phenylephrine-hydrochloride and Rhabdomyosarcoma

Topics: Child, Preschool; Female; Humans; Meningeal Neoplasms; Nose; Paranasal Sinus Neoplasms; Rhabdomyosarcoma

Although the medial and inferior orbital apex are considered safely accessible using the endonasal endoscopic approach, the lateral apex has been considered unsafe to access since the optic nerve lies between the surgeon and the pathology. The authors present the case of a 4-year-old girl with recurrent rhabdomyosarcoma attached to the lateral rectus muscle located lateral and inferior to the optic nerve in the orbital apex. The tumor was totally resected through an endoscopic endonasal transmaxillary transpterygoidal approach using a 45° endoscope. A gross-total resection was achieved, and the patient's vision was unchanged. This procedure is a safe, minimal-access alternative to open procedures in selected cases and provides evidence that increases the applicability of the endonasal endoscopic approach to reach the lateral compartment of the orbital apex.

Topics: Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Neuroendoscopy; Nose; Orbital Neoplasms; Rhabdomyosarcoma

Sarcomas of the head and neck are rare tumours accounting for less than 1% of all malignant neoplasms in this region. The prognosis of these tumours and the survival in adults (< 50% at 5 years) is directly related to histological tumour type, tumour size and the possibility of adequate tumour resection. In the present paper, the authors present the course of sarcomas with special reference to rhabdomyosarcoma and osteosarcoma in the nose and paranasal sinuses. Surgical resection with pathologically free margins represents the best modality of initial therapy. Additional adjuvant radiotherapy and/or chemotherapy have shown better survival rates in pediatric patients and, to some degree, also in adults. The purpose of future studies should be the development of new therapy protocols which could further elucidate the beneficial effects of adjuvant therapy in the treatment of sarcomas of the head and neck.

Topics: Adolescent; Adult; Biopsy; Chemotherapy, Adjuvant; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Neoplasm Staging; Nose; Nose Neoplasms; Osteosarcoma; Paranasal Sinus Neoplasms; Paranasal Sinuses; Radiotherapy, Adjuvant; Rhabdomyosarcoma

4 cases of malignant tumors of the head and neck diagnosed in our department in 1983-1987 are presented. They are: rhabdomyosarcoma (RMS) of the nose and the ethmoid sinuses, RMS of the nasal vestibulum, nasopharyngeal lymphoma malignum. Diagnostic difficulties were met by the histopathological evaluation of the tumors specimens, but the applied treatment was effective. There are no signs of recurrence during the observation period of 4-8 years.

Topics: Carcinoma, Adenoid Cystic; Child; Child, Preschool; Female; Head and Neck Neoplasms; Humans; Lymphoma; Male; Nose; Nose Neoplasms; Pharynx; Rhabdomyosarcoma

Rhabdomyosarcomas are malignant tumors, and especially occur in childhood. In adults they are extremely rare. A pleomorphe rhabdomyosarcoma of the skin, localized on the nose of an 85-year old female patient, is reported. After surgical removal the defect was reconstructed with a full skin graft. The four histologic types of rhabdomyosarcoma (pleomorphic, alveolair, embryonal, botryoid) are discussed.

Topics: Aged; Female; Humans; Nose; Rhabdomyosarcoma; Skin Neoplasms; Skin Transplantation; Transplantation, Autologous

In a study of non-epithelial tumors involving the nasal cavity, paranasal sinuses and nasopharynx, 256 lesions, 156 benign and 100 malignant, were identified. Of these, six were classified as myxoma. Myxomas of facial bones, neoplasms of uncertain histogenesis, infiltrate adjacent tissues and if not completely excised will recur locally. In this series, three patients at one time were treated with limited local excisions. Tumor persisted or recurred in all three. Five patients were treated with en bloc resection (following recurrences in two patients). None of these patients subsequently developed recurrent tumor. We believe that myxomas should be widely resected to prevent recurrence. The extent of the surgical resection should depend on the size, extent and location of the lesion.

Topics: Adolescent; Adult; Child; Diagnosis, Differential; Female; Humans; In Vitro Techniques; Liposarcoma; Maxillary Neoplasms; Maxillary Sinus; Middle Aged; Myxoma; Nasal Cavity; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Neurilemmoma; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Rhabdomyosarcoma

The clinical, microscopical, and gross pathological features of 14 cases of intranasal and paranasal sinus polyposis with unusual stromal cell atypia are described. In gross appearance, the lesions were polypoid, translucent masses, similar to the usual nasal polyp. Although clinically the lesions were indicative of allergic and inflammatory nasal polyposis, microscopical examination showed numerous large, often pleomorphic histiocytes or facultative fibroblasts that were suggestive or sarcomatous, malignant degeneration. Diagnoses by the original contributing pathologists included embryonal rhabdomyosarcoma, stromal neoplasia, and juvenile masopharyngeal angiofibroma. Follow-up data showed no evidence of neoplasia, despite the remarkable cytological changes found in the stroma. The stromal atypia most likely represents a reactive phenomenon secondary to inflammation.

Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Female; Histiocytoma, Benign Fibrous; Humans; Male; Nasal Cavity; Nasal Polyps; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses; Rhabdomyosarcoma

Topics: Carcinoma; Carcinoma, Squamous Cell; Diagnosis, Differential; Humans; Methods; Nose; Nose Diseases; Nose Neoplasms; Paranasal Sinus Neoplasms; Radiography; Rhabdomyosarcoma

Topics: Adult; Child; Child, Preschool; Ethmoid Sinus; Female; Head and Neck Neoplasms; Humans; Infant; Lymph Nodes; Male; Maxillary Neoplasms; Mesenchymoma; Neoplasm Metastasis; Nose; Palatal Neoplasms; Pregnancy; Pregnancy Complications; Respiratory Tract Neoplasms; Rhabdomyosarcoma

Topics: Humans; Maxillary Sinus; Maxillary Sinus Neoplasms; Medical Records; Nose; Nose Neoplasms; Rhabdomyosarcoma; Rhabdomyosarcoma, Embryonal

Topics: Child; Face; Facial Neoplasms; Humans; Infant; Neoplasms; Nose; Rhabdomyosarcoma

Topics: Child; Glioma; Humans; Infant; Nose; Nose Neoplasms; Rhabdomyosarcoma