phenylephrine-hydrochloride and Margins-of-Excision

Basal cell carcinoma (BCC) is the most common skin cancer and originates from the basal layer of the epidermis. It is most common in the head and neck region. It usually grows slowly and rarely metastasizes. The gold standard treatment is surgical excision.. In this study, it was aimed to discuss the demographic and medical data of patients treated with the diagnosis of BCC.. Sixty-seven tumors of 55 patients who were operated for BCC in our clinic between 2016 and 2020 were retrospectively analyzed. Demographic and medical data were analyzed.. The tumor was most commonly localized to the nose. The most common (50%) histological type was the nodular type. Recurrence occurred in one of our patients (1.5%). Surgical margin positivity was observed in six patients.. Basal cell carcinomas are most common in the head and neck region. Its frequency increases with age and is more common in men. In our patients, 98.5% of the tumors were located in the head and neck, and 89.5% were over 60 years of age. Nodular is the most common type of BCC, and the most common nodular type was detected in our study. Surgical margin positivity is observed between 9% and 37.2% after surgery, and the recurrence rate is around 5%. In our study, surgical margin positivity was 9% and recurrence was 1.5%. Evaluating the excision margins carefully in a well-lit environment and taking into account cosmetic concerns, obtaining an adequately intact surgical margin in one go may lead to the ideal treatment result.

Topics: Aged; Carcinoma, Basal Cell; Humans; Male; Margins of Excision; Middle Aged; Neoplasm Recurrence, Local; Nose; Retrospective Studies; Skin Neoplasms

Topics: Humans; Margins of Excision; Nose

Topics: Aged, 80 and over; Carcinoma, Squamous Cell; Female; Humans; Margins of Excision; Nose; Nose Neoplasms; Skin; Skin Neoplasms; Treatment Outcome; Tumor Burden

Merkel cell carcinoma (MCC) is a rare but more lethal cutaneous cancer than melanoma. However, spontaneous regression of a number of MCC has been reported, although the cause of this regression remains unclear. In most cases, MCC regresses after a surgical procedure, for example, biopsy. Herein, we report a case of Merkel cell polyomavirus-negative MCC coincident with squamous cell carcinoma (SCC) that underwent true spontaneous regression without biopsy. One month after the patient's first visit, clinical examination revealed that the tumor had not grown, but its surface showed changes in texture and color. Histopathologically, the excised specimen was indicative of MCC coincident with SCC and showed extensive necrosis in the upper portion of the tumor, numerous caspase-3-positive apoptotic cells, an accumulation of CD68-positive foam cells and vascular invasion. These findings suggested that the tumor had regressed. We hypothesize that extensive coagulative necrosis resulting from an insufficient local blood supply triggered the shedding of some products or components of MCC and SCC, which in turn induced antitumor immunity against both lesions.

Topics: Aged, 80 and over; Biopsy; Carcinoma, Merkel Cell; Carcinoma, Squamous Cell; Female; Humans; Margins of Excision; Merkel cell polyomavirus; Neoplasm Regression, Spontaneous; Neoplasms, Multiple Primary; Nose; Skin; Skin Neoplasms

Reconstruction of the nasal tip defects is challenging because of variable contours of the region and the unique texture, thickness, color, and limited amount of available skin. There are several well-known local flaps for this purpose. Unfortunately, most of these flaps are suitable for small sized defects up to 2 cm in diameter. In this study, the authors are presenting a new flap for reconstruction of nasal tip and supratip defects larger than 2 cm in diameter.. Pincer flap was used for reconstruction of nasal tip defects in 12 patients, between 2011 and 2014. The mean age was 67 (43-88). All patients had a basal cell carcinoma. Defects were located at the central nasal, lateral nasal, and supratip areas. All tumors were excised with safe margins. After the excision, defects were reconstructed with pincer flap in the same session.. The mean follow-up period was 11 (6-18) months. There was not any flap loss. Infection and venous congestion was observed in 2 patients but the patient did not require any further surgical intervention, and healed with local and systemic antibiotherapy. No recurrence occurred and the outcome was aesthetically favorable.. The authors concluded that pincer flap is reliable and may provide a single-stage reconstruction for the nasal tip defects larger than 2 cm and up to 3 cm in diameter.

Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; Female; Humans; Hyperemia; Male; Margins of Excision; Middle Aged; Neoplasm Recurrence, Local; Nose; Nose Neoplasms; Postoperative Complications; Rhinoplasty; Skin Neoplasms; Skin Pigmentation; Surgical Flaps