phenylephrine-hydrochloride and Hepatitis-C

The prosthetic rehabilitation is a surgical alternative in functional-aesthetic facial reconstruction when the conventional reconstructive surgery cannot be applied either because of the psychophysical conditions of the patient or because of an excessive substance loss. From May 2002, 35 facial prosthesis (111 implants) have been positioned. Defects were congenital (N = 12), consequent to trauma (N = 8) and to demolitive surgery for malignant tumors (N= 8), and infection (N = 7). In 4 patients, implants were placed in previously irradiated areas. A total of 111 titanium implants were placed to support 21 auricular prostheses (bilateral in 2 cases), 4 orbital prostheses, 8 nasal prostheses, and 2 complex midfacial prostheses. Implant failure was observed for 2 of the 3 implants placed to support a nasal epithesis in a patient with hepatitis C virus, with an important parodontal disease, who experienced a postinfective necrosis of the nose after a liver transplantation; it was necessary to place an adhesive prosthesis. An implant failure was also observed in a diabetic patient with an extensive midfacial defects due to a mycotic infection, but it did not compromise the retention of the prosthesis. According to our experience, the indication to epithesis is when the conventional reconstructive interventions is inapplicable.

Topics: Adult; Aged; Craniofacial Abnormalities; Diabetes Complications; Ear Auricle; Face; Female; Head and Neck Neoplasms; Hepatitis C; Humans; Liver Transplantation; Male; Maxillofacial Injuries; Maxillofacial Prosthesis Implantation; Middle Aged; Mycoses; Nose; Opportunistic Infections; Orbital Implants; Periodontal Diseases; Prosthesis Design; Prosthesis Failure; Prosthesis Implantation; Surgical Wound Infection; Titanium

Topics: Adult; Cocaine-Related Disorders; Cryoglobulinemia; Ear, External; Hepatitis C; Humans; Ischemia; Male; Nose; Skin Diseases, Vascular

Plasma, tear fluid and swabs from eye, nose and pharynx of 33 patients were examined for presence of hepatitis C virus (HCV) RNA by polymerase chain reaction (PCR). All samples from plasma, tear fluid and eyeswabs were found to show a positive reaction in HCV-RNA PCR. Remarkably, we regularly found greater amounts of amplification products in tear fluid and eyeswabs compared to plasma using the same conditions for sample preparation.

Topics: Base Sequence; Blood; Body Fluids; DNA Primers; DNA Probes; Eye; Hepacivirus; Hepatitis C; Humans; Molecular Sequence Data; Nose; Pharynx; RNA, Viral; Tears; Tissue Distribution