phenylephrine-hydrochloride and Glaucoma

To study the relationship between amplitude of spontaneous retinal venous pulsatility (SRVP) and retinal nerve fibre layer (RNFL) thickness in glaucomatous eyes, and to determine if this parameter may be a potential marker for glaucoma severity.. 85 subjects including 50 glaucoma (21 males, 67±10 yrs) and 35 normals (16 males, 62±11 yrs) were studied. SRVP amplitude was measured using the Dynamic Vessel Analyser (DVA, Imedos, Germany) at four regions of the retina simultaneously within one disc diameter from the optic disc--temporal-superior (TS), nasal-superior (NS), temporal-inferior (TI) and nasal-inferior (NI)). This was followed by RNFL thickness measurement using spectral domain optical coherence tomography (Spectralis OCT). The correlation between SRVP amplitude and corresponding sectoral RNFL thickness was assessed by means of non-linear regression (i.e. logarithmic). Linear regression was also applied and slopes were compared using analysis of covariance (ANCOVA).. Greater SRVP amplitude was associated with thicker RNFL. Global SRVP amplitude was significantly lower in glaucoma eyes compared with normals (p<0.0001). The correlation coefficient of the linear regression between RNFL and SRVP at TS, NS, TI and NI quadrants in the glaucoma group were r = 0.5, 0.5, 0.48, 0.62. Mean SRVP amplitude and RNFL thickness for TS, NS, TI and NI quadrants were 4.3±1.5, 3.5±1.3, 4.7±1.6, 3.1±1 μm and 96±30, 75±22, 89±35 and 88±30 μm, respectively. The ANCOVA test showed that the slope of linear regression between the four quadrants was not significant (p>0.05). Since the slopes are not significantly different, it is possible to calculate one slope for all the data. The pooled slope equals 10.8 (i.e. RNFL = 10.8SRVP+41).. While SRVP was present and measurable in all individuals, the amplitude of SRVP is reduced in glaucoma with increasing RNFL loss. Our findings suggest the degree of SRVP may be an additional marker for glaucoma severity. Further studies are needed to determine the mechanism of reduction in SRVP, and whether changes can predict increased risk of progression.

Topics: Aged; Case-Control Studies; Female; Follow-Up Studies; Glaucoma; Humans; Linear Models; Male; Middle Aged; Nerve Fibers; Nose; Retina; Retinal Vein; Time Factors

A newborn evaluated at 20 days old due to occasional nystagmus. Her mother had presented with oculodentodigital dysplasia (ODDD) and glaucoma. The physical examination revealed opaque micro-corneas, and horizontal nystagmus. The tonometry showed 35 mm Hg in OD and 40 mm Hg in OS and the fundus examination was normal. She had a narrow nasal bridge with narrow nostrils, and fourth and fifth finger syndactylyl in both hands. A bilateral trabeculectomy was performed with a good response.. ODDD is a rare autosomal dominant disease with heterogeneous phenotype manifestations. The most frequent cause of loss of visual acuity is the glaucoma, requiring long-term follow up with periodical control of the intraocular pressure (IOP).

Topics: Abnormalities, Multiple; Adult; Corneal Dystrophies, Hereditary; Female; Glaucoma; Humans; Infant, Newborn; Male; Micrognathism; Nose; Nystagmus, Pathologic; Syndactyly; Syndrome; Trabeculectomy

Topics: Conjunctiva; Glaucoma; Glaucoma Drainage Implants; Humans; Nose; Oculomotor Muscles; Sclera; Stents; Surgical Flaps; Sutures

Topics: Aging; Anesthesia, General; Anesthesia, Local; Arteriosclerosis; Bronchitis; Cataract Extraction; Diabetes Complications; Diabetes Mellitus; Drug Interactions; Eye Diseases; Eye Injuries; Glaucoma; Hemorrhage; Humans; Hypertension; Hypoglycemic Agents; Intraocular Pressure; Intubation; Lacrimal Apparatus; Middle Aged; Monoamine Oxidase Inhibitors; Nose; Ophthalmologic Surgical Procedures; Preanesthetic Medication

Topics: Abnormalities, Multiple; Cleft Palate; Congenital Abnormalities; Deafness; Esophageal Stenosis; Female; Glaucoma; Hernia, Umbilical; Hernias, Diaphragmatic, Congenital; Hip Dislocation, Congenital; Humans; Hydronephrosis; Hymen; Infant, Newborn; Intestinal Atresia; Jaw Abnormalities; Lip; Nose; Tongue

Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics; Animals; Atropa belladonna; Cats; Child; Glaucoma; Humans; Infant; Infant, Newborn; Intraocular Pressure; Intubation; Mannitol; Nose; Pharynx; Plants, Medicinal; Plants, Toxic; Postoperative Complications; Potassium; Preanesthetic Medication; Respiration, Artificial; Scopolamine; Succinylcholine; Ventilators, Mechanical

Topics: Adolescent; Blindness; Female; Glaucoma; Humans; Male; Middle Aged; Nose; Retrospective Studies; Time Factors; Visual Fields

Topics: Cerebral Ventriculography; Child; Dental Enamel Hypoplasia; Electroencephalography; Epilepsy; Eye Abnormalities; Female; Fingers; Glaucoma; Hair; Humans; Intellectual Disability; Iris; Microphthalmos; Nose; Radiography; Toes; Tooth Discoloration

Topics: Egypt; Glaucoma; Humans; Iris; Nose; Pupil

Topics: Arteriovenous Fistula; Blindness; Carotid Arteries; Cataract; Cavernous Sinus; Facial Injuries; Fistula; Glaucoma; Humans; Nose

Topics: Glaucoma; Humans; Nose; Scotoma; Tetrahymenina; Vision, Ocular