phenylephrine-hydrochloride and Laryngeal-Neoplasms

Case 1 was a 75-year-old Japanese man who presented with a poorly demarcated, dark-red nodule with a destructive defect in the center, measuring 3 cm × 2 cm on the right wing of his nose. The histological diagnosis was a common form of infundibular squamous cell carcinoma. Atypical neoplastic cells radiated from the wall of a follicular infundibulum. The majority of neoplastic cells were positive for AE1/AE3 and 34βE12. Cytokeratin 17 expression was seen in the suprabasal cells of the deeply situated neoplastic components. Case 2 was a 73-year-old Japanese man who presented with a poorly demarcated, dark-red nodule with an irregularly shaped ulcer in the center, measuring 3 cm × 2 cm on the left wing of his nose. The histological diagnosis was a crater form of infundibular squamous cell carcinoma. Atypical neoplastic cells radiated from the broad base of the central keratin-filled crater, continuous with two infundibular canals. In both cases, some of the more deeply situated aggregations were composed of neoplastic keratinocytes with eosinophilic glassy or pale cytoplasm. In addition, no atypical keratinocytes could be seen in the interfollicular epidermis. In case 1, a hematogenous metastasis to the vocal cord and the forehead occurred in addition to a lymph node metastasis. In case 2, a local recurrence occurred with an intralymphatic dissemination. We describe two cases of infundibular squamous cell carcinoma on the nose with aggressive clinical behavior, one of which was accompanied by a hematogenous metastasis while another revealed a local recurrence.

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy, Adjuvant; Granuloma, Pyogenic; Humans; Laryngeal Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Neoplasm Recurrence, Local; Nose; Plaque, Atherosclerotic; Skin Neoplasms; Vocal Cords

Topics: Epiglottis; Glottis; Humans; Laryngeal Neoplasms; Laryngoscopy; Larynx; Nasopharyngeal Neoplasms; Neck; Nose; Paranasal Sinus Neoplasms; Paranasal Sinuses; Pharyngeal Neoplasms; Radiography; Radiotherapy Dosage; Tomography; Vocal Cords

The paper is a continuation of the author's research on pathophysiology of the nose in patients subjected to total laryngectomy due to cancer of the larynx. The aim of the research was to discover how the condition of the nasal mucous and its physiology are affected by the elimination of the nose from the respiratory pathway which is the case in laryngectomy, and also the evaluation of the influence that the nose can exert on the physiology of the respiratory and circulatory systems, despite the elimination of the nose as a first section of the respiratory pathway. The research material was obtained from 110 patients who were subjected to total laryngectomy due to malignancy of the larynx and from a control group number of 30. The research was carried out before the surgery and in different periods after an operation. The condition of the nasal mucous was estimated on the basis of clinical examination including rhinoscopy, measurement of the warmth of the air in the nose and the temperature of the nasal mucous and also on the basis of observation of mucociliary transport. From patients who underwent laryngectomy a cytological material was obtained for examination. In all patients naso-cardiac and naso-pulmonary reflexes were examined. On the basis of the research it was stated that the morphological condition of the nasal mucous does not undergo significant changes despite the elimination of the nose from the respiratory pathway and the nose still maintains its potential ability to perform physiological functions. It can also be said that the elimination of the nose from the first section of the respiratory pathway not only does not remove reflex reactions from the side of the nose, but also often changes their course and character.

Topics: Female; Humans; Laryngeal Neoplasms; Laryngectomy; Male; Mucociliary Clearance; Nasal Mucosa; Nose

Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Delayed Diagnosis; Ear Auricle; Fatal Outcome; Humans; Keratosis; Laryngeal Neoplasms; Male; Middle Aged; Nose; Paraneoplastic Syndromes; Radiotherapy

Topics: Adult; Carcinoma, Squamous Cell; Endoscopy; Humans; Laryngeal Neoplasms; Nose; Nose Neoplasms; Papilloma; Pharyngeal Neoplasms; Pharynx; Retrospective Studies; Tomography, X-Ray Computed

Transnasal fiberoptic laryngoscopy (TFL) has been used to guide various in-office procedures for the past 3 decades. Publications on in-office laryngeal biopsy have concurred that this procedure is safe, feasible, and easy to perform. However, the accuracy of in-office biopsy via TFL has not yet been established. The aim of this study was to examine this issue.. To compare pathologic results obtained via in-office TFL with those of subsequent direct laryngoscopy to assess the accuracy of TFL as a diagnostic tool.. Prospective cohort study.. Tertiary reference medical center.. One-hundred two patients with suspicious laryngeal lesions.. All patients underwent in-office biopsies.. All patients with malignant lesions were referred to appropriate services for treatment, and those with a diagnosis of a benign lesion or carcinoma in situ were referred for direct laryngoscopy for definitive diagnosis. The results of the pathologic testing on specimens from in-office and direct laryngoscopy were compared.. Adequate tissue for diagnostic purposes was obtained in 96 of 102 in-office TFL biopsies (94.1%). The biopsy results revealed invasive carcinoma in 34 patients (35.4%), carcinoma in situ in 17 patients (17.7%), and benign lesions in 45 patients (46.9%). All patients with benign lesions and carcinoma in situ were referred for biopsy of samples obtained using direct laryngoscopy, to which 57 patients agreed. The final pathologic results identified from the biopsies on direct laryngoscopy revealed that there was an underestimation of the TFL results in 30 of 91 patients (false-negative rate, 33.0%) and an overestimation in 1 patient (false-positive rate, 1.1%). The sensitivity of TFL biopsy compared with that of direct laryngoscopy biopsy was 69.2% and the specificity was 96.1%.. Transnasal fiberoptic laryngoscopy yielded low sensitivity in assessing suspicious lesions of the larynx. These results may indicate that direct laryngoscopy represents the definitive pathologic diagnostic procedure whenever the pathologic results of an in-office TFL procedure are interpreted as benign or as carcinoma in situ.

Topics: Adult; Aged; Aged, 80 and over; Biopsy; Diagnosis, Differential; Female; Fiber Optic Technology; Follow-Up Studies; Humans; Laryngeal Neoplasms; Laryngoscopy; Larynx; Male; Middle Aged; Nose; Prospective Studies; Reproducibility of Results

The aim of this study was to define and quantitate the normal anatomy of the extracranial head and neck with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). This information was used to study 12 patients with primary squamous cell carcinomas. In all cases, the lymphoid tissue of the Waldeyer ring and the palatine and lingual tonsils could be differentiated from the airway, striated muscle, osseous structures, and salivary glands. Striated muscle had markedly less activity than lymphoid or salivary gland tissue. In the 12 patients with primary tumors, FDG PET depicted the tumor as an area of increased activity significantly higher than that of normal tissue. In one instance, FDG PET allowed detection of a tumor not seen at magnetic resonance (MR) imaging or computed tomography. Of the 34 lymph nodes positive for carcinoma, 24 were positive according to MR size criteria and 25 were detected with FDG PET. FDG PET allowed detection of three nonenlarged metastatic nodes that were negative at MR imaging.

Topics: Contrast Media; Deoxyglucose; Fluorodeoxyglucose F18; Head; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Lymphatic Metastasis; Magnetic Resonance Imaging; Mouth Neoplasms; Neck; Nose; Orbit; Parotid Neoplasms; Pharynx; Tomography, Emission-Computed; Tongue Neoplasms

Topics: Humans; Laryngeal Neoplasms; Nose; Precancerous Conditions

Topics: Adult; Aged; Carcinoma, Squamous Cell; Connective Tissue; Facial Injuries; Fibroma; Fibromyalgia; Humans; Laryngeal Neoplasms; Larynx; Male; Nose; Skin

Topics: Adult; Female; Humans; Laryngeal Neoplasms; Larynx; Leiomyoma; Leiomyosarcoma; Male; Muscle, Smooth; Nose; Nose Neoplasms

Topics: Adolescent; Adult; Aged; Bronchi; Bronchial Neoplasms; Child; Demography; Female; Humans; Laryngeal Neoplasms; Lung; Lung Neoplasms; Male; Middle Aged; Nasopharyngeal Neoplasms; Nasopharynx; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Respiratory Tract Neoplasms; Uganda

Topics: Animals; Antigens; Carcinoma; Cell Line; Child; Child, Preschool; Culture Techniques; Cytodiagnosis; Cytopathogenic Effect, Viral; Fluorescent Antibody Technique; Haplorhini; Humans; Infant; Kidney; Laryngeal Neoplasms; Lung; Methods; Nose; Orthomyxoviridae Infections; Pharynx; Respiratory Syncytial Viruses; Respiratory Tract Infections; Virus Cultivation

Topics: Bites and Stings; Bronchi; Burns; Foreign Bodies; Humans; Inflammation; Laryngeal Diseases; Laryngeal Neoplasms; Larynx; Nose; Otorhinolaryngologic Diseases; Pharyngeal Neoplasms; Respiratory Insufficiency

Topics: Adolescent; Anesthesia; Anesthesia, Local; Child; Esophagoscopy; Gastroscopy; Geriatrics; Humans; Laryngeal Neoplasms; Laryngoscopy; Lidocaine; Nose; Otolaryngology; Polyps; Surgical Procedures, Operative; Tonsillectomy