phenylephrine-hydrochloride and Neoplasms

The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear. We found that suppression of 6PGD decreased lipogenesis and RNA biosynthesis and elevated ROS levels in cancer cells, attenuating cell proliferation and tumour growth. 6PGD-mediated production of ribulose-5-phosphate (Ru-5-P) inhibits AMPK activation by disrupting the active LKB1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis. Ru-5-P and NADPH are thought to be precursors in RNA biosynthesis and lipogenesis, respectively; thus, our findings provide an additional link between the oxidative PPP and lipogenesis through Ru-5-P-dependent inhibition of LKB1-AMPK signalling. Moreover, we identified and developed 6PGD inhibitors, physcion and its derivative S3, that effectively inhibited 6PGD, cancer cell proliferation and tumour growth in nude mice xenografts without obvious toxicity, suggesting that 6PGD could be an anticancer target.

Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

Infectious diseases and cancer change a patient's metabolism and hence the metabolic compounds produced. The composition of volatile organic compounds (VOCs) in exhaled breath or urine or stool samples can therefore be characteristic of a particular disease. In recent years many studies have been conducted into the training of animals, including dogs, to recognise diseases by smell. Besides trained animals, electronic noses (e-noses) are also being developed. These devices can identify disease-specific odour profiles in VOCs. Although the results of research in the field of scent diagnosis are promising, the medical community remains largely sceptical. We discuss applications of scent detection as a diagnostic tool in modern medicine.

Topics: Animals; Breath Tests; Communicable Diseases; Dogs; Early Detection of Cancer; Humans; Neoplasms; Nose; Odorants; Smell; Volatile Organic Compounds

Analysis and comparison of clinical guidelines (CG) on malignant neoplasms of the respiratory system, placed in the CG rubricator of the Ministry of Health of Russia, for the information they contain on the role of factors and working conditions of the working environment in the etiology of respiratory diseases, including the upper respiratory tract, and comparison this information with published and regularly updated data from the International Agency for Research on Cancer (IARC).. Clinical recommendations from the heading of the Ministry of Health of Russia "Cancer of the laryngopharynx", "Cancer of the nasopharynx", "Cancer of the oropharynx", "Cancer of the nasal cavity and paranasal sinuses", "Cancer of the larynx", "Cancer of the trachea", "Cancer of the lung", and IARC data according to the List of Classifications by cancer sites with sufficient or limited evidence in humans dated 11/29/2019.. The low level of registration of occupational cancer of the upper respiratory tract in Russia is due to an inadequate system of criteria for detecting this form of occupational pathology, a long latency period of diseases, and insufficient assessment of the history of information on the potential role of occupational carcinogens. The CGs developed to optimize the diagnosis and treatment of malignant neoplasms of the respiratory system do not contain up-to-date information on the role of professional potential carcinogens in the genesis of malignant neoplasms.. Recognition of the professional nature of malignant neoplasms of the respiratory system implies, firstly, strengthening the role of otorhinolaryngologists in early diagnosis and rehabilitation of patients, and secondly, it has a pronounced preventive focus in the form of tasks facing the employer to reduce the carcinogenic load and develop preventive measures aimed to reduce and prevent the development of malignant tumors in workers, including the respiratory system.. Анализ клинических рекомендаций (КР) по злокачественным новообразованиям органов дыхания, размещенных в рубрикаторе КР Минздрава России, на предмет содержащихся в них сведений о роли факторов и условий труда рабочей среды в этиологии заболеваний органов дыхания, в том числе верхних дыхательных путей, и сопоставление этих сведений с публикуемыми и регулярно обновляемыми данными Международного агентства по изучению рака (МАИР).. Изучены клинические рекомендации из рубрикатора Минздрава России «Рак гортаноглотки» «Рак носоглотки», «Рак ротоглотки», «Рак полости носа и придаточных пазух», «Рак гортани» «Рак трахеи», «Рак легкого» и данные МАИР по List of Classifications by cancer sites with sufficient or limited evidence in humans от 29.11.19.. Низкий уровень регистрации профессионального рака верхних дыхательных путей в России обусловлен неадекватной системой критериев выявления данной формы профессиональной патологии, длительным латентным периодом заболеваний, недостаточной оценкой имеющейся в анамнезе информации о потенциальной роли производственных канцерогенов. Разрабатываемые с целью оптимизации диагностики и лечения злокачественных новообразований органов дыхания КР не содержат актуальных сведений о роли профессиональных потенциальных канцерогенов в генезе злокачественных новообразований.. Признание профессионального характера злокачественных новообразований органов респираторной системы подразумевает, во-первых, усиление роли специалистов оториноларингологов в вопросах ранней диагностики и реабилитации пациентов, во-вторых, носит выраженную профилактическую направленность в виде встающих перед работодателем задач по снижению канцерогенной нагрузки и разработке превентивных мер, направленных на снижение и профилактику развития у работников злокачественных опухолей, в том числе органов дыхания.

Topics: Carcinogens; Humans; Larynx; Neoplasms; Nose; Occupational Diseases; Trachea

Topics: Child; Granuloma, Plasma Cell; Humans; Infant; Neoplasms; Nose

Tricho-rhino-phalangeal syndrome (TRPS) is a rare autosomal dominant genetic disorder characterized by distinctive craniofacial and skeletal abnormalities, while non-ossifying fibroma (NOF) is a common benign bone tumour in children and adolescents. To date, no case of TRPS coexisting with NOF has been reported. This report presents a 12-year-old girl who had the characteristic features of tricho-rhino-phalangeal syndrome and non-ossifying fibroma with a fibula fracture.. A 12-year-old girl was admitted to the Department of Endocrinology and Diabetes for evaluation of brachydactyly and a right fibula fracture. Clinical examination revealed sparse scalp hair, a characteristic bulbous pear-shaped nose, and brachydactyly with significant shortening of the fourth metatarsal. Neither intellectual disability nor multiple exostoses were observed. Radiography of both hands showed brachydactyly and cone-shaped epiphyses of the middle phalanges of the digits of both hands with deviation of the phalangeal axis. Genetic analysis of TRPS1 identified a heterozygous germline sequence variant (p.Ala932Thr) in exon 6 in the girl and her father. Approximately 1 month before being admitted to our department, the girl experienced a minor fall and suffered a fracture of the proximal fibula in the right lower limb. The pathological cytological diagnosis of the osteolytic lesion was NOF. Ten months following the surgery, the lesion on the proximal fibula of the girl disappeared.. In conclusion, the present study is the first to report a rare case of NOF with a pathologic fracture in the fibula of a girl with TRPS. The identification of a missense mutation, (p.Ala932Thr), in exon 6 of TRPS1 in this kindred further suggested that the patient had type I TRPS and indicated that mutations in this exon may be correlated with more pronounced features of the syndrome. Radiological techniques and genetic analysis played key roles in the definitive diagnosis.

Topics: Adult; Base Sequence; Bone Neoplasms; Brachydactyly; Child; DNA-Binding Proteins; Exons; Female; Fibroma; Fibula; Fingers; Fractures, Spontaneous; Gene Expression; Hair Diseases; Humans; Langer-Giedion Syndrome; Male; Mutation; Neoplasms; Nose; Paternal Inheritance; Radiography; Repressor Proteins; Transcription Factors

The clinical, microbiological, and histopathological findings of six patients with mucosal leishmaniasis are reported. Five of these patients were Spanish with no history of travel abroad, while the other was from Bolivia but had lived in Spain for more than 5 years. Two patients had no underlying disease, while the other four had several other medical conditions. Lesions were located in the nose in three patients and in the larynx in the other three. Symptoms included difficulty in swallowing, nasal obstruction, dysphonia, and polypoid lesions mimicking cancer. The diagnosis was based on the identification of parasites, or on PCR assay or culture. Five patients were treated with liposomal amphotericin B and the other with antimonial compounds.

Topics: Adult; Aged; Amphotericin B; Animals; Female; Humans; Larynx; Leishmania infantum; Leishmaniasis, Mucocutaneous; Male; Middle Aged; Neoplasms; Nose; Polymerase Chain Reaction; Spain

To investigate the therapeutic effects of the image navigation system in nasal endoscopic surgery in treatment of basicranial tumor.. Retrospective analysis was carried out in 17 patients with basicranial tumor who underwent nasal endoscopic resection via image navigation system. The accuracy of image navigation system, operation procedure time, curative effect and complications were analyzed and summarized to evaluate the effect.. The image navigation system provided an accurate anatomical localization 0.5-2.0 mm localization error (mean 1.2 mm). The operation procedure time was 1.5-3.0 h. Postoperative complications occurred in 3 of 17 patients including cerebrospinal fluid rhinorrhea and injury of sieve plate. Two patients recrudesce within half a year.. The image navigation system in combination with a nasal endoscope is helpful in the resection of basicranial tumor with minimal trauma, increasing the curative effect and avoiding complications.

Topics: Cerebrospinal Fluid Rhinorrhea; Endoscopy; Humans; Nasal Surgical Procedures; Neoplasm Recurrence, Local; Neoplasms; Nose; Postoperative Complications; Retrospective Studies; Skull Base; Surgery, Computer-Assisted

Infections with methicillin-resistant Staphylococcus aureus (MRSA), in community-settings, especially with strains carrying the Panton-Valentine Leukocidin (PVL) genes, have increased markedly in recent years. Colonization with S. aureus is a risk factor for infection. However, there are few studies that examine colonization and infection with PVL-positive strains of MRSA in cancer patients.. The epidemiology of colonization and infection with MRSA was studied in children with cancer during two time periods: 2000/2001 and 2006/2007. PVL genes were screened and spa typing performed on the isolates.. The prevalence of colonization with MRSA increased from 0.6% in 2000/2001 to 2.9% in 2006/2007 (P = 0.0003). MRSA colonization at admission was associated with infection (P < 0.0001; RR 38.32; 95% CI: 23.36-62.84). The prevalence of infection increased from 0.99% in 2000/2001 to 3.78% in 2006-2007 (P = 0.0002). Of the 32 colonized patients, 18 (56%) had infection. None of the 14 colonized but non-infected patients had dual colonization of nares and rectum, while 8 of the 18 infected patients had colonization of both of these sites (P = 0.004). Ten patients (31%) were colonized with PVL-positive strains. Patients colonized with PVL-positive strains were more likely to be colonized both in the nares and rectum (P = 0.005), and more likely to have infection (P = 0.001). Recurrent MRSA infections were seen in 22% of patients.. An increasing prevalence of colonization with MRSA was observed in children with cancer at our institution. Colonization with MRSA especially with PVL-positive strains was associated with infection.

Topics: Bacterial Toxins; Child; Exotoxins; Female; Humans; Leukocidins; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Neoplasms; Nose; Rectum; Staphylococcal Infections

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the proliferation and self-renewal of NSCs, which we refer to as the 'ground state', remains largely uncharacterized. Although the candidate gene approach has uncovered vital pathways in NSC biology, so far only a few highly studied pathways have been investigated. Based on the intimate relationship between NSC self-renewal and neurosphere proliferation, we undertook a chemical genetic screen for inhibitors of neurosphere proliferation in order to probe the operational circuitry of the NSC. The screen recovered small molecules known to affect neurotransmission pathways previously thought to operate primarily in the mature central nervous system; these compounds also had potent inhibitory effects on cultures enriched for brain cancer stem cells. These results suggest that clinically approved neuromodulators may remodel the mature central nervous system and find application in the treatment of brain cancer.

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

ENDS (external nasal dilator strips) are adhesive bands containing a central elastic strip providing a spring action. The possibility of reducing the cumulated effort of continuous breathing or decreasing the perception of exertion would be of major benefit to oncological dyspneic patients, namely in presence of a cachexia-asthenia complex.. Nine patients complaining of dyspnea were included in this pilot study. The ENDS were applied at 0800 and at 1600. Perception of dyspnea and tolerability was assessed 12 h after the first application of the ENDS. No other treatment changes were performed during the evaluation time.. As a result of the application of ENDS, one patient perceived a good improvement of dyspnea, three moderate, two little, and three none. Tolerability was good for four patients and moderate for another four. Seven out of nine patients decided to carry on with the application of ENDS afterwards.. The application of ENDS may be useful in cancer patients with dyspnea. It could be particularly helpful to patients suffering from cachexia and profound fatigue. However, further research is needed to affirm that ENDS might have an important place in relieving dyspnea.

Topics: Aged; Aged, 80 and over; Dilatation; Dyspnea; Female; Humans; Male; Middle Aged; Neoplasms; Nose; Pilot Projects; Respiration; Treatment Outcome

Dipropylene glycol is found in antifreeze, air fresheners, cosmetic products, solvents, and plastics. We studied the effects of dipropylene glycol on male and female rats and mice to identify potential or cancer-related hazards to humans.. We gave groups of 50 male and female mice drinking water containing dipropylene glycol at concentrations of 10,000, 20,000, or 40,000 parts per million (corresponding to 1%, 2%, or 4%) for two years. Male and female rats received concentrations of 2,500, 10,000, or 40,000 parts per million. Other groups received untreated water and were the control group. Tissues from more than 40 sites were examined for every animal.. The groups of animals receiving 40,000 ppm dipropylene glycol weighed less than the control animals. All the make rats receiving 40,000 ppm dipropylene glycol died before the end of the study, mainly because of kidney disease. All the other animal group survived as well as the controls. No increase in tumor rates were seen in any of the groups of rats or mice.. We conclude that dipropylene glycol did not cause cancer in male or female rats or mice. Exposure to dipropylene glycol did increase the rate and severity of kidney nephropathy and inflammation of the liver and salivary gland in male rats and some atrophy of the epithelial tissue of the nose in male and female rats.

Topics: Administration, Oral; Animals; Atrophy; Dose-Response Relationship, Drug; Female; Humans; Inflammation; Kidney Diseases; Liver; Male; Mice; Neoplasms; Nose; Propylene Glycols; Rats; Rats, Inbred F344; Risk Assessment; Salivary Glands; Sex Factors; Water Supply

To assess the risk of infection of either subcutaneously implanted central venous access devices or percutaneous central venous catheters inserted via a subcutaneous tunnel in cancer patients with a positive staphylococcal nasal carriage.. Prospective study.. The study included 266 patients undergoing cancer chemotherapy.. A nasal swab was taken prior to insertion of the venous access device and the patients were followed over 30 days for the occurrence of a staphylococcal infection (hemoculture and device or site of insertion).. A nasal staphylococcal nasal carriage was found in 227 patients. Out of the 15 developing a device infection, a staphylococcal nasal colonization was existing in nine patients. Bacteriological screening a sensitivity of 60% and a specificity of 13%.. Bacteriological screening at the time of device insertion of a central venous access device is of no value for the detection of patients at risk of staphylococcal infection of the device.

Topics: Carrier State; Catheterization, Central Venous; Catheters, Indwelling; Equipment Contamination; Humans; Neoplasms; Nose; Prospective Studies; Risk Factors; Sensitivity and Specificity; Staphylococcal Infections

The present study comprises 300 cases of epistaxis. The analysis of these cases revealed a higher incidence in young males. Unilateral bleeding was seen in almost 60% each of indoor and outdoor cases. Litte's area was the most common site responsible for epistaxis in 28.8% of the indoor and 26.2% of the outdoor patients. Hypertension was the most common systemic cause among indoor patients (62.2%) and sickle cell disorder among the outdoor patients (37.5%). Atrophic rhinitis with myiasis was the local cause of epistaxis in maximum (27%) of the indoor patients and traumatic epistaxis was the commonest cause (33%) among outdoor patients-fingernail trauma in 75.9% of them. Idiopathic epistaxis contributed for 16.5% indoor and 26.1% of outdoor cases. Intractable epistaxis was seen in one case following accidental facial trauma.

Topics: Adolescent; Adult; Child; Diagnosis, Differential; Epistaxis; Facial Injuries; Female; Hematologic Diseases; Humans; Hypertension; Incidence; India; Male; Neoplasms; Nose; Prospective Studies; Retrospective Studies; Rhinitis, Atrophic

Topics: Birth Injuries; Cleft Lip; Cleft Palate; Esophageal Atresia; Heart Defects, Congenital; Hematoma, Subdural; Hernias, Diaphragmatic, Congenital; Humans; Hydrocephalus; Infant, Newborn; Infant, Newborn, Diseases; Larynx; Lung Diseases; Neoplasms; Neural Tube Defects; Nose; Parenteral Nutrition; Postoperative Care; Preoperative Care

Topics: Antineoplastic Agents; Bacterial Infections; Ear, Middle; Hemorrhage; Humans; Larynx; Mouth; Mucous Membrane; Neoplasms; Nose; Paralysis; Pharynx; Skin; Virus Diseases

Microflora of the pharynx, nose, sputum and excrements was investigated. It was found that bleomycin therapy may induce or aggravate the shifts in microbiocenosis of the pharynx and sputum in the direction of pathogenization (increase in the number of Staph. aureus, hemolytic streptococci, enterobacteria). A tendency to elimination of bifidobacteria and appearance of Proteus in the excrements was observed. Complications associated with the treatment are rarely of infectious origin.

Topics: Bacteria; Bleomycin; Feces; Humans; Neoplasms; Nose; Pharynx; Sputum; USSR

Topics: Age Factors; Aged; Carcinoma, Squamous Cell; Ear; Head; Head and Neck Neoplasms; Humans; Larynx; Middle Aged; Mouth; Nasopharynx; Neoplasms; Nose; Ophthalmologic Surgical Procedures; Postoperative Complications; Salivary Glands; Surgical Procedures, Operative

Topics: Adenocarcinoma; Adult; Age Factors; Aged; Back; Brain Neoplasms; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Squamous Cell; Cecum; Colonic Neoplasms; Female; Gallbladder Neoplasms; Glioblastoma; Humans; Intestinal Neoplasms; Male; Middle Aged; Neoplasms; Nose; Oligodendroglioma; Skin Neoplasms; Stomach Neoplasms; Uterine Neoplasms; Vitiligo

Topics: Aged; Bile Ducts; Breast; Digestive System; Ear; Female; Humans; Liver; Lymph Nodes; Male; Mediastinum; Microtomy; Middle Aged; Neoplasms; Nose; Parathyroid Glands; Peritoneum; Pharynx; Retroperitoneal Space; Salivary Glands; Skin; Thymus Gland; Thyroid Gland

Topics: Antineoplastic Agents; Eye Manifestations; Facial Neuralgia; Facial Paralysis; Maxillary Sinus; Maxillary Sinus Neoplasms; Mouth; Neoplasms; Neurologic Manifestations; Nose; Paranasal Sinus Neoplasms; Prognosis; Skin Transplantation; Surgical Procedures, Operative

Topics: Diagnosis; Diagnosis, Differential; Granuloma; Granulomatosis with Polyangiitis; Hodgkin Disease; Humans; Kidney Diseases; Lung Diseases; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mastoid; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Prednisolone; Radiotherapy; Sarcoma

Topics: Burns; Edema; Humans; Inflammation; Neoplasms; Nose; Oxyphenbutazone; Postoperative Complications; Skin Transplantation; Surgery, Plastic; Wounds and Injuries

Topics: Humans; Neoplasms; Nose; Olfaction Disorders; Paranasal Sinus Neoplasms; Paranasal Sinuses; Sensory Deprivation; Smell

Topics: Air Pollution; Anatomy; Body Temperature; Environment; Geography; Humans; Humidity; Mucous Membrane; Neoplasms; Nose; Physiology; Respiratory Tract Neoplasms; Smoking

Topics: Antineoplastic Agents; Humans; Nasopharyngeal Neoplasms; Neck; Neoplasms; Nose; Pharynx; Staining and Labeling; Triaziquone

Topics: Fistula; Humans; Neoplasms; Nose; Paranasal Sinuses

Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Carcinoma, Transitional Cell; Humans; Nasal Polyps; Neoplasms; Nose; Nose Neoplasms; Papilloma; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Radiation Injuries

Topics: Chordoma; Glioma; Humans; Multiple Myeloma; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinuses; Plasma Cells; Plasmacytoma

Topics: Blood Group Antigens; Ear Neoplasms; Head and Neck Neoplasms; Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Medical Records; Neoplasms; Nose; Nose Neoplasms; Papilloma; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Cerebrospinal Fluid; Cerebrospinal Fluid Rhinorrhea; Humans; Neoplasms; Nose; Pituitary Gland

Topics: Neoplasms; Nose; Nose Neoplasms; Paranasal Sinuses

Topics: Hemorrhage; Hemostasis; Humans; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Carcinoma; Humans; Metaplasia; Myoepithelioma; Neoplasms; Nose; Nose Neoplasms

Topics: Head and Neck Neoplasms; Neoplasms; Nose; Nose Neoplasms; Otolaryngology; Pharynx

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Papilloma; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Maxillary Sinus; Nasopharyngeal Neoplasms; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Nasopharyngeal Neoplasms; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Lymphangioma; Medical Records; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Dermoid Cyst; Dura Mater; Frontal Bone; Humans; Medical Records; Neoplasms; Nose; Nose Neoplasms; Teratoma

Topics: Humans; Multiple Myeloma; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Paranasal Sinuses; Pharynx; Plasma Cells; Plasmacytoma

Topics: Humans; Nasopharyngeal Neoplasms; Neck; Neoplasms; Nose; Pharynx

Topics: Child; Glioma; Humans; Infant; Infant, Newborn; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Nasopharyngeal Neoplasms; Neck; Neoplasms; Nose; Pharynx; Radiology

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Plastic Surgery Procedures; Plastics; Surgery, Plastic

Topics: Brain Neoplasms; Encephalocele; Humans; Nasal Surgical Procedures; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses; Sinusitis

Topics: Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Leiomyosarcoma; Maxillary Sinus; Maxillary Sinus Neoplasms; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Hemangioma; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Respiratory Tract Neoplasms

Topics: Dermoid Cyst; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Teratoma

Topics: Hemangiopericytoma; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Humans; Nasal Cavity; Neoplasms; Neuroblastoma; Nose; Paranasal Sinus Neoplasms

Topics: Humans; Neoplasms; Nose; Otorhinolaryngologic Diseases; Pharynx

Topics: Ganglioneuroma; Humans; Medical Records; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Blood Sedimentation; Ear Neoplasms; Fibrinogen; Neoplasms; Nose; Nose Neoplasms; Pharynx

Topics: Chronic Disease; Humans; Medical Records; Nasal Polyps; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses; Polyps

Topics: Europe; Fungi; Humans; Mycoses; Nasopharyngeal Diseases; Neoplasms; Nose

Topics: Child; Face; Facial Neoplasms; Humans; Infant; Neoplasms; Nose; Rhabdomyosarcoma

Topics: Humans; Neoplasms; Nickel; Nose; Nose Neoplasms; Occupational Diseases

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Early Diagnosis; Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Child; Growth; Humans; Infant; Neoplasms; Nose; Respiratory System; Respiratory Tract Neoplasms

Topics: Disease Management; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Medical Records; Melanoma; Nasal Cavity; Nasopharyngeal Neoplasms; Nasopharynx; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Nasal Cavity; Neck; Neoplasms; Nose; Paranasal Sinus Neoplasms; Pharynx; Staining and Labeling

Topics: Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Fibroma; Humans; Medical Records; Nasal Cavity; Neoplasms; Nose; Osteoma; Paranasal Sinus Neoplasms; Paranasal Sinuses; Telangiectasis

Topics: Nasal Cavity; Neck; Neoplasms; Nose; Paranasal Sinus Neoplasms; Pharynx; Staining and Labeling

Topics: Animals; Histiocytosis, Non-Langerhans-Cell; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Medical Records; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Sarcoma

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinuses

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Early Detection of Cancer; Neoplasms; Nose; Nose Neoplasms; Pharynx

Topics: Child; Ganglioneuroma; Humans; Infant; Maxillary Sinus; Maxillary Sinus Neoplasms; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Carcinoma, Basal Cell; Humans; Nasal Cavity; Neoplasms; Nose; Papilloma; Paranasal Sinus Neoplasms; Skin Neoplasms

Topics: Chordoma; Humans; Medical Records; Neoplasms; Nose; Notochord; Skull; Skull Neoplasms

Topics: Carcinoma, Adenoid Cystic; Humans; Neoplasms; Neoplastic Syndromes, Hereditary; Nose; Nose Neoplasms; Skin Neoplasms

Topics: Bone Neoplasms; Chondrosarcoma; Ear, External; Hemangiosarcoma; Humans; Medical Records; Neoplasms; Nose; Nose Neoplasms; Tuberculosis

Topics: Ear, External; Humans; Neoplasms; Nose; Nose Neoplasms; Skin Neoplasms

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Rhinoplasty

Topics: Humans; Nasopharyngeal Neoplasms; Neoplasms; Nose; Pharynx

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Rhinoplasty

Topics: Eye; Humans; Neoplasms; Nose; Pituitary Gland; Pituitary Neoplasms; Radiotherapy; Stereotaxic Techniques

Topics: Disease; Eye; Neoplasms; Nose; Optic Nerve; Optic Nerve Diseases; Wounds and Injuries

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Fibrosarcoma; Humans; Medical Records; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Humans; Nasopharyngeal Neoplasms; Neoplasms; Nose; Pharynx

Topics: Eustachian Tube; Folic Acid; Humans; Larynx; Neoplasms; Nose; Respiratory Tract Neoplasms

Topics: Neck; Neoplasms; Nose; Otolaryngology; Pharynx

Topics: Fistula; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Carcinoma; Humans; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Radiotherapy

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Acanthosis Nigricans; Disease; Ear Diseases; Ear, External; Humans; Mouth Diseases; Neck; Neoplasms; Nose; Pharynx; Pylorus

Topics: Ear, External; Humans; Melanoma; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Ethmoid Sinus; Frontal Sinus; Humans; Neoplasms; Nose; Osteoma; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Cortisone; Hodgkin Disease; Humans; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms

Topics: Body Constitution; Humans; Nasal Cavity; Nasal Polyps; Neoplasms; Nose; Paranasal Sinus Neoplasms; Rhinitis

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Skin Transplantation

Topics: Dermoid Cyst; Fistula; Frontal Sinus; Humans; Neoplasms; Nose; Paranasal Sinus Neoplasms; Teratoma

Topics: Granuloma; Humans; Nasal Cavity; Neoplasms; Nose; Nose Diseases; Paranasal Sinus Neoplasms; Polyarteritis Nodosa

Topics: Early Diagnosis; Ethmoid Sinus; Humans; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms

Topics: Bone Neoplasms; Frontal Bone; Humans; Neoplasms; Nose; Osteoma; Plastics

Topics: Carcinoma; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Pharynx

Topics: Adrenocorticotropic Hormone; Face; Granuloma; Humans; Neoplasms; Nose; Nose Diseases

Topics: Adrenocorticotropic Hormone; Face; Granuloma; Humans; Neoplasms; Nose; Nose Diseases

Topics: Carcinoma, Basal Cell; Humans; Neoplasms; Nose; Nose Neoplasms; Orbit; Orbital Neoplasms; Radiotherapy; Skin Neoplasms

Topics: Ear Neoplasms; Humans; Neoplasms; Nose; Nose Neoplasms; Pharynx

Topics: Head and Neck Neoplasms; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses; Pharynx

Topics: Early Diagnosis; Humans; Maxilla; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Nasal Cavity; Nasal Polyps; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Brain Neoplasms; Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Ear Neoplasms; General Practitioners; Neck; Neoplasms; Nose; Pharynx

Topics: Neoplasms; Nose; Nose Neoplasms; Pharynx

Topics: Neoplasms; Nose; Nose Neoplasms; Pharynx

Topics: Dermoid Cyst; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Teratoma

Topics: Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mononuclear Phagocyte System; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Sarcoma

Topics: Carcinoma, Adenoid Cystic; Humans; Nasal Cavity; Neoplasms; Neoplastic Syndromes, Hereditary; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses; Skin Neoplasms

Topics: Dentigerous Cyst; Humans; Maxillary Sinus; Maxillary Sinus Neoplasms; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Papilloma; Paranasal Sinus Neoplasms

Topics: Humans; Hypopharynx; Nasal Cavity; Nasopharyngeal Neoplasms; Nasopharynx; Neoplasms; Nose; Palatine Tonsil; Paranasal Sinus Neoplasms; Paranasal Sinuses; Tonsillar Neoplasms

Topics: Ear; Humans; Neoplasms; Nose; Pharynx

Topics: Humans; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma; Turbinates

Topics: Administration, Intranasal; Humans; Neoplasms; Neuroblastoma; Nose

Topics: Ear; Humans; Larynx; Neoplasms; Nose; Oculomotor Muscles; Pharynx; Research

Topics: Humans; Nasal Cavity; Neoplasms; Neuroblastoma; Nose; Peripheral Nervous System Neoplasms

Topics: Ear; Humans; Neoplasms; Nose; Pharynx

Topics: Face; Gastrointestinal Tract; Humans; Jaw; Mouth; Neoplasms; Nose

Topics: Face; Humans; Mouth; Neoplasms; Nose; Plastic Surgery Procedures; Surgery, Plastic

Topics: Cadaver; Neoplasms; Nose; Pharynx; X-Ray Therapy

Topics: Humans; Neck; Neoplasms; Nose; Pharynx; Staining and Labeling

Topics: Humans; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma; Turbinates

Cancer involving the antrum can be cured in a greater percentage of cases if the lesions are detected earlier, specifically diagnosed histologically, and radically managed at the time of the initial treatment. The procedure of choice is, first, surgical removal (with a scalpel) of as much of the tumor as is possible without risk of operative death, then limited but specific cancerocidal radiation as indicated by operative findings or regular postoperative observation. The period of convalescence will be less distressing and shorter with this procedure than with others; and, in those cases in which cure is not effected, palliation will be more satisfactory. The cured patients are cosmetically acceptable without functional disability except for unilateral loss of vision in cases in which exenteration of the orbit is necessary.

Topics: Disease Management; Female; Humans; Male; Nasal Cavity; Neoplasms; Nose; Orbit; Paranasal Sinuses

Topics: Cysts; Dermoid Cyst; Humans; Neoplasms; Nose

Topics: Chondroma; Face; Humans; Neoplasms; Nose

Topics: Humans; Neoplasms; Nose; Paranasal Sinuses; Sarcoma

Topics: Neoplasms; Nose; Nose Neoplasms; Pharynx

Topics: Adamantinoma; Cysts; Dentigerous Cyst; Humans; Maxilla; Neoplasms; Nose

Topics: Glioma; Humans; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms

Topics: Humans; Maxillary Sinus; Maxillary Sinus Neoplasms; Neoplasms; Nose

Topics: Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Humans; Nasal Cavity; Neoplasms; Neurilemmoma; Nose; Paranasal Sinus Neoplasms

Topics: Glioma; Humans; Neoplasm Recurrence, Local; Neoplasms; Nose; Nose Diseases

Topics: Humans; Nasal Polyps; Neoplasms; Nose; Polyps

Topics: Fistula; Humans; Nasal Cavity; Neoplasms; Nose; Paranasal Sinuses

Topics: Humans; Neoplasms; Neoplasms, Plasma Cell; Nose; Plasmacytoma

Topics: Humans; Nasal Septum; Neoplasms; Nose

Topics: Humans; Neoplasms; Nose; Tuberculoma; Tuberculosis; Vitamin D; Vitamins

Topics: Adenoma, Pleomorphic; Humans; Neoplasms; Nose

Topics: Carcinoma; Carcinoma, Squamous Cell; Gallbladder; Humans; Neoplasms; Nose

Topics: Hemangioma; Humans; Neoplasms; Nose; Surgery, Plastic

Topics: Humans; Nasal Cavity; Neoplasms; Neuroblastoma; Nose

Topics: Hemangioma; Humans; Neoplasms; Nose; Plastics

Topics: Humans; Neoplasms; Nose

Topics: Humans; Nasal Cavity; Neoplasms; Neoplasms, Plasma Cell; Nose; Paranasal Sinuses; Plasmacytoma

Topics: Dermoid Cyst; Humans; Neoplasms; Nose

Topics: Dermoid Cyst; Humans; Neoplasms; Nose

Topics: Choroid; Humans; Lacrimal Apparatus; Meninges; Neoplasms; Nose; Optic Nerve; Orbit

Topics: Fibroma; Humans; Neoplasms; Nose; Pharynx

Topics: Adenoma, Pleomorphic; Neck; Neoplasms; Nose; Pharynx

Topics: Humans; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Paranasal Sinuses; Sarcoma

Topics: Glioma; Humans; Neoplasms; Nose

Topics: Humans; Lymphangioma; Neoplasms; Nose

Topics: Adenoma, Pleomorphic; Humans; Neoplasms; Nose; Salivary Glands

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinuses

Topics: Humans; Neoplasms; Nose

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Pituitary Gland; Pituitary Neoplasms

Topics: Neoplasms; Nose; Nose Neoplasms; Pharyngeal Neoplasms; Pharynx

Topics: Lymphoma, Non-Hodgkin; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Sarcoma

Topics: Humans; Mouth; Mouth Neoplasms; Neoplasms; Nose; Nose Neoplasms; Plasmacytoma

Topics: Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Carcinoma, Basal Cell; Humans; Neoplasm Recurrence, Local; Neoplasms; Nose; Nose Neoplasms; Skin Neoplasms

Topics: Humans; Nasopharyngeal Neoplasms; Nasopharynx; Neoplasms; Nose; Pharynx

Topics: Bone Neoplasms; Humans; Nasal Bone; Neoplasms; Nose; Nose Neoplasms; Osteosarcoma; Sarcoma; X-Ray Therapy

Topics: Adenoma, Pleomorphic; Humans; Neoplasms; Nose; Turbinates

Topics: Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Nasal Polyps; Neoplasms; Nose; Polyps; Recurrence

Topics: Glioma; Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Rhinoplasty

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Plastic Surgery Procedures; Surgery, Plastic

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Pharynx

Topics: Brain; Brain Neoplasms; Humans; Neoplasms; Nose

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinuses

Topics: Mouth; Neoplasms; Nose; Pharyngeal Neoplasms; Pharynx

Topics: Fistula; Humans; Mucocele; Neoplasms; Nose; Orbit; Orbital Neoplasms; Paranasal Sinuses

Topics: Neoplasms; Nose; Ophthalmology; Pharynx

Topics: Humans; Nasal Cavity; Neoplasms; Neurilemmoma; Nose; Nose Neoplasms; Paranasal Sinuses

Topics: Dermoid Cyst; Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Neoplasms; Nose; Nose Neoplasms

Topics: Frontal Sinus; Hemiplegia; Humans; Neoplasms; Nose; Osteoma; Paranasal Sinuses; Pneumocephalus

Topics: Fibroma; Humans; Neoplasms; Nose; Sphenoid Sinus

Topics: Fibroma; Humans; Neoplasms; Nose; Pharyngeal Neoplasms; Pharynx

Topics: Humans; Neoplasms; Nose

Topics: Forehead; Humans; Neoplasms; Nose; Nose Neoplasms; Skin Neoplasms

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Sarcoidosis

Topics: Ear; Ear Neoplasms; Head and Neck Neoplasms; Humans; Neck; Neoplasms; Nose; Nose Neoplasms

Topics: Adenoma, Pleomorphic; Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Nasal Polyps; Neoplasms; Nose; Polyps; Postoperative Period; Radium; Recurrence; Zinc

Topics: Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Neoplasms; Nose; Nose Neoplasms

Topics: Glioma; Humans; Neoplasms; Neuroblastoma; Nose; Nose Neoplasms

Topics: Neoplasms; Nose; Nose Neoplasms; Pharyngeal Neoplasms; Pharynx

Topics: Humans; Neoplasms; Nervous System Neoplasms; Nose; Nose Neoplasms

Topics: Neoplasms; Neuroma; Nose; Nose Neoplasms; Pharyngeal Neoplasms; Pharynx

Topics: Neoplasms; Nose; Nose Neoplasms; Pharyngeal Neoplasms; Pharynx

Topics: Humans; Melanoma; Neoplasms; Nose; Nose Neoplasms

Topics: Hemangioma; Humans; Male; Neoplasms; Nose; Nose Neoplasms

Topics: Neoplasms; Nose; Nose Neoplasms; Pharyngeal Neoplasms; Pharynx

Topics: Bronchiectasis; Constitution and Bylaws; Humans; Nasal Polyps; Neoplasms; Nose; Nose Neoplasms; Viscera

Topics: Humans; Neoplasms; Nose; Nose Neoplasms; Tongue; Tongue Neoplasms

Topics: Glioma; Humans; Mouth; Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Lipoma; Neoplasms; Nose; Nose Neoplasms

Topics: Neoplasms; Nose; Nose Neoplasms; Pharyngeal Neoplasms; Pharynx

Topics: Neoplasms; Nose; Nose Neoplasms

Topics: Humans; Maxillary Sinus; Maxillary Sinus Neoplasms; Nasal Polyps; Nasopharynx; Neoplasms; Nose; Nose Neoplasms; Polyps

Topics: Cysts; Dermoid Cyst; Humans; Neoplasms; Nose; Nose Diseases

Topics: Bone Neoplasms; Chondrosarcoma; Humans; Nasal Septum; Neoplasm Recurrence, Local; Neoplasms; Nose; Nose Neoplasms; Sarcoma

Topics: Humans; Mucous Membrane; Myxoma; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinuses

Topics: Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma

Topics: Humans; Nasopharyngeal Neoplasms; Nasopharynx; Neoplasms; Nose; Nose Neoplasms; Pharynx; Plasmacytoma