phenylephrine-hydrochloride and Lupus-Erythematosus--Systemic

Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Female; Foreign Bodies; Humans; Iatrogenic Disease; Infant; Infant, Newborn; Lupus Erythematosus, Systemic; Male; Middle Aged; Nasal Septum; Nose; Nose Neoplasms; Occupational Diseases; Rhinitis, Atrophic; Sex Factors; Tuberculosis, Pulmonary; Ulcer; Wounds and Injuries

The aims of our research were: estimation of asymptomatic bacteriuria (a.b.) incidence in population of women with systemic lupus erythematodes (SLE), evaluation its clinical significance and examination of bacterial colonisation of nostrils and pharynx in SLE patients with a.b. 85 women aged 24-77 (mean 49.3) with mean SLE duration 7.8 (range 1-32) years were examined. All of them fulfilled ARA criteria for the classification of SLE. Among group of patients with a.b. were counted women who had significant bacteriuria > or = 10(4) in ml urine in two cultures. Asymptomatic bacteriuria was found in 14 cases of 85 women with SLE (16.5%). In two following urine cultures bacteria from family Enterobacteriaceae were dominated: the same types of bacteria were in 85.7%--bacteriuria persistens, in others 14.3% were observed change of bacteria--bacteriuria transistens. In 9 from 14 patients with (64.3%) a.b. very massive growth of Staphylococcus aureus in culture from vestibulae of the nose swab was, in other cultures very massive growth of physiological flora was seen. All patients with a.b. were in clinical remission of SLE and they had no clinical symptoms of infection in urinary tract in 5 months of observation. However clinical significance of asymptomatic bacteriuria and pathogenic bacteria colonisation of nostrils as a precedence to symptomatic infections needs further investigations.

Topics: Adult; Aged; Bacteriuria; Female; Humans; Incidence; Leukocyte Count; Lupus Erythematosus, Systemic; Middle Aged; Nose; Pharynx; Staphylococcus aureus; Urine

Mycophenolate mofetil has been shown to have teratogenic properties in animal studies and clinical reports. We report a case of major fetal malformation likely caused by mycophenolate mofetil exposure in utero in a 36 year old patient with systemic lupus erythematosus. The diagnosis was made by ultrasonography at 22 weeks of gestation.

Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Ear, External; Facies; Female; Fetus; Humans; Imaging, Three-Dimensional; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mycophenolic Acid; Nose; Pregnancy; Pregnancy Complications; Ultrasonography, Prenatal

To determine if B cells of lupus prone NZB mice possess intrinsic defects that directly lead or contribute to T-cell hyper-responsiveness, we injected age-, sex- and MHC II-matched NZB and Balb/c mice with histone peptide H471 representing a dominant Th cell epitope in histone H4 of the nucleosome. We found that B220+ B cells of NZB mice express high levels of surface CD86 following antigen priming. We cocultured CD4+ T and B220+ B cells of naïve or peptide primed NZB and Balb/c mice in the presence of peptide. Antigen presentation by autoimmune B cells of NZB mice induced hyper-responsiveness from normal CD4+ T cells of Balb/c mice. T-cell hyper-responsiveness is a result of CD86 costimulation by B cells of NZB mice. Induction of nasal tolerance to H471 in NZB mice suppressed CD86 surface expression and led to downregulation of T-cell proliferative response and cytokine production. More interestingly, B220+ B cells from nasally tolerized NZB mice induced T-cell anergy to anti-CD3 and anti-CD28 antibody stimulation in vitro. The anergic T cells do not possess suppressive function in coculture with naïve responder T cells nor produce suppressive cytokines interleukin 10 and transforming growth factor-beta in vitro.

Topics: Animals; Antibody Formation; Antigen Presentation; Antigen-Presenting Cells; B-Lymphocytes; B7-2 Antigen; CD4-Positive T-Lymphocytes; Clonal Anergy; Coculture Techniques; Down-Regulation; Female; Histones; Immunodominant Epitopes; Leukocyte Common Antigens; Lupus Erythematosus, Systemic; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred NZB; Nose; T-Lymphocytes; Th1 Cells

The authors have developed a method for coproporphyrin III measurements in nasal sebaceous gland orifices by contact biomicroscopy. Increased levels of coproporphyrin III were detected with this method in patients with lupus erythematosus, photodermatitis, acne vulgaris.

Topics: Acne Vulgaris; Coproporphyrins; Humans; Lupus Erythematosus, Systemic; Microscopy, Fluorescence; Nose; Photosensitivity Disorders; Psoriasis; Sebaceous Glands

A three generation family from northern Sweden with both trichorhinophalangeal syndrome type I (TRP I) and systemic lupus erythematosus (SLE)-like syndrome with complement C4 homozygous null alleles is described. Five family members in three generations were affected by the TRP I syndrome, indicating autosomal dominant inheritance. Two members had clinical and laboratory signs of SLE and two other members SLE-like syndrome. All living family members in the first and second generation had homozygous C4A null alleles. In three of the adults the two syndromes occurred simultaneously, probably in this family by coincidence.

Topics: Abnormalities, Multiple; Adolescent; Aged; Alleles; Anaphylatoxins; Complement C4a; Female; Fingers; Genes, Dominant; Hair Diseases; Homozygote; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Nose; Pedigree; Syndrome

Topics: Animals; Antibodies; Antibodies, Anti-Idiotypic; Antibodies, Antinuclear; Arthritis, Rheumatoid; Binding Sites, Antibody; Cartilage; Cattle; Diabetes Complications; Ear; False Positive Reactions; Female; Fluorescent Antibody Technique; Humans; Insulin Resistance; Lupus Erythematosus, Systemic; Middle Aged; Neutralization Tests; Nose; Polychondritis, Relapsing; Rabbits; Rats; Trachea

Topics: Aged; Chilblains; Diagnosis, Differential; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Lymph Nodes; Nose; Tuberculosis; Tuberculosis, Lymph Node

Topics: Animals; Humans; Hydrozoa; Lupus Erythematosus, Systemic; Nose; Rosacea; Telangiectasis