phenylephrine-hydrochloride and Hamartoma

Perifollicular fibroma (PFF) is a rare cutaneous hamartoma that shows differentiation to the connective tissue sheath of the hair follicle. It may be solitary or multiple; the latter has been suggested to exhibit autosomal dominant inheritance and association with colonic polyposis. We report a 72-year-old Japanese female with multiple PFF on the face, possibly familial, who developed colon cancer in addition to colonic polyps.

Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Colonic Polyps; Female; Hamartoma; Humans; Nose; Skin Neoplasms

Hamartomas are benign tumor-like lesions composed of disorganized growth of mature mesenchymal or epithelial tissues indigenous to the organ involved. Sporadically observed in ruminants, vascular, fibrous, nasal, and pulmonary hamartomas have been reported in calves; pulmonary and cutaneous forms have been reported in sheep. A full-term elk calf found dead had a large intrathoracic mass replacing the left caudal lung lobe and compressing other thoracic organs. Histologically, cross- and tangential sections of bronchi were separated by collagenous mesenchyme and irregularly shaped canaliculi and saccules resembling terminal bronchioles. Rarely present were regions in which saccules, lined by simple cuboidal epithelium, transitioned into attenuated epithelium lining fully developed alveoli. These findings are consistent with a pulmonary hamartoma. To our knowledge, pulmonary hamartoma has not been reported previously in a non-domestic ruminant.

Topics: Animals; Animals, Wild; Deer; Epithelium; Fatal Outcome; Hamartoma; Lung Neoplasms; Nose; Pulmonary Alveoli; Sheep; Sheep Diseases

浆液黏液腺错构瘤（seromucinous hamartoma，SMH）是一种罕见的鼻腔鼻窦良性腺体增生性病变，目前国内外文献仅报道了40余例。本文报道1例山东大学齐鲁医院（青岛）耳鼻咽喉头颈外科收治的发生于蝶筛隐窝的SMH病例，并结合文献复习，介绍鼻腔SMH的临床和影像学特点、诊治及预后。.

Topics: Diagnosis, Differential; Hamartoma; Humans; Nasal Cavity; Nose; Nose Diseases

We report a case of a slowly growing papule on the nasal bridge of an elderly woman. Histopathological findings revealed a very unusual type of folliculosebaceous cystic hamartoma with a retiform and primitive epithelial proliferation associated with the stromal component. Folliculosebaceous cystic hamartoma is an uncommon lesion that involves a cystically dilated follicle embedded in a stroma of distinct mesenchymal tissue. Because folliculosebaceous cystic hamartoma is a rare and clinically indistinct lesion, clinical photographs of the lesion are not widely available. A recent search on PubMed revealed less than 50 published articles on folliculosebaceous cystic hamartoma; among these manuscripts there was a scarcity of clinical images of the lesion. This disparity is to be expected as the lesion typically has a very indistinct presentation. We thus describe an inconspicuously appearing case of folliculosebaceous cystic hamartoma to bring attention to the indistinct clinical morphology of the lesion and to report a histopathologically uncommon variant.

Topics: Aged; Female; Hair Follicle; Hamartoma; Humans; Nose; Sebaceous Glands; Skin Diseases

Rhabdomyomatous mesenchymal hamartoma is a rare congenital tumor and usually occurring in the head and neck. Characteristically, this tumor is composed of various mesenchymal elements such as adipose tissue, blood vessels, collagen fibers, elastic fibers, and peripheral nerves in random orientation. We present a 7-year-old boy with an intranasal mass developed after the trauma and who had a diagnosis of rhabdomyomatous mesenchymal hamartoma.

Topics: Child; Diagnosis, Differential; Hamartoma; Humans; Male; Mesoderm; Nose; Nose Neoplasms; Rhabdomyoma; Tomography, X-Ray Computed

Seventeen solitary nasal tumors that fulfilled all diagnostic criteria of so-called neurofollicular hamartoma, apart from distinct S100-positivity, were compared histopathologically and immunohistochemically with seven typical trichodiscomas from a similar clinical setting. Both the S100-negative neurofollicular hamartoma-like tumors and the trichodiscomas expressed an identical CD13-positive/CD34-positive fibrocytic immunophenotype without co-expression of neural/perineural (S100, neurofilament, epithelial membrane antigen), myogenic (desmin, calponin, muscle-specific actin, and alpha-smooth muscle actin), or melanocytic (S100, HMB45, NKI/C3, MelanA) epitopes. Histopathologically, there was striking morphologic overlap between trichodiscoma and S100-negative neurofollicular hamartoma-like tumor, apart from a highly characteristic fascicularly organized cellular fibrocytic stroma in the latter. We conclude that fibrofolliculoma/trichodiscoma and neurofollicular hamartoma-like tumor are morphologic variants of a single hamartomatous entity in which neurofollicular hamartoma-like tumor occupies the cellular pole of the morphologic spectrum. The entity formerly known as neurofollicular hamartoma appears to be nothing but a particularly cellular trichodiscoma with a distinctively organized stroma composed of CD34-positive fibrocytes. We therefore propose the new term spindle cell predominant trichodiscoma (SCPT) for this particular variant of the morphologic fibrofolliculoma/trichodiscoma spectrum.

Topics: Adult; Aged; Biomarkers; Female; Hair Diseases; Hair Follicle; Hamartoma; Humans; Immunohistochemistry; Male; Middle Aged; Nose; Skin

Topics: Forehead; Hamartoma; Humans; Infant, Newborn; Macular Degeneration; Male; Nose; Skin Diseases; Syndrome

Topics: Child; Diagnosis, Differential; Hamartoma; Humans; Male; Muscular Diseases; Nose; Skin Diseases; Terminology as Topic

A case of folliculosebaceous cystic hamartoma associated with rosacea is presented. Clinically, a solid, 5-mm-sized nodule was observed on the nose which showed telangiectasia and a waxy appearance. Histologically, a large horn cyst was located in the dermis, and was continuous with the surface epidermis. It was associated with mature sebaceous glands and immature hair follicles. Folliculosebaceous cystic hamartoma and similar cases have recently been reported, but this is the first report accompanied by rosacea.

Topics: Cysts; Female; Hair; Hamartoma; Humans; Middle Aged; Nose; Rosacea; Sebaceous Glands; Skin Diseases

The nasolabial cyst is an uncommon midfacial cyst. Twenty-six patients with nasolabial cysts were treated at the New York Eye and Ear Infirmary from 1969 to 1986. Most of these lesions manifested facial deformity, unilateral nasal obstruction, and pain when infected. The nasolabial cyst is often unrecognized or confused with other intranasal masses, or fissural and odontogenic cysts. Infection of these lesions--which occurred in 50% of the patients--may mimic facial cellulitis, periodontal abscess, acute maxillary sinusitis, or nasal furuncles. This cyst is considered to be a hamartoma because of its developmental origin from entrapped epithelium in an embryonic fusion plane. Simple aspiration invariably leads to recurrence, and complete surgical excision is the accepted treatment. The nasolabial cyst should be considered in the differential diagnosis of intranasal masses, midface infections, and swelling in the nasolabial area.

Topics: Adult; Aged; Cysts; Female; Hamartoma; Humans; Lip; Lip Neoplasms; Male; Middle Aged; Nose; Nose Neoplasms

Topics: Angiomatosis; Brain; Brain Neoplasms; Corpus Callosum; Hamartoma; Hemangioma; Holoprosencephaly; Humans; Infant; Medical Records; Nose