phenylephrine-hydrochloride and Psoriasis

Topics: Adult; Aged; Blood Protein Electrophoresis; Clinical Trials as Topic; Drug Evaluation; Female; Fusidic Acid; Humans; Male; Middle Aged; Nose; Petrolatum; Pharynx; Placebos; Psoriasis; Skin; Streptococcus

Topics: Adult; Carrier State; Dermatologic Agents; Female; Humans; Male; Middle Aged; Nails; Nose; Prospective Studies; Psoriasis; Severity of Illness Index; Staphylococcus aureus

Topics: Australia; Cellulitis; Emergency Service, Hospital; Follow-Up Studies; Humans; Interleukin-12; Male; Middle Aged; Nocardia; Nocardia Infections; Nose; Psoriasis; Severity of Illness Index; Tertiary Care Centers; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Ustekinumab

Staphylococcus aureus colonization is a determiner of disease activation in psoriasis patients. Here we evaluate the presence of genes encoding Panton-Valentine leukocidin (PVL), enterotoxins, TSST-1, exfoliative toxins, and the accessory gene regulatory locus by polymerase chain reaction (PCR) in S. aureus isolates obtained from healthy and diseased skin regions and anterior nares of psoriasis patients and healthy controls.. The presence of PVL and toxin genes was investigated, and agr typing was performed by PCR.. Eighteen of the isolated strains carried the sei, 1 carried the seb-sec, and 1 carried the seg enterotoxin gene. Eight of the strains carrying enterotoxin genes were isolated from nasal swabs, 6 from diseased skin swabs, and 4 from healthy skin swabs. None of the strains isolated from the control group carried the agr locus. On the other hand, 11 of the S. aureus strains isolated from the patients carried type 1, 7 carried type 1 + 3, 4 carried type 2, 4 carried type 3, and 1 carried type 1 + 2 agr loci.. Enterotoxin production and the carried accessory gene regulatory locus may be important in the aggravation of psoriasis.

Topics: Bacterial Proteins; Bacterial Toxins; Case-Control Studies; Enterotoxins; Exfoliatins; Exotoxins; Humans; Leukocidins; Nose; Polymerase Chain Reaction; Psoriasis; Skin; Staphylococcus aureus; Trans-Activators

The authors have developed a method for coproporphyrin III measurements in nasal sebaceous gland orifices by contact biomicroscopy. Increased levels of coproporphyrin III were detected with this method in patients with lupus erythematosus, photodermatitis, acne vulgaris.

Topics: Acne Vulgaris; Coproporphyrins; Humans; Lupus Erythematosus, Systemic; Microscopy, Fluorescence; Nose; Photosensitivity Disorders; Psoriasis; Sebaceous Glands

Qualitative and quantitative studies of cutaneous bacterial flora were carried out in psoriatic patients and normal healthy controls. In psoriatics, the flora isolated from the affected skin was compared with the flora of adjacent normal skin. No significant qualitative difference was observed. The total number of bacteria isolated from the psoriatic plaque was significantly higher than on the adjacent normal skin. Flora of normal skin of psoriatics when compared with the skin of healthy controls did not reveal any qualitative difference, but a statistically significant difference was observed in the total bacterial counts. The nasal carriage rate of Staphylococcus aureus in psoriatics was higher than the control groups.

Topics: Humans; Nose; Psoriasis; Skin; Staphylococcus; Staphylococcus aureus

The incidence and acquisition of Candida albicans and other yeasts in two wards of a skin hospital is described. Carriage rates on the skin in hospital patients is higher than is generally supposed, and cutaneous sites may act as sources of infection with these organisms.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Axilla; Candida; Candida albicans; Cross Infection; Eczema; Female; Hospitals, Special; Humans; Male; Nose; Psoriasis; Skin; Skin Diseases; Thorax; Yeasts