phenylephrine-hydrochloride and Prader-Willi-Syndrome

This report describes the polysomnographic findings and the respiratory alterations during sleep in a 20-year-old patient with the Prader-Willi syndrome. Nocturnal recordings and a variant of the multiple sleep latency test showed excessive daytime sleepiness, sleep onset rapid eye movement episodes, snoring and sleep apnea. Treatment with nasal continuous positive airway pressure normalized the respiratory pattern and the sleep structure, except for rapid eye movement sleep onset. Whereas upper airway obstruction and obesity may explain the respiratory disorders, as shown by their resolution with continuous positive airway pressure treatment, hypothalamic dysfunction could play a role in the disruption of the normal nonrapid eye movement/rapid eye movement sleep periodicity.

Topics: Adult; Airway Obstruction; Heart Rate; Humans; Hypothalamus; Male; Nose; Positive-Pressure Respiration; Prader-Willi Syndrome; Sleep Apnea Syndromes; Sleep Wake Disorders; Sleep, REM; Snoring