phenylephrine-hydrochloride and Keratosis

Nasal hyperkeratosis may cause discomfort in dogs by predisposing them to fissures and secondary bacterial infection. Approaches to treatment have been described anecdotally; the effectiveness of such therapies remains unproven.. To investigate the efficacy of a balm containing essential oils and essential fatty acids in dogs with idiopathic nasal hyperkeratosis.. Client-owned dogs with noncomplicated nasal hyperkeratosis.. The study was conducted as a randomized, double-blind, placebo-controlled clinical trial with parallel group design and two month follow-up period. Dogs received daily topical application of a commercial balm product (group DBB) or placebo (aqueous gelling agent with preservatives, group PB). The main outcome variables were lichenification, dryness, suppleness and extent of lesions. Subjective owner satisfaction index score was a secondary variable. Evaluation was performed on days (D)0, 30 and 60. Response to treatment was assessed as the change from baseline to each examination day for each criterion.. Forty eight dogs, principally French (26 of 48) and English (seven of 48) bulldogs, were included and 39 completed the study. No major adverse events were reported. On D60, changes from baseline for lichenification, lesion extent, suppleness and total score were -31.2%, -18.3%, -72.8% and -36.8% in group DBB (23 dogs) and -11.9%, 2.3%, -42.1% and -14% in group PB (16 dogs), respectively. The total score was significantly improved on D60 in group DBB compared to PB (Wilcoxon-Mann-Whitney U-test, P = 0.0016).. The balm proved safe and helpful in managing canine idiopathic noncomplicated nasal hyperkeratosis.

Topics: Animals; Dermatitis, Atopic; Dogs; Double-Blind Method; Fatty Acids, Essential; Female; Keratosis; Male; Nose; Oils, Volatile; Pruritus

Topics: Humans; Keratosis; Nose; Skin Abnormalities; Warts

Topics: Acne Vulgaris; Child; Dermoscopy; Facial Dermatoses; Female; Humans; Hypopigmentation; Keratosis; Nose; Skin

Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Delayed Diagnosis; Ear Auricle; Fatal Outcome; Humans; Keratosis; Laryngeal Neoplasms; Male; Middle Aged; Nose; Paraneoplastic Syndromes; Radiotherapy

Topics: Anilides; Biopsy, Needle; Carcinoma, Basal Cell; Epidermal Cyst; Face; Follow-Up Studies; Humans; Immunohistochemistry; Keratosis; Male; Middle Aged; Mohs Surgery; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Nose; Pyridines; Risk Assessment; Skin Neoplasms; Treatment Outcome

Topics: Aged, 80 and over; Female; Humans; Keratosis; Nose; Plastic Surgery Procedures; Surgical Flaps

Keratoacanthoma is a relatively common benign squamous neoplasm that may show spontaneous clearing. Although the cause of the tumour is unknown, there are some reports describing keratoacanthoma following various types of trauma or secondary to other skin lesions. Thermal burns are reported to be important preceding traumas in the development of keratoacanthomas. whereas there is only one report of cold trauma of cryotherapy. We report a rare case of keratoacanthoma arising in the site of cryotherapy applied for solar keratosis.

Topics: Cicatrix; Cryotherapy; Diagnosis, Differential; Humans; Keratoacanthoma; Keratosis; Male; Middle Aged; Nose; Skin Diseases; Sunlight

Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminoquinolines; Antineoplastic Agents; Carcinoma in Situ; Carcinoma, Squamous Cell; Female; Humans; Imiquimod; Keratosis; Male; Middle Aged; Nose; Photosensitivity Disorders; Precancerous Conditions; Skin Neoplasms; Thorax

Topics: Aged; Carcinoma, Basal Cell; Humans; Keratosis; Middle Aged; Nose; Nose Diseases; Nose Neoplasms; Plastic Surgery Procedures; Surgical Flaps

Bazex syndrome is a paraneoplastic acrokeratosis appearing mostly at the same time as the underlying neoplasm. We report a typical case with a squamous cell carcinoma of the tongue and classical cutaneous symptoms disappearing with the treatment of the tumour.

Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Ear, External; Fluorouracil; Foot; Hand; Humans; Keratosis; Male; Middle Aged; Nose; Paraneoplastic Syndromes; Tongue Neoplasms

Topics: Acanthosis Nigricans; Adult; Disease Progression; Edema; Fingers; Foot Deformities, Congenital; Hand Deformities, Congenital; Humans; Keratoderma, Palmoplantar; Keratosis; Lip; Male; Mouth; Mouth Mucosa; Nose; Toes; Tretinoin

A large cutaneous horn was excised from the left side of the nose and cheek of a 68-year-old woman. Reconstruction was performed with a split-thickness skin graft. Histologically the lesion represented squamous cell carcinoma. The nature of malignant degeneration in cutaneous horns is discussed.

Topics: Aged; Carcinoma, Squamous Cell; Female; Humans; Keratosis; Nose; Plastic Surgery Procedures; Skin Neoplasms; Skin Transplantation

A 71-year-old woman suffered from pronounced erosion of her nose after soft X-ray therapy (total dose 28 Gy, half dose depth 10.5-11.5 mm). 5 weeks after the end of the irradiation no healing tendency was observed. This unusual clinical course was caused by a simultaneously existing pemphigus vulgaris that worsened after radiotherapy, presumably as a consequence of the release of epidermal antigens. In this case it is improbable that the pemphigus was induced by the radiotherapy, as has been reported on several occasions in the literature. However, this possibility cannot be entirely excluded.

Topics: Aged; Biopsy; Facial Dermatoses; Female; Humans; Keratosis; Nose; Nose Diseases; Pemphigus; Radiodermatitis; Skin; Wound Healing

A retrospective study of 643 cutaneous horns examined in our department between 1970 and 1989 revealed that 38.9% were derived from malignant or premalignant epidermal lesions, and 61.1% from benign lesions. Four main features were associated with premalignant or malignant histopathological change at the base of a cutaneous horn (base pathology). These were: (i) age--the mean age of the patients whose cutaneous horns showed premalignant or malignant base pathology was 8.9 years greater than the mean age of the patients where base pathology was benign (P less than 0.0005); (ii) sex--males were more likely to develop a cutaneous horn with (pre)malignant base pathology (P less than 0.001); (iii) site--over 70% of all (pre)malignant lesions were found on the nose, pinnae, backs of hands, scalp, forearms and the face; a cutaneous horn found at these sites was 2.1 times more likely to have derived from a (pre)malignant base than from any other part of the body (P less than 0.0001); (iv) geometry of the lesion--lesions with a wide base or a low height-to-base ratio were significantly more likely to show (pre)malignant base pathology. Of those solar keratoses giving rise to cutaneous horns, 8.9% also showed histological evidence of change to squamous cell carcinoma (SCC); this figure was not significantly different from the 6.2% of solar keratoses without horns that showed SCC change during the same period (1970-89).

Topics: Age Factors; Carcinoma, Squamous Cell; Ear, External; Face; Female; Forearm; Hand; Humans; Keratosis; Male; Microcomputers; Nose; Precancerous Conditions; Retrospective Studies; Risk Factors; Scalp; Sex Factors; Skin; Skin Diseases; Skin Neoplasms

Topics: Adult; Aged; Arm; Blister; Carcinoma, Squamous Cell; Cheek; Diagnosis, Differential; Eosinophils; Epidermal Cyst; Epithelium; Facial Dermatoses; Female; Granulation Tissue; Humans; Keratosis; Male; Middle Aged; Nose; Skin; Skin Neoplasms

Topics: Abnormalities, Multiple; Adolescent; Blood Cells; Child; Deafness; Diseases in Twins; Eye Diseases; Eyebrows; Face; Female; Foot Deformities, Congenital; Genes, Dominant; Hand Deformities, Congenital; Humans; Intellectual Disability; Iris; Karyotyping; Keratosis; Male; Middle Aged; Nose; Pedigree; Pigmentation Disorders; Waardenburg Syndrome

Topics: Adult; Aged; Carcinoma, Basal Cell; Cicatrix; Facial Dermatoses; Female; Hodgkin Disease; Humans; Keloid; Keratosis; Male; Middle Aged; Nose; Skin Diseases; Skin Neoplasms; Skin Transplantation; Surgery, Plastic; Transplantation, Autologous