phenylephrine-hydrochloride and Conjunctivitis

Allergic airway disease is a chronic airway allergic inflammatory disease including allergic rhinitis (AR) and allergic asthma which is common in children and adolescents. Recently the probiotics has been becoming a supplementary or alternative therapy to allergic diseases, however the effect of them has not been clearly established.. The purpose of the present meta-analysis was to evaluate the effectiveness of probiotics on allergic airway disease including AR and allergic asthma in children and adolescents.. We performed a comprehensive search on PubMed, Cochrane Library, EMBASE for relevant publications from 1 Jan 2000 to 1 July 2021. Physical examinations, Pediatric Rhinoconjunctivitis Quality of Life Questionnaires (PRQLQs), Total Nasal Symptom Score (TNSS), Nasal or Eye Symptom Score (NSS or ESS), serum allergen-specific IgE, and eosinophil were used as evaluating indicators for AR and allergic asthma in children and adolescents. The meta-analysis was performed using Review Manager (RevMan, Version 5.3).. 15 randomized controlled trials (RCTs) with a total of 1388 participants were included for the meta-analysis. Among them, 729 patients treated with probiotics served as the probiotics group, and 659 patients with placebo as control group. Significantly greater reduction in PRQLQs from baseline to endpoint (SMD = -2.57, 95% CI [ - 4.66, -0.48] P < 0.01), NSS (SMD = -1.43, 95% CI [ - 1.63, - 1.23], P < 0.01) and ESS (total MD = -1.67, 95% CI [ - 1.79, - 1.55], P < 0.01) were observed in probiotics group compared to control group. Probiotics have no significant effect to serum IgE and eosinophils (P > 0.01).. The results of this meta-analysis indicated that probiotics treatment may reduce PRQLQs, NSS, ESS in patients with allergic airway disease. More research involving the mechanism of probiotics are needed to clarify the role of probiotics in AR and allergic asthma in children and adolescents.

Topics: Adolescent; Asthma; Child; Conjunctivitis; Humans; Immunoglobulin E; Nose; Probiotics; Randomized Controlled Trials as Topic; Rhinitis, Allergic

Patients with respiratory tract allergy present certain auditory and visual signs which, when correlated with the history, aid substantially in arriving at a conclusive diagnosis. The physician should be alert to the signs that indicate allergic disease. Early recognition followed by modern allergy management will help to prevent progression of the allergic process.

Topics: Adolescent; Adult; Child; Conjunctiva; Conjunctivitis; Corneal Diseases; Eczema; Eye Diseases; Eye Manifestations; Eyelashes; Eyelids; Female; Gingival Hyperplasia; Glossitis, Benign Migratory; Habits; Humans; Male; Malocclusion; Maxillary Sinus; Mouth Breathing; Nasal Septum; Nose; Oral Manifestations; Pharyngeal Diseases; Polyps; Respiratory Hypersensitivity; Rhinitis, Allergic, Seasonal; Seasons

Topics: Adolescent; Adult; Antibodies; Body Temperature; Child; Clinical Trials as Topic; Common Cold; Conjunctivitis; Exanthema; Female; Hemagglutination Inhibition Tests; Humans; Lymphatic Diseases; Male; Neutralization Tests; Nose; Pharyngitis; Pharynx; Rubella Vaccine; Rubella virus; Tonsillitis; Vaccination; Viral Vaccines; Virus Cultivation

Allergic rhinoconjunctivitis (ARC) and allergic rhinitis (AR) are prevalent allergic diseases. People are becoming increasingly aware of the impact of microbial disorders on host immunity and allergic diseases. Studies have demonstrated an association between allergic diseases and the microbiome, but much remains unknown. We assessed changes in the conjunctival microbiome and nasal microbiome in patients with ARC or AR.. Conjunctival swabs and nasal swabs were collected from each participant for 16S rRNA amplicon sequencing. Bacterial communities were analyzed.. Forty patients with ARC, 20 patients suffering from AR, and 34 healthy controls (HCs) were recruited. This study found the abundance of conjunctival microbiome in patients with ARC or AR was significantly lower than that in HCs. The diversity of conjunctival microbiome in patients with AR was significantly lower than those in the other two groups. There is no significant difference in abundance of nasal microbiome between the three groups. The diversities of nasal microbiome in patients with ARC or AR were significantly lower than that in HCs. We found significant differences in microbiota compositions in patients with ARC or AR compared with those in HCs. However, no significant difference in microbiota compositions was found between patients with ARC and patients with AR. Microbiome functions in the ARC group and AR group were also altered compared with HCs.. We revealed changes in the composition and function of the conjunctival microbiome and nasal microbiome of patients with ARC or AR, which suggests that there is a relationship between allergic conditions and the local microbiome.

Topics: Conjunctivitis; Dysbiosis; Humans; Microbiota; Nose; Rhinitis, Allergic; RNA, Ribosomal, 16S

Nondiphtherial Corynebacterium species are normal residents of human skin and mucosa, including the conjunctiva and nose, but can cause conjunctivitis and keratitis. Recently, resistance against various classes of antibiotics has been reported in Corynebacterium. The present study investigated the type of species and antibiotic susceptibilities of the conjunctival and nasal Corynebacterium species.. This study examined 183 strains of Corynebacterium species that were isolated from patients undergoing preoperative examinations for cataract surgery. Species were identified by RNA polymerase β-subunit-encoding gene (rpoB) sequencing. Antibiotic susceptibility tests were performed by the microdilution method according to the Clinical and Laboratory Standards Institute standard method M45.. Corynebacterium macginleyi was the most predominant species (84%; 46 of 55) in the conjunctiva. The 2 major species in the nasal cavity were Corynebacterium accolens and Corynebacterium propinquum (44% and 31%, respectively), followed by Corynebacterium pseudodiphtheriticum (8%), Corynebacterium jeikeium (7%), and C. macginleyi (3%). In contrast to other nasal Corynebacterium species, only C. macginleyi showed a high susceptibility to macrolides. However, among nonconjunctival Corynebacterium species, C. propinquum, was unique in having a high resistance rate to levofloxacin (29%), comparable with that observed in C. macginleyi (36%). Penicillin G and tobramycin showed good susceptibility in almost all strains.. Drug resistance against fluoroquinolones and macrolides was observed in Corynebacterium species, with the antibiotic susceptibility profiles correlating with differences of the species and niche. Nasal and conjunctival Corynebacterium profiles of drug resistance suggest habitat segregation strictly at the species level.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Conjunctiva; Conjunctivitis; Corynebacterium; Corynebacterium Infections; Eye Infections, Bacterial; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Nose; Young Adult

Following Tx for facial blisters, our patient returned with what appeared to be viral conjunctivitis. Further evaluation revealed a missed tip-off to the proper Dx.

Topics: Anti-Bacterial Agents; Antiviral Agents; Conjunctivitis; Ear; Erythromycin; Female; Herpes Labialis; Humans; Keratitis, Herpetic; Lip; Middle Aged; Mouth; Nose; Otitis Media; Treatment Outcome; Trifluridine; Valacyclovir

Sebaceous carcinoma of the eyelid is an uncommon tumour with unusual modes of presentation. It can remain occult at the primary site, without producing any mass, masquerading as chronic blepharoconjunctivitis, while setting up metastases in the regional lymph nodes especially in the pre-auricular group. We report here a case that not only masqueraded as chronic blepharoconjunctivitis with nodal metastases from an 'unknown primary' in the neck, but whose tumour spread in a pagetoid manner along the nasolacrimal duct producing a nasal tumour that was believed to be the 'unknown primary'. This case emphasizes the need for ophthalmologists, ENT surgeons and pathologists to keep sebaceous carcinoma in mind while evaluating patients with chronic blepharoconjunctivitis and cervical node metastases from 'unknown primary'. Histological clues for picking up a sebaceous carcinoma at a metastatic site include a tumour with comedo or ductal growth pattern and intracytoplasmic lipid.

Topics: Adenocarcinoma, Sebaceous; Aged; Blepharitis; Conjunctivitis; Diagnosis, Differential; Eyelid Neoplasms; Humans; Lymphatic Metastasis; Male; Neoplasm Invasiveness; Neoplasms, Unknown Primary; Nose; Syndrome

Topics: Bacteria; Conjunctivitis; Cross Infection; Female; Gastric Juice; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Male; Nose; Pneumonia; Skin; Umbilical Cord; Vulva

Recognition of the allergic individual is facilitated by an awareness of certain characteristic actions and various facial lesions which may be clues to other allergic problems. A gaping expression, clearing of the throat and rubbing or mashing of the eyes and nose may indicate significant rhinitis. Dark circles and bags under the eyes, long, silky eyelashes and injected conjunctivas are other signs. Bruxism and malocclusion may also be related to an allergic diathesis.

Topics: Adolescent; Adult; Behavior; Bruxism; Child; Conjunctivitis; Eczema; Eye Manifestations; Eyelid Diseases; Female; Glossitis, Benign Migratory; Habits; Humans; Hypersensitivity; Male; Mouth Breathing; Nose; Oral Manifestations; Rhinitis, Allergic, Seasonal

Neonatal staphylococcal disease occurred in the nurseries of a university hospital three weeks after discontinuation of routine, daily, whole-body bathing of newborns with hexachlorophene. Of 16 infants who had clinical manifestations within a two-week period, 11 cases were confirmed bacteriologically. Shortly after onset of the outbreak, daily clinical and microbiologic surveillance and control measures on all infants and personnel were inaugurated. Clinical surveillance after the outbreak did not yield any new case. Average incidence of cultures positive for coagulase-positive Staphylococcus aureus was highest (13% per week) during the first three weeks of microbiologic surveillance (when hexachlorophene was not used). This is lower than that reported in most previous studies. These findings indicate the importance of scrupulous hand washing before and after handling each infant and of enforcement of other basic nursery techniques.

Topics: Baths; Conjunctiva; Conjunctivitis; Cross Infection; Female; Fingers; Hexachlorophene; Humans; Infant Care; Infant, Newborn; Infant, Newborn, Diseases; Male; Nose; Nurseries, Hospital; Nursing Staff, Hospital; Pneumonia; Soaps; Staphylococcal Infections; Staphylococcus Phages; Time Factors; Umbilicus

Topics: Adenoviridae; Antibodies; Antigens, Viral; Biopsy; Brain; Cells, Cultured; Cerebrospinal Fluid; Conjunctivitis; Encephalitis; Fluorescent Antibody Technique; Humans; Influenza A virus; Nose; Respiratory Syncytial Viruses; Simplexvirus; Trachea; Virus Diseases

Topics: Aged; Autoimmune Diseases; Complement System Proteins; Conjunctiva; Conjunctivitis; Fluorescent Antibody Technique; Humans; Immunoglobulin A; Immunoglobulin D; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Male; Microscopy, Fluorescence; Middle Aged; Mucous Membrane; Nose; Skin; Skin Diseases

In two epidemics of acute enterovirus conjunctivitis the diagnosis could only be established by the use of human embryonic organ cultures. In one instance cultures of ciliated respiratory epithelium proved sensitive to the virus but similar culture failed to support growth of the virus from the second outbreak which was isolated in organ cultures of conjunctiva. The virus associated with a third outbreak had previously been isolated from the original material by culture in human embryo kidney cells, but it required passage in organ culture for its detection after the specimens had been diluted.

Topics: Animals; Conjunctivitis; Embryo, Mammalian; England; Enterovirus; Epithelium; Haplorhini; Humans; Indonesia; Intestines; Kidney; Nose; Organ Culture Techniques; Singapore; Trachea

Topics: Administration, Oral; Animals; Cattle; Cattle Diseases; Cerebral Cortex; Conjunctivitis; Corpus Striatum; Germ-Free Life; Herpesvirus 1, Bovine; Meningoencephalitis; Nose; Pons; Tectum Mesencephali

Topics: Administration, Intranasal; Animals; Cattle; Cattle Diseases; Conjunctivitis; Herpesviridae; Herpesviridae Infections; Immunity, Active; Lung; Male; Nose; Pneumonia, Viral; Respiratory Tract Infections; Trachea

Topics: Adult; Bacterial Infections; Blepharitis; Child; Conjunctivitis; Humans; Keratoconjunctivitis; Moraxella; Mucous Membrane; Nose; Seasons; Skin

Topics: Ammonia; Animals; Conjunctivitis; Dust; Epithelium; Germ-Free Life; Housing, Animal; Nose; Swine; Swine Diseases; Time Factors; Trachea; Turbinates; Zea mays

Topics: Animals; Conjunctivitis; Dacryocystitis; Dog Diseases; Dogs; Eye Foreign Bodies; Female; Lacrimal Apparatus; Lacrimal Duct Obstruction; Male; Methods; Nose; Radiography

Topics: Aerosols; Animals; Bronchopneumonia; Cat Diseases; Cats; Conjunctiva; Conjunctivitis; Fluorescent Antibody Technique; Histological Techniques; Lung; Nose; Pharynx; Picornaviridae; Rectum; Rhinitis; Spleen; Ulcer; Virus Diseases

Topics: Child; Child, Preschool; Conjunctivitis; Eye Manifestations; Facial Expression; Female; Fingersucking; Glossitis, Benign Migratory; Humans; Male; Malocclusion; Nail Biting; Nose; Oral Manifestations; Pharyngeal Diseases; Pulmonary Emphysema; Respiratory Hypersensitivity; Rhinitis