phenylephrine-hydrochloride and Sarcoma

Topics: Abdominal Pain; Adult; Ascitic Fluid; Early Detection of Cancer; Hearing Loss; Humans; Male; Myofibroblasts; Nose; Pleural Effusion; Sarcoma; Treatment Outcome

A 4-year-old boy presented with a 6-month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistochemistry the tumor cells were positive for cytokeratin, epithelial membrane antigen, vimentin, and CD34, but negative for S-100, CD31, factor VIII-related antigen, CD68, actin, desmin and myoglobin. Epithelioid sarcoma is an uncommon tumor of uncertain histogenesis that typically arises in the extremities of young adults. Both the age of our patient and the location of his tumor are unusual, emphasizing the spectrum of presentations that may occur with epithelioid sarcoma. Epithelioid sarcoma should be considered in the differential diagnosis of granulomatous diseases and epithelioid tumors of children, even in unusual locations.

Topics: Antigens, CD34; Biomarkers, Tumor; Child, Preschool; Diagnosis, Differential; Humans; Immunohistochemistry; Keratins; Male; Mucin-1; Neoplasm Proteins; Nose; Sarcoma; Skin Neoplasms; Vimentin

When a sarcomatous neoplasm is identified in the breast, distinguishing metaplastic carcinoma, malignant phyllodes tumor (MPT), and primary sarcoma is a diagnostic challenge, especially on small biopsies, as all these tumors may have overlapping morphological features, thoroughly grossing with histological examination and immunohistochemical staining being the standard approach to aid in classifying these lesions. Recently, we identified a highly sensitive and specific breast carcinoma marker TRPS1 with high expression in metaplastic breast carcinoma. In the current study, we tested TRPS1 in MPTs and primary sarcoma of the breast. We found TRPS1 was highly expressed (95%) within spindle cell, chondro-osseous, and/or liposarcomatous components of MPTs, in all breast primary chondrosarcomas and extraskeletal osteosarcomas, but not in other sarcomas of the breast. In extramammary sarcomas, TRPS1 was expressed in 28% of conventional chondrosarcomas and 56% of osteosarcomas of bone, but rarely in undifferentiated pleomorphic sarcomas (UPSs), liposarcomas, and angiosarcomas. In summary, MPTs may share similar genetic background with metaplastic carcinoma exhibiting TRPS1 expression, and TRPS1 may play a role in chondro-osseous differentiation because of its expression in chondro-osseous sarcomas from both breast and extramammary sites. Our findings suggest TRPS1 may be clinically useful in distinguishing MPT and metaplastic carcinoma from primary breast sarcoma except for tumors with chondro-osseous differentiation.

Topics: Bone Neoplasms; Breast Neoplasms; Carcinoma; Chondrosarcoma; Female; Fingers; Hair Diseases; Humans; Langer-Giedion Syndrome; Nose; Osteosarcoma; Phyllodes Tumor; Repressor Proteins; Sarcoma; Soft Tissue Neoplasms

Topics: Diagnosis, Differential; Ethmoid Bone; Female; Hemangioma, Cavernous; Humans; Middle Aged; Nose; Nose Neoplasms; Ossification, Heterotopic; Radiography; Sarcoma; Skull Neoplasms

Topics: Diagnosis; Diagnosis, Differential; Granuloma; Granulomatosis with Polyangiitis; Hodgkin Disease; Humans; Kidney Diseases; Lung Diseases; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mastoid; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Prednisolone; Radiotherapy; Sarcoma

Topics: Animals; Histiocytosis, Non-Langerhans-Cell; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Medical Records; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Sarcoma

Topics: Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mononuclear Phagocyte System; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Sarcoma

Topics: Humans; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma; Turbinates

Topics: Humans; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma; Turbinates

Topics: Humans; Neoplasms; Nose; Paranasal Sinuses; Sarcoma

Topics: Humans; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Paranasal Sinuses; Sarcoma

Topics: Lymphoma, Non-Hodgkin; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Sarcoma

Topics: Bone Neoplasms; Humans; Nasal Bone; Neoplasms; Nose; Nose Neoplasms; Osteosarcoma; Sarcoma; X-Ray Therapy

Topics: Fibrosarcoma; Humans; Nasal Cavity; Nose; Sarcoma

Topics: Bone Neoplasms; Chondrosarcoma; Humans; Nasal Septum; Neoplasm Recurrence, Local; Neoplasms; Nose; Nose Neoplasms; Sarcoma

Topics: Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma