phenylephrine-hydrochloride and Adenocarcinoma

The advances in endoscopy have revolutionized the management of sinonasal and skull base lesions. Many complex cancers that traditionally required open approaches are now amenable to purely endoscopic endonasal resection, providing less invasive surgery with lower morbidity but with comparable oncologic outcomes in terms of survival rates. This article discusses the current evidence for the multimodal management of sinonasal and anterior skull base cancers focusing on the different treatment protocols driven by histologic subtypes.

Topics: Adenocarcinoma; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Neuroendocrine; Carcinoma, Squamous Cell; Disease Management; Endoscopy; Esthesioneuroblastoma, Olfactory; Hemangiopericytoma; Humans; Maxillary Sinus Neoplasms; Nose; Professional Corporations; Skull Base; Skull Base Neoplasms; Survival Rate

Perifollicular fibroma (PFF) is a rare cutaneous hamartoma that shows differentiation to the connective tissue sheath of the hair follicle. It may be solitary or multiple; the latter has been suggested to exhibit autosomal dominant inheritance and association with colonic polyposis. We report a 72-year-old Japanese female with multiple PFF on the face, possibly familial, who developed colon cancer in addition to colonic polyps.

Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Colonic Polyps; Female; Hamartoma; Humans; Nose; Skin Neoplasms

The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer.. Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine). Transanal Endoscopic Microsurgery (TEM) will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response.Primary objective is to determine the number of patients with a (near) complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol.. The CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov (NCT01273051).

Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Microsurgery; Middle Aged; Natural Orifice Endoscopic Surgery; Nose; Prospective Studies; Radiotherapy, Adjuvant; Rectal Neoplasms; Rectum; Treatment Outcome

Cutaneous manifestations of disease are exceedingly rare and commonly overlooked in clinical practice. Allergies or contact dermatitis, autoimmune disease or skin cancer are the most common conditions typically associated with skin lesions. Rarely, cutaneous lesions may be the first sign of internal malignancy, or even resemble recurrent disease in those with history of cancer.. Herein, we report a case of an otherwise healthy male who presented to his primary care provider (PCP) with a skin lesion misdiagnosed as a furuncle, which eventually led to diagnosis of metastatic esophageal cancer. The patient was a 64-year-old male, presenting with a fungating lesion on the tip of his nose which was biopsied, confirming adenocarcinoma likely from a gastrointestinal source. Staging imaging showed extensive lung, liver, and boney metastatic disease. He was initially treated with chemotherapy and trastuzumab.. Cutaneous lesions are a rare presenting sign of malignancy, but rapidly growing lesions should be evaluated for possible metastatic disease.

Topics: Adenocarcinoma; Esophageal Neoplasms; Humans; Male; Middle Aged; Nose; Skin

Topics: Adenocarcinoma; Humans; Neck; Nose; Pharynx

Topics: Adenocarcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Carotid Artery Injuries; Carotid Artery, Common; China; Cholesterol; Granuloma, Foreign-Body; Humans; Ligation; Natural Orifice Endoscopic Surgery; Nose; Retrospective Studies; Salivary Gland Neoplasms; Salvage Therapy; Skull Base

Topics: Adenocarcinoma; Animals; Cats; Female; Nose; Nose Neoplasms

The feasibility and safety of Natural Orifice Translumenal Endoscopic Surgery (NOTES) transanal endoscopic rectosigmoid resection using transanal endoscopic microsurgery (TEM) was previously demonstrated in human cadavers and a porcine survival model. We report the first clinical case of a NOTES transanal resection for rectal cancer using TEM and laparoscopic assistance, performed by a team of surgeons from Barcelona and Boston with extensive experience with NOTES and minimally invasive approaches to colorectal diseases.. Transanal endoscopic rectal resection with total mesorectal excision using the TEM platform was performed in a 76-year-old woman with a T2N2 rectal cancer treated with preoperative chemoradiation. Laparoscopic visualization and assistance with retraction and exposure during rectosigmoid mobilization was provided through one 5-mm port, which was later used as the stoma site, and 2-mm needle ports, one of which was used as a drain site. The specimen was transected transanally followed by handsewn coloanal anastomosis.. The procedure was completed successfully with an operative time of 4 hours and 30 minutes. Mesorectal excision was complete. The postoperative course was uneventful, and the patient was discharged on the fourth postoperative day. The final pathology demonstrated pT1N0 with 23 negative lymph nodes and negative proximal, distal, and radial margins.. NOTES transanal endoscopic rectosigmoid resection using TEM and laparoscopic assistance is feasible and safe. Careful patient selection and improvement in NOTES instrumentation are critical to optimize this approach before widespread clinical application.

Topics: Adenocarcinoma; Aged; Anastomosis, Surgical; Biopsy; Colon, Sigmoid; Endoscopy; Female; Follow-Up Studies; Humans; Ileostomy; Laparoscopy; Magnetic Resonance Imaging; Microsurgery; Nose; Rectal Neoplasms; Rectum; Tomography, X-Ray Computed

Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Female; Gefitinib; Humans; Hypertrichosis; Lung Neoplasms; Nose; Quinazolines

A series of ethmoidal tumors was resected by an entirely extracranial approach through a lateral rhinotomy incision, with partial maxillectomy and removal of the cribriform plate and dura mater from below.. Thirty-four consecutive patients (32 male, 2 female; mean age 64 years, range 45-78) with malignant tumors of the ethmoid sinus were operated by this technique between July 1998 and February 2002. All had complete tumor resection, including the cribriform plate and the dura mater. Excision was performed en bloc 23 times (68%). Although cerebral involvement was encountered in four cases (T4 IC), this technique was adequate for tumor resection, together with corticectomy when necessary. The method used for tumor resection and rebuilding of the anterior skull base is described in detail.. There were no immediate postoperative deaths. One patient developed pneumococcal meningitis with cerebrospinal fluid leakage as a result of a technical error and required further surgery. Four patients presented a confusion syndrome that regressed during the hospital stay, 2 complained of transient diplopia, and 4 had hematoma of the abdominal wall. Mean follow-up of 10.4 months (1-41 months) is still too short to reach definitive conclusions about oncologic results.. This approach is particularly suitable for removal of tumors in contact with or invading the cribriform plate. Tumor resection is as extensive as with the traditional mixed approach, but does not require the frontal lobes to be drawn aside.

Topics: Adenocarcinoma; Aged; Dura Mater; Ethmoid Bone; Ethmoid Sinus; Female; Humans; Male; Middle Aged; Neoplasm Staging; Neurosurgical Procedures; Nose; Paranasal Sinus Neoplasms; Treatment Outcome

To determine a putative role and relation between human papilloma virus (HPV) and p53 in the etiology of sinonasal carcinomas associated with papillomas.. The study group consists of all patients with sinonasal carcinomas associated with papillomas diagnosed in Denmark from 1980 to 1998. After reviewing our national pathological files, tumor tissues from 36 patients were collected, comprising 15% of the total cases of sinonasal carcinomas. In 35 cases a squamous cell carcinoma was demonstrated and in one case an adenocarcinoma was evident. Inverted papilloma was associated with carcinoma in 31 cases and exophytic papillomas in 5 cases. The material was investigated for HPV using polymerase chain reaction analyses with two sets of consensus primers (GP5+/GP6+ and MY09/MY11). The HPV-positive cases were submitted to dot-blot hybridization to establish the HPV type. Using immunohistochemistry, the p53 expression was determined. A p53 overexpression is defined as positive staining in 10% or more of the tumor cells.. Among 30 examined cases of carcinomas associated with inverted papillomas, 4 cases were HPV-positive (13%). P53 overexpression was not shown among the HPV-positive cases, whereas p53 overexpression was seen in 21 of the 24 (88%) examined HPV-negative cases. Among the 5 carcinomas associated with exophytic papillomas, HPV was demonstrated together with p53 overexpression in 3 cases (60%). In addition, one case more was with p53 overexpression.. An inverse relation between HPV and p53 overexpression in sinonasal carcinomas associated with inverted papillomas appears to have been demonstrated. HPV and p53 might also have an etiological role among the carcinomas associated with exophytic papillomas.

Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Denmark; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nose; Nose Neoplasms; Papilloma; Papilloma, Inverted; Papillomaviridae; Papillomavirus Infections; Paranasal Sinus Neoplasms; Paranasal Sinuses; Polymerase Chain Reaction; Retrospective Studies; Tumor Suppressor Protein p53; Tumor Virus Infections

Spontaneous nasal tumors are rare in mice, and only one adenocarcinoma and two more primary neoplasms of the nose have been observed in our files of long-term feeding studies, which are composed of 3,419 male and 3,521 female CD-1 (Crl:CD-1 (ICR)BR) mice. This adenocarcinoma was a 1-cm-diameter mass observed grossly in the right nasal cavity of a 454-day-old, male CD-1 mouse from a treated group in a bioassay study conducted with 340 males and 340 females. The neoplastic epithelial cells affected the normal nasal architecture on the right side of the nose. Roughly, tumor neoplastic cells of the outer, lateral portion occurred as cuboidal to low columnar cells with basilarily located nuclei and eosinophilic cytoplasm. These cells were arranged in cylindrical profiles and frequently entrapped acini of the glands of the maxillary sinus. Neoplastic epithelial cells of the inner, medial portion appeared as serous acinar or ductular structures circumscribed by multiple lagers of myoepithelial-like cells. Staining failed to demonstrate mucous secretion. The site of origin of this neoplasm appeared to be the serous glands of the maxillary sinus. The adenocarcinoma was believed to be spontaneous.

Topics: Adenocarcinoma; Animals; Female; Male; Mice; Mice, Inbred ICR; Myoepithelioma; Nose; Nose Neoplasms; Rodent Diseases

A case-control study on cancer of the nose and paranasal sinuses, and several risk factors including previous nasal diseases and symptoms, was performed in France from January 1986 through February 1988. The frequency of previous nasal diseases and symptoms was analyzed by histologic type of cancer. Different results were observed for squamous cell carcinomas and adenocarcinomas. In men, there were statistically significant associations between squamous cell carcinomas and sinusitis, bleeding from the nose, polyps, rhinitis, and trauma to the nose; and between adenocarcinomas, bleeding from the nose, and rhinitis. In women, there was an association between squamous cell carcinomas and nasal polyps.

Topics: Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Epistaxis; Female; France; Humans; Male; Middle Aged; Nasal Polyps; Nose; Nose Diseases; Nose Neoplasms; Paranasal Sinus Neoplasms; Rhinitis; Risk Factors; Sex Factors; Sinusitis; Time Factors

Various surgical approaches to the region are discussed, and the procedure according to Hernandez Altemir (1986) described in detail. Six cases are presented to illustrate how this versatile osteoplastic technique may be adapted for individual patients.

Topics: Adenocarcinoma; Adenoma, Pleomorphic; Adolescent; Adult; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Ethmoid Bone; Face; Female; Head and Neck Neoplasms; Histiocytoma, Benign Fibrous; Humans; Male; Maxilla; Middle Aged; Neoplasms, Multiple Primary; Neurilemmoma; Nose; Nose Neoplasms; Osteoma; Osteotomy; Palatal Neoplasms; Pharynx; Skull Neoplasms

A young pregnant woman had facial swelling in the upper nasal region. This was initially considered to be lymphedema in view of a history of past severe facial acne. A biopsy was done when the lesion progressed; the specimen showed adenocarcinoma. This responded well to radiotherapy, the favorable response being maintained for more than 24 months.

Topics: Adenocarcinoma; Adult; Dacryocystorhinostomy; Facial Neoplasms; Female; Humans; Nose; Pregnancy; Pregnancy Complications, Neoplastic; Tomography, X-Ray Computed; Visual Acuity

After longterm exposition (30.5 years) to beech and oak wood dust in woodworking, a formation of adenocarcinomas of the inner nose is possible in joiners, parquet layers and similar professions. They develop after a latency of 39 years on an average. These tumors appear generally in the area of the middle nasal concha and the ethmoid bone and invade continually into the orbit, the paranasal sinuses and the intracranial space. The incidence of regional and hematogenous metastases is low. Among the various forms of adenocarcinomas of the nose only those adenocarcinomas which are very similar to gastrointestinal carcinomas have been developed after an exposition to dust of wood. The most frequent tumors are adenocarcinomas of cylindrical cells with a papillary tubular structure. Alveolar goblet cell carcinomas with much mucous secretion and carcinomas of the signet ring cells are less frequent. There are evident correlations between the differentiation degree and the development of these tumors. In some of them polypeptide hormones have been demonstrated by histochemical and electron-optical methods. This report is based on 177 cases compiled by the professional association of woodworkers in the Federal Republic of Germany.

Topics: Adenocarcinoma; Dust; Germany, West; Humans; Lymphatic Metastasis; Nose; Nose Neoplasms; Occupational Diseases; Wood

Ethmoid sinus neoplasms have traditionally been associated with a poor prognosis. Their advanced stage at presentation and proximity to vital structures have made them difficult to treat. Bilateral ethmoidal tumors impinging on or actively infiltrating the cribriform plate have been particularly resistant to cure. We have used the superior rhinotomy in conjunction with a bifrontal craniotomy in three patients to effect an en bloc resection of both ethmoid labyrinths and cribriform plate in an oncologically acceptable fashion.

Topics: Adenocarcinoma; Craniotomy; Ethmoid Bone; Ethmoid Sinus; Humans; Male; Methods; Middle Aged; Neuroectodermal Tumors, Primitive, Peripheral; Nose; Paranasal Sinus Neoplasms; Postoperative Complications

Malignant tumours of the nasal cavity and paranasal sinuses are uncommon amounting to 0.3-1% of all tumours and 3%-5% of carcinomas of the upper respiratory tract. Modern diagnostic techniques include endoscopy and computer tomography. Prognosis and therapy depend on the histological type, site of origin and extent of the tumour. The variety of possible treatment modalities demands individual therapy planning. A combined surgical and radiotherapeutic approach, possibly supplemented by small volume intracavitary brachytherapy or polychemotherapy in some defined histological tumour types, has been generally accepted, enabling a five year survival rate of 35%-45% to be achieved. The causes for failure are firstly local persistence of tumour (18%) or a local recurrence (37%). The cumulative recurrence rate after one and two years was 76% and 95% respectively. Late recurrences occur in 2.5% of cases. The complication rate with combined-modality therapy reaches 27% with minor complications occurring in 12% and major complications in 15% especially affecting the irradiated homolateral eye. The present statistical results show a number of weak points that cast doubt on their validity. We recommend a controlled, prospective, randomised, multi-centre and multi-disciplinary study to define the prognostic parameters for tumours of the paranasal sinuses and to choose the most effective, individually tailored therapy.

Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Combined Modality Therapy; Endoscopy; Humans; Lymph Nodes; Lymphatic Metastasis; Neoplasm Staging; Neuroectodermal Tumors, Primitive, Peripheral; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms; Paranasal Sinuses; Prognosis; Tomography, X-Ray Computed

The evaluation of 40 patients with adenocarcinoma of the nasal cavity shows that these patients had been exposed to oak and beech dusts proving the causal connection between this type of wood dust and adenocarcinoma of the nose. In view of this knowledge, compensation in accordance with section 551 (2) RVO (Reichsversicherungsordnung: social insurance statute) can be recommended in individual cases after intensive occupational exposure to oak or beech dust over many years.

Topics: Adenocarcinoma; Dust; Endoscopy; Humans; Nose; Nose Neoplasms; Occupational Diseases; Paranasal Sinus Neoplasms; Paranasal Sinuses; Prognosis; Trees

Total rhinotomy is a technique previously used to gain access to the sella in hypophyseal surgery. In our experience, total rhinotomy is an excellent approach not only for benign midline naso-ethmoidal lesions but also for bilateral malignant tumours of the ethmoid complex and the nose, provided that there is no dural or orbital involvement. Total rhinotomy is contraindicated for malignant lesions extending into the nasopharynx.

Topics: Adenocarcinoma; Carcinoma, Transitional Cell; Ethmoid Bone; Humans; Male; Methods; Middle Aged; Nose; Nose Neoplasms; Papilloma; Postoperative Complications; Skull Neoplasms

Topics: Adenocarcinoma; Cartilage; Female; Fluorouracil; Humans; Middle Aged; Necrosis; Nose; Pelvic Neoplasms

Neuroendocrine (Merkel cell) carcinoma of the skin is usually a tumor found in elderly individuals. Microscopically, the tumor is a small cell carcinoma that involves primarily the dermis. The dominant ultrastructural features are the presence of short cell processes containing small, dense-core, membrane-bound granules. The tumor is often locally aggressive, has the potential to metastasize to lymph nodes, and eventually causes death. The authors report a case of such a neoplasm that affected a 24-year-old man with congenital ectodermal dysplasia. It was associated with a concurrent basal cell carcinoma.

Topics: Adenocarcinoma; Adult; Humans; Male; Nose; Skin Neoplasms

In 186 cases of nasal cancer diagnosed over the decade 1965-74, in a population of 2-0 million, 114 of 157 ectodermal tumours were found in men. Adenocarcinoma was found in 17 patients, two women and 15 men; 12 of these had a history of occupational exposure to wood dust in the furniture industry. The period of latency was from 28 to 57 years. Among the remaining 99 tumours in men there was occupational exposure to wood dust in 10 cases. Wood dust concentrations in the breathing zone, respiratory symptoms and upper airway function were studied in 68 workers in the furniture industry. The dust concentrations affecting 63% of the workers were higher than 5 mg/m3 (TLV). Middle ear inflammation and common colds were more frequent at high dust concentrations, and the number of workers with nasal mucostasis was directly proportional to the wood dust concentration.

Topics: Adenocarcinoma; Adolescent; Adult; Aged; Dust; Environmental Exposure; Humans; Male; Middle Aged; Nasal Mucosa; Nose; Nose Neoplasms; Occupational Diseases; Wood

Topics: Adenocarcinoma; Adult; Auscultation; Biopsy; Carcinoma, Squamous Cell; Child; Endoscopy; Head and Neck Neoplasms; Humans; Laryngoscopy; Medical History Taking; Neoplasm Metastasis; Nose; Palpation; Pharynx; Radiography

Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Adenoma, Pleomorphic; Adolescent; Adult; Aged; Carcinoma, Adenoid Cystic; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Papillary; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Child; Female; Follow-Up Studies; Humans; Larynx; Lymphatic Metastasis; Male; Middle Aged; Nasopharyngeal Neoplasms; Nasopharynx; Nose; Palatal Neoplasms; Palate; Salivary Gland Neoplasms

Topics: Adenocarcinoma; Adult; Age Factors; Aged; Back; Brain Neoplasms; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Squamous Cell; Cecum; Colonic Neoplasms; Female; Gallbladder Neoplasms; Glioblastoma; Humans; Intestinal Neoplasms; Male; Middle Aged; Neoplasms; Nose; Oligodendroglioma; Skin Neoplasms; Stomach Neoplasms; Uterine Neoplasms; Vitiligo

Topics: Adenocarcinoma; Animals; Bronchial Neoplasms; Carcinoma, Squamous Cell; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nose; Orthomyxoviridae; Orthomyxoviridae Infections

Topics: Adenocarcinoma; Aged; Cecal Diseases; Colonic Neoplasms; Female; Granuloma; Humans; Intestinal Obstruction; Intubation, Gastrointestinal; Mercury; Mercury Poisoning; Mesentery; Nose; Peritonitis; Radiography; Rupture, Spontaneous

Topics: Adenocarcinoma; Humans; Nose; Nose Neoplasms; Paranasal Sinus Neoplasms

Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Carcinoma, Transitional Cell; Humans; Nasal Polyps; Neoplasms; Nose; Nose Neoplasms; Papilloma; Paranasal Sinus Neoplasms; Paranasal Sinuses