phenylephrine-hydrochloride and Drug-Hypersensitivity
phenylephrine-hydrochloride has been researched along with Drug-Hypersensitivity* in 9 studies
Trials
1 trial(s) available for phenylephrine-hydrochloride and Drug-Hypersensitivity
Article | Year |
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Salicylate pre-treatment attenuates intensity of bronchial and nasal symptoms precipitated by aspirin in aspirin-intolerant patients.
Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. However, salicylate moiety appears to interfere with aspirin inhibitory action on platelets and vascular COX. Such interaction, if present at the level of respiratory tract, may be of interest to pathogenesis of ASA-induced asthma. We performed a double-blind, placebo-controlled, randomized cross-over study on the effect of choline magnesium trisalicylate (CMT, trilisate) pre-treatment on ASA-induced adverse reactions in nine patients. Pulmonary function tests, nasal symptoms score, PNIF and serum salicylate levels were monitored following challenges with threshold doses of ASA. Trilisate administered at a dose of 3000 mg daily for 3 days, offered a moderate protection against ASA-induced symptoms; it diminished the severity and/or delayed the appearance of FEV1 fall. Maximal decreases in FEV1 as well as reaction intensity indexes were significantly lower (P less than 0.02 and P less than 0.002, respectively) after trilisate pre-treatment as compared to placebo. Trilisate also attenuated nasal symptoms in three out of five patients. Although the precise mechanism of the protective action of trilisate is unknown, our data support the possibility of interaction between salicylate and ASA on cyclo-oxygenase locus in the respiratory tract in ASA-intolerant patients. Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Spasm; Choline; Double-Blind Method; Drug Hypersensitivity; Drug Tolerance; Female; Humans; Male; Middle Aged; Nose; Salicylates | 1990 |
Other Studies
8 other study(ies) available for phenylephrine-hydrochloride and Drug-Hypersensitivity
Article | Year |
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Long-term outcomes following functional endoscopic sinus surgery in Samter's triad.
This study aimed to assess the long-term outcome of functional endoscopic sinus surgery for Samter's triad patients using an objective visual analogue scale and nasal endoscopy.. Using a retrospective database, 33 Samter's triad patients who underwent functional endoscopic sinus surgery were evaluated pre- and post-operatively between 1987 and 2007 in Hospital of La Chaux-de-Fonds, Switzerland.. A total of 33 patients participated in the study, and the mean follow-up period was 11.6 years (range 1.2-20 years). Patients were divided into two groups based on visual analogue scale scores of the five parameters with the greatest difference in intensity of symptoms between the beginning and end of follow up. Group 1 included patients with a mean visual analogue scale score of 6 and below at the end of follow up and group 2 included patients with a mean visual analogue scale score of more than 6. The only statistically significant difference noted between the two groups was the endonasal findings: stage III-IV polyposis was present in 1 out of 24 patients (4 per cent) in group 1 and in 5 out of 9 patients (56 per cent) in group 2.. The results of our study indicate that functional endoscopic sinus surgery helps stabilise disease progression. Stage III-IV polyposis had a significant adverse effect on long-term outcome. Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Drug Hypersensitivity; Female; Follow-Up Studies; Forecasting; Humans; Male; Nasal Polyps; Natural Orifice Endoscopic Surgery; Nose; Otorhinolaryngologic Surgical Procedures; Pain Measurement; Pain, Postoperative; Retrospective Studies; Tomography, X-Ray Computed | 2015 |
Effect of millimeter waves on cyclophosphamide induced suppression of the immune system.
The effect of millimeter electromagnetic waves (MWs) on cyclophosphamide (CPA) induced toxicity to leukocytes, bone marrow cells, and T-cell-mediated immunity was examined. For studying the effect of MWs on CPA induced leukopenia and myelosuppression, BALB/C mice were irradiated for 3 days, 30 min each day, prior to administration of CPA (200 mg/kg). MWs were produced with a Russian made YAV-1 generator. The device produced 42.2 +/- 0.2 GHz modulated wave radiation through a 10 mm x 20 mm rectangular output horn. The animals were irradiated on the nose area. Peak SAR and incident power density were measured as 622 +/- 100 W/kg and 31 +/- 5 mW/cm(2), respectively. For studying the effect of MWs on CPA induced suppression of T-cell mediated immunity, a delayed type hypersensitivity (DTH) assay in mouse skin was used. The DTH reaction in mouse skin was induced by topical application of dinitrochlorobenzene (DNCB) and quantified by measuring the increase in ear thickness and by histological examination. Treatment of animals with CPA significantly (P < 0.05) reduced leukocyte and bone marrow cell population, but MW irradiation did not show any significant protection from the immunosuppressive effects of CPA. Furthermore, MW irradiation did not protect the animals from CPA induced suppression of T-cell mediated immunity. Topics: Administration, Topical; Animals; Body Weight; Bone Marrow Cells; Cyclophosphamide; Dinitrochlorobenzene; Drug Hypersensitivity; Ear; Hypersensitivity, Delayed; Immune Tolerance; Immunity, Cellular; Immunosuppression Therapy; Injections, Intraperitoneal; Leukocyte Count; Leukocytes; Leukopenia; Male; Mice; Mice, Inbred BALB C; Microwaves; Nose; Reference Values; Skin; T-Lymphocytes, Regulatory; Whole-Body Irradiation | 2002 |
Ultrastructural and functional studies of cilia from patients with asthma, aspirin intolerance, and nasal polyps.
"Triad" asthmatics often have sinus disease, nasal polyps, and obstructive airways disease. This presentation is reminiscent of the symptoms of persons afflicted with various forms of ciliary dyskinesia. Therefore, we examined tissues from seven "triad" asthmatic patients for ciliary structural or functional abnormalities. Transmission and scanning electron microscopy revealed no specific abnormalities. Cultures of nasal epithelia were maintained for up to 20 weeks. They showed normal ciliary activity which was not influenced by perfusing the tissue with medium containing aspirin. In contrast, control tissue from a patient with situs inversus and sinusitis showed the expected structural and functional ciliary abnormalities. In culture, the ciliary function of tissue from this patient could be partly restored by perfusion with ATP or ATPase. Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Adolescent; Adult; Aspirin; Asthma; Cells, Cultured; Cilia; Drug Hypersensitivity; Epithelium; Female; Humans; Male; Microtubules; Nasal Polyps; Nose | 1983 |
[Method of diagnosing the hypothalamic syndrome in persons with allergoses of a chemical etiology].
Topics: Allergens; Bacteria; Brain Diseases; Drug Hypersensitivity; Dust; Humans; Hypothalamus; Methods; Nose; Syndrome | 1977 |
Lypressin (Diapid) and other drugs for diabetes insipidus.
Topics: Aerosols; Blood Pressure; Breast; Costs and Cost Analysis; Diabetes Insipidus; Diuresis; Drug Combinations; Drug Hypersensitivity; Female; Humans; Intestines; Nose; Oxytocin; Tannins; Uterus; Vasopressins; Water Intoxication | 1972 |
Nasal test for hypersensitivity. Including a positive reaction to lignocaine.
Topics: Adult; Anesthesia, Dental; Drug Hypersensitivity; Female; Humans; Lidocaine; Methods; Nose; Solutions | 1971 |
Nasal test for hypersensitivity.
Topics: Allergens; Desensitization, Immunologic; Drug Hypersensitivity; Haptens; Humans; Hypersensitivity; Nose; Skin Tests | 1971 |
Hypersensitivity angiitis in a dormant black bear (Ursus americanus).
Topics: Animals; Carnivora; Drug Hypersensitivity; Ear; Female; Foot; Hibernation; Humans; Necrosis; Nose; Penicillins | 1970 |