phenylephrine-hydrochloride and Lymphoma--Non-Hodgkin

Topics: Antineoplastic Combined Chemotherapy Protocols; CD56 Antigen; Connective Tissue Diseases; Cyclophosphamide; Diagnostic Errors; Doxorubicin; Epstein-Barr Virus Infections; Eyelid Neoplasms; Fatal Outcome; Female; Herpesvirus 4, Human; Humans; Immunophenotyping; Killer Cells, Natural; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Male; Nose; Prednisolone; Skin; Skin Neoplasms; T-Lymphocyte Subsets; Vincristine; Young Adult

Extranodal non-Hodgkin's lymphoma in the head and neck, especially T-cell lymphoma of the lethal midline granuloma (LMG) type, has unique clinical and histologic features differentiating it from other lymphomas. The authors measured soluble intercellular adhesion molecule-1 (ICAM-1) in sera from 12 patients with T-cell lymphoma of the LMG type and from 52 patients with other head and neck non-Hodgkin's lymphomas, by double-determinant immunoassay. The expression of ICAM-1 in lymphoma tissue was examined in 26 patients by the avidin-biotin immunoperoxidase method. The serum ICAM-1 levels were significantly higher in T-cell lymphoma of the LMG type than in other head and neck lymphomas or in healthy adult controls. Elevated levels of serum ICAM-1 were associated with increased levels of serum lactate dehydrogenase, poor prognosis, and impaired T-cell-dependent immune functions, both in T-cell lymphoma of the LMG type and in other head and neck lymphomas. When we monitored serum ICAM-1 levels in individual patients, the level decreased in the complete remission interval compared to before treatment and went up again when the lymphoma relapsed. Although the staining intensities of ICAM-1 in lymphoma cells were not related to serum ICAM-1 levels, a markedly intense expression of ICAM-1 was found on the angiocentric or angiodestructive lymphoreticular infiltrate region in the tissues from T-cell lymphoma of the LMG type. A higher serum ICAM-1 level and its tissue expression in T-cell lymphoma of the LMG type may be one of the clues to understanding this particular lymphoma. The serum ICAM-1 level could be an efficient parameter for monitoring the clinical course of head and neck non-Hodgkin's lymphomas.

Topics: Adult; Aged; CD4 Antigens; CD8 Antigens; Female; Granuloma, Lethal Midline; Humans; Intercellular Adhesion Molecule-1; L-Lactate Dehydrogenase; Lymphoma, Non-Hodgkin; Male; Middle Aged; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Paranasal Sinuses

Topics: Adult; Female; Humans; Lymphoma, Non-Hodgkin; Nose; Nose Neoplasms; Skin; Skin Neoplasms

Topics: Animals; Cat Diseases; Cats; Lymphoma, Non-Hodgkin; Male; Nose; Nose Neoplasms

Topics: Cell Transformation, Neoplastic; Eyelid Neoplasms; Facial Neoplasms; Female; Humans; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Middle Aged; Neoplasm Metastasis; Nose; Orbital Neoplasms; Parotid Neoplasms

Topics: Animals; Animals, Newborn; Atrophy; Bone Marrow Diseases; Cat Diseases; Cats; Germ-Free Life; Leukemia; Lymph Nodes; Lymphoma, Non-Hodgkin; Microscopy, Electron; Nose; Retroviridae; Thymus Gland

Topics: Adult; Cortisone; Diagnosis, Differential; Face; Facial Neoplasms; Female; Granuloma, Lethal Midline; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Lymphoma, Non-Hodgkin; Male; Middle Aged; Nasal Mucosa; Nose; Nose Neoplasms

Topics: Diagnosis; Diagnosis, Differential; Granuloma; Granulomatosis with Polyangiitis; Hodgkin Disease; Humans; Kidney Diseases; Lung Diseases; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mastoid; Neoplasms; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Prednisolone; Radiotherapy; Sarcoma

Topics: Humans; Lymphoma, Non-Hodgkin; Medical Records; Neck; Nose; Pharyngeal Neoplasms; Pharynx

Topics: Disease; Face; Granuloma; Hodgkin Disease; Lymphoma, Non-Hodgkin; Medical Records; Nose

Topics: Animals; Histiocytosis, Non-Langerhans-Cell; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Medical Records; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Sarcoma

Topics: Humans; Lymphoma; Lymphoma, Non-Hodgkin; Nose; Nose Neoplasms

Topics: Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mononuclear Phagocyte System; Nasal Cavity; Neoplasms; Nose; Paranasal Sinus Neoplasms; Sarcoma

Topics: Humans; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma; Turbinates

Topics: Humans; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma; Turbinates

Topics: Humans; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Paranasal Sinuses; Sarcoma

Topics: Lymphoma, Non-Hodgkin; Nasal Cavity; Neoplasms; Nose; Nose Neoplasms; Sarcoma

Topics: Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Nose; Sarcoma