phenylephrine-hydrochloride and Breast-Neoplasms

When a sarcomatous neoplasm is identified in the breast, distinguishing metaplastic carcinoma, malignant phyllodes tumor (MPT), and primary sarcoma is a diagnostic challenge, especially on small biopsies, as all these tumors may have overlapping morphological features, thoroughly grossing with histological examination and immunohistochemical staining being the standard approach to aid in classifying these lesions. Recently, we identified a highly sensitive and specific breast carcinoma marker TRPS1 with high expression in metaplastic breast carcinoma. In the current study, we tested TRPS1 in MPTs and primary sarcoma of the breast. We found TRPS1 was highly expressed (95%) within spindle cell, chondro-osseous, and/or liposarcomatous components of MPTs, in all breast primary chondrosarcomas and extraskeletal osteosarcomas, but not in other sarcomas of the breast. In extramammary sarcomas, TRPS1 was expressed in 28% of conventional chondrosarcomas and 56% of osteosarcomas of bone, but rarely in undifferentiated pleomorphic sarcomas (UPSs), liposarcomas, and angiosarcomas. In summary, MPTs may share similar genetic background with metaplastic carcinoma exhibiting TRPS1 expression, and TRPS1 may play a role in chondro-osseous differentiation because of its expression in chondro-osseous sarcomas from both breast and extramammary sites. Our findings suggest TRPS1 may be clinically useful in distinguishing MPT and metaplastic carcinoma from primary breast sarcoma except for tumors with chondro-osseous differentiation.

Topics: Bone Neoplasms; Breast Neoplasms; Carcinoma; Chondrosarcoma; Female; Fingers; Hair Diseases; Humans; Langer-Giedion Syndrome; Nose; Osteosarcoma; Phyllodes Tumor; Repressor Proteins; Sarcoma; Soft Tissue Neoplasms

Ondansetron can rarely induce extrapyramidal reactions in susceptible individuals. Our patient had a history of drug-induced dystonic reaction; therefore, these patients may be susceptible to extrapyramidal adverse reactions after ondansetron.

Topics: Adult; Antiemetics; Basal Ganglia Diseases; Breast Neoplasms; Cross Reactions; Female; Humans; Mastectomy; Middle Aged; Nose; Ondansetron; Plastic Surgery Procedures; Prochlorperazine

A transnasal trans-sphenoidal surgical approach to the pituitary gland is described. The operative and post-operative experiences with the use of this technique on 21 patients with hormone-dependent malignant disease are reported. In 2 patients the procedure was abandoned because of intrasellar haemorrhage and in 1 an empty sella was found. Fifteen patients developed diabetes insipidus and 1 patient died in the postoperative period.

Topics: Adult; Aged; Breast Neoplasms; Diabetes Insipidus; Female; Humans; Hypophysectomy; Male; Middle Aged; Nose; Prostatic Neoplasms; Remission, Spontaneous

Topics: Breast Neoplasms; Face; Nose; Rhinoplasty; Xeroradiography

Topics: Adenocarcinoma; Adult; Age Factors; Aged; Back; Brain Neoplasms; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Squamous Cell; Cecum; Colonic Neoplasms; Female; Gallbladder Neoplasms; Glioblastoma; Humans; Intestinal Neoplasms; Male; Middle Aged; Neoplasms; Nose; Oligodendroglioma; Skin Neoplasms; Stomach Neoplasms; Uterine Neoplasms; Vitiligo