phenylephrine-hydrochloride and Erythema

Topics: Acne Vulgaris; Adult; Carcinoma, Basal Cell; Dermatitis; Diagnosis, Differential; Erythema; Exanthema; Eye Manifestations; Female; Humans; Lupus Vulgaris; Male; Middle Aged; Nose; Rosacea; Sarcoidosis; Skin Neoplasms; Telangiectasis

Pressure ulcers related to oronasal masks used with noninvasive ventilation (NIV), along with patient discomfort, occur due to improper fit of the mask. We developed a personalized fitting device using a 3-dimensional (3D) scanning solution to prevent the formation of NIV mask-related pressure ulcers. This study aimed to evaluate the effectiveness of the proposed personalized fitting device.. We conducted a randomized crossover experimental study of 20 healthy participants to study the use of this personalized fitting device between the face and an NIV mask designed with 3D solutions. The fitting device was not used under the NIV mask for the control. The outcome measures were the presence of blanchable erythema, standardized redness intensity, discomfort level, and contact pressure.. The incidence of blanchable erythema and standardized redness intensity values were significantly lower for subjects who used the fitting device when worn for 30 min (. Personalized fitting devices that incorporate 3D scanning solutions may contribute to the prevention of NIV mask-related pressure ulcers and the reduction of discomfort.

Topics: Adult; Cheek; Cross-Over Studies; Equipment Design; Erythema; Female; Forehead; Humans; Imaging, Three-Dimensional; Male; Masks; Noninvasive Ventilation; Nose; Pain; Pressure; Pressure Ulcer; Printing, Three-Dimensional

The objectives of this study were (1) to devise a nasal trauma score for preterm infants receiving non-invasive respiratory support, (2) to compare the incidence of nasal trauma in preterm infants <32 weeks gestation randomised to either nasal continuous positive airway pressure (NCPAP) or heated humidified high-Flow nasal cannulae (HHHFNC), in the first 7 days post-extubation and (3) to assess the effect of two different nasal dressings in those assigned to NCPAP. We randomly assigned preterm ventilated infants to receive Vapotherm® HHHFNC or NCPAP post-extubation. Infants receiving HHHFNC were treated with Sticky Whiskers® and infants receiving NCPAP received either Sticky Whiskers® or Cannualaide® nasal dressings. Bedside nursing staff scored six sites on each infant's nose for erythema, bleeding or ulceration. Scores were recorded three times daily for the first 7 days post-extubation. The sum of these 21 scores was used as the summary measure of nasal trauma. The mean nasal trauma score for infants assigned HHHFNC was 2.8 (SD 5.7) compared to 11.7 for NCPAP (SD 10.4), p < 0.001. There was no difference in mean trauma score between infants on NCPAP assigned Sticky Whiskers® 14.4 (SD 12.5) or Cannualaide® 9.5 (SD 7.3), p = 0.06.. HHHFNC resulted in significantly less nasal trauma in the first 7 days post-extubation than NCPAP and was most significant in infants <28 weeks of gestation. The use of protective dressings was not associated with decreased nasal trauma for infants on NCPAP.

Topics: Airway Extubation; Bandages; Catheters; Continuous Positive Airway Pressure; Epistaxis; Equipment Design; Erythema; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Nose; Respiratory Insufficiency; Trauma Severity Indices; Ulcer

Topics: Erythema; Humans; Nose; Rhinoplasty

Nonsurgical rhinoplasty with injectable dermal fillers has become an increasingly popular alternative to surgical procedures, in view of its relative low cost, convenience and rapid recovery, and low risk profile. The safety and efficacy of nonsurgical rhinoplasty remains a relatively contentious and ambiguous matter, given that there are few large-scale series reporting results or complications. This study reports the experience of a single clinician performing nonsurgical rhinoplasty in the largest cohort to date.. Patient demographics, indications, treatment details, and outcomes of patients treated between March of 2016 and January of 2019 were reviewed. The nonsurgical rhinoplasty technique described previously by Harb was used using hyaluronic acid dermal filler.. Nonsurgical rhinoplasty was performed in 5000 patients. The commonest indication was dorsal hump (44 percent). Swelling and erythema were self-limiting side effects encountered in approximately half of patients. Infection was seen in two patients, and localized skin necrosis was observed in three patients.. Nonsurgical rhinoplasty is a safe procedure with positive aesthetic results when performed by an experienced clinician. Knowledge of nasal anatomy, comprehensive training, and use of appropriate materials are key in ensuring safety and results.. Therapeutic, IV.

Topics: Adolescent; Adult; Aged; Cosmetic Techniques; Dermal Fillers; Edema; Erythema; Esthetics; Female; Humans; Hyaluronic Acid; Male; Middle Aged; Necrosis; Nose; Patient Satisfaction; Retrospective Studies; Rhinoplasty; Skin; Treatment Outcome; Young Adult

Topics: Anti-Bacterial Agents; Biopsy; Drug Therapy, Combination; Erythema; Eyelashes; Female; Humans; Klebsiella pneumoniae; Leprostatic Agents; Leprosy, Lepromatous; Lost to Follow-Up; Middle Aged; Mycobacterium leprae; Nose; Rhinoscleroma

Topics: Biopsy, Needle; Dermatomyositis; Disease Progression; Erythema; Fatal Outcome; Female; Humans; Immunohistochemistry; Interferon-Induced Helicase, IFIH1; Lung Diseases, Interstitial; Middle Aged; Nose; Risk Assessment; Skin Diseases

Rosacea is characterized by erythema on face, especially erythema and linear telangiectasia on the nose. Currently, various vascular lasers are used for treatment, and among them, are long-pulsed Nd:YAG(LPNY) and pulsed dye laser (PDL).. This study compared the efficacy of LPNY and PDL in treating rosacea-associated nasal telangiectasia.. Patients with rosacea who showed erythema and telangiectasia on the nose were included. Each patient was treated with PDL on the left side of the nasal bridge, and LPNY on the right side, three times with 4-week intervals. At the end of the treatment, two independent dermatologists evaluated overall treatment response compared with baseline.. The physician's assessment of treatment concluded that good improvement was seen in six PDL and seven LPNY patients, and excellent improvement five PDL and four LPNY patients. There was no significant difference (p = 0.62, 95%CI) between the groups. Overall improvement was similar; however, LPNY induced a greater response in thick, dilated vessels, while erythema with mild telangiectasia was more responsive to PDL.. Both LPNY and PDL are effective in treating rosacea-associated nasal telangiectasia. If LPNY is used properly to avoid side effects with careful consideration, it can also be used as a good modality.

Topics: Adult; Aged; Erythema; Facial Dermatoses; Female; Humans; Lasers, Dye; Lasers, Solid-State; Low-Level Light Therapy; Male; Middle Aged; Nose; Rosacea; Telangiectasis; Treatment Outcome

Topics: Adrenal Cortex Hormones; Betamethasone; Biomarkers; Biopsy; Cell Movement; Erythema; Female; Humans; Injections, Intralesional; Lymphocytes; Nose; Phenotype; Remission Induction; Skin; Treatment Outcome; Young Adult

We report a case of skin necrosis of the nasal tip after an injection of ribose cross-linked porcine atelocollagen (Evolence; Colbar Life Science Ltd, Herzliya, Israel). A 22-year-old woman had a nasal augmentation. From the glabella to the nasal tip, 10 strokes were injected using 0.6 mL of Evolence. On the day of the injection, her nasal tip became cyanotic; a day after it, an erythematous condition developed and a white cheeselike material appeared. On the second day, it became necrotic. Epithelialization was completed for 2 weeks. Despite laser therapy, permanent scarring of the nasal tip was prominent at the 18-month follow-up. It was thought that the skin necrosis is caused by vascular interruption rather than by hypersensitivity because the skin necrosis was confined to the nasal tip. To avoid vascular interruption from a filler injection, aspiration is needed before injection. The least amount of filler should be released in each stroke with low-pressure injection.

Topics: Cicatrix; Collagen; Cosmetic Techniques; Cross-Linking Reagents; Cyanosis; Dermal Fillers; Erythema; Female; Follow-Up Studies; Humans; Injections; Laser Therapy; Necrosis; Nose; Re-Epithelialization; Ribose; Skin; Young Adult

Topics: Body Piercing; Chronic Disease; Erythema; Facial Dermatoses; Female; Humans; Nose; Telangiectasis; Young Adult

A preliminary survey showed half of the participating Royal Netherlands Air Force (RNLAF) F-16 fighter pilots to have nasal integument and osteocartilagenous disorders related to wearing in-flight oxygen masks.. To make an inventory of these disorders and possible associated factors.. All RNLAF F-16 pilots were requested to fill out a semi-structured questionnaire for a cross-sectional survey. Additionally, one squadron in The Netherlands and pilots in operational theater were asked to participate in a prospective study that required filling out a pain score after each flight. Pilot- and flight-related variables on all participants were collected from the RNLAF database. A linear mixed model was built to identify associated factors with the post-flight pain score.. The response rate to the survey was 83%. Ninety of the 108 participants (88%, 6 missing) reported tenderness, irritation, pain, erythema, skin lesions, callous skin, or swelling of nasal bridge integument or architecture. Seventy-two participants (71%, 6 missing) reported their symptoms to be troublesome after a mean of 6±3 out of 10 flights (0;10, 54 missing). Sixty-six pilots participated in scoring post-flight pain. Pain scores were significantly higher if a participant had ≥3 nasal disorders, after longer than average flights, after flying abroad, and after flying with night vision goggles (respectively +2.7 points, p = 0.003; +0.2 points, p = 0.027; +1.8 points, p = 0.001; +1.2 points p = 0.005). Longer than average NVG flights and more than average NVG hours per annum decreased painscores (respectively -0.8 points, p = 0.017; -0.04 points, p = 0.005).. The majority of the RNLAF F-16 fighter pilot community has nasal disorders in the contact area of the oxygen mask, including pain. Six pilot- or flight-related characteristics influence the experienced level of pain.

Topics: Adult; Aircraft; Cartilage Diseases; Cross-Sectional Studies; Erythema; Humans; Masks; Middle Aged; Military Personnel; Nose; Occupational Diseases; Oxygen; Pain; Prospective Studies; Risk Factors; Surveys and Questionnaires; Young Adult

To evaluate the incidence and severity of nasal trauma secondary to nasal continuous positive airway pressure (nCPAP) in neonates.. Prospective observational study.. Neonatal intensive care unit (NICU) of the University Hospital of Lausanne, Switzerland.. All neonates admitted between January 2002 and December 2007 treated by nCPAP were eligible.. Patients' noses were monitored during nCPAP. Nasal trauma was reported into three stages: (I) persistent erythema; (II) superficial ulceration; and (III) necrosis.. 989 neonates were enrolled. Mean gestational age was 34 weeks (SD 4), mean birth weight 2142 g (SD 840). Nasal trauma was reported in 420 (42.5%) patients and it was of stage I, II and III in 371 (88.3%), 46 (11%) and 3 (0.7%) patients, respectively. Incidence and severity of trauma were inversely correlated with gestational age and birth weight. The risk of nasal trauma was greater in neonates <32 weeks of gestational age (OR 2.48, 95% CI 1.59 to 3.86), weighing <1500 g at birth (OR 2.28, 95% CI 1.43 to 3.64), treated >5 days by nCPAP (OR 5.36, 95% CI 3.82 to 7.52), or staying >14 days in the NICU (OR 1.67, 95% CI 1.22 to 2.28). Most cases of nasal trauma (90%) appeared during the first 6 days of nCPAP. Persistent visible scars were present in two cases.. Nasal trauma is a frequent complication of nCPAP, especially in preterm neonates, but long-term cosmetic sequelae are very rare. This study provides a description of nasal trauma and proposes a simple staging system. This could serve as a basis to develop strategies of prevention and treatment of this iatrogenic event.

Topics: Birth Weight; Continuous Positive Airway Pressure; Erythema; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Intensive Care, Neonatal; Male; Necrosis; Nose; Nose Diseases; Prospective Studies; Trauma Severity Indices; Ulcer

In the present work, nasolabial skin condition and the influence of seasonal changes during autumn and winter were studied in 16 healthy female volunteers. Apart from visual scoring of erythema and skin scaliness, transepidermal water loss (TEWL), skin hydration, apparent skin pH, skin colour and skin desquamation were biophysically measured. The study results showed that nasolabial TEWL was significantly higher during wintertime than in autumn. Also skin colour measurements and squamometry scorings revealed higher values, indicating a more reddish and scaly nasolabial skin during winter compared to autumn. Results from tape stripping and skin surface lipid analysis by high-performance thin-layer chromatography demonstrated significant differences for triglycerides and cholesterol esters, indicating a functionally inferior hydrolipidic layer during the winter season.

Topics: Adult; Cholesterol Esters; Chromatography, Thin Layer; Erythema; Female; Humans; Hydrogen-Ion Concentration; Nose; Seasons; Severity of Illness Index; Skin; Skin Diseases; Skin Pigmentation; Triglycerides; Water Loss, Insensible; Young Adult

The purpose of this study was to evaluate the potential irritating effects and the systemic exposure level of an antibacterial ointment containing REP8839 as a single agent or in combination with mupirocin versus Bactroban Nasal in rabbits. Additionally, the reversibility of REP8839 effects during a 14-day recovery period was assessed. Five treatment groups of six male and six female New Zealand White rabbits received dose levels of 1%, 2%, and 4% REP8839, 2% Bactroban Nasal, or 2% REP8839/2% mupirocin combination. One additional group of six animals/sex served as the control and received the vehicle, Petrolatum/Softisan 649. The test article or vehicle was administered to all groups via topical administration to the external nares, twice a day (approx. 8h intervals between the doses) for 21 consecutive days, at a dose volume of 100 microL per nare/dose for a total of 400 microL per day (200 microL per nare). Two animals/sex/group were maintained for a 14-day recovery period. The external nares were reflected back and the mucosal lining was evaluated and scored for erythema and edema within 30-60 min following the first dose each day. Blood samples were collected from all animals at designated time points on Day 21 of the study to assess systemic exposure levels. Cross-sectioning of the nasal tract was conducted in all the groups for microscopic evaluation. Mucosal scoring of the nares did not reveal any edema or erythema in any of the dose groups with the antibacterial alone, with the combination product, or with Bactroban Nasal. Mean body weights and food consumption were not adversely impacted by the test articles. Minimal plasma exposure was observed in the rabbits (<5 ng/mL). The REP8839 groups did appear to have dose-responsive exposure (from below the limit of quantitation to 5 ng/mL with 1%, 2%, and 4% REP8839, respectively). Microscopic changes on the nasal sectioning noted in these animals were infrequent and considered incidental findings unrelated to administration of the test articles. In conclusion doses of up to 4% of REP8839 ointment as a single agent or 2% in the combination product, as well as 2% Bactroban Nasal, were not found to induce mucosal irritation when applied topically to the external nares twice a day for 21 consecutive days. Additionally, no delayed effects were observed in the recovery animals.

Topics: Administration, Intranasal; Animals; Anti-Bacterial Agents; Biological Availability; Diamines; Dose-Response Relationship, Drug; Drug Combinations; Edema; Erythema; Female; Irritants; Male; Mupirocin; Nasal Mucosa; Nose; Ointments; Rabbits; Thiophenes

Injection of dermal fillers is one of the most commonly performed cosmetic procedures. Serious complications from fillers are rare but potentially devastating to patients and physicians. Skin necrosis, such as nasal alar necrosis, is one of the most feared serious complications of dermal fillers, but there is a paucity of literature on the incidence of such events, as well as potential treatment options.. We present a review of the literature and three cases of nasal alar necrosis after dermal filler injection.. Nasal alar necrosis associated with dermal filler injection is a rare event. Proper technique and recognition of risk factors may reduce the incidence of this complication. Physicians should be aware of early intervention and treatment options should impending necrosis become apparent.

Topics: Adult; Anti-Bacterial Agents; Bacitracin; Bandages, Hydrocolloid; Biocompatible Materials; Collagen; Cosmetic Techniques; Debridement; Dermatologic Agents; Drug Therapy, Combination; Erythema; Face; Female; Glucocorticoids; Humans; Hyaluronoglucosaminidase; Injections, Intradermal; Male; Necrosis; Nose; Rejuvenation; Risk Factors; Skin Aging; Treatment Outcome; Triamcinolone

A 4.5-year-old, male castrated ferret was examined with a 27-day history of severe pruritus, generalized erythema and scaling. Skin scrapings and a trichogram were negative for mites and dermatophyte organisms. A fungal culture of hair samples was negative. The ferret was treated presumptively for scabies and secondary bacterial and yeast infection with selamectin, enrofloxacin, fluconazole, diphenhydramine and a miconazole-chlorhexidine shampoo. The ferret showed mild improvement in clinical signs over the subsequent 3 weeks, but was inappetent and required supportive feeding and subcutaneous fluids by the owner. The ferret was then examined on an emergency basis at the end of 3 weeks (53 days following initial signs of illness) for severe blood loss from a haematoma over the interscapular region, hypotension and shock. The owners elected euthanasia due to a poor prognosis and deteriorating condition. On post-mortem examination intraepithelial canine distemper viral inclusions were identified systemically, and abundant canine distemper virus antigen was identified with immunohistochemical staining. It is important to note the prolonged course of disease along with the absence of respiratory and neurological signs because this differs from the classic presentation of canine distemper virus infection in ferrets. Canine distemper virus should remain a clinical suspicion for ferrets with skin lesions that do not respond to appropriate therapy, even in animals that were previously vaccinated.

Topics: Animals; Distemper; Distemper Virus, Canine; Erythema; Ferrets; Fever; Foot; Male; Nose; Pruritus; Skin

Topics: Abdomen; Abnormalities, Multiple; Biopsy; Cheek; Cryptorchidism; Diagnosis, Differential; Erythema; Extremities; Focal Dermal Hypoplasia; Hand Deformities, Congenital; Humans; Infant, Newborn; Male; Nose; Skin

An 18-year-old man presented with erythematous lesions over the nose of 1 year's duration without sensitivity to sunlight. He was otherwise well and there was no relevant family history. Physical examination showed excessive sweating of the nose, cheeks, and upper lip, and erythema of the nose covered by beads of sweat and vesicles (Fig. 1). The rest of the physical examination was normal. The skin biopsy showed a discrete mononuclear cell perivascular infiltrate.

Topics: Adolescent; Diagnosis, Differential; Erythema; Facial Dermatoses; Granulomatous Disease, Chronic; Humans; Male; Nose; Skin Diseases, Vesiculobullous

Topics: Administration, Inhalation; Adrenal Cortex Hormones; Budesonide; Child; Dermatitis, Allergic Contact; Diagnosis, Differential; Erythema; Humans; Male; Nose; Patch Tests; Rhinitis, Allergic, Seasonal

Topics: Aged; Aged, 80 and over; Carcinoma, Merkel Cell; Diagnosis, Differential; Erythema; Female; Humans; Nose; Skin Neoplasms

Cutaneous sarcoidosis may occur at sites of trauma. Two patients are reported in whom lupus pernio developed in the area of facial fractures. Injury may be a factor in the site of development of lupus pernio in some individuals and may have medico-legal implications. Cutaneous sarcoidosis is known to occur at the sites of scars and trauma but lupus pernio has not been widely recognized to show this phenomenon. We report two patients in whom lupus pernio developed at the site of facial trauma.

Topics: Erythema; Facial Dermatoses; Female; Fractures, Bone; Humans; Lupus Vulgaris; Middle Aged; Nose

Augmentation rhinoplasty has become a popular plastic operation in Asia. In Korea most surgeons prefer using silicone rubber prosthesis instead of autogenous material. The authors have used the standard shaped silicone prosthesis, boat-shaped and also L-shaped prostheses. The standard shape prosthesis has less extrusion and fixation problems. In over 1,500 cases, there were 357 complications (20.8%). All the complications were due to the silicone prosthesis acting as a foreign body or failure in design of implant or unskillful operative technique. In order to minimise complications, care should be taken to use the proper size of prosthesis, the correct shape of implant and to ensure that there is adequate undermining and meticulous closure technique. To minimise the overlying skin tension at the tip and on the dorsum of the nose, the cutting of the depressor septi nasi muscle and transverse part of the nasalis muscle are recommended. In this review, we report the types and incidence of complications by analysing the cases seen during the past 10 years in our Unit and offer a few solutions to overcome these complications.

Topics: Asian People; Cerebrospinal Fluid Rhinorrhea; Enterobacteriaceae Infections; Epistaxis; Erythema; Humans; Korea; Nose; Postoperative Complications; Prostheses and Implants; Rhinoplasty; Serratia marcescens; Silicone Elastomers; Staphylococcal Infections; Staphylococcus aureus; Surgical Wound Infection; Time Factors

Prior to anticipated nasal surgery, the nasal and facial skin should be examined for any vascular lesions. The skin type should be ascertained. A history of any prior nasal surgery, particularly on the nasal dorsum, should be noted. If rosacea is a clinical possibility, a trial of 1.5 to 2.0 gm q.d. of tetracycline for 6 to 8 weeks is warranted. If, after rhinoplasty, a diffuse "redness" on the nasal dorsum results and one can exclude other diagnoses, then argon laser therapy should be considered. A 3-mm punch biopsy should be obtained to see whether superficial ectatic vessels are present, a finding that would be indicative of a good result from laser therapy.

Topics: Diagnosis, Differential; Erythema; Female; Humans; Laser Therapy; Middle Aged; Nose; Rhinoplasty; Rosacea; Skin; Telangiectasis

Topics: Candidiasis, Oral; Chordoma; Darier Disease; Dermatitis; Diagnosis, Differential; Erythema; Gingival Neoplasms; Herpes Simplex; Humans; Hypersensitivity; Nose; Palatal Neoplasms; Papilloma; Precancerous Conditions; Purpura; Skin Diseases; Skin Neoplasms; Syndrome

Topics: Disease; Erythema; Humans; Lymph Nodes; Lymphatic Diseases; Mycoses; Nose