phenylephrine-hydrochloride and Leukemia

Topics: Animals; Bone Marrow Cells; Carcinogens; Cells, Cultured; Formaldehyde; Hematopoietic Stem Cells; Inhalation Exposure; Leukemia; Lung; Male; Mice; Mice, Inbred BALB C; Nose; Specific Pathogen-Free Organisms; Spleen

Most of palatal fistula occur from poor repairation of cleft palate, leaving an abnormal channel between mouth and nose. Palatal fistula can cause a series of complications, such as voice and hearing disorder, poor oral and nasal hygiene, psychological diseases and so on. However, hard palate fistula secondary to Leukemia infection is rarely seen, it hasn't been reported yet. We report one case with hard palate fistula and nasal septum perforation after Leukemia infection.

Topics: Fistula; Humans; Infections; Leukemia; Nasal Septal Perforation; Nose; Nose Diseases; Oral Fistula; Palate, Hard; Postoperative Complications

To evaluate the following: the incidence of invasive Aspergillus sinusitis (AS); the value of surveillance nasal cultures and screening radiologic studies in predicting AS; the clinical criteria used to decide on surgical biopsy in patients suspected of having AS; the surgical and medical management of AS; and the outcome of AS in the peritransplantation period of children who underwent bone marrow transplantation.. Retrospective medical chart review.. Tertiary care children's hospital.. Eighty pediatric patients who underwent bone marrow transplantation for a variety of refractory malignant neoplasms or lymphohematopoietic disorders at the Children's National Medical Center, Washington, DC, from April 1, 1988, to September 30, 1993.. Diagnostic surgical biopsies, surgical débridement, and treatment with amphotericin B.. Resolution of AS and discharge from the hospital.. Seventy-two patients had screening sinus radiographs, 27 of which showed abnormalities. Aspergillus sinusitis developed in three of the patients with abnormal screening radiographs. Fifty-eight patients had screening nasal cultures. One culture was positive for Aspergillus, and histopathologically proved AS developed in this patient. Twelve diagnostic biopsies were done in nine patients. Three biopsy specimens showed histopathologic evidence of AS. The three patients with AS were successfully treated with aggressive surgical and medical therapy and were discharged from the hospital.. The incidence of AS was 4% (3/80) in the patients who underwent bone marrow transplantation. Screening radiographs, while not a good predictor of AS, have a role in evaluation of patients undergoing bone marrow transplantation to define preexisting sinus disease. Screening nasal cultures do not reliably predict AS. When AS is suspected and diagnostic biopsy is considered, the seven clinical criteria outlined in this article should be used. Survival of immunocompromised patients with AS requires early diagnosis and aggressive surgical and medical therapy.

Topics: Adolescent; Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Biopsy; Bone Marrow Transplantation; Child; Child, Preschool; Debridement; Female; Follow-Up Studies; Forecasting; Humans; Immunocompromised Host; Incidence; Infant; Leukemia; Male; Nose; Postoperative Complications; Radiography; Retrospective Studies; Sinusitis; Treatment Outcome

A strict nutritional requirement for lipid and similar components of cell wall fatty acids and sugars are features common to both JK coryneforms (JK) that are resistant to multiple antibiotics and to lipophilic diphtheroids (LD) that are sensitive to antibiotics. We surveyed 123 subjects for LD and JK. Twenty-eight patients with leukemia (776 samples) were cultured longitudinally during 42 hospitalizations; 15 other patients hospitalized for at least two weeks and 80 controls were sampled once. JK were isolated from at least one of four skin sites in 82.1% of the leukemic patients, 73.3% of other patients, and 15.7% of controls. There was an inverse correlation between the density of LDs and JKs in all groups (P = .03). The perineum was the most frequent, and usually the first, site of JK colonization. Once present, colonization persisted for as long as follow-up continued. Systemic vancomycin did not eliminate or prevent skin colonization with JK. Leukemic patients may have a greater risk of JK infection but probably no increased risk of skin colonization.

Topics: Actinomycetales; Adult; Anti-Bacterial Agents; Axilla; Drug Resistance, Microbial; Female; Hospitalization; Humans; Leukemia; Lipids; Male; Nose; Perineum; Skin; Toes; Vancomycin

Topics: Acute Disease; Axilla; Bacteria; Cross Infection; Enterobacteriaceae; Gingiva; Humans; Leukemia; Nose; Pseudomonas aeruginosa; Rectum; Sepsis

Topics: Acute Disease; Aged; Aspergillosis; Aspergillus fumigatus; Female; Humans; Leukemia; Nose; Paranasal Sinus Diseases

During the 20 year interval from 1958 to 1978 a change in the spectrum of disease, etiology, and diagnosis of mucormycosis was observed at The Mount Sinai Hospital. Although the rhinocerebral and pulmonary forms of mucormycosis were still the most frequent forms of disease, hospital acquired cutaneous and subcutaneous infections emerged. Since 1974, 14 of 15 cases of mucormycosis were diagnosed during life. Rizopus species, especially R. rhizopodoformis, have been the etiologic agents identified in 13 of 14 culturally proven cases. The presence or absence of antirhizopus fungistatic activity and antirhizopus antibody in the sera of six of the patients was correlated with the severity of clinical disease. Preliminary results showed a relationship between the extent of disease and the degree of serum fungistatic activity that was independent of antibody production.

Topics: Acute Disease; Adolescent; Adult; Aged; Antibodies, Fungal; Diabetes Complications; Female; Humans; Infant, Newborn; Leukemia; Lung; Male; Middle Aged; Mucormycosis; Nose; Rhizopus; Skin

Aspergillosis in cancer patients is a problem. Because not all patients can undergo invasive procedures, we sought other methods for diagnosis. We reviewed the data from all patients with acute nonlymphocytic leukemia treated at our center during a 3-year period. Of 125 patients, 18 had invasive aspergillosis (cases). Eleven patients had nose cultures growing Aspergillus flavus or A. fumigatus; 10 of these 11 had aspergillosis, whereas only eight of 114 without such nose cultures had invasive disease (P less than 0.000001). Thus, A. flavus on nose culture appears "predictive" for aspergillosis. Absence of such a culture does not preclude infection. Of 125 patients, 61 had sterile nose culture(s) and 14 of the 18 cases had such a sterile nose culture. Only four of the 64 patients without sterile nose cultures developed aspergillosis (P less than 0.008), suggesting a relation between sterile nose culture and aspergillosis. Carbenicillin was used for a longer period among cases and patients with predictive nose cultures than among patients without aspergillosis. These data may help identify patients at risk of aspergillosis and help determine antifungal therapy when invasive procedures are contraindicated.

Topics: Acute Disease; Agranulocytosis; Anti-Bacterial Agents; Aspergillosis; Aspergillus flavus; Aspergillus fumigatus; Carbenicillin; Drug Therapy, Combination; Humans; Leukemia; Nose

Topics: Bacteria; Blood; Candida; Escherichia coli; Humans; Klebsiella; Leukemia; Lung; Mouth; Nose; Pneumonia; Sputum; Staphylococcus; Streptococcus; Streptococcus pneumoniae

Topics: Animals; Animals, Newborn; Atrophy; Bone Marrow Diseases; Cat Diseases; Cats; Germ-Free Life; Leukemia; Lymph Nodes; Lymphoma, Non-Hodgkin; Microscopy, Electron; Nose; Retroviridae; Thymus Gland

Topics: Acute Disease; Antineoplastic Agents; Bacteria; Candida; Escherichia coli; Feces; Humans; Leukemia; Nose; Pharynx; Staphylococcus; Streptococcus

Topics: Acute Disease; Adult; Air Microbiology; Anti-Bacterial Agents; Antisepsis; Candida; Ear; Escherichia coli; Humans; Infection Control; Infections; Leukemia; Male; Methods; Middle Aged; Nose; Patient Isolators; Skin; Urine

Topics: Acute Disease; Adult; Amphotericin B; Blood Cell Count; Blood Platelets; Candida; Candidiasis; Cytarabine; Feces; Fever; Humans; Hypersplenism; Leukemia; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Nose; Pharynx; Prednisone; Skin; Spleen

Topics: Anemia; Arteriosclerosis; Deafness; Diagnosis, Differential; Ear; Hemangioma; Hematologic Diseases; Hematoma; Hemophilia A; Histiocytoma, Benign Fibrous; Humans; Infectious Mononucleosis; Leukemia; Nose; Pathology; Pharynx; Polycythemia; Telangiectasis