine showed a statistically significantly greater relief in eye symptoms as compared with BDP (P less than 0.05). The side-effects caused by the 2 treatments were few and insignificant. We conclude that loratadine and intranasal BDP were effective in the treatment of seasonal allergic rhinitis, but the spectrum of individual symptoms controlled was different for the 2 drugs.

Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Beclomethasone; Cyproheptadine; Double-Blind Method; Eye; Female; Histamine Antagonists; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Nose; Poaceae; Pollen; Pruritus; Rhinitis, Allergic, Seasonal; Sneezing; Time Factors; Trees

This paper presents the results of a randomized, double-blind, placebo-controlled study of the efficacy of chlorpheniramine in relieving the symptoms and attenuating the pathophysiologic correlates of a rhinovirus "common cold." Forty healthy, adult, nonatopic subjects were randomly assigned to one of two treatment groups: active drug and placebo. On study Day 0, all subjects were challenged intranasally with rhinovirus type 39 (dose = 100 TCID50). Subjects were cloistered from Day 2 to Day 7, at which time they were treated with either chlorpheniramine or placebo. From 3 days before challenge to study Day 19, subjects had nasal patency assessed by rhinomanometry, eustachian tube function assessed by the 9-step test and sonotubometry, middle ear pressure assessed by tympanometry and nasal clearance assessed by the dyed-saccharin technique. Symptom diaries were maintained throughout the period of follow-up. During cloister, symptoms also were scored by interview, nasal secretions were quantified and nasal washings were performed for viral culture. Results showed that 19 (95%) subjects in the active-treatment group and 18 (90%) subjects in the placebo-treatment group shed virus. Symptomatic colds were observed in 63% of the active-treated and 83% of the placebo-treated subjects. Symptoms increased on Day 1 and peaked at Days 4 to 5. Detrimental changes in other measured functions consistent with those previously reported were observed. During the period of treatment, significant differences in the average symptom scores favoring the active-treatment group were observed for sneezing. Also, weight of expelled secretions was greater and mucociliary clearance rate less on some cloister days for the placebo-treated group. No significant differences between treatment groups in the objective measures of nasal congestion or the response of the middle ear and eustachian tube were documented.

Topics: Acoustic Impedance Tests; Adult; Chlorpheniramine; Clinical Trials as Topic; Common Cold; Double-Blind Method; Ear, Middle; Eustachian Tube; Female; Humans; Male; Manometry; Mucociliary Clearance; Mucus; Nose; Random Allocation; Sneezing

During 3 years of immunotherapy with tree pollen extracts, 31 patients were provoked annually. Changes in nasal reactivity were followed by registration of expiratory nasal peak flow, number of sneezes, and amount of secretion. The reproducibility of the peak flow measurements was studied. The results from all three parameters were used to form a total nasal provocation score which, better than each parameter separately, could demonstrate the variation in sensitivity. Provocation with an allergen concentration of 1 HEP was the most effective means of showing changes in specific sensitivity of nasal mucosa.

Topics: Administration, Inhalation; Adult; Allergens; Clinical Trials as Topic; Desensitization, Immunologic; Evaluation Studies as Topic; Female; Humans; Immunotherapy; Male; Nasal Mucosa; Nasal Provocation Tests; Nose; Peak Expiratory Flow Rate; Pollen; Sneezing

Topics: Humans; Nose; Pharynx; Sneezing; Trachea; Tracheal Diseases

Topics: Humans; Nose; Skin Diseases; Sneezing

A 47-year-old woman presented to the emergency department with sudden onset of swelling in her face, which had been triggered by blowing her nose. She had no other symptoms, but was known to have Ehlers-Danlos syndrome. A CT confirmed bilateral subcutaneous facial emphysema attributed to a defect in her left nasal cartilage. The condition was managed conservatively with prophylactic antibiotics and self-resolved within 48 hours. Only eight cases of sudden facial subcutaneous emphysema following nose blowing or sneezing have been found in the English literature and this is the first known case in a patient with a connective tissue disorder. In this case, her condition is suspected to have contributed to her presentation and may be underlying in other similar cases.

Topics: Connective Tissue; Ehlers-Danlos Syndrome; Female; Humans; Middle Aged; Nose; Sneezing; Subcutaneous Emphysema

Sneezing is a vital respiratory reflex frequently associated with allergic rhinitis and viral respiratory infections. However, its neural circuit remains largely unknown. A sneeze-evoking region was discovered in both cat and human brainstems, corresponding anatomically to the central recipient zone of nasal sensory neurons. Therefore, we hypothesized that a neuronal population postsynaptic to nasal sensory neurons mediates sneezing in this region. By screening major presynaptic neurotransmitters/neuropeptides released by nasal sensory neurons, we found that neuromedin B (NMB) peptide is essential for signaling sneezing. Ablation of NMB-sensitive postsynaptic neurons in the sneeze-evoking region or deficiency in NMB receptor abolished the sneezing reflex. Remarkably, NMB-sensitive neurons further project to the caudal ventral respiratory group (cVRG). Chemical activation of NMB-sensitive neurons elicits action potentials in cVRG neurons and leads to sneezing behavior. Our study delineates a peptidergic pathway mediating sneezing, providing molecular insights into the sneezing reflex arc.

Topics: Animals; Brain Stem; Disease Models, Animal; Hypersensitivity; Male; Mice, Inbred C57BL; Neurokinin B; Neurons; Neuropeptides; Nose; Reflex; RNA, Small Interfering; Sensory Receptor Cells; Sneezing; TRPV Cation Channels; Video Recording

Cystic fibrosis (CF) patients almost regularly reveal sinonasal pathology. The purpose of this study was to assess association between objective and subjective measurements of sinonasal involvement comparing nasal airflow obtained by active anterior rhinomanometry (AAR), nasal endoscopic findings, and symptoms assessed with the Sino-Nasal Outcome Test-20 (SNOT-20).. Nasal cavities were explored by anterior rigid rhinoscopy and findings were compared to inspiratory nasal airflow measured by AAR to quantify nasal patency and subjective health-related quality of life in sinonasal disease obtained with the SNOT-20 questionnaire. Relations to upper and lower airway colonization with Pseudomonas aeruginosa, medical treatment, and sinonasal surgery were analysed.. A total of 124 CF patients were enrolled (mean age 19.9 ± 10.4 years, range 4-65 years). A significant association of detection of nasal polyposis (NP) in rhinoscopy was found with increased primary nasal symptoms (PNS) which include "nasal obstruction," "sneezing," "runny nose," "thick nasal discharge," and "reduced sense of smell." At the same time patients with pathologically decreased airflow neither showed elevated SNOT-20 scores nor abnormal rhinoscopic findings. Altogether, rhinomanometric and rhinoscopic findings are not significantly related.. Among SNOT-20 scores the PNS subscore is related to rhinoscopically detected polyposis and sinonasal secretion. Therefore, we recommend including short questions regarding PNS into CF-routine care. At the same time our results show that a high inspiratory airflow is not associated with a good sensation of nasal patency. Altogether, rhinomanometry is not required within routine CF-care, but it can be interesting as an outcome parameter within clinical trials. Pediatr Pulmonol. 2017;52:167-174. © 2016 Wiley Periodicals, Inc.

Topics: Adolescent; Adult; Aged; Carrier State; Child; Child, Preschool; Cystic Fibrosis; Endoscopy; Female; Humans; Male; Middle Aged; Nasal Cavity; Nasal Obstruction; Nose; Olfaction Disorders; Pseudomonas aeruginosa; Pseudomonas Infections; Quality of Life; Rhinomanometry; Sneezing; Surveys and Questionnaires; Young Adult

In this paper, the airflow field including the velocity, pressure and turbulence intensity distributions during sneezing of a female subject was simulated using a computational fluid dynamics model of realistic upper airways including both oral and nasal cavities. The effects of variation of reaction of the subject during sneezing were also investigated. That is, the impacts of holding the nose or closing the mouth during sneezing on the pressure and velocity distributions were studied. Few works have studied the sneeze and therefore different aspects of this phenomenon have remained unknown. To cover more possibilities about the inlet condition of trachea in different sneeze scenarios, it was assumed that the suppressed sneeze happens with either the same inlet pressure or the same flow rate as the normal sneeze. The simulation results showed that during a normal sneeze, the pressure in the trachea reaches about 7000Pa, which is much higher than the pressure level of about 200Pa during the high activity exhalation. In addition, the results showed that, suppressing the sneeze by holding the nose or mouth leads to a noticeable increase in pressure difference in the tract. This increase was about 5 to 24 times of that during a normal sneeze. This significant rise in the pressure can justify some reported damage due to suppressing a sneeze.

Topics: Adult; Air Pressure; Computer Simulation; Exhalation; Female; Humans; Models, Biological; Nose; Sneezing; Trachea

To establish the murine models of local allergic rhinitis (LAR) and allergic rhinitis (AR) by using ovalbumin (OVA), and to investigate the relationship between them.. Thirty BALB/c mice were divided into 5 groups, (1) the nasally sensitized group (group A1) that was challenged with OVA by a 10 d procedure, (2) the control group of A1 that was challenged with phosphate-buffered saline (PBS), (3) the nasally sensitized group (group A2) that was challenged with OVA by a 25 d procedure, (4)the control group of A2 that was challenged with PBS, (5) the intraperitoneally sensitized group (group B) .The numbers of sneezing after final challenge were counted, and the serum OVA-specific immunoglobulin E (OVA-sIgE), interleukin (IL) -4, IL-13, IL-5 levels in nasal lavage fluid were measured by ELISA. Hematoxylin-eosin staining was performed to evaluate the histological change of nose and lung tissues. Graph Pad Prism 6 software was used to analyze the data.. Nasally sensitized group A1 displayed LAR symptoms of sneezing and eosinophilic infiltrating, but without increased OVA-sIgE in serum on day 10 compared with the control group of A1(t=0.697, P>0.05), OVA-sIgE in serum of group A2(2.710±1.406)ng/ml reached to statistical significance and with airway remodeling on day 25 compared with the control group of A2((0.221±0.080)ng/ml, t=4.329, P<0.05). IL-5 and IL-13 in nasal fluid showed a significant increase in the nasally sensitized group A1, compared with the group A2(t values were 2.442, 2.804, P values were less then 0.05).. A short time intranasal instillation with OVA could establish LAR murine model, continuing OVA challenge could increase serum sIgE level and with airway remodeling. LAR mice show a unique characteristic by expressing higher IL-5 and IL-13 in nose than AR mice, but sIgE in serum remains at a normal level.

Topics: Administration, Intranasal; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Immunoglobulin E; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Mice; Mice, Inbred BALB C; Nose; Ovalbumin; Rhinitis, Allergic; Sneezing; Sodium Chloride

The fruits of Xanthium strumarium L. (Asteraceae) have been used extensively in China for treatment of various diseases such as allergic rhinitis (AR), tympanitis, urticaria and arthritis or ozena. This study was designed to systemically investigate the effects of the caffeoylxanthiazonoside (CXT) isolated from fruits of X. strumarium on AR in rodent animals. Animals were orally administered with CXT. Anti-allergic activity of CXT was evaluated by passive cutaneous anaphylaxis test (PCA); acetic acid-induced writhing tests were used to evaluate the analgesic effects of CXT; acetic acid-induced vascular permeability tests were performed to evaluate anti-inflammatory effect of CXT. Then, the model AR in rats was established to evaluate the effects of CXT on AR with the following tests: the sneezing and nasal scratching frequencies, IgE level in serum, and histopathological examinations. Our results demonstrated that CXT had favorable anti-allergic, anti-inflammatory and analgesic effects. Additionally, we found that CXT was helpful to ameliorate the nasal symptoms and to down-regulate IgE levels in AR rats. Thus, we suggested that CXT can be treated as a candidate for treating AR.

Topics: Acetic Acid; Analgesics; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Caffeic Acids; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Fruit; Immunoglobulin E; Inflammation; Mice, Inbred ICR; Nose; Pain; Phytotherapy; Rats, Sprague-Dawley; Rhinitis, Allergic; Sneezing; Xanthium

Transnasal resection of the posterior nasal nerve (TRPN) is the surgical procedure for drug therapy-resistant, intractable allergic rhinitis (AR). Submucous inferior turbinectomy also improves nasal symptoms in severe AR. Surgical injury to this peripheral nerve fibre may be the major cause of the decrease in allergic symptoms. During submucous turbinectomy, we have identified the peripheral branches of the posterior nasal nerve in the inferior turbinate and resected them (SRPN). The aim of this study was to evaluate the therapeutic effects of turbinoplasty with SRPN in severe AR.. Improvements in subjective symptoms were compared between 13 patients who underwent SRPN with turbinoplasty (Group 1) and 11 who underwent TRPN combined with turbinoplasty and SRPN (Group 2) by retrospective chart review. Pre- and postoperative sneezing, rhinorrhea, and nasal obstruction were evaluated with questionnaires. Postoperative complications and drug therapy before and after surgery were investigated.. All symptoms improved postoperatively in both groups, with no significant differences in the improvements in nasal symptom scores between the groups.. SRPN combined with submucosal turbinectomy was shown to be a safe, useful, and efficient approach to patients with AR unresponsive to medical therapy. Although this is a short-term study, the results of this study suggest that SRPN represents one of the treatment options for intractable AR.

Topics: Adult; Denervation; Endoscopy; Female; Humans; Male; Nasal Mucosa; Nasal Obstruction; Nasal Surgical Procedures; Nose; Retrospective Studies; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Sneezing; Treatment Outcome; Turbinates

Topics: Adult; Blepharoptosis; Emphysema; Humans; Male; Nose; Rhinitis, Allergic, Seasonal; Sneezing

Although it has been suggested that the use of tachykinin receptor antagonists might prove to be an effective treatment for allergic rhinitis (AR), they are not used clinically. Therefore, we decided to examine the effects of tachykinin receptor antagonists on AR symptoms in an appropriate experimental model.. To evaluate newly developed tachykinin receptor antagonists in a Japanese cedar pollen-induced AR model and to determine their effect on allergen-induced sneezing, nasal blockage, and nasal hyperresponsiveness (NHR).. Sensitized guinea-pigs were challenged by forced inhalation of pollen once every week. Sneezing and nasal blockage were observed after pollen challenges. NHR (nasal blockage) to an intranasal application of leukotriene D(4) was assessed 2 days after an antigen challenge. We also evaluated whether intranasal dosing with a tachykinin causes NHR. NK(1) and NK(2) receptor antagonists were administered before an intranasal treatment with antigen or tachykinin. Amounts of tachykinins present in nasal cavity lavage fluid were measured by an enzyme immunoassay.. Although an NK(1) and NK(2) receptor dual antagonist showed no effect on pollen-induced sneezing and biphasic nasal blockage, it did completely suppress the development of NHR. Experiments using specific NK(1) or NK(2) receptor antagonists revealed that NK(2) receptor activation was preferentially involved in the development of hyperresponsiveness. Increases in the levels of substance P (SP) and neurokinin A (NKA) in the nasal tissue were noted 20 min-1 h after the challenge. Intranasal instillation of either SP or NKA-induced NHR, which was almost completely inhibited by NK(2) receptor antagonists and partially inhibited by NK(1) receptor antagonists.. SP and NKA, which are released early after the challenge, mediate the development of NHR by preferentially activating NK(2) receptors. Therefore, NK(2) receptor antagonists might prove to be effective treatment of AR.

Topics: Allergens; Animals; Disease Models, Animal; Guinea Pigs; Humans; Nasal Lavage Fluid; Nasal Obstruction; Nasal Provocation Tests; Neurokinin A; Nose; Pollen; Receptors, Neurokinin-2; Receptors, Tachykinin; Rhinitis, Allergic, Seasonal; Sneezing; Substance P; Tachykinins

We studied the effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. A single administration of propolis caused no significant effect on both antigen-induced nasal rubbing and sneezing at a dose of 1000 mg/kg, but a significant inhibition was observed after repeated administration for 2 weeks at this dose. Propolis caused no significant inhibitory effect on the production of total IgE level after repeated administration of 1000 mg/kg. The drug also caused no significant inhibition of histamine-induced nasal rubbing and sneezing at a dose of 1000 mg/kg. On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by antigen and compound 48/80 at a concentration of more than 10 microg/ml. These results clearly demonstrated that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.

Topics: Allergens; Animals; Brazil; Histamine; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Nose; Propolis; Pruritus; Rats; Rhinitis, Allergic, Perennial; Sneezing

Nasal symptoms such as sneezing, stuffy nose and runny nose occur in allergic and nonallergic rhinitis. Normal nose also sometimes has these symptoms. It is necessary to define what is the symptom of normal nose in order to make a proper diagnosis of rhinitis, grading of severity of nasal symptom in rhinitis and criteria of normalization after the treatment of rhinitis.. 235 persons who had no perceptive nasal symptom and history of nasal disease at present and past, and cold at present, were sampled from the registered list of a health care organization, and examined their nasal symptom by mailing a self-administered questionnaire of nasal symptom. In addition, 54 patients, who visited 4 otolarngology clinics due to diseases other than rhinitis and were diagnosed as normal nose, were examined, using the same questionnaire.. Response rate from persons mailed was 49.8%. Nasal symptom was infrequent in patients at clinic more than persons sampled from the list. Nasal symptom in 117 responders with normal nose had none or occasional and momentary stuffy nose. Sneezing and/or nose blow was less than 5 times a day, and itchy nose and postnasal drip were 30% and 25% respectively. These symptoms, if appeared, were less than 4 days per week.. Grading "minus", normal, is zero in sneezing and runny nose and none in stuffy nose in the grading system of nasal symptom used commonly in Japan. These should be changed to none or occasional, momentary, easily tolerable in stuffy nose, less than once a day or grading "plus one" (1-5 times per day) occasionally in sneezing and nose blow. Normalization after treatment could be defined according to this change.

Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Nose; Nose Diseases; Pruritus; Reference Values; Severity of Illness Index; Sneezing; Surveys and Questionnaires

Rhinitis is defined as an inflammatory disease, but in clinical practice the diagnosis is based on the occurrence of nasal symptoms. As all persons occasionally sneeze and blow the nose, it is necessary to define what is normal. In this study the daily number of sneezes and of nose blowing were recorded in diary-cards over a 14 day period by 80 hospital employees and medical students, who considered themselves not to suffer from rhinitis. The results showed that more than 95% of the normal persons sneezed and blew the nose less than 4 times a day, on average. It is concluded that it is normal to sneeze and blow the nose less than 4 times daily while a higher number can be a sign of rhinitis. It is recommended that counting of sneezes and of nose blowing is used in clinical trials in order to define the study population. Together with an objective measurement of nasal patency this can be useful in defining the effect profile of different types of treatment.

Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Nose; Prevalence; Reference Values; Rhinitis; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index; Sneezing; Surveys and Questionnaires

Nasal reflexes elicited by mechanical or electrical stimulation of nasal afferents were studied in anesthetized guinea pigs. Probing the nasal cavity of one side evoked a greater activation of the contralateral than the ipsilateral nasal muscles and, occasionally, sneezing. Similarly, electrical stimulation of the ethmoidal nerve often caused sneezing, with a greater activation of the nasal muscles and a greater increase in resistance on the contralateral side. Asymmetrical activation of the nasal muscles in response to mechanical stimuli induces asymmetrical airflows, especially during sneezing, between the two sides of the nasal cavity. Most of the expired air is forcibly blown out through the ipsilateral nostril, thus improving the elimination of irritants from the nose.

Topics: Airway Resistance; Anesthesia; Animals; Electromyography; Guinea Pigs; Male; Nasal Mucosa; Neurons, Afferent; Nose; Physical Stimulation; Reflex; Respiratory Muscles; Sneezing; Trigeminal Nerve

We reviewed the records of 136 patients who had inner ear disorders including hearing loss and vertigo caused by pressure change. We divided them into three groups, according to the aetiology: group A, change in atmospheric pressure (diving, airplane travel, etc.); group B, rapid change in ear pressure in normal atmosphere (nose blowing, heavy lifting, etc.); and group C, blast injury. A flat initial audiogram was the most common type in groups A and B. In group C, high-tone hearing loss was the most common type of audiogram. These results correspond to findings previously reported in animal experiments. Exploratory tympanotomy was performed more than 12 days after the pressure change in 16 patients. Although the vertigo disappeared after surgery, hearing did not improve.

Topics: Adolescent; Adult; Aged; Animals; Audiometry; Aviation; Barotrauma; Blast Injuries; Child; Diving; Female; Hearing Disorders; Hearing Loss, High-Frequency; Hearing Loss, Sensorineural; Humans; Labyrinth Diseases; Lifting; Male; Middle Aged; Mountaineering; Nose; Pressure; Sneezing; Treatment Outcome; Tympanic Membrane; Vertigo

Topics: Child; Foreign Bodies; Humans; Nose; Sneezing

The sneeze reflex is a valuable tool for exploring the maturation of the respiratory control in the newborn as it alters both inspiratory and expiratory activities. Air puff stimulation of the superior nasal meatus innervated by ethmoidal afferents consistently evokes sneeze in adult cats. Such stimulation evokes only a reinforcement of expiratory activities in newborn kittens. This study demonstrates that the pattern of Fos-like immunoreactivity evoked by nasal stimulation changes during functional maturation of sneeze. Nasal stimulation evoked immunoreactivity (i) in the trigeminal sensory complex, at the levels where nasal afferents project, (ii) in the reticular formation, (iii) in the solitary complex and (iv) in the parabrachial area of mature kittens. The evoked immunoreactivity was the same in newborn kittens as in mature kittens in the projection areas of the nasal primary afferents. Fos response was less than half that in mature kittens in the reticular formation and absent in the solitary complex or the parabrachial area. Sneeze can be elicited from the time when evoked immunoreactivity in the solitary complex and the parabrachial area is above control levels. These data provide evidence that the maturation of sneeze is dependent on the development of central relays allowing peripheral inputs to be integrated by neurons engaged in respiratory control.

Topics: Aging; Animals; Animals, Newborn; Brain Stem; Cats; Functional Laterality; Nose; Olfactory Pathways; Physical Stimulation; Proto-Oncogene Proteins c-fos; Reflex; Regression Analysis; Respiration; Reticular Formation; Sneezing; Trigeminal Nerve

In intranasal vaccination it is important that the adjuvant does not have any toxic effect on the sensitive nasal mucosa. In this study a histological and clinical evaluation of the effects of two different adjuvants in a vaccine containing detoxified diphtheria (DT) and tetanus toxoid (TT) in guinea pigs was done. The guinea pigs were divided in four groups and treated daily for 14 days with different formulations. Group I with saline, Groups 2 and 3 with the vaccines in a non-ionic surfactant formulation containing glycerides and Group 4 with tetraethyleneglycol formulation containing glycofurol. The guinea pigs in Groups 1, 2 and 4 were sacrificed on day 15 and Group 3, 1 week later and the tissues processed for histological examination. The animals remained healthy during the treatment and minor clinical signs, such as nose-blowing, decreased with time. The histological appearance, including the development of lymphoid tissue, was comparable in all groups. A specific toxic effect on the nasal mucosa by the different vaccine and adjuvant formulations was not observed.

Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Body Weight; Female; Guinea Pigs; Inflammation; Leukocytes, Mononuclear; Lymphoid Tissue; Nasal Cavity; Nasal Mucosa; Nasal Septum; Nose; Sneezing; Time Factors; Turbinates; Vaccination

In cats, we studied the activity of laryngeal, thoracic and abdominal muscles and the variations in oesophageal pressure in response to air puff stimulations of the nasal mucosa. Following single stimulations, inspiratory and laryngeal dilator muscles were transiently inhibited. During inspiratory inhibition, expiratory muscles and laryngeal constrictor were transiently activated. Repetitive air puff stimulations, which induced sneeze, evoked a similar pattern of transient activities during the inspiratory preparation of sneeze. This resulted in transient fluctuations of the oesophageal pressure, whose mean value became more negative as the preparatory inspiration enhanced. Our results suggest that the entire pool of respiratory neurons (bulbospinal, vagal and facial) works together in the sneeze reflex. Study of transient inspiratory inhibition demonstrates two periods during the preparatory inspiration phase of sneeze. In the first period transient effects are related to each shock of the stimulation. The second period is characterized by a diminution or a lack of transient effects associated with the stimulation. At the end of the expulsive phase, the diaphragm and the glottal dilator were further activated.

Topics: Abdominal Muscles; Air; Animals; Cartilage; Cats; Electromyography; Esophagus; Laryngeal Muscles; Muscles; Nasal Mucosa; Nose; Physical Stimulation; Pressure; Sneezing; Thorax

The aim of this study was to determine the role of histamine receptors in the nose. The effects of intranasal histamine challenge were compared with those of a specific H1-receptor agonist, betahistine and a specific H2-receptor agonist, impromidine, in 11 normal individuals and four with rhinitis. Sneezing, nasal irritation and hypersecretion were induced by histamine and the H1-receptor agonist, betahistine only. Nasal airway resistance (Rna) was measured by passive anterior rhinomanometry. Histamine, betahistine and impromidine all induced rises in Rna in both normal individuals and those with rhinitis but histamine had the most potent effect; the H2-receptor effect on Rna was predominant over that of the H1-receptor. The sensitivity to all three agonists was greater in the individuals with rhinitis.

Topics: Adult; Airway Resistance; Betahistine; Dose-Response Relationship, Drug; Female; Flushing; Histamine; Humans; Impromidine; Male; Nasal Mucosa; Nasal Provocation Tests; Nose; Receptors, Histamine H1; Receptors, Histamine H2; Rhinitis; Single-Blind Method; Sneezing

To understand better the response of patients with allergic rhinitis to nasal challenge with antigen, we studied the mechanism of priming, that is, the increased clinical response to daily sequential nasal challenges. Ten subjects with ragweed hay fever were challenged four times with increasing doses of ragweed pollen. The first 2 challenge days were separated by 2 weeks, whereas the last three challenges occurred on sequential days. Nasal lavages, performed before and after each nasal challenge, were evaluated for levels of inflammatory mediators and cellular content. In contrast to control days, a significant (p less than 0.05) increase in the number of sneezes occurred on both priming days. Priming was associated with a significant increase in the level of histamine on both priming days, whereas the second priming day was also associated with an increase in TAME-esterase activity, kinins, and prostaglandin D2 obtained after challenge (p less than 0.05 for all). In the lavages before challenge on the priming days, the total number of cells and the number of neutrophils, eosinophils, and alcian blue-positive cells were significantly increased, but in contrast, basal levels of mediators were not. The net increase in the number of alcian blue-positive cells correlated with the net increase in the amount of histamine released on the priming days (r = 0.661; p less than 0.05). These studies suggest that priming results, in part, from increased mediator release from influxing inflammatory cells.

Topics: Eosinophils; Histamine Release; Humans; Hypersensitivity; Nose; Pollen; Prostaglandin D2; Sneezing

For the clinical evaluation of vidian neurectomy, questionnaires were sent to 250 cases operated on from 1971 to 1982, with answers obtained from 171. For sneezing, 56.8% of cases were evaluated markedly effective, 36.7% effective, 4.3% unchanged, and 2.2% aggravated. For rhinorrhea, markedly effective was 54.7%; effective, 39.4%; unchanged, 3.7%; aggravated, 2.2%. For nasal obstruction, markedly effective was 67.5%; effective, 27.4%; unchanged, 5.1%; and aggravated, 0%. On the other hand, 20% of cases complained of relapse of nasal allergic symptoms. Concerning the side effects, 28.7% of cases complained of cheek, upper lip, or palate numbness. Decrease of lacrimation was noted in 9.4% of cases. Several kinds of disturbances in the eye movement were observed in 4% of cases. Among them, 16 cases showed complete recovery within 24 h. In 3 cases, abducens paralysis continued for several months. Postoperative arterial bleeding occurred in one case. My recent strategy for the treatment of allergic rhinitis is conservative treatment at first, secondary nasal surgery such as septoplasty or turbinotomy, and at last vidian neurectomy if the patient agrees to be operated on after understanding the side effects.

Topics: Abducens Nerve; Cranial Nerve Diseases; Evaluation Studies as Topic; Eye Movements; Follow-Up Studies; Humans; Lacrimal Apparatus Diseases; Nasal Obstruction; Nose; Paralysis; Postoperative Complications; Rhinitis, Allergic, Perennial; Sneezing; Surveys and Questionnaires

Topics: Adolescent; Adult; Airway Resistance; Biological Factors; Female; Histamine; Humans; Male; Middle Aged; Nasal Mucosa; Nasal Provocation Tests; Nose; Platelet Activating Factor; Prostaglandin D2; Rhinitis, Allergic, Perennial; Sneezing; SRS-A

Rhinitis causes both clinical and social discomfort to patients, and in clinical practice is often underdiagnosed. We have examined a simple method for the assessment of a positive nasal provocation test to help in the diagnosis of rhinitis. In patients with histories suggestive of house dust mite (HDM) sensitivity and positive skin-prick tests or specific IgE to Dermatophagoides pteronyssinus, there was a fall in nasal inspiratory peak flow (NIPF) following nasal challenge with allergen. This was not seen in control subjects or in pollen-sensitive patients when challenged with house dust mite. Frequency of sneezing and degree of rhinorrhoea increased in these patients following challenge, and based on these findings we propose a simplified scoring system for the diagnosis of allergic rhinitis. We examined non-specific nasal reactivity using hyperosmolar solutions as a challenge system and found that allergic subjects responded with a fall in NIPF, although the clinical response was not identical to that seen with allergen. Control subjects did not respond to hyperosmolar challenge.

Topics: Adolescent; Adult; Allergens; Female; Humans; Male; Middle Aged; Nose; Osmolar Concentration; Palate; Rhinitis, Allergic, Perennial; Sneezing

Topics: Animals; Cardiovascular Physiological Phenomena; Cats; Humans; Neural Pathways; Nose; Rabbits; Reflex; Respiratory Physiological Phenomena; Sneezing

An in vivo model of human allergic disease has been developed in which nasal challenge with antigen leads to physiologic changes, together with a release of increased amounts of inflammatory mediators into nasal secretions obtained by washing the nose with saline. In 105 experiments involving 35 subjects, only allergic subjects consistently demonstrated an increase in the concentrations of the mast cell mediator, histamine, and the putative mast cell mediators, TAME-esterase and PGD2. The release of each mediator was significantly (p less than 0.001) related to the physiologic change (sneezing). The release of each mediator also correlated significantly with the release of the other 2 mediators (p less than 0.001). This system, for the first time, clearly relates an in vivo symptom and mediator release and thus should provide an excellent tool for the further study of the allergic response and nasal pathophysiology.

Topics: Adolescent; Adult; Airway Resistance; Allergens; Bronchial Provocation Tests; Female; Histamine; Humans; Male; Nose; Peptide Hydrolases; Prostaglandin D2; Prostaglandins D; Rhinitis, Allergic, Seasonal; Sneezing

The incidence of respiratory reactions to stimulation of the nasal and propharyngeal mucose was studied in 44 newborn premature infants. The inhalation of menthol fumes or the administration of drops of Mukoseptonex to the nasal mucosa caused transient respiratory arrest or a drop in the respiration rate. The heart rate rose during chemical stimulation of the nasal mucosa, possibly in association with a general arousal reaction. Mechanical stimulation of the nasal mucosal with a nylon fibre elicited an expulsive reaction in 95% of the cases. As distinct from experimental animals, sneezing was not preceded by a deep initial inspiration. Stimulation of the oropharyngeal region produced transient apnoea in 24.5% of the cases, in 18% expiratory reactions reminiscent of the expiration reflex, in 33% independent, intensive inspiratory reactions and in 24.5% cough. Cough from both the oropharyngeal and the laryngeal region had a pronounced inspiratory component. Independent inspiratory reactions may to some extent be co-responsible for the high incidence of aspirations in the neonatal period.

Topics: Cough; Electrocardiography; Esophagus; Heart Rate; Humans; Infant, Newborn; Infant, Premature; Manometry; Nose; Oropharynx; Physical Stimulation; Pressure; Reflex; Respiration; Sneezing; Stimulation, Chemical

An experimental set-up is described permitting the evaluation and quantification under controlled conditions of retention efficiencies of surgical mask materials and different types of masks, using bacterial aerosols standardized both quantitatively and qualitatively. Screening of various materials used in one-way surgical paper masks has shown that, apart from the one-layered thin models, present paper masks with bacterial transmittance under 1% are far superior to the muslin masks of the past. For meeting the aseptical requirements in hospital operating rooms, adaptable masks (green exterior) provided with multi-layered polyester filter pads have proven most suitable by their virtual impenetrability for bacteria. After several hours use and heavy wetting of the filters layers, no increase of bacterial transmittance was observed.

Topics: Bacteria; Cough; Humans; Masks; Mouth; Nose; Sneezing

Rhinovirus was transmitted from experimentally infected volunteers (donors) to susceptible recipients and the efficiencies of spread by hand-to-hand contact and large- and small-particle aerosols compared. Transmission of infection was very efficient by the hand route: 11 of 15 hand-contact exposures initiated infection, compared with one of 12 large-particle (P less than 0.005) and none of 10 small-particle (P less than 0.005) exposures. Rhinovirus was present in nine of 18 (50%) nasal swab specimens, 28 of 43 (65%) hand rinses, and seven of 18 (39%) saliva specimens of donors; geometric mean titers of positive specimens were 10(1.5), 10(1.4), and 10(1.2) tissue culture infectious dose 50/ml (TCID 50/ml), respectively. Rhinovirus was present in 20 of 43 (46%) recipient hand rinses, with a geometric mean titer of 10(1.4)TCID50/ml. Virus on donors' hands was transferred to recipients' fingers during 20 of 28 (71%) 10-second hand-contact exposures. These findings support the concept that hand contact/self-inoculation may be an important natural route of rhinovirus transmission.

Topics: Adolescent; Aerosols; Common Cold; Cough; Hand; Humans; Nose; Rhinovirus; Sneezing

Topics: Adult; Humans; Leprosy; Male; Mouth; Mycobacterium leprae; Nose; Sneezing

Topics: Animals; Bronchi; Epithelial Cells; Epithelium; Humans; Immunization; Immunoglobulins; Leukocytes; Lung; Lymph Nodes; Macrophages; Mucous Membrane; Nose; Phagocytosis; Pulmonary Alveoli; Reflex; Respiratory Physiological Phenomena; Respiratory System; Sneezing

Sneezes were induced in anestized cats by repetitive stimulation of the ethmoidal nerve. Activity of bulbar respiratory neurons during sneezing was recorded extracellularly through tungsten microelectrodes. Most expiratory neurons could be locked onto the stimulus pulses so that they responded either throughout inspiration as well as expiration or so that they began responding at some time during inspiration. As inspiration approached termination, multiple spiking occurred, finally to result in high-frequency bursts which just preceded active expiration. A fraction of expiratory neurons were activated only in bursts. Latent expiratory neurons were recruited in sneezing. Inspiratory neurons near nucleus ambiguus and most of those near fasciculus solitarius displayed similar response patterns consisting of silent periods followed by delayed smooth activations. Temporal characteristics of the silent periods, "inhibitory gaps," suggested that they resulted from inhibition whose source was the expiratory neurons which were driven throughout inspriation. Some inspiratory neurons in the area of fasciculus solitarius failed to exhibit inhibitory gaps.

Topics: Animals; Cats; Electric Stimulation; Laryngeal Nerves; Lung; Nose; Peripheral Nerves; Reflex; Respiration; Sneezing

Topics: Adult; Asthma; Epistaxis; Female; Finland; Headache; Heart Diseases; Humans; Male; Middle Aged; Nose; Nose Deformities, Acquired; Nose Diseases; Posture; Pressure; Respiration; Rhinitis; Rhinitis, Allergic, Seasonal; Sleep; Smell; Smoking; Sneezing; Spirometry

Topics: Child; Foreign Bodies; Humans; Nose; Respiration; Sneezing

Topics: Airway Resistance; Ammonia; Animals; Cats; Laryngeal Nerves; Larynx; Nose; Respiration; Sneezing; Vagotomy

Sampling of human subjects, who had been in contact with animals infected with foot-and-mouth disease (FMD) virus, showed that virus could be recovered from the nose, throat, saliva and from air expelled during coughing, sneezing, talking and breathing. The amounts of virus recovered paralleled those collected with a large-volume sampler and multistage impinger and these findings confirmed that the highest recovery of airborne virus was from infected pigs followed by cattle and sheep. More virus was found in the noses of those examining infected animals than in those operating the samplers, but there was variation between the subjects. In the majority there was a 1.8 log fall in titre by 3.5 hr., but virus persisted in the nose of one subject for 28 hr. Nose blowing or washing the nostrils did not remove virus completely, nor were cloth or industrial masks completely effective in preventing inhalation of virus. It was possible to transmit virus from infected subjects to others on one occasion. No clinical cases of FMD in man resulted from exposure, nor was there any rise in antibody. Use was made of these findings in determining sites of aerosol excretion in animals, and the results are discussed in relation to FMD in man and to the spread of respiratory viruses by the airborne route.

Topics: Air Microbiology; Animals; Aphthovirus; Cattle; Cattle Diseases; Cough; Foot-and-Mouth Disease; Humans; Masks; Nose; Pharynx; Respiration; Saliva; Sheep; Sheep Diseases; Sneezing; Swine; Swine Diseases

1. The effects of mechanical stimulation in the nose, epipharynx, laryngopharynx and tracheobronchial tree, and of chemical irritation of the nasal mucosa, were studied on various somatic and autonomic functions in cats.2. Action potentials were recorded from the diaphragm and rectus abdominis muscles of spontaneously breathing cats, and from the phrenic and lumbar nerves of paralysed, artificially ventilated cats. Expulsive processes such as sneezing and coughing evoked from the nasal, laryngopharyngeal and tracheobronchial mucosae were characterized by strong diaphragmatic and abdominal expiratory discharges; synchronous discharges in these antagonistic respiratory muscles and their motoneurones often occurred especially during laryngopharyngeal stimulation of coughing.3. The ;aspiration reflex' elicited from the epipharynx was characterized by brief bursts of high-frequency activity in the phrenic nerve and diaphragm, and was usually not followed by any expiratory activity in the rectus abdominis or its motoneurones.4. In paralysed, artificially ventilated cats stimulation of the laryngeal and tracheobronchial regions caused large increases both in total lung resistance and in tracheal constrictor nerve fibre activity, indicating reflex tracheo-bronchoconstriction; similar stimulation of the epipharyngeal and nasal mucosae decreased both total lung resistance and tracheal constrictor nerve fibre activity, indicating reflex bronchodilation.5. In paralysed cats, stimulation of each of the four sites in the respiratory tract caused a reflex increase in systemic blood pressure, the largest hypertensive response coming from the epipharynx. Nervous activity in cervical sympathetic efferent fibres was increased by the stimulations, especially those of the epipharyngeal and laryngopharyngeal regions.6. There was good correlation in time and magnitude between the changes in total lung resistance and in bronchoconstrictor fibre activity, and also between the changes in blood pressure and in efferent sympathetic discharge, although the mechanical changes lagged behind the nervous ones.7. In anaesthetized, spontaneously breathing cats stimulation of the respiratory tract evoked large variations in blood pressure accompanying the spasmodic respiratory efforts, probably by mechanical effects.

Topics: Action Potentials; Animals; Blood Pressure; Bronchi; Cats; Cough; Diaphragm; Electromyography; Larynx; Motor Neurons; Muscles; Nasal Mucosa; Nasopharynx; Nose; Paralysis; Pharynx; Phrenic Nerve; Reflex; Respiratory Physiological Phenomena; Sneezing; Trachea

Topics: Barium Sulfate; Carcinogens; Hydrocarbons; Maxillary Neoplasms; Nicotiana; Nose; Plants, Toxic; Sneezing

Topics: Black People; Emotions; Genetics, Medical; Humans; Hypersensitivity; Light; Nose; Parasympathetic Nervous System; Physiology; Reflex; Reflex, Abnormal; Respiratory Hypersensitivity; Rhinitis; Sex; Sneezing; Sunlight; Vasomotor System

Topics: Clinical Laboratory Techniques; Cold Temperature; Cytoplasm; Humans; Laryngectomy; Lysosomes; Nasal Mucosa; Nose; Paranasal Sinuses; Pathology; Respiratory Hypersensitivity; Respiratory Tract Infections; Rhinitis, Allergic, Seasonal; Saliva; Sneezing; Statistics as Topic; Tracheotomy

Topics: Humans; Nasal Mucosa; Nose; Rhinitis; Rhinitis, Allergic, Seasonal; Sneezing