phenylephrine-hydrochloride and Bladder-Exstrophy

The combination of complex congenital heart disease (double outlet right ventricle with pulmonary atresia, malalignment ventriculoseptal defect, right-sided aortic arch with left ductus arteriosus) and bladder exstrophy occurred in an infant with Opitz syndrome. Neither of these defects has previously been reported in association with Opitz syndrome. These malformations, which are midline defects, further characterize this syndrome as an impairment in midline development. The spectrum of congenital heart disease and genitourinary anomalies seen in Opitz syndrome is reviewed.

Topics: Abnormalities, Multiple; Bladder Exstrophy; Ear; Echocardiography; Heart Defects, Congenital; Humans; Hypertelorism; Hypospadias; Infant, Newborn; Male; Nose; Pulmonary Atresia; Syndrome; Testis