phenylephrine-hydrochloride and Calcinosis

Rhinoliths consist of a central nidus with calcification resulting in calcareous concretions within the nasal cavity. They are uncommon in the literature despite a propensity particularly in children to insert foreign bodies into their nose and ears. We present the case of a 62-year-old woman with a longstanding undetected rhinolith with mild uncharacteristic symptoms. Radiographic examination revealed anatomical alteration of the inferior turbinate that was attributed to the long presence of the rhinolith in the nasal cavity. The management of the rhinolith and a review of the literature are presented.

Topics: Calcinosis; Female; Foreign Bodies; Humans; Middle Aged; Nasal Cavity; Natural Orifice Endoscopic Surgery; Nose; Nose Deformities, Acquired; Nose Diseases; Tomography, X-Ray Computed; Turbinates

Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Calcinosis; Diagnosis, Differential; Epiphyses; Female; Fetal Diseases; Humans; Infant, Newborn; Nose; Pregnancy; Prenatal Exposure Delayed Effects; Prognosis; Syndrome; Vitamin K Deficiency; Warfarin

We describe a newborn girl with a lethal sclerosing bone dysplasia leading to prenatal skeletal alterations and microcephaly, proptosis, hypoplastic nose and midface, small jaw, cleft palate, hypertrophied gums, intracranial calcifications, and generalized osteosclerosis. There is a remarkable similarity between our patient and six previously reported infants subsequently categorized as having a distinct entity: Raine syndrome. Autosomal recessive inheritance is postulated based on parental consanguinity in several of the previous cases and in our patient.

Topics: Brain Diseases; Calcinosis; Exophthalmos; Facies; Female; Genes, Recessive; Humans; Infant, Newborn; Nose; Osteosclerosis; Radiography; Syndrome

The Gorlin-Goltz syndrome is characterized by four primary symptoms: multiple nevoid basal cell epitheliomas that usually undergo malignant transformation; jaw keratocysts that show constant growth; skeletal anomalies; and intracranial calcifications. A myriad of additional findings may also be noted. Among the most frequent are: palmar and plantar pits, a characteristic flattened facies and broad nasal root, frontal and parietal bossing, mandibular prognathia, hypertelorism, strabismus, dystrophia of the canthi, and clefts of the lip, alveolus, and/or palate. In this study, we review the literature and our 25 cases of Gorlin-Goltz syndrome patients, questioning their incidence of cleft formations (8.5%) as compared to the general population (0.1%). It is our contention that all patients who present with an orofacial cleft warrant deeper investigation as to the presence of additional signs indicative of Gorlin-Goltz syndrome. The nevi turn malignant with time, and thus, early diagnosis, follow-up, and treatment are imperative.

Topics: Adult; Alveolar Process; Basal Cell Nevus Syndrome; Brain Diseases; Calcinosis; Cell Transformation, Neoplastic; Cleft Lip; Cleft Palate; Diagnosis, Differential; Eyelid Diseases; Face; Facies; Female; Follow-Up Studies; Foot Deformities; Frontal Bone; Hand Deformities; Humans; Hypertelorism; Incidence; Jaw Cysts; Male; Mouth Abnormalities; Nose; Parietal Bone; Prognathism; Strabismus

Premature cartilaginous calcification and nasal hypoplasia following first trimester exposure to warfarin are known as the Foetal Warfarin Syndrome (FWS). There are over 40 cases reported in the literature, many of which describe breathing and feeding difficulties in the first few months of life. We report a case where a child had had difficulties breathing and feeding in the first months of life. These had been attributed to nasal hypoplasia. After proper ENT assessment the child benefitted from adenoidectomy. ENT surgeons should be aware of the syndrome as more women of child bearing age are taking warfarin following cardiac surgery and treatment of thromboembolic disease. ENT surgeons may be asked to review these children who often present with airway and feeding problems which have been attributed to nasal hypoplasia.

Topics: Calcinosis; Cartilage Diseases; Female; Humans; Infant; Male; Nasal Obstruction; Nose; Pregnancy; Prenatal Exposure Delayed Effects; Warfarin

Topics: Calcinosis; Humans; Nose

Topics: Calcinosis; Humans; Nose; Plastic Surgery Procedures; Silicones; Skin Neoplasms

This report described a case of the wry nose and rhinolith patients. A 25 years old female patient complained a sense of persistent left side of nasal congestion runny with 10 years. During the 10 years the symptom repeatedly occurrence, aggravated with peculiar smell of 1 months. A combined treatment including endoscopic sinus surgery with correction of the deviated nose and removal of nasal stone was performed in the patient.Three monthsafter operation, the patient recovered well, without recurrence, external nasal deformity, foreign bodies remain.

Topics: Adult; Calcinosis; Endoscopy; Female; Foreign Bodies; Humans; Lithiasis; Nasal Obstruction; Nose; Nose Deformities, Acquired; Nose Diseases; Paranasal Sinuses; Treatment Outcome

Tumoral calcinosis is a rare calcifying disorder with deposition of calcium phosphate and calcium hydroxyapatite within the soft tissue at periarticular sites. There have been series of sporadic cases of tumoral calcinosis in the trunk and the extremities due to renal failure. However, we describe a 35-year-old woman without renal problems or trauma history who had tumoral calcinosis in the nose. This is the first report on facial occurrence.

Topics: Adult; Calcinosis; Female; Humans; Mixed Connective Tissue Disease; Nose; Nose Diseases

Keutel syndrome is a rare autosomal recessive disorder, characterized by brachytelephalangia (short, broad distal phalanges), midfacial hypoplasia, abnormal cartilage calcifications, peripheral pulmonary stenosis and hearing loss. Binder profile is a well known maxillonasal dysplasia composed of midfacial hypoplasia with absence of anterior nasal spine and facial dysmophism (short nose, flat nasal bridge, perialar flatness, convex upper lip). Here we report a Keutel syndrome presenting with Binder phenotype, abnormal calcifications, hearing loss and respiratory insufficiency in the newborn period. Keutel syndrome should be considered in the differential diagnosis of children with tracheobronchial calcifications, midfacial hypoplasia and stippled epiphysis.

Topics: Abnormalities, Multiple; Calcinosis; Cartilage Diseases; Chondrodysplasia Punctata; Diagnosis, Differential; Fatal Outcome; Hand Deformities, Congenital; Humans; Infant, Newborn; Maxilla; Maxillofacial Abnormalities; Nose; Pulmonary Valve Stenosis

Rhinoliths are calcareous concretions that are formed by the deposition of salts on an intranasal foreign body over a number of years. We describe a rare case of rhinolithiasis, whereby a small foreign body has been lodged in a man's nasal cavity for over 80 years. He presented to the ear, nose and throat clinic with a sore throat and an incidental finding of a rhinolith was made which was confirmed by x-ray. This was managed conservatively.

Topics: Aged, 80 and over; Calcinosis; Calculi; Diagnosis, Differential; Endoscopy; Foreign Bodies; Humans; Male; Nasal Cavity; Nose; Nose Diseases

Topics: Adult; Calcinosis; Female; Foreign Bodies; Humans; Nose; Tomography, X-Ray Computed; Turbinates

A form of idiopathic calcinosis cutis, subepidermal calcified nodule (SCN), recurred twice on the nasal ala of a healthy 6-year-old girl whose serum calcium and phosphorus levels were within normal limits. Basophilic granular material and numerous mast cells were present in the superficial dermis. The pathogenesis of SCN is uncertain, but the clinical and histologic features of this lesion are distinctive.

Topics: Biopsy; Calcinosis; Child; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Nose; Recurrence; Staining and Labeling

A case of relapsing polychondritis with atrophic lesions in nose and ears and conjunctivitis is presented. The patient was treated with dapsone during 18 months with remission of the acute breaks.

Topics: Atrophy; Basal Ganglia; Calcinosis; Cartilage Diseases; Conjunctiva; Dapsone; Ear, External; Female; Humans; Middle Aged; Nose; Recurrence

Topics: Adult; Audiometry; Calcinosis; Cardiac Catheterization; Cartilage Diseases; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Congenital Abnormalities; Female; Fingers; Hearing Disorders; Heart Function Tests; Humans; Labyrinth Diseases; Male; Nose; Pedigree; Pulmonary Valve Stenosis

The author has previously shown the conditioning role of the anaphylactoid reaction in the calcification of the snout and paws of the rat after the injection of certain metallic compounds. The present experiments show that it is the dextrin fraction of these compounds which causes these anaphylactoid phenomena before the calcifying response. This fact deserves special attention since dextrin is frequently used in the preparation of certain drugs.

Topics: Anaphylaxis; Calcification, Physiologic; Calcinosis; Dextrins; Edema; Extremities; Hypersensitivity; Nose; Polysaccharides; Rats; Research; Toxicology