phenylephrine-hydrochloride and Anemia

Johanson-Blizzard syndrome (JBS); (OMIM: 243800) presents with features of malabsorption and dysmorphic features with onset of symptoms in infantile age group. The disorder was first described in the year 1971 with report of the first Indian case in 2004. We discuss two rare phenotypes (hepatitis and anemia) in a molecularly confirmed case of JBS.

Topics: Anemia; Anus, Imperforate; Chromosomes, Human, Pair 15; Ectodermal Dysplasia; Genes, Recessive; Genetic Testing; Genotype; Growth Disorders; Hearing Loss, Sensorineural; Hematologic Tests; Hepatitis; Humans; Hypothyroidism; Infant; Intellectual Disability; Male; Mutation; Nose; Pancreatic Diseases; Phenotype; Ubiquitin-Protein Ligases

Staphylococcus aureus bacteremia (SAB) acquired in hospitals continues to be a frequent and serious complication to hospitalization, and no previous case-control studies dealing with risk factors of this severe disease are available.. Based on a 1-year prospective analysis, the data from all patients with hospital-acquired SAB admitted to 4 hospitals in Copenhagen County, Denmark, from May 1, 1994, through April 30, 1995, were evaluated. Eighty-five patients with hospital-acquired SAB were matched to 85 control patients with a similar primary diagnosis at admission (matched controls). Of these, 62 patients with hospital-acquired SAB were compared with 118 other patients with a similar time of admission, who were randomly selected with no clinical evidence of SAB (unmatched controls).. The incidence of hospital-acquired SAB was 0.71 per 1000 hospital admissions. The presence of a central venous catheter (odds ratio, 6.9; 95% confidence interval [CI], 2.8-17.0), anemia (odds ratio, 3.3; 95% CI, 1.4-7.6), and hyponatremia (odds ratio, 3.3; 95% CI, 1.5-7.0) was significantly associated with hospital-acquired SAB in a conditional and a usual logistic regression analysis. Nasal carriage was not an independent risk factor, but nasal carriers among patients in surgery (odds ratio, 4.0; 95% CI, 1.3-13.0) had a significantly higher risk for hospital-acquired SAB compared with matched and unmatched controls. The presence of hospital-acquired SAB increased the mortality rate 2.4-fold (95% CI, 1.1-5.2).. The presence of a central venous catheter is an important risk factor, and hyponatremia and anemia are associated with the development of hospital-acquired SAB. Furthermore, hospital-acquired SAB in itself increases mortality.

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Anti-Bacterial Agents; Bacteremia; Case-Control Studies; Catheterization, Central Venous; Child; Child, Preschool; Cross Infection; Denmark; Female; Hospitals, Community; Humans; Hyponatremia; Immunocompromised Host; Infant; Infusions, Intravenous; Male; Middle Aged; Nose; Odds Ratio; Prospective Studies; Regression Analysis; Renal Dialysis; Risk Factors; Sex Factors; Staphylococcal Infections; Staphylococcus aureus; Surgical Procedures, Operative; Survival Analysis; Transfusion Reaction

Topics: Adolescent; Anemia; Arm; Australia; Bacteria; Body Height; Body Weight; Child; Child, Preschool; Ear, External; Eosinophilia; Health Surveys; Hearing Disorders; Humans; Infant; Infant Mortality; Intestinal Diseases, Parasitic; Native Hawaiian or Other Pacific Islander; Nose; Protein-Energy Malnutrition; Residence Characteristics

Topics: Anemia; Arteriosclerosis; Deafness; Diagnosis, Differential; Ear; Hemangioma; Hematologic Diseases; Hematoma; Hemophilia A; Histiocytoma, Benign Fibrous; Humans; Infectious Mononucleosis; Leukemia; Nose; Pathology; Pharynx; Polycythemia; Telangiectasis