phenylephrine-hydrochloride and Amyloidosis

Localized amyloidosis is a benign rare process in the head and neck. From 1972 to 1992, 12 patients with amyloid deposits of the head and neck were treated at the ENT Department of the University of Erlangen-Nürnberg. Negative congo red staining of rectal biopsy specimens established that the amyloidosis was not systemic. Localized amyloidosis appeared as a diffuse grey-to-yellow mass in the nose (n = 1) or larynx (n = 11). In 10 of the 12 cases excision of amyloid was possible with preservation of adjacent functional structures. Two patients refused surgery and underwent only symptomatic treatment with clinical followup investigations. Amyloid deposits completely excised did not recur during a mean postoperative period of 10 years. When not operated, the amyloid tumors showed a slowly progressive growth pattern.

Topics: Adolescent; Adult; Aged; Amyloidosis; Female; Humans; Laryngeal Diseases; Larynx; Laser Therapy; Male; Middle Aged; Nose; Nose Diseases; Retrospective Studies

Topics: Amyloidosis; Humans; Nose; Pharynx

Topics: Amyloidosis; Humans; Male; Middle Aged; Nose; Skin Diseases; Surgical Flaps

Topics: Amyloidosis; Humans; Male; Middle Aged; Nose; Skin Diseases

Localized nasal, conjunctival and corneal amyloidosis was diagnosed in a 15-year-old pony with nasal and conjunctival masses and severe dyspnoea. Multiple swellings had been evident in the nostrils for at least two years and had gradually increased in size before presentation due to dyspnoea and exercise intolerance. Surgical debulking of the masses was performed and histological examination revealed large amounts of extracellular, hyaline, eosinophilic, Congo red positive material in the lamina propria of the nasal mucosa. A tentative diagnosis of localized nasal amyloidosis was made. The treatment relieved the clinical signs, however, the nasal masses recurred and bilateral conjunctival, papillary masses developed. The horse was euthanized. Nodular nasal and papillary conjunctival masses consisting of rubbery, grey to yellow tissue were found at necropsy. At the limbus this tissue infiltrated and expanded the cornea. The masses consisted of amyloid and moderate infiltrates of T lymphocytes and B lymphocytes were present in the tissue. No predominance of either cell type was observed and no distinct neoplastic mass could be identified. Ultrastructural examination of the nasal mucosa and cornea confirmed the presence of abundant extracellular deposits of non-branching fibrils ranging from 9-11 nm in diameter consistent with amyloid. Immunohistochemistry of amyloid revealed no labelling for AA amyloid, and no peptides representing serum amyloid A (SAA) were detected by microscopic laser dissection and subsequent mass spectrometry. Peptides from immunoglobulin kappa-like light chains were detected and are suggestive of AL amyloidosis, however the results were inconclusive and a final identification of the amyloid protein could not be made.Nasal amyloidosis is a clinical entity of localized amyloid deposits in the horse. Localized amyloidosis involving the conjunctiva of the horse is previously described in only seven cases and the present case is the first case of combined, localized nasal and corneal amyloidosis in the horse. In several reported cases surgical excision has provided clinical improvement and return to normal levels of exercise, while medical treatment has had no effect. The present case however, shows that rapid recurrence and progression of nasal amyloidosis to involve ocular tissues can occur and lead to recurrent respiratory obstruction.

Topics: Amyloidosis; Animals; Eye; Eye Diseases; Fatal Outcome; Female; Horse Diseases; Horses; Norway; Nose; Nose Diseases

Topics: Aged; Amyloidosis; Humans; Male; Nose; Nose Deformities, Acquired; Skin Diseases

Topics: Amyloidosis; Dermatitis; Humans; Immunoglobulin Light Chains; Male; Middle Aged; Nose; Plasmacytoma

We describe a patient with a large nodular basal cell carcinoma (BCC), which was excised following apparent failure to respond to radiotherapy. Histological examination of the fully excised lesion demonstrated a solid mass of amyloid, which stained positively for cytokeratins, but there was no residual BCC.

Topics: Aged; Amyloidosis; Carcinoma, Basal Cell; Female; Humans; Nose; Radiation Tolerance; Skin Diseases; Skin Neoplasms; Treatment Failure

Topics: Adult; Amyloidosis; Biopsy; Ear Canal; Epistaxis; Female; Humans; Larynx; Male; Middle Aged; Nasopharynx; Nose; Otitis Media; Otorhinolaryngologic Diseases; Tomography, X-Ray Computed

Nodular amyloidosis is a rare cutaneous disorder for which many treatments have been described, including carbon dioxide (CO2) laser vaporization.. We describe the intraoperative tissue effects encountered during successful treatment of nodular amyloidosis with CO2 laser surgery.. Two nodules of cutaneous amyloid on the nose of a patient were vaporized with a defocused, continuous-wave CO2 laser.. The tissue was found to be highly friable and hemostasis was difficult to achieve during the surgery. These clinical observations were correlated with amyloid infiltration of the dermis and blood vessels on preoperative histologic examination.. CO2 laser vaporization of nodular amyloidosis may be associated with prominent tissue friability and poor hemostasis.

Topics: Amyloidosis; Female; Humans; Laser Therapy; Middle Aged; Nose; Skin; Skin Diseases

A case of facial primary nodular cutaneous amyloidosis is reported. This illustrates: the striking appearance of this unusual condition; the investigations appropriate to establish the diagnosis and to exclude underlying systemic amyloidosis or a condition which might contribute to amyloidosis; and the difficulty of successful management. Initial investigation failed to reveal any evidence of systemic amyloidosis or an associated internal illness. Two amyloid nodules were excised, but 7 years later the patient developed further nodules on the adjacent facial skin and again sought dermatological advice. He was reinvestigated and again no underlying condition was found. A trial of cryotherapy was unsuccessful, but curettage and cautery produced a cosmetically acceptable result.

Topics: Adult; Amyloidosis; Facial Dermatoses; Humans; Male; Nose

Topics: Adult; Amyloidosis; Diagnosis, Differential; Humans; Male; Middle Aged; Nose; Skin; Skin Diseases

Topics: Aged; Amyloid; Amyloidosis; Carcinoma, Basal Cell; Collagen; Epithelial Cells; Female; Fibroblasts; Head; Humans; Male; Mast Cells; Microscopy, Electron; Microtomy; Middle Aged; Nose; Skin Neoplasms; Staining and Labeling

Topics: Aged; Amyloidosis; Diagnostic Errors; Female; Humans; Maxillary Sinus; Middle Aged; Nose; Nose Diseases; Nose Neoplasms; Paranasal Sinus Neoplasms; Respiratory Tract Diseases

Topics: Adult; Amyloidosis; Humans; Male; Nose; Skin; Skin Diseases