phenylephrine-hydrochloride and Neoplasm-Metastasis

Squamoid eccrine ductal carcinoma (SEDC) is an extremely rare cutaneous tumor of unknown etiology. We report the case of a 77-year-old man with a history of treated chronic lymphocytic leukemia along with numerous basal cell and squamous cell carcinomas who presented for evaluation of a 5-cm, stellate, sclerotic plaque on the left chest of approximately 2 years' duration and a suspicious 3-mm pink papule on the right nasal sidewall of 2 months' duration. Initial histology of both lesions revealed carcinoma with squamous and ductal differentiation that extended from the undersurface of the epidermis, favoring a diagnosis of SEDC. It was later determined that the patient had distant metastasis of SEDC. This report of an immunocompromised patient with SEDC is a rare case of distant metastasis of SEDC. A review of the literature on the diagnosis, treatment, and surveillance of SEDC also is provided.

Topics: Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diagnosis, Differential; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Neoplasm Metastasis; Neoplasms, Multiple Primary; Nose; Skin Neoplasms; Sweat Gland Neoplasms; Thorax

Metastatic renal cell carcinoma (RCC) in the nose and paranasal sinuses is very rare. We report an unusual case of metastatic RCC that presented as recurrent epistaxis ten years after curative nephrectomy. The purpose of this report is to draw the attention of clinicians to the possibility of metastatic RCC in patients with recurrent epistaxis and nasal mass. We also discuss treatment options and review the relevant literature.

Topics: Adult; Carcinoma, Renal Cell; Chemoradiotherapy; Diagnosis, Differential; Epistaxis; Humans; Indoles; Kidney Diseases; Male; Neoplasm Metastasis; Nose; Nose Neoplasms; Positron-Emission Tomography; Pyrroles; Recurrence; Sunitinib; Tomography, X-Ray Computed

The aim of this study was to define the types of endoscopic endonasal resection for sinonasal malignancies according to their origin and extension.. Patients who underwent endoscopic endonasal surgery for the removal of malignant tumors of the nasal passages, paranasal sinuses, and the anterior cranial base between 2003 and 2010 were included in the study. Patients' data were collected retrospectively. Patients were grouped according to types of endoscopic tumor resection as follows: type I: en bloc resection, type II: resection of intranasal free part piecemeal and origin of tumor en bloc, type III: resection of intranasal free part and origin of tumor piecemeal with curative intent, and type IV: resection of intranasal free part and origin of tumor piecemeal with palliative intent or removal of tumor with positive margin. The follow-up period varied from 2 to 7 years (mean, 4.35 years).. Twenty patients were included in the study. Five patients underwent type I, 6 patients type II, 4 patients type III, and 5 patients underwent type IV resection. No local tumor recurrence was seen after types I, II, and III resections, whereas 2 patients (10%) with the type IV resection had a local recurrence. Distant metastasis was observed in 4 patients (20%) postoperatively (1 patient in type I, 1 patient in type III, and 2 patients in type IV resection). Disease-specific death was 15% (1 case in type I and 2 cases in type IV).. Classification of endoscopic tumor resection used in the present study may help preoperative planning.

Topics: Adult; Aged; Aged, 80 and over; Endoscopy; Ethmoid Sinus; Female; Follow-Up Studies; Humans; Male; Maxillary Sinus Neoplasms; Middle Aged; Nasal Septum; Neoplasm Metastasis; Nose; Nose Neoplasms; Orbital Neoplasms; Paranasal Sinus Neoplasms; Retrospective Studies; Skull Base Neoplasms; Sphenoid Sinus; Turbinates; Young Adult

Primary sinonasal malignant melanoma (SNMM) is a rare clinical entity. There is neither a classification nor a staging system nor an evidence-based treatment concept established. Our objective was to find potential risk factors predicting the outcome.. Twenty-five patients with histologically confirmed SNMM were consecutively included and retrospectively analyzed. Staging methods were nasal endoscopy, CT, MRI, and positron emission tomography (PET) scan. Patients were selected for a curative or palliative concept. All patients had postoperative follow-up with control-MRI at 3 and 6 months. Restaging was performed when local recurrence occurred.. Nineteen patients underwent primary surgery with curative intention; in 16 cases with tumor free margins. Thirteen patients (68%) had transnasal endoscopic surgery, 4 lateral rhinotomy, and 2 transfacial approach with orbital exenteration. Six patients (32%) had palliative therapy and 7 patients (37%) had adjuvant radiotherapy. Despite radical operations, 6 patients (37%) showed local recurrence and 8 patients (50%) developed distant metastasis. In 2 patients with incomplete surgery, regional metastasis was noted. The median disease-free interval was 18 months, and the median overall survival rate was 23 months.. SNMMs of the ethmoid and maxillary sinuses have a worse prognosis than other localizations in the nasal cavity; infiltration into the skull base, orbit, or facial soft tissue correlates with a very poor outcome corresponding to the palliative situations. Furthermore, local recurrence insinuates aggressive disease with short survival rate. A main difference from its cutaneous counterpart seems to be a primary tendency to hematogenic spread. Further research is needed to confirm these findings.

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Diagnostic Imaging; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nose; Nose Neoplasms; Palliative Care; Paranasal Sinus Neoplasms; Paranasal Sinuses; Radiotherapy, Adjuvant; Retrospective Studies

Topics: Adult; Carcinoma; Carcinoma, Adenoid Cystic; Epidermal Cyst; Female; Forehead; Granular Cell Tumor; Heel; Humans; Male; Middle Aged; Mohs Surgery; Neoplasm Metastasis; Nose; Pilomatrixoma; Scalp; Skin Neoplasms

Ultrasound is commonly performed to diagnose pathological processes of the neck and the salivary glands. In contrast, pathological changes of the sinuses and the bony structures of the face are only rarely examined sonographically. This paper deals with the diagnostic scope of ultrasound in the case of orbital and nasal fractures as well as for cases of sinus pathology excluding acute sinusitis. 51 patients with different diseases of this area were examined using US and X-ray or CT scan. Fractures of the nose could all be diagnosed correctly by ultrasound, which is of clinical importance if children or pregnant patients are examined. Blow-out fractures of the orbit were not detected. In contrast, pathological changes of the orbit itself could be distinguished sufficiently well from those infiltrating the orbit and originating from the sinuses. Real-time examination allows the detection of infiltration of orbital muscles and the bulb of the eye better than any other imaging method.

Topics: Carcinoma, Renal Cell; Female; Fractures, Bone; Humans; Kidney Neoplasms; Male; Neoplasm Metastasis; Nose; Nose Diseases; Nose Neoplasms; Paranasal Sinus Diseases; Paranasal Sinuses; Reproducibility of Results; Tomography, X-Ray Computed; Ultrasonography

This study presents a retrospective look at 115 patients evaluated here from 1957 to 1974. In this series, 57 percent were males and 43 percent females, 84 percent were Caucasian and 16 percent Negro. Lesions confined to or originating in the antrum made up 67 percent while nonantral lesions were 33 percent. Mean age at diagnosis was 59.1 years. Smoking and drinking history did not appear to be contributory. Antral lesions were retrospectively staged according to Sisson's TNM classification. Sixteen tumor types were involved, with the most common being epidermoid. Diagnosis was most often made by intranasal or Caldwell-Luc biopsy. Most frequent symptoms, as well as earliest symptoms, were nasal obstruction, localized pain, and epistaxis. Average duration of symptoms was 6.4 months. Therapy was generally in the form of radiotherapy alone, preoperative radiotherapy and surgery, surgery and postoperative radiotherapy, or surgery alone. Local recurrences occurred in 44 percent of antral lesions and 50 percent of non-antral lesions. Regional (cervical) nodal metastases developed in 25 percent of antral lesions and 11 percent of non-antral lesions. Distant metastases developed in 30 percent of antral cases and 35 percent of non-antral cases. Five-year survival was 32 percent (35 percent determinate) for the total group. The more advanced the staging of the antral lesions, the worse the prognosis. Best survival figures were in the areas of preoperative radiotherapy and surgery at 38 percent (43 percent) and surgery alone at 56 percent (59 percent).

Topics: Adolescent; Adult; Aged; Carcinoma, Squamous Cell; Child; Cobalt Radioisotopes; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nasal Cavity; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Prognosis; Radioisotope Teletherapy; Recurrence; Retrospective Studies

The experience with 40 consecutive cases of cancer of the nasal cavity seen over a period of 15 years is presented. Males outnumbered females in a ratio or 5 to 3. Age ranged from 35 to 88 years, and the median age was 67 years. Epidermoid carcinoma accounted for 78% of the cases. Smoking from early age was a noticeable habit among these patients. The median length of smoking history was 51 years. Most lesions were diagnosed in an advanced stage of the disease, 58% of the cases being T3 lesions. Regional lymph nodes metastases were infrequent; only 12% of the patients presented nodes on admission; another 5% developed metastatic nodes during the follow-up period. An overall 5-year survival of 56% was obtained. The survival of cases with T1N0 lesions was 91%. Radiation therapy was the treatment of choice employed in 85% of the cases. A 5-year survival of 50% was obtained in these patients. Irradiation offers an additional means of salvaging recurrences after surgery. The special characteristics of tumors of the nasal cavity merit the evaluation of such lesions separately from tumors of the paranasal sinuses.

Topics: Adult; Aged; Carcinoma, Squamous Cell; Female; Humans; Male; Middle Aged; Nasal Cavity; Neoplasm Metastasis; Nose; Nose Neoplasms; Prognosis; Remission, Spontaneous; Smoking

Topics: Aged; Biopsy; Carcinoma, Transitional Cell; Cystitis; Cystoscopy; Humans; Male; Neoplasm Metastasis; Nose; Nose Neoplasms; Prostate; Prostatic Neoplasms; Skin; Skin Neoplasms

Topics: Adenocarcinoma; Adult; Auscultation; Biopsy; Carcinoma, Squamous Cell; Child; Endoscopy; Head and Neck Neoplasms; Humans; Laryngoscopy; Medical History Taking; Neoplasm Metastasis; Nose; Palpation; Pharynx; Radiography

Topics: Adolescent; Biopsy; Blepharoptosis; Blood Transfusion; Female; Humans; Maxillary Sinus; Neoplasm Metastasis; Neuroectodermal Tumors, Primitive, Peripheral; Nose; Nose Neoplasms; Palate; Radiography; Skull

Topics: Cell Transformation, Neoplastic; Eyelid Neoplasms; Facial Neoplasms; Female; Humans; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Middle Aged; Neoplasm Metastasis; Nose; Orbital Neoplasms; Parotid Neoplasms

Topics: Animals; Biological Evolution; Brain Neoplasms; Cats; Central Nervous System Diseases; Cerebral Arteries; Cerebral Cortex; Craniocerebral Trauma; Diagnosis, Differential; Electroencephalography; Encephalocele; Endocrine System Diseases; Female; Genital Diseases, Female; Genital Diseases, Male; Haplorhini; Humans; Hypothalamus; Limbic System; Lymphatic Metastasis; Male; Manometry; Neoplasm Metastasis; Neural Conduction; Neuroectodermal Tumors, Primitive, Peripheral; Neurons; Nose; Nose Neoplasms; Olfaction Disorders; Olfactory Mucosa; Olfactory Nerve; Rabbits; Sensory Receptor Cells; Smell

Topics: Animals; Brain Neoplasms; Carcinoma, Squamous Cell; Epithelium; Ethers; Hydrocarbons, Halogenated; Lung; Lung Neoplasms; Neoplasm Metastasis; Neoplasms, Experimental; Neuroectodermal Tumors, Primitive, Peripheral; Nose; Nose Neoplasms; Occupational Diseases; Paranasal Sinus Neoplasms; Rats; Respiratory Tract Neoplasms

Topics: Aged; Carcinoma, Basal Cell; Female; Humans; Lip Neoplasms; Male; Methods; Middle Aged; Mouth Neoplasms; Neoplasm Metastasis; Nose; Postoperative Complications; Skin Transplantation; Surgery, Plastic; Suture Techniques; Transplantation, Autologous

Topics: Adult; Child; Child, Preschool; Ethmoid Sinus; Female; Head and Neck Neoplasms; Humans; Infant; Lymph Nodes; Male; Maxillary Neoplasms; Mesenchymoma; Neoplasm Metastasis; Nose; Palatal Neoplasms; Pregnancy; Pregnancy Complications; Respiratory Tract Neoplasms; Rhabdomyosarcoma

Topics: Child; Hemangioma; Humans; Melanoma; Neoplasm Metastasis; Neuroblastoma; Nose; Nose Neoplasms; Rhinosporidiosis; Tuberculosis