phenylephrine-hydrochloride and Enterocolitis--Pseudomembranous

The excessive accumulation of gas in the gastrointestinal tracts was invariably induced on experimental animals (mice, rats, guinea pigs, hamsters and rabbits) by simply obstructing nasal passages. The analysis of the gas showed the almost identical composition to the ambient air or flutus which was largely due to swallowed air. Also the numerous small foams were found on and underneath the epithelial lining of small intestine. The pathological evaluation was done both macroscopically and microscopically. Dying animals after nasal obstruction showed hemorrhagic and necrotic changes in the jejunum and ileum. This observation may cast some light to the pathogenesis of necrotizing enterocolitis in human neonatal.

Topics: Aerophagy; Air; Animals; Cricetinae; Digestive System; Disease Models, Animal; Enterocolitis, Pseudomembranous; Female; Guinea Pigs; Humans; Male; Mice; Mouth Breathing; Nose; Rabbits; Rats; Respiratory Insufficiency

Topics: Catheterization; Duodenum; Enteral Nutrition; Enterocolitis, Pseudomembranous; Humans; Infant Food; Infant, Newborn; Infant, Newborn, Diseases; Nose; Prospective Studies; Staphylococcal Infections; Staphylococcus aureus; Stomach

Topics: Enteral Nutrition; Enterocolitis, Pseudomembranous; Humans; Infant, Newborn; Intestinal Perforation; Intubation, Gastrointestinal; Intussusception; Jejunum; Necrosis; Nose; Osmolar Concentration; Polyvinyls; Silicones