phenylephrine has been researched along with Hypertrophy in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.59) | 18.7374 |
| 1990's | 14 (22.22) | 18.2507 |
| 2000's | 26 (41.27) | 29.6817 |
| 2010's | 21 (33.33) | 24.3611 |
| 2020's | 1 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Ceci, M; Romano, N | 1 |
| Burris, TP; Chan, RE; Fu, C; Griffin, AC; Jain, MK; Liao, X; Shen, Y; Sugi, K; Tien, CL; Zhang, L; Zhang, R | 1 |
| Deng, W; Duan, MX; Jiang, XH; Liao, HH; Tang, QZ; Wu, QQ; Xiao, Y; Yang, Z; Yuan, Y | 1 |
| Chen, S; Deng, W; Feng, H; Li, WJ; Liao, HH; Liu, XY; Tang, QZ; Yang, JJ; Zhang, N | 1 |
| Bers, DM; Bossuyt, J; Chuprun, JK; Gao, E; Gold, JI; Hullmann, J; Koch, WJ; Lee, L; Martini, JS; Rabinowitz, JE; Tilley, DG | 1 |
| Abdul-Ghani, M; Brunette, S; Dick, SA; Fernando, P; Megeney, LA; Putinski, C; Stiles, R | 1 |
| Fritz, JM; Hahn, NE; Krijnen, PA; Meischl, C; Musters, RJ; Niessen, HW; Pagano, PJ; Paulus, WJ; van Rossum, AC; Vonk, AB | 1 |
| Amisten, S; Arányi, T; Denning, C; Dolatshad, NF; Földes, G; Harding, SE; Ketteler, R; Kodagoda, T; Kolker, L; Kriston-Vizi, J; Leja, T; Matsa, E; Mioulane, M; Schneider, MD; Vauchez, K | 1 |
| Kang, JJ; Kang, PM; Ke, Q; Kim, UK; Samad, MA | 1 |
| Asakura, M; Bin, J; Cao, S; Huang, X; Kitakaze, M; Liao, Y; Wei, X; Wu, B; Xu, D; Xuan, W; Zeng, Z; Zhao, J | 1 |
| Deng, KQ; Gao, L; Jiang, DS; Jiang, X; Li, H; Luo, Y; Zhang, P; Zhang, XF; Zhao, GN; Zhu, X | 1 |
| Li, L; Li, Q; Lin, X; Ma, Y; Xiao, L; Yang, X; Yu, Y; Zhang, F; Zhou, X | 1 |
| Atsma, DE; Schalij, MJ; Umar, S; van der Laarse, A; van der Valk, EJ; van der Wall, EE | 1 |
| Fujita, M; Hasegawa, K; Kawamura, T; Kita, T; Morimoto, T; Shimatsu, A; Sunagawa, Y; Takaya, T; Wada, H; Yoshida, Y | 1 |
| Kerkelä, R; Ola, A; Pikkarainen, S; Ruskoaho, H; Skoumal, R; Tokola, H; Vuolteenaho, O | 1 |
| Fujita, M; Hasegawa, K; Kaichi, S; Kawamura, T; Kita, T; Morimoto, T; Shimatsu, A; Sunagawa, Y; Takaya, T; Wada, H | 1 |
| Brown, RD; Colucci, WS; Jeong, MY; Long, CS; Moore, RL; Vinson, CS; Walker, JS | 1 |
| Abouelnaga, ZA; Alhaj, M; Awad, MM; Elnakish, MT; Goldschmidt-Clermont, PJ; Hassanain, H; Hassona, MD | 1 |
| Faruq, NS; Gan, XT; Guo, J; Haist, JV; Karmazyn, M; Rajapurohitam, V; Zeidan, A | 1 |
| Firth, AL; Gao, MH; Guo, T; Hammond, HK; Lai, NC; Miyanohara, A; Tang, R; Tang, T; Yuan, JX | 1 |
| Hu, X; Li, T; Liu, Z; Ma, K; Zhou, C | 1 |
| Arons, E; Christou, H; Khalil, RA; Kourembanas, S; Mam, V; Mitsialis, SA; Reslan, OM; Tanbe, AF; Touma, M; Vitali, SH | 1 |
| Ali, MI; Belin de Chantemèle, EJ; Fulton, DJ; Mintz, JD; Rainey, WE; Stepp, DW; Tremblay, ML | 1 |
| Adcock, IM; Gusterson, RJ; Jazrawi, E; Latchman, DS | 1 |
| Andreucci, M; Bhattacharya, K; Dotto, P; Force, T; Haq, S; Kilter, H; Michael, A; Walters, B; Woodgett, J | 1 |
| Bicknell, KA; Brooks, G; Coxon, CH; Vara, D | 1 |
| Karmazyn, M; Xia, Y | 1 |
| Chan, AY; Dyck, JR; Proud, CG; Soltys, CL; Young, ME | 1 |
| Asakura, M; Asano, Y; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Kitamura, S; Liao, Y; Minamino, T; Ogai, A; Sanada, S; Shintani, Y; Takashima, S; Tomoike, H | 1 |
| Chidiac, P; Cook, MA; Gan, XT; Haist, JV; Karmazyn, M; Rajapurohitam, V | 1 |
| Chou, MY; Chueh, PJ; Huang, CY; Kuo, WW; Tseng, CT; Yang, JJ | 1 |
| Cook, MA; Karmazyn, M; Rajapurohitam, V; Xia, Y | 1 |
| Langeveld, B; Roks, AJ; Tio, RA; van Gilst, WH; Zijlstra, F | 1 |
| Laguna, JC; Planavila, A; Vázquez-Carrera, M | 1 |
| Aoyama, T; Hemmings, B; Matsui, T; Novikov, M; Park, J; Rosenzweig, A | 1 |
| Chen, H; Chen, K; Dedhar, S; Guo, L; Huang, XN; Sepulveda, JL; St-Arnaud, R; Tummalapali, L; Wu, C; Yan, W | 1 |
| Chidiac, P; Karmazyn, M; Kirshenbaum, LA; Roy, AA; Zhao, Q; Zou, MX | 1 |
| Gao, J; Han, QD; Lan, XM; Luo, DL; Wang, G; Wei, S; Xiao, RP | 1 |
| Cuevas, J; Henning, RJ | 1 |
| Force, T; Goruppi, S; Kyriakis, JM; Patten, RD | 1 |
| Brors, B; Frank, D; Frey, N; Hanselmann, C; Katus, HA; Kuhn, C; Lüdde, M | 1 |
| Alenina, N; Bader, M; Feng, X; Li, PF; Murtaza, I; Prabhakar, BS; Wang, HX | 1 |
| Adams, LD; Beaudry, D; Deblois, D; Geary, RL; Gunaje, J; Mahoney, WM; Pabón, LM; Schwartz, SM; Wang, X | 1 |
| Johnson, IM; Kale, S; Majumdar, G; Raghow, R | 1 |
| Andersen, LC; Clark, WA; LaPres, JJ; Rudnick, SJ | 1 |
| Liou, YM; Morgan, KG | 1 |
| Arner, A; Boels, PJ; Malmqvist, U; Uvelius, B | 1 |
| Frost, JA; Thorburn, A; Thorburn, J | 1 |
| Kessler-Icekson, G; Pinson, A; Piper, HM; Schlüter, KD; Schwartz, P; Zhou, XJ | 1 |
| Benessiano, J; Caputo, L; Duriez, M; Henrion, D; Heymes, C; Levy, BI; Poitevin, P; Samuel, JL | 1 |
| Byron, KL; Eble, DM; Lucchesi, PA; Qi, M; Samarel, AM; Waldschmidt, S | 1 |
| Kanda, Y; Nishio, E; Watanabe, Y | 1 |
| Clerk, A; Michael, A; Sugden, PH | 1 |
| Araki, M; Hasegawa, K; Kaburagi, S; Masaki, T; Morimoto, T; Sasayama, S; Sawamura, T | 1 |
| O'Brien, TX; Rackley, MS; Schuyler, GT; Thompson, JT | 1 |
| Hama, J; Hidaka, H; Horiuchi, M; Ishikawa, K; Kamoi, K; Katori, R; Kondo, H; Kurroka, A; Shimada, S; Watanabe, M; Yamamoto, Y | 1 |
| De Windt, LJ; Lim, HW; Molkentin, JD; Taigen, T | 1 |
| Averbukh, Z; Berman, S; Cohn, M; Galperin, E; Modai, D; Weissgarten, J | 1 |
| Bogoyevitch, MA; Long, CS; Ng, DC | 1 |
| Abe, M; Hasegawa, K; Kawamura, T; Morimoto, T; Sasayama, S; Wada, H; Yanazume, T | 1 |
| Aceto, JF; Baker, KM | 1 |
| Morgan, KG; Papageorgiou, P | 1 |
| Braunwald, E; Eckberg, DL; Higgins, CB; Vatner, SF | 1 |
63 other study(ies) available for phenylephrine and Hypertrophy
| Article | Year |
|---|---|
Are microRNAs responsible for cardiac hypertrophy in fish and mammals? What we can learn in the activation process in a zebrafish ex vivo model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; HSP70 Heat-Shock Proteins; Hypertrophy; Mammals; MicroRNAs; Pericardium; Phenylephrine; Zebrafish | 2020 |
REV-ERBα ameliorates heart failure through transcription repression.
Topics: Animals; Cardiotonic Agents; Gene Expression; Gene Regulatory Networks; Heart Failure; Humans; Hypertrophy; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Nuclear Receptor Subfamily 1, Group D, Member 1; Phenylephrine; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 2017 |
Aucubin protects against pressure overload-induced cardiac remodelling via the β
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Animals; Cardiotonic Agents; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Heart Failure; Hypertrophy; Iridoid Glucosides; Male; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Nitric Oxide Synthase Type I; Oxidative Stress; Phenylephrine; Protective Agents; Rats; Receptors, Adrenergic, beta-3; Ventricular Remodeling | 2018 |
Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro.
Topics: AMP-Activated Protein Kinases; Animals; Cardiomegaly; Epimedium; Flavonoids; Hypertrophy; Mechanistic Target of Rapamycin Complex 1; Myocytes, Cardiac; Phenylephrine; Rats, Sprague-Dawley; Signal Transduction; Ventricular Remodeling | 2018 |
Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.
Topics: Active Transport, Cell Nucleus; Adenoviridae; Angiotensin II; Animals; Calmodulin; Cell Membrane; Cell Nucleus; G-Protein-Coupled Receptor Kinase 5; Gene Expression Regulation, Enzymologic; GTP-Binding Protein alpha Subunits, Gq-G11; Hypertrophy; Ligands; Male; Mice; Mice, Transgenic; Myocardium; Phenylephrine; Protein Binding; Protein Structure, Tertiary; Rabbits; Rats | 2013 |
Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy.
Topics: Angiotensin II; Animals; Animals, Newborn; Apoptosis; Bronchodilator Agents; Cardiomegaly; Caspase 3; Caspase 9; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelin-1; Enzyme Activation; Fluorescent Antibody Technique; Hypertrophy; In Vitro Techniques; Isoproterenol; Membrane Potential, Mitochondrial; Myocardium; Myocytes, Cardiac; Oligopeptides; Phenylephrine; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasoconstrictor Agents | 2013 |
Early NADPH oxidase-2 activation is crucial in phenylephrine-induced hypertrophy of H9c2 cells.
Topics: Acetophenones; Animals; Cell Line; Enzyme Activation; Hypertrophy; Membrane Glycoproteins; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; Phenylephrine; Rats; Reactive Oxygen Species | 2014 |
Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Cell Line; Cell Size; Embryonic Stem Cells; Gene Expression; Humans; Hypertrophy; Imidazoles; Induced Pluripotent Stem Cells; Isoproterenol; Microscopy, Confocal; Myocytes, Cardiac; Phenylephrine; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2014 |
Endothelin A receptor antagonist, atrasentan, attenuates renal and cardiac dysfunction in Dahl salt-hypertensive rats in a blood pressure independent manner.
Topics: Animals; Atrasentan; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Endothelin A Receptor Antagonists; Gene Expression; Heart Diseases; Hemodynamics; Hypertension; Hypertrophy; Kidney Function Tests; Male; Myocytes, Cardiac; Phenylephrine; Pyrrolidines; Rats; Receptor, Endothelin A; Renal Insufficiency, Chronic | 2015 |
Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9.
Topics: Animals; Aortic Valve Stenosis; Calcineurin; Calgranulin A; Calgranulin B; Cardiomyopathy, Hypertrophic; Cells, Cultured; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Genetic Vectors; Heart Failure; Hypertrophy; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Rats; Recombinant Fusion Proteins; RNA, Messenger | 2015 |
Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Female; Humans; Hypertrophy; Male; Mice; Mice, Knockout; Mice, Transgenic; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TNF Receptor-Associated Factor 3; Up-Regulation | 2015 |
[MicroRNA-133a antagonizes phenylephrine-induced hypertrophy of neonatal rat cardiomyocytes in vitro].
Topics: Adenoviridae; Animals; Cells, Cultured; Genetic Vectors; Hypertrophy; MicroRNAs; Myocytes, Cardiac; Phenylephrine; Rats; RNA, Messenger; Transfection | 2015 |
Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent.
Topics: Animals; Animals, Newborn; Calcium; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Hypertrophy; Integrins; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oligopeptides; Phenylephrine; Protein Kinase C; Rats; Signal Transduction | 2009 |
Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Chlorocebus aethiops; COS Cells; Disease Models, Animal; E1A-Associated p300 Protein; GATA4 Transcription Factor; Hypertrophy; Mice; Myocytes, Cardiac; NIH 3T3 Cells; Phenylephrine; Rats; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; Transfection | 2010 |
The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Carbazoles; Cardiomegaly; Cell Nucleus; Endothelin-1; Genes, jun; Heart; Hypertrophy; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Natriuretic Peptide, Brain; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor AP-1; Transcription Factors | 2010 |
Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclin-Dependent Kinase 9; E1A-Associated p300 Protein; GATA4 Transcription Factor; HeLa Cells; Histones; Humans; Hypertrophy; Myocytes, Cardiac; Phenylephrine; Rats; Transcription, Genetic | 2010 |
AFos inhibits phenylephrine-mediated contractile dysfunction by altering phospholamban phosphorylation.
Topics: Adenoviridae; Animals; beta-Galactosidase; Calcium; Calcium-Binding Proteins; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Female; Genes, fos; Heart Ventricles; Hypertrophy; Myocardial Contraction; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1 | 2010 |
Vascular hypertrophy-associated hypertension of profilin1 transgenic mouse model leads to functional remodeling of peripheral arteries.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension; Hypertrophy; Integrin alpha1; Integrin beta1; Male; Mesenteric Arteries; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Phenylephrine; Profilins; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents | 2010 |
Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cells, Cultured; Disease Models, Animal; GATA4 Transcription Factor; Heart Failure; Hypertrophy; Myocytes, Cardiac; NFATC Transcription Factors; Panax; Phenylephrine; Plant Extracts; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchangers | 2011 |
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
Topics: Adenylyl Cyclases; Animals; Apoptosis; Calcineurin; Calcium; Calcium-Binding Proteins; Cyclic AMP; Gene Expression Regulation; Hypertrophy; Muscle Proteins; Myocytes, Cardiac; Nuclear Proteins; Phenylephrine; Phosphorylation; Point Mutation; Rats; Rats, Sprague-Dawley; Repressor Proteins; Troponin I | 2011 |
Involvement of ERK-RSK cascade in phenylephrine-induced phosphorylation of GATA4.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; GATA4 Transcription Factor; Hypertrophy; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction | 2012 |
Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.
Topics: Acetylcholine; Acidosis, Respiratory; Airway Remodeling; Ammonium Chloride; Animals; Antihypertensive Agents; Blood Pressure; Carbon Dioxide; Cholinergic Agonists; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Hypoxia; In Vitro Techniques; Lung; Male; Monocrotaline; Nitroprusside; Organ Size; Phenylephrine; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents | 2012 |
Increasing peripheral insulin sensitivity by protein tyrosine phosphatase 1B deletion improves control of blood pressure in obesity.
Topics: Adrenergic alpha-1 Receptor Agonists; Albuminuria; Aldosterone; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Ganglionic Blockers; Heart Rate; Hypertension; Hypertrophy; In Vitro Techniques; Insulin Resistance; Kidney Glomerulus; Male; Mecamylamine; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Phenylephrine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptors, Leptin; Sympathetic Nervous System; Vasoconstriction | 2012 |
The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity.
Topics: Acetyltransferases; Animals; Animals, Newborn; Cardiomegaly; Cardiotonic Agents; Cell Separation; CREB-Binding Protein; Culture Media, Serum-Free; E1A-Associated p300 Protein; Flow Cytometry; Genes, Dominant; Genes, Reporter; Green Fluorescent Proteins; Histone Acetyltransferases; Hypertrophy; Luciferases; Luminescent Proteins; Microscopy, Fluorescence; Myocardium; Nuclear Proteins; Oligonucleotides, Antisense; Phenylephrine; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae Proteins; Signal Transduction; Time Factors; Trans-Activators; Transcriptional Activation; Transfection | 2003 |
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth.
Topics: Animals; beta Catenin; Cell Division; Cells, Cultured; Cytoskeletal Proteins; Drug Stability; Endothelin-1; Gene Transfer Techniques; Glycogen Synthase Kinase 3; Heterotrimeric GTP-Binding Proteins; Hypertrophy; Myocytes, Cardiac; Phenylephrine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, Cell Surface; Signal Transduction; Trans-Activators; Wnt Proteins; Zebrafish Proteins | 2003 |
Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy.
Topics: 3T3 Cells; Animals; Cell Cycle Proteins; Cyclin E; Dimerization; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; E2F5 Transcription Factor; Female; Flow Cytometry; G1 Phase; Hypertrophy; Hypertrophy, Left Ventricular; Immunoblotting; Luciferases; Mice; Myocardium; Peptides; Phenylephrine; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; S Phase; Time Factors; Transcription Factors; Up-Regulation | 2003 |
Obligatory role for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: evidence for two distinct mechanisms for endothelin regulation.
Topics: Angiotensin II; Animals; Animals, Newborn; Aspartic Acid Endopeptidases; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Gene Expression; Heart Ventricles; Hypertrophy; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Muscle Cells; Myocardium; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin | 2004 |
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Elongation Factor 2 Kinase; Enzyme Activation; Green Fluorescent Proteins; Hypertrophy; Hypoglycemic Agents; Immunoblotting; Luminescent Proteins; Metformin; Microscopy, Fluorescence; Multienzyme Complexes; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Ribose; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Time Factors | 2004 |
Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Celiprolol; Cells, Cultured; Disease Progression; Drug Evaluation, Preclinical; Enzyme Induction; Fibrosis; Gene Expression Regulation; Heart Failure; Hypertrophy; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phenylephrine; Pressure; Rats; RNA, Messenger; Transcription, Genetic; Vasodilator Agents | 2004 |
Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A3 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Drug Interactions; Hypertrophy; Myocytes, Cardiac; Phenethylamines; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3 | 2005 |
Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK.
Topics: Actins; Angiotensin II; Animals; Anthracenes; Atrial Natriuretic Factor; Cell Size; Cells, Cultured; Humans; Hypertrophy; Interleukins; MAP Kinase Kinase 7; MAP Kinase Kinase Kinases; Myocytes, Cardiac; Phenylephrine; Protein Kinase Inhibitors; Protein Kinases; Rats; Recombinant Fusion Proteins; Signal Transduction; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vasoconstrictor Agents | 2004 |
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cardiomegaly; Cell Size; Cells, Cultured; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Hypertrophy; Mitochondria; Myocardium; Myocytes, Cardiac; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Rats | 2004 |
Angiotensin-(1-7) attenuates neointimal formation after stent implantation in the rat.
Topics: Angiotensin I; Animals; Aorta, Abdominal; Aorta, Thoracic; Hypertrophy; Infusion Pumps, Implantable; Infusions, Intravenous; Male; Methacholine Chloride; Peptide Fragments; Phenylephrine; Rats; Rats, Wistar; Sodium Nitrite; Stents; Tunica Intima; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Cell Line; DNA; Down-Regulation; Fatty Acids; Heart; Hypertrophy; Immunoblotting; Immunoprecipitation; Lipid Metabolism; Lipopolysaccharides; Male; Myocardium; NF-kappa B; Oxygen; Phenylephrine; PPAR delta; PPAR-beta; Protein Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2005 |
Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response.
Topics: Adaptation, Physiological; Animals; Apoptosis; Cells, Cultured; Hypertrophy; Immediate-Early Proteins; Myocytes, Cardiac; Phenylephrine; Phosphoproteins; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Stress, Mechanical; Transfection; Up-Regulation | 2005 |
Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy.
Topics: Actinin; Adaptor Proteins, Signal Transducing; Adenoviridae; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cell Culture Techniques; Cells, Cultured; DNA-Binding Proteins; Drug Synergism; Fibronectins; Heart Ventricles; Hypertrophy; LIM Domain Proteins; Membrane Proteins; Mice; Myocardium; Myocytes, Cardiac; Phenylephrine; Protein Serine-Threonine Kinases; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2005 |
RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes.
Topics: Animals; Atrial Natriuretic Factor; Cell Size; Cells, Cultured; Enzyme Activation; Gene Expression; Heart Ventricles; Humans; Hypertrophy; MAP Kinase Signaling System; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; RGS Proteins; RNA, Messenger; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Time Factors; Up-Regulation | 2006 |
Role of inositol 1,4,5-trisphosphate receptors in alpha1-adrenergic receptor-induced cardiomyocyte hypertrophy.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; Boron Compounds; Calcium; Calcium Signaling; Cells, Cultured; Heart Ventricles; Hypertrophy; Inositol 1,4,5-Trisphosphate Receptors; Leucine; Macrocyclic Compounds; Myocytes, Cardiac; Oxazoles; Phenylephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2006 |
Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Heart Ventricles; Hypertrophy; Male; Membrane Potentials; Myocytes, Cardiac; Myosin Heavy Chains; Patch-Clamp Techniques; Peptides; Phenylephrine; Phosphorus Radioisotopes; Phosphorylation; Rats; Rats, Sprague-Dawley; Sarcolemma | 2006 |
Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction.
Topics: Animals; Atrial Natriuretic Factor; Basic Helix-Loop-Helix Transcription Factors; Chromatin; Endothelin-1; Enzyme Induction; Fibroblasts; Gene Expression Regulation, Enzymologic; Heart Failure; HeLa Cells; Humans; Hypertrophy; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Myocardium; Myocytes, Cardiac; Neoplasm Proteins; Phenylephrine; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2007 |
Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Animals, Newborn; Gene Expression; Gene Expression Profiling; Genome; Heart Ventricles; Hypertrophy; Microarray Analysis; Myocytes, Cardiac; Phenylephrine; Rats; Receptors, Angiotensin; Signal Transduction; Stress, Mechanical | 2008 |
Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy.
Topics: Angiotensin II; Angiotensinogen; Animals; Apoptosis Regulatory Proteins; Cardiotonic Agents; Casein Kinase II; Catalase; Cell Membrane Permeability; Down-Regulation; Gene Expression Regulation, Enzymologic; Hypertrophy; Mice; Mice, Transgenic; Mitochondria, Heart; Muscle Proteins; Myocytes, Cardiac; Oxidation-Reduction; Phenylephrine; Phosphorylation; Protein Carbonylation; Protein Processing, Post-Translational; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2008 |
RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy.
Topics: Animals; Aorta; Blotting, Western; Cells, Cultured; Hypertension; Hypertrophy; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phenylephrine; Rats; Reverse Transcriptase Polymerase Chain Reaction; RGS Proteins; RNA, Messenger; Serotonin; Signal Transduction; Vasoconstriction | 2008 |
Epigenetic regulation of cardiac muscle-specific genes in H9c2 cells by Interleukin-18 and histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide.
Topics: Angiotensin II; Cardiotonic Agents; Cell Line; Cinnamates; Epigenesis, Genetic; Gene Expression Regulation; Heart; Histone Code; Histone Deacetylase Inhibitors; Humans; Hypertrophy; Interleukin-18; Myocardium; Organ Specificity; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphorylation; PTEN Phosphohydrolase; Ventricular Myosins | 2008 |
Myosin heavy chain synthesis is independently regulated in hypertrophy and atrophy of isolated adult cardiac myocytes.
Topics: Actins; Animals; Atrophy; Calcium Channels; Cats; Cells, Cultured; Desmin; Gene Expression Regulation; Hypertrophy; Isoproterenol; Muscle Contraction; Myocardium; Myofibrils; Myosins; Nifedipine; Phenylephrine | 1994 |
Redistribution of protein kinase C isoforms in association with vascular hypertrophy of rat aorta.
Topics: Animals; Aorta; Aortic Coarctation; Biological Transport; Fluorescent Antibody Technique; Hypertrophy; Image Processing, Computer-Assisted; Isoenzymes; Male; Microscopy; Phenylephrine; Phorbol Esters; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reference Values; Subcellular Fractions; Tissue Distribution | 1994 |
Structure and mechanics of growing arterial microvessels from hypertrophied urinary bladder in the rat.
Topics: Animals; Arterioles; Carbachol; Female; Histocytochemistry; Hypertrophy; Microscopy, Electron; Muscle Contraction; Muscle Development; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Urinary Bladder; Urinary Bladder Diseases | 1994 |
Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy.
Topics: Actins; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytoskeleton; Enzyme Activation; Gene Expression Regulation; Hypertrophy; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Mutation; Myocardium; Phenotype; Phenylephrine; Rats; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Alpha- and beta-adrenergic stimulation of protein synthesis in cultured adult ventricular cardiomyocytes.
Topics: Animals; Cells, Cultured; Creatine Kinase; Hypertrophy; Isoenzymes; Isoproterenol; Male; Muscle Proteins; Myocardium; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1993 |
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Collagen; Elastin; Fibrosis; Hypertension; Hypertrophy; Imidazoles; Infusions, Parenteral; Losartan; Male; Muscle, Smooth, Vascular; Phenylephrine; Pyridines; Rats; Rats, Wistar; Reference Values; Tetrazoles | 1996 |
Contractile activity is required for sarcomeric assembly in phenylephrine-induced cardiac myocyte hypertrophy.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Gene Expression; Heart; Hypertrophy; Intracellular Membranes; Myocardial Contraction; Myocardium; Osmolar Concentration; Phenylephrine; Rats; Rats, Sprague-Dawley; Sarcomeres | 1998 |
Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates.
Topics: Adrenergic alpha-Agonists; Animals; Anticholesteremic Agents; Aorta, Thoracic; Carbon Radioisotopes; Cell Count; Cells, Cultured; Cholesterol; Drug Interactions; Farnesol; Hypertrophy; Leucine; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Phenylephrine; Protein Prenylation; Rats; Receptors, Adrenergic, alpha-1; Transferases | 1998 |
Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Size; Cell Survival; Cells, Cultured; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Heart Ventricles; Hypertrophy; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Receptors, Cell Surface; Virulence Factors, Bordetella | 1998 |
The role of endothelin-converting enzyme-1 in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Cells, Cultured; Cricetinae; Endothelin-1; Endothelin-Converting Enzymes; Hypertrophy; Mesocricetus; Metalloendopeptidases; Myocardium; Myosin Heavy Chains; Phenylephrine; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetracyclines; Transcription, Genetic | 1999 |
F1-ATP synthase beta-subunit and cytochrome c transcriptional regulation in right ventricular hemodynamic overload and hypertrophically stimulated cardiocytes.
Topics: 3T3 Cells; Animals; beta-Galactosidase; Cats; Cell Culture Techniques; Cytochrome c Group; Female; Gene Expression Regulation; Hypertrophy; Luciferases; Male; Mice; Myocardium; Phenylephrine; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Time Factors; Transfection; Up-Regulation; Ventricular Dysfunction, Right; Verapamil | 1999 |
Alpha1-adrenergic stimulation induced hypertrophy in protein kinase C down-regulated cultured cardiac myocytes.
Topics: Adrenergic alpha-Agonists; Animals; Cardiomegaly; Cell Size; Cells, Cultured; Down-Regulation; Hypertrophy; Myocardium; Phenylephrine; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate | 1999 |
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.
Topics: Adenoviridae; Angiotensin II; Animals; Apoptosis Regulatory Proteins; Atrial Natriuretic Factor; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Carrier Proteins; Cattle; Cells, Cultured; DNA-Binding Proteins; Fetal Blood; Gene Expression Regulation; Genes; Genetic Therapy; Genetic Vectors; Hypertrophy; Myocardium; NFATC Transcription Factors; Nuclear Proteins; Phenylephrine; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transfection | 2000 |
Proliferative responses of mesangial cells to growth factors during compensatory versus dietary hypertrophy.
Topics: Animals; Arginine Vasopressin; Cell Division; Culture Techniques; Dietary Proteins; Endothelins; Epidermal Growth Factor; Epinephrine; Glomerular Mesangium; Growth Substances; Hypertrophy; Nephrectomy; Phenylephrine; Rats; Rats, Wistar | 2000 |
A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte
Topics: Acute-Phase Proteins; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cell Nucleus; Cells, Cultured; Culture Media, Serum-Free; Cycloheximide; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; Heart; Heart Ventricles; Hypertrophy; Imidazoles; Interleukin-1; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Kinetics; Leukemia Inhibitory Factor; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Protein Transport; Pyridines; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Trans-Activators | 2001 |
Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.
Topics: 3T3 Cells; Actins; Amides; Animals; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; COS Cells; DNA-Binding Proteins; Enzyme Activation; GATA4 Transcription Factor; Hypertrophy; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Luciferases; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Myocardium; Phenylephrine; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Thiazoles; Thiazolidines; Transcription Factors; Transcription, Genetic; Transfection; Zinc Fingers | 2002 |
[Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells.
Topics: Angiotensin II; Animals; Cell Division; Cells, Cultured; DNA; Hypertrophy; Muscle Proteins; Myocardium; Phenylephrine; Receptors, Angiotensin; RNA; Time Factors | 1990 |
Increased Ca2+ signaling after alpha-adrenoceptor activation in vascular hypertrophy.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aortic Coarctation; Calcium; Fura-2; Hypertension; Hypertrophy; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Inbred Strains; Signal Transduction | 1991 |
Alterations in the baroreceptor reflex in conscious dogs with heart failure.
Topics: Animals; Blood Flow Velocity; Cardiomegaly; Carotid Arteries; Dogs; Heart Failure; Heart Rate; Hypertension; Hypertrophy; Kidney; Mesenteric Arteries; Phenylephrine; Pressoreceptors; Pulmonary Valve Stenosis; Reflex; Tricuspid Valve; Vascular Resistance | 1972 |