phenylephrine-hydrochloride and Blepharitis

Demodicidosis is an ectoparasitosis, common to humans and many mammals. It is caused by the proliferation of a mite Demodex sp in the pilosebaceous follicles. Its pathogenic role remains controversial. The aim of our study was to report epidemiological and clinical particularities of cases of demodicidosis diagnosed in our region. Over a period of nine years (January 2000 to December 2008), 427 cases of demodicidosis were diagnosed. 73.2% of cases were blepharitis and 26.8% of cases were facial dermatosis. The mean age was 44 years. Women were slightly more affected (56%) than men. Among 787 chronic blepharitis, 243 cases were due to Demodex sp (30.9%). They were treated with yellow oxide of mercury (Ophtergine® 1%). In the face, this mite has been isolated from erythematous and pruritic papulopustular lesions, and their distribution was as follows: cheeks (22.1%), forehead (13.4%), and nose (11.5%). The diagnosis was confirmed by parasitological examination of scales showing more than 5 Demodex sp/cm(2) and response to treatment with metronidazole (Flagyl®) for three months. Currently, there were a large number of arguments for the incrimination of Demodex sp in pathogenesis of dermatosis and blepharitis. Dermatologists and ophthalmologists must therefore think to this mite. The density of Demodex sp found by parasitological exam is a determining factor in establishing an anti-Demodex treatment whose effectiveness is a further argument for the diagnosis.

Topics: Adolescent; Adult; Aged; Animals; Antiprotozoal Agents; Blepharitis; Child; Ear; Female; Forehead; Humans; Male; Metronidazole; Middle Aged; Mite Infestations; Mites; Nose; Tunisia

Sebaceous carcinoma of the eyelid is an uncommon tumour with unusual modes of presentation. It can remain occult at the primary site, without producing any mass, masquerading as chronic blepharoconjunctivitis, while setting up metastases in the regional lymph nodes especially in the pre-auricular group. We report here a case that not only masqueraded as chronic blepharoconjunctivitis with nodal metastases from an 'unknown primary' in the neck, but whose tumour spread in a pagetoid manner along the nasolacrimal duct producing a nasal tumour that was believed to be the 'unknown primary'. This case emphasizes the need for ophthalmologists, ENT surgeons and pathologists to keep sebaceous carcinoma in mind while evaluating patients with chronic blepharoconjunctivitis and cervical node metastases from 'unknown primary'. Histological clues for picking up a sebaceous carcinoma at a metastatic site include a tumour with comedo or ductal growth pattern and intracytoplasmic lipid.

Topics: Adenocarcinoma, Sebaceous; Aged; Blepharitis; Conjunctivitis; Diagnosis, Differential; Eyelid Neoplasms; Humans; Lymphatic Metastasis; Male; Neoplasm Invasiveness; Neoplasms, Unknown Primary; Nose; Syndrome

The incidence of follicle mites (Demodex) has been studied in 206 non-selected subjects by means of adhesive tape impressions on skin during daytime of nose and lids and moist storage of the tape. The incidence was seen to rise with increasing age: 4% in young subjects, 30% in the age group of 20 to 80, and 47% in older. The mite was more often present on the skin of the nose (17%) than on that of the upper lid (8%), while the incidence on the lower lid was between these 2 extremes (13%). A total of 126 Demodex mites were detected (123 Demodex folliculorum and 3 Demodex brevis), all full-grown. Of these, 41% were ghosts. The migration was evenly distributed in all directions within the areas examined. About 0.2% of the mites can be roughly estimated to have migrated at a certain point of time from the follicles of the nose to its skin.

Topics: Adolescent; Adult; Aged; Blepharitis; Child; Child, Preschool; Eyelids; Hair; Humans; Infant; Infant, Newborn; Microbiological Techniques; Middle Aged; Mites; Nose; Skin

Topics: Blepharitis; Cartilage; Entropion; Eyelid Diseases; Humans; Mucous Membrane; Nose; Tissue Adhesions; Transplantation, Autologous

Topics: Adult; Bacterial Infections; Blepharitis; Child; Conjunctivitis; Humans; Keratoconjunctivitis; Moraxella; Mucous Membrane; Nose; Seasons; Skin