phenylephrine has been researched along with Cardiomegaly in 306 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (5.23) | 18.7374 |
| 1990's | 51 (16.67) | 18.2507 |
| 2000's | 96 (31.37) | 29.6817 |
| 2010's | 113 (36.93) | 24.3611 |
| 2020's | 30 (9.80) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, M; Dong, DL; Fu, Y; Gao, JL; Hu, N; Jiang, M; Li, WF; Ma, MH; Sun, ZJ; Yang, XR; Zhao, J | 1 |
| Han, X; Luo, X; Mao, Q; Peng, B; Peng, C; Wu, S; Zhang, H | 1 |
| Chen, H; Guo, W; Lu, R; Qian, D; Shan, X; Tian, J; Wang, S; Xu, M; Zhang, C; Zhao, P | 1 |
| Cao, J; Jiang, Y; Qian, J; Wang, X; Zhang, J; Zhang, W | 1 |
| Cen, XF; Guo, YY; Huang, SH; Li, D; Liu, LB; Ma, YL; Qiu, HL; Tang, QZ; Xu, M | 1 |
| Bertone, R; Bonvissuto, D; Ceci, M; Cervia, D; Gornati, R; Lauri, C; Romano, N; Sette, C; Volpe, V | 1 |
| Li, X; Qu, X; Wang, Y; Xu, X; Yang, Y | 1 |
| Chen, J; Huang, N; Li, J; Sun, X; Wang, X; Zeng, Z; Zhang, H; Zou, Z | 1 |
| Funamoto, M; Hamabe-Horiike, T; Hasegawa, K; Katanasaka, Y; Kawaguchi, S; Kawase, Y; Komiyama, M; Miyazaki, Y; Mori, K; Morimoto, T; Murakami, A; Shimizu, K; Shimizu, S; Sunagawa, Y | 1 |
| Alharbi, HO; Clerk, A; Cooper, STE; Cull, JJ; Fuller, SJ; Glennon, PE; Hardyman, MA; Markou, T; Sugden, PH | 1 |
| Chen, W; Fang, Y; Guo, N; Guo, Q; Lv, J; Wang, Z; Zeng, S; Zhao, Z | 1 |
| Jia, B; Jia, S; Leng, M; Liu, R; Weng, L; Xiong, Y; Yan, S; Yang, F; Ye, J; Zhao, J; Zheng, M; Zhou, Y | 1 |
| Chen, Y; Feng, X; Hou, H; Xu, G; Yan, M | 1 |
| Jiang, X; Jiang, Z; Sun, Y; Xu, C | 1 |
| Chen, Y; Deng, KQ; Li, HP; Li, J; Tu, J; Wan, F; Wang, CQ; Xiao, WC | 1 |
| Cao, Y; He, Q; Jia, S; Liu, L; Liu, R; Liu, Y; Qiao, X; Weng, L; Xu, C; Ye, J; Zhang, C; Zhang, X; Zheng, M | 1 |
| Baruscotti, M; Guo, R; Liu, H; Liu, N; Wang, Y; Zhang, H; Zhang, J; Zhao, L | 1 |
| Chen, W; Feng, X; Gao, H; Geng, Y; Li, L; Liu, S; Shen, A; Wang, Y; Xu, S; Zhang, L | 1 |
| Conejeros, C; Olmedo, I; Parra, V; Pedrozo, Z; Sanchez, G | 1 |
| Ceci, M; Romano, N | 1 |
| Chen, Z; He, X; Liu, X; Lu, Y; Miao, R; Wang, J | 1 |
| Li, B; Wang, W; Wang, X; Yang, P; Yu, M | 1 |
| An, P; Fan, D; Guo, Z; Hasan, SG; Liu, FY; Ma, SQ; Tang, N; Tang, QZ; Wang, MY; Wu, HM; Yang, D; Yang, Z | 1 |
| Accornero, F; Dorn, LE; Hund, TJ; Janssen, PML; Lawrence, W; Mohler, PJ; Petrosino, JM; Schlosser, A; Sorensen, GL; Stratton, MS; Whitson, BA; Xu, X | 1 |
| Chen, Y; Fu, X; Guo, J; Liang, T; Pan, R; Sun, T; Wang, L; Zhang, J; Zhang, L | 1 |
| Antoons, G; Coumans, WA; Geraets, IME; Glatz, JFC; Kapsokalyvas, D; Luiken, JJFP; Nabben, M; Schianchi, F; Schönleitner, P; Strzelecka, A; Willemars, MMA | 1 |
| Gao, H; Gao, S; Jiang, X; Liu, X; Wei, Q | 1 |
| Cheng, YX; Li, XX; Liu, SY; Tan, JL; Wang, JJ; Yan, YM; Yang, HT; Yang, Y; Zhang, P; Zhang, YY; Zheng, YJ | 1 |
| Cai, S; Ding, Y; Li, J; Li, Z; Liu, P; Wang, M | 1 |
| Huang, L; Luo, X; Mao, Q; Peng, B; Peng, C; Wu, S; Zhang, H | 1 |
| Funamoto, M; Hasegawa, K; Katanasaka, Y; Katayama, A; Miyazaki, Y; Morimoto, T; Nurmila, S; Shimizu, K; Shimizu, S; Sunagawa, Y | 1 |
| Archer, CR; Drawnel, FM; Robinson, EL; Roderick, HL | 1 |
| Chen, S; Deng, W; Li, J; Liao, H; Ren, J; Tang, Q; Xu, L; Yang, Z; Zhang, N | 1 |
| Dong, B; Dong, Y; Liu, C; Sun, Y; Xue, R | 1 |
| Che, Y; Deng, W; Jin, YG; Liao, HH; Tang, QZ; Wang, SS; Wei, WY; Yang, Z; Zhang, N | 1 |
| Gao, S; Liu, P; Liu, XP; Lu, J; Wei, LH | 1 |
| Chen, Y; Dong, B; Dong, Y; Jiang, J; Liu, C; Sun, Y; Tan, W; Xue, R; Zhao, J | 1 |
| Alloatti, G; Brancaccio, M; Carullo, P; Condorelli, G; Di Pasquale, E; Gallo, MP; Gesmundo, I; Ghigo, E; Granata, R; Hare, JM; Larcher, V; Mazzola, M; Miragoli, M; Penna, C; Schally, AV; Sorge, M; Taliano, M; Trovato, L; Villanova, T | 1 |
| Li, HX; Li, XM; Luo, J; Wang, SH; Zhao, ZH | 1 |
| Ceci, M; Gallo, P; Ricciardi, S; Romano, N | 1 |
| Gao, H; Huang, P; Huang, X; Li, Y; Liu, H; Peng, Y; Tang, T; Wang, D | 1 |
| Jiang, J; Wang, DW; Wu, L; Yan, H; Yi, S; Zhuang, H | 1 |
| Dong, B; Dong, Y; Huang, H; Li, Y; Liu, C; Liu, J; Peng, L; Sun, Y; Xue, R | 1 |
| Feng, X; James Kang, Y; Li, R; Yin, W | 1 |
| Li, Q; Li, Z; Liu, P; Lu, J; Tan, Y; Wang, L; Wang, P; Yang, H | 1 |
| Chatterjee, K; Desingu, PA; Hasan, J; Jain, A; Sundaresan, NR | 1 |
| Koch, WJ; Purcell, NH; Yeh, ST; Zambrano, CM | 1 |
| Cai, W; Hua, J; Lai, W; Liu, Z; Ren, H; Xu, D; Zeng, Q; Zhan, Q | 1 |
| Guo, Z; Li, Q; Li, ZM; Liu, PQ; Lu, J; Sun, SY; Wang, LP; Wang, PX; Yang, HW; Ye, JT | 1 |
| Cai, YY; Chen, HY; He, JH; Jiang, W; Lan, J; Li, H; Li, RL; Li, X; Tang, CS; Wang, W; Wang, XX; Wu, SS; Wu, Y; Xin, JJ; Xue, KY; Zhang, HY; Zhuo, CL | 1 |
| Chen, S; Deng, W; Feng, H; Li, WJ; Liao, HH; Liu, XY; Tang, QZ; Yang, JJ; Zhang, N | 1 |
| Chen, J; Chen, L; Chen, W; Chen, Y; Liu, X; Sun, G; Wu, X; Zhang, Y; Zhao, Y | 1 |
| Dai, G; Dong, B; Dong, Y; Fan, W; Huang, H; Jiang, J; Liang, Z; Liu, C; Su, Q; Sun, Y; Wang, Y; Xue, R; Zhao, J | 1 |
| Cao, Y; Chen, Y; Cheng, H; Jia, S; Liu, J; Qiao, X; Wang, T; Weng, L; Xu, C; Ye, J; Zhao, L; Zheng, M; Zheng, Q | 1 |
| Bers, DM; Fukui, G; Hamada, Y; Ishiguchi, H; Kato, T; Kobayashi, S; Kono, M; Nakamura, Y; Nanno, T; Oda, T; Okamoto, Y; Okuda, S; Uchinoumi, H; Yamamoto, T; Yano, M | 1 |
| Chen, X; Cui, S; Cui, Y; Ding, S; Guo, H; Li, Y; Qin, W; Wang, H; Wu, D; Zhang, Y | 1 |
| Cai, X; Dong, B; Dong, Y; Jiang, J; Liu, C; Xue, R; Yao, F; Zeng, J; Zhao, J | 1 |
| Duan, W; Feng, P; Gao, E; Jin, Z; Liang, H; Liu, J; Sun, Y; Tan, Y; Wang, X; Yi, D; Yi, W; Yu, S; Zhang, B; Zhang, P; Zhang, Z | 1 |
| Cai, ZL; Deng, W; Duan, MX; Liu, C; Tang, QZ; Wu, QQ; Xie, QW; Xie, SY; Yuan, Y | 1 |
| Chen, L; Li, SH; Shui, X; Tang, LL; Wen, ZQ; Zheng, JR | 1 |
| Geenen, DL; Gupta, M; Gupta, MP; Nagalingam, RS; Solaro, RJ; Sundaresan, NR | 1 |
| Liu, R; Proud, CG; Townsend, PA; Zhang, Z | 1 |
| Gabrielli, LA; Giralt, M; Hondares, E; Iglesias, R; Munts, C; Planavila, A; Redondo, I; Sitges, M; van Bilsen, M; Villarroya, F; Vinciguerra, M | 1 |
| Chang, YT; Chang, YW; Chen, CC; Chen, YJ; Lin, JJ; Wang, Q | 1 |
| Abdul-Ghani, M; Brunette, S; Dick, SA; Fernando, P; Megeney, LA; Putinski, C; Stiles, R | 1 |
| Banach, K; Burmeister, BT; Carnegie, GK; Conklin, BR; DeSantiago, J; Johnson, KR; Monasky, MM; Spindler, MJ; Taglieri, DM | 1 |
| de Boer, RA; Lu, B; Silljé, HH; Tigchelaar, W; van Gilst, WH; Westenbrink, BD; Yu, H | 1 |
| Baines, CP; Douglas, DL; Krenz, M; McCommis, KS | 1 |
| Hasenfuß, G; Kramann, N; Seidler, T | 1 |
| Chidiac, P; Gros, R; Lee, KN; Nguyen, CH; Sobiesiak, AJ | 1 |
| Gan, XT; Huang, CX; Karmazyn, M; Taniai, S; Urquhart, BL; Velenosi, TJ; Xue, J; Zhao, G | 1 |
| Gurin, MI; Huang, H; Joseph, LC; Morrow, JP; Thorp, EB | 1 |
| Deng, J; Ding, W; Dong, M; Liu, J; Liu, Y; Xu, T; Yan, D | 1 |
| Abou-Leisa, R; Cartwright, EJ; Lim, DS; Maqsood, A; Mohamed, TM; Neyses, L; Oceandy, D; Oh, S; Prehar, S; Ray, SG; Robertson, A; Zi, M | 1 |
| Feng, X; Gao, S; Liu, P; Liu, Z; Wang, J; Xu, S | 1 |
| Ding, W; Dong, M; Liao, Y; Liu, J; Liu, S; Liu, Y; Wang, R; Yan, D; Zhang, Y; Zheng, N | 1 |
| Chen, C; Chen, Y; Dong, Y; Liu, C; Tan, W; Wu, D; Wu, L; Xue, R | 1 |
| Chen, J; Chen, X; Gan, X; Guo, Y; Lei, J; Yang, X; Zhou, H; Zou, J | 1 |
| Enomoto, T; Hayakawa, S; Hiramatsu-Ito, M; Ito, M; Joki, Y; Kambara, T; Kihara, S; Matsuo, K; Murohara, T; Ogawa, H; Ohashi, K; Ouchi, N; Shibata, R; Uemura, Y; Yuasa, D | 1 |
| Deng, CY; Fu, YH; Huang, S; Kuang, SJ; Liang, YY; Liao, YL; Lin, QX; Shan, ZX; Yu, XY; Zhang, MZ; Zheng, XL; Zhu, JN; Zou, X | 1 |
| Chen, S; Huang, J; Huang, Q; Liu, B; Liu, P; Luo, J; Pan, X; Zang, L; Zeng, Z; Zhou, S | 1 |
| Bissoli, NS; Boëchat, GA; Brasil, GA; Costa, HB; de Andrade, TU; de Lima, EM; do Nascimento, AM; Endringer, DC; Fronza, M; Lenz, D; Romão, W; Ronchi, SN; Scherer, R | 1 |
| Chen, S; Huang, J; Huang, Q; Liu, P; Lu, Y; Luo, J; Wang, P; Xu, L; Yuan, X; Zhou, S | 1 |
| Cadar, AG; Chiusa, M; Davidson, JM; Lim, CC; Lin, A; Samaras, S; Zhong, L | 1 |
| Kang, JJ; Kang, PM; Ke, Q; Kim, UK; Samad, MA | 1 |
| Arbiser, JL; Bonner, MY; Gius, D; Gupta, MP; Jones, DP; Kim, G; Pillai, VB; Raghuraman, H; Samant, S; Sundaresan, NR; Walker, DI | 1 |
| Deng, KQ; Gao, L; Jiang, DS; Jiang, X; Li, H; Luo, Y; Zhang, P; Zhang, XF; Zhao, GN; Zhu, X | 1 |
| Campiglia, P; Ciccarelli, M; Cipolletta, E; Crola, C; De Luca, N; Del Giudice, C; Franco, A; Gomez-Monterrey, I; Iaccarino, G; Illario, M; Maione, AS; Rusciano, MR; Sala, M; Santulli, G; Sorriento, D; Trimarco, B | 1 |
| Chen, M; Gao, E; Huang, S; Shang, X; Sun, J; Talarico, JA; Tilley, DG; Wang, N; Yan, G; Yi, B; Zhang, GX; Zhu, N | 1 |
| Boheler, KR; Huang, Y; Kong, CW; Li, RA; Li, ZC; Poon, E; Wang, Y; Yao, X; Zhang, P | 1 |
| Böhm, M; Devaux, Y; Fries, P; Kazakov, A; Maack, C; Müller, A; Puhl, SL; Wagner, DR | 1 |
| Bloch, DB; Bloch, KD; Buys, ES; Cheng, J; Ernande, L; Kolodziej, SA; Leyton, PA; Mayeur, C; Rhee, DK; Scherrer-Crosbie, M; Shahid, M; Spagnolli, E; Tainsh, RE; Thoonen, R; Wu, MX; Zapol, WM | 1 |
| Bernstein, SI; Cammarato, A; Harding, SE; Kass, DA; Kooij, V; Kronert, WA; Lee, DI; Rainer, PP; Schmidt, W; Van Eyk, JE; Viswanathan, MC | 1 |
| Huang, J; Jiang, F; Zhou, X | 1 |
| Feng, X; Huang, X; Li, J; Li, Z; Liu, P; Liu, S; Lu, J; Lu, X; Shen, P; Ye, J; You, J; Zhang, X | 1 |
| Cai, S; Gao, H; Huang, J; Huang, Y; Li, J; Li, Z; Liu, P; Luo, W; Shen, P; Wang, P; You, J; Zhang, X | 1 |
| Bloks, VW; de Boer, RA; de Jong, AM; Silljé, HH; Tigchelaar, W; van Gilst, WH | 1 |
| Bei, Y; Li, S; Li, X; Shen, S; Sun, Q; Zhang, H; Zhou, Q; Zhou, Y | 1 |
| Li, J; Lin, YH; McKinsey, TA; Russell, B; Warren, CM | 1 |
| Funamoto, M; Hasegawa, K; Katanasaka, Y; Miyazaki, Y; Morimoto, T; Sunagawa, Y; Suzuki, H; Wada, H | 1 |
| Addepalli, V; Bhatt, LK; Parkar, NA | 1 |
| Ping, P; Scruggs, SB; Wang, D | 1 |
| Abramowitz, J; Birnbaumer, L; Han, JW; Kim, JY; Lee, MG; Lee, YH; Yoen, SI | 1 |
| Burton, JP; Ettinger, G; Gloor, GB; Reid, G | 1 |
| Chen, C; Chen, Y; Dong, B; Dong, Y; Liu, C; Sun, Y; Tan, W; Xue, R; Zeng, J; Zhao, J | 1 |
| Li, S; Luo, X; Peng, C; Sun, H | 1 |
| Egashira, T; Fukuda, K; Hashimoto, H; Hayashi, K; Hayashiji, N; Ito, S; Kashimura, S; Kodaira, M; Kunitomi, A; Kusumoto, D; Lachmann, M; Motoda, C; Nagai, T; Nakanishi, C; Sakata, K; Seki, T; Shimojima, M; Takei, M; Tohyama, S; Yamagishi, M; Yozu, G; Yuasa, S | 1 |
| Baksh, S; Chan, AY; Dolinsky, VW; Dyck, JR; Light, PE; Soltys, CL; Viollet, B | 1 |
| Huang, BP; Johnson, JD; Luciani, DS; Proud, CG; Wang, X; Wang, Y | 1 |
| Chen, CL; Chen, GH; Guo, YH; Shen, T; Zheng, M; Zhu, XJ | 1 |
| Bristow, MR; Carnegie, GK; Diviani, D; Kunkel, MT; Langeberg, LK; Newton, AC; Pedroja, BS; Scott, JD; Smith, FD; Soughayer, J; Zhang, F | 1 |
| Cieslak, D; Gaitanaki, C; Lazou, A; Markou, T | 1 |
| Huang, BP; Proud, CG; Wang, X; Wang, Y; Wang, Z | 1 |
| Javadov, S; Karmazyn, M; Kilić, A | 1 |
| Inesi, G; Prasad, AM | 1 |
| Hartman, TJ; Martin, JL; Russell, B; Samarel, AM; Solaro, RJ | 1 |
| Hikoso, S; Hori, M; Mano, T; Masuyama, T; Miwa, T; Nishio, M; Ohtani, T; Otsu, K; Sakata, Y; Takeda, Y; Yamamoto, K | 1 |
| Frank, D; Frauen, R; Frey, N; Jaschinski, C; Katus, HA; Kuhn, C; Will, R | 1 |
| Chow, FL; Cooper, S; Fernandez-Patron, C; Finegan, BA; Hao, L; Kassiri, Z; Kelly, S; Lopaschuk, GD; Lopez-Campistrous, A; Odenbach, J; Oka, T; Schulz, R; Wang, X | 1 |
| Loftus, JC; Menashi, EB | 1 |
| Hill, JA; Keller, RS; Yund, EE | 1 |
| Bourcy, K; Kang, YJ; Zhou, Y | 1 |
| Campreciós, G; Navarro, M; Ramírez, I; Soley, M | 1 |
| Armesilla, AL; Baudoin-Stanley, F; Cartwright, EJ; Mohamed, TM; Nadif, R; Neyses, L; Oceandy, D; Pfeifer, GP; Pickard, A; Prehar, S; Stanley, PJ; Tommasi, S; Zi, M | 1 |
| Abdullah, MH; Abdullah, NA; Anand Swarup, KR; Fathihah, B; Johns, EJ; Khan, AH; Munavvar, AS; NurJannah, MH; Raisa, NA; Rathore, HA; Salman, IM | 1 |
| Chen, P; Jia, ZQ; Li, BH; Liu, YN; Ma, KT; Zhang, CG; Zhang, H; Zhou, CY | 1 |
| Cook, MA; Freeman, DJ; Gan, XT; Karmazyn, M; Pang, T | 1 |
| Lu, YJ; Mei, DH; Pan, ZW; Wang, JH; Xu, CQ; Yang, BF; Zhang, R; Zhang, XY; Zhang, Y | 1 |
| Kerkelä, R; Ola, A; Pikkarainen, S; Ruskoaho, H; Skoumal, R; Tokola, H; Vuolteenaho, O | 1 |
| Backx, P; Clement, S; Dziak, E; Kabir, G; Opas, M; Papp, S | 1 |
| Cook, MA; Karmazyn, M; Pang, T; Rajapurohitam, V | 1 |
| Cha, H; Choi, BY; Hajjar, RJ; Jang, SP; Jeong, D; Jeong, MH; Kim, J; Lee, MA; Park, WJ; Yang, DK; Yoon, PO | 1 |
| Jing, Q; Li, DF; Li, Q; Lin, L; Qin, YW; Ren, AJ; Song, XW; Wang, GK; Wang, XC; Wang, YR; Yuan, WJ | 1 |
| Jing, Q; Kremneva, E; Lappalainen, P; Li, Q; Li, XQ; Qin, YW; Song, XW; Sun, T; Wang, GK; Yuan, WJ; Zhu, N; Zou, J | 1 |
| Chen, BL; Dong, YG; Liu, C; Ma, YD; Meng, RS; Wang, HN; Xiong, ZJ; Zeng, JY | 1 |
| Dong, D; Jiang, N; Kang, YJ; Xie, H; Zhu, H; Zuo, X | 1 |
| Hu, X; Jia, Z; Li, T; Liu, Y; Ma, K; Wang, W; Xu, M; Zhang, C; Zhang, Y; Zhou, C | 1 |
| Ali, NN; Földes, G; Gorelik, J; Harding, SE; Liu, AQ; Merkely, B; Mioulane, M; Novak, P; Schneider, MD; Wright, JS | 1 |
| Cooley, N; Filtz, TM; Grubb, DR; Iliades, P; Luo, J; Woodcock, EA; Yu, YL | 1 |
| Didié, M; Dullin, C; Grau, SP; Grebe, C; Hasenfuss, G; Jacobshagen, C; Klingebiel, TM; Seidler, T; Toischer, K | 1 |
| Battiprolu, PK; Cao, DJ; Gillette, TG; Hill, JA; Jiang, N; Kong, Y; Morales, CR; Rothermel, BA; Wang, ZV | 1 |
| Nassi, PA; Passariello, CL; Pignatti, C; Stefanelli, C; Zini, M | 1 |
| Jing, Q; Li, Q; Qin, YW; Song, XW; Wang, GK; Xu, XD | 1 |
| Aronow, BJ; Elrod, JW; Molkentin, JD; Pu, WT; van Berlo, JH | 1 |
| Chen, C; Li, Y; Li, Z; Liao, W; Lu, Z; Ma, X; Song, Y; Zhang, H; Zhang, Y | 1 |
| Cai, YB; Gong, KZ; Li, Z; Liu, N | 1 |
| Acton, ST; Bass, GT; Dang, ST; Katikapalli, A; Ryall, KA; Saucerman, JJ; Taylor, BE | 1 |
| de Boer, RA; Lu, B; Ruifrok, WP; Silljé, HH; Tigchelaar, W; van Gilst, WH | 1 |
| Brainard, RE; Facundo, HT; Hamid, T; Jones, SP; Ngoh, GA; Prabhu, SD; Watson, LJ | 1 |
| El-Armouche, A; Lutz, S; Vettel, C; Vogt, A; Wieland, T; Wittig, K; Wuertz, CM | 1 |
| Ryall, KA; Saucerman, JJ | 1 |
| de Morais Gomes, ER; Gros, R; Guatimosim, C; Guatimosim, S; Ladeira, MS; Lara, A; Prado, MA; Prado, VF; Resende, R; Rocha-Resende, C; Roy, A | 1 |
| Basu, R; Das, SK; Kassiri, Z; Lopaschuk, GD; McLean, BA; Mori, J; Oudit, GY; Patel, VB; Wagg, CS; Zhang, L | 1 |
| Anestopoulos, I; Kavo, A; Kortsaris, A; Lazou, A; Panayiotidis, M; Pappa, A; Tentes, I | 1 |
| Gao, E; Gold, JI; Koch, WJ; Premont, RT; Shang, X | 1 |
| Abreu, GR; Balarini, CM; Cabral, AM; Gava, AL; Meyrelles, SS; Peotta, VA; Vasquez, EC | 1 |
| Askar, SF; Atsma, DE; Bingen, BO; de Vries, AA; Pijnappels, DA; Schalij, MJ; Schutte, CI; Swildens, J; Ypey, DL; Zeppenfeld, K | 1 |
| Brown, BF; Casey, JR; Dyck, JR; Quon, A | 1 |
| Gao, X; Jia, C; Li, Y; Ma, X; Song, Y; Xie, X; Xu, J; Zhang, L; Zhang, Y; Zhu, D | 1 |
| Ago, T; Kuroda, J; Matsushima, S; Park, JY; Sadoshima, J; Tian, B; Xie, LH; Zhai, P | 1 |
| Hori, YS; Horio, Y; Hosoda, R; Kuno, A; Miura, T; Shimamoto, K; Tanno, M | 1 |
| Barreiro, EJ; do Nascimento, JH; Ferraz, EB; Fraga, CA; Kummerle, AE; Pereira, SL; Rocha, Nde N; Sudo, RT; Zapata-Sudo, G | 1 |
| Adachi, S; Hayashida, K; Ikeda, MA; Ito, H; Kawauchi, J; Kitajima, S; Nobori, K; Tamamori-Adachi, M | 1 |
| Granberry, MC; Kennedy, RH; Liu, H; Melchert, RB | 1 |
| Backx, PH; Kassiri, Z; Meng, Y; Nguyen, TT; Zobel, C | 1 |
| Proud, CG; Wang, L | 1 |
| Eckhart, AD; Greene, EA; Keys, JR; Koch, WJ | 1 |
| Adcock, IM; Gusterson, RJ; Jazrawi, E; Latchman, DS | 1 |
| Kawahara, Y; Maki, T; Takeo, S; Tanonaka, K; Yagi, A | 1 |
| Altruda, F; Brancaccio, M; De Acetis, M; Fratta, L; Guazzone, S; Hirsch, E; Lembo, G; Marino, G; Notte, A; Poulet, R; Silengo, L; Tarone, G; Vecchione, C | 1 |
| Barron, AJ; Finn, SG; Fuller, SJ | 1 |
| Chun, JS; Kim, DJ; Kim, JK; Lim, CS; Park, SH; Song, WK | 1 |
| Busk, PK; Enevoldsen, M; Haunsø, S; Sheikh, SP; Strøm, CC; Thirstrup, K; Wulf-Andersen, L | 1 |
| Kajimoto, K; Molina, CA; Nazmy, M; Sadoshima, J; Tomita, H; Yehia, G | 1 |
| Ahn, Y; Cook, SA; Matsui, T; Novikov, MS; Rosenzweig, A | 1 |
| GAQUIERE, A | 1 |
| Pollack, JR; Sugimoto, JT; Witt, RC | 1 |
| Cokkinos, D; Karageorgiou, C; Kostopanagiotou, G; Mourouzis, C; Mourouzis, I; Pantos, C; Saranteas, T; Tesseromatis, C; Varonos, D | 1 |
| Best, P; Helmig, S; Piper, HM; Schlüter, KD; Taimor, G | 1 |
| Cupesi, M; Gannon, J; Huang, H; Lee, RT; MacGillivray, C; Schulze, PC; Sylvan, JD; Yoshioka, J | 1 |
| Asahi, M; Higuchi, Y; Hikoso, S; Hirotani, S; Hori, M; Kashiwase, K; Matsumura, Y; Nakayama, H; Nishida, K; Otsu, K; Sasaki, T; Takeda, T; Taniike, M; Tsujimoto, I; Watanabe, T; Yamaguchi, O | 1 |
| Kovacs, R; Shaikh, SR; Siddiqui, RA; Stillwell, W; Zaloga, G | 1 |
| Asakura, M; Asano, Y; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Kitamura, S; Liao, Y; Minamino, T; Ogai, A; Sanada, S; Shintani, Y; Takashima, S; Tomoike, H | 1 |
| Akhter, SA; Bodi, I; Koch, SE; Petrashevskaya, NN; Schwartz, A | 1 |
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| Iwata, Y; Katanosaka, Y; Kobayashi, Y; Shibasaki, F; Shigekawa, M; Wakabayashi, S | 1 |
| Arya, R; Hwang, JR; Kedar, V; Li, HH; McDonough, H; Patterson, C; Taylor, J | 1 |
| Jové, M; Laguna, JC; Michalik, L; Planavila, A; Rodríguez-Calvo, R; Vázquez-Carrera, M; Wahli, W | 1 |
| Bergamaschi, CT; Beutel, A; Campos, RR | 1 |
| Dautreaux, B; Henry, JP; Isabelle, M; Monteil, C; Moritz, F; Mulder, P; Richard, V; Thuillez, C | 1 |
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| Chin, MT; Cui, L; Liao, JK; Liao, R; Nakagami, H; Sakata, Y; Xiang, F; Youngblood, JM | 1 |
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| Cokkinos, DV; Dimopoulos, A; Kokkinos, AD; Kostopanagiotou, G; Markakis, K; Mourouzis, I; Panagiotou, M; Pantos, C; Saranteas, T; Xinaris, C | 1 |
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| Arimoto, T; Bilim, O; Goto, K; Ishino, M; Kitahara, T; Kubota, I; Nakajima, O; Niizeki, T; Sasaki, T; Suzuki, S; Takeishi, Y; Walsh, RA | 1 |
| Jiang, Y; Kang, YJ; Zhou, Y | 1 |
| Cassiola, F; Dallabrida, SM; Dickie, R; Durand, EM; Ismail, NS; Lai, J; Parodi, EM; Pravda, EA; Rogers, RA; Rupnick, MA | 1 |
| Harri, M; Kuusela, P | 1 |
| Hirshfeld, JW; Laskey, WK; Reichek, N; St John Sutton, M; Untereker, WJ | 2 |
| Ross, J | 1 |
| Burke, W; DePace, NL; Glazier, EE; Kotler, MN | 1 |
| Hartogensis, WE; Long, CS; Simpson, PC | 1 |
| Chien, KR; Evans, RM; Sucov, HM; Zhou, MD | 1 |
| Itoh, H; Kishimoto, I; Komatsu, Y; Nakagawa, O; Nakao, K; Nishino, K; Ogawa, Y; Suga, S; Yoshimasa, T | 1 |
| Chiesi, M; Grueninger, S; Lesniak, W; Schaefer, C | 1 |
| Alali, A; Higashiyama, S; Kelly, RA; Mäki, T; Perrella, MA; Pimental, D; Prasad, S; Singh, K; Takahashi, N; Yoshizumi, M | 1 |
| McMahon, M; Thorburn, A; Thorburn, J | 1 |
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| Mertens, MJ; Pfaffendorf, M; van Zwieten, PA | 1 |
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| Absher, D; Brown, JH; Chien, KR; Feramisco, JR; Knowlton, KU; LaMorte, VJ; Spiegel, A; Thorburn, J | 1 |
| Bogoyevitch, MA; Glennon, PE; Sugden, PH | 1 |
| Chen, SY; Chien, KR; Feramisco, JR; Powers, S; Shubeita, HE; Thorburn, A; Thorburn, J | 1 |
| Bell, D; McDermott, BJ; Piper, HM; Schlüter, KD; Zhou, XJ | 1 |
| Brown, JH; Glembotski, CC; Goldstein, D; Post, GR; Thuerauf, DJ | 1 |
| Boluyt, MO; Crow, MT; Lakatta, EG; Long, X; O'Neill, L; Zheng, JS | 1 |
| Fuller, SJ; Glennon, PE; Kaddoura, S; Sale, EM; Sale, GJ; Sugden, PH | 1 |
| Hannan, RD; Moss, T; Rothblum, LI; Stefanovsky, V; Taylor, L | 1 |
| Bunting, S; Cheng, J; Jin, H; King, KL; Ko, A; Lai, J; Li, W; Paoni, NF; Winer, J; Yang, R; Yen, R; Zeigler, F | 1 |
| Aikawa, R; Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Yamazaki, T; Yazaki, Y; Zou, Y | 1 |
| Thorburn, A; Thorburn, J; Xu, S | 1 |
| Bezstarosti, K; Dekkers, DH; Eskildsen-Helmond, YE; Lamers, JM; van Heugten, HA | 1 |
| Glembotski, CC; Hanford, DS; McDonough, PM; Thuerauf, DJ; Zechner, D | 1 |
| Fukuzawa, A; Ikeda, T; Ishigai, Y; Mori, T; Shibano, T | 1 |
| Brosnan, MJ; Devlin, AM; Dominiczak, AF; Graham, D; Hamilton, CA; McIntyre, M; McPhaden, AR; Morton, JJ; Reid, JL | 1 |
| Berecek, KH; Bishop, SP; Gelband, CH; Katovich, MJ; Lu, D; Martens, JR; Raizada, MK; Reaves, PY | 1 |
| Arnott, D; King, KL; O'Connell, KL; Stults, JT | 1 |
| de Jong, YF; Jans, SW; Reutelingsperger, CP; van Bilsen, M; van der Vusse, GJ | 1 |
| Antos, CL; Grant, SR; Lu, JR; Markham, B; Molkentin, JD; Olson, EN; Richardson, J; Robbins, J | 1 |
| Lin, A; Nemoto, S; Sheng, Z | 1 |
| Balser, C; Piper, HM; Schäfer, M; Schlüter, KD; Taimor, G | 1 |
| Fenczik, C; Ginsberg, MH; Glembotski, CC; Goldhaber, JI; Loftus, JC; Pham, C; Ross, RS; Shai, SY | 1 |
| Chemtob, S; Deng, XF; Li, JF; Mulay, S; Peri, KG; Sculptoreanu, A; Varma, DR; Zheng, WH | 1 |
| Clerk, A; Michael, A; Sugden, PH | 1 |
| Gaughan, JP; Hefner, CA; Houser, SR | 1 |
| Guo, W; Hojo, M; Kamiya, K; Kodama, I; Toyama, J | 1 |
| Blazina, DR; Bruder, JT; Finkel, T; Goldshmidt-Clermont, PJ; Hegland, DD; Irani, K; Kim, KS; Kovesdi, I; Lee, L; Pracyk, JB; Rovira, II; Sethi, R; Tanaka, K | 1 |
| Abdellatif, M; Charng, MJ; Michael, LH; Packer, SE; Schneider, MD; Zhang, D | 1 |
| King, KL; Mather, JP; Phillips, DM; Quach, J; Williams, PM; Winer, J | 1 |
| Goldberg, Y; Piper, HM; Schäfer, M; Schlüter, KD; Taimor, G | 1 |
| Blumer, KJ; Muslin, AJ; Tamirisa, P | 1 |
| Dolber, PC; Iaccarino, G; Koch, WJ; Lefkowitz, RJ | 1 |
| Montessuit, C; Thorburn, A | 1 |
| Hama, J; Hidaka, H; Horiuchi, M; Ishikawa, K; Kamoi, K; Katori, R; Kondo, H; Kurroka, A; Shimada, S; Watanabe, M; Yamamoto, Y | 1 |
| Piper, HM; Schäfer, M; Schlüter, KD; Simm, A; Taimor, G | 1 |
| Gorenc, T; Hershberger, RE; Roberts, CT; Silberbach, M; Steyger, PS; Stork, PJ | 1 |
| Alpert, L; Chalifour, LE; Saadane, N | 2 |
| Horio, T; Kangawa, K; Matsuo, H; Nishikimi, T; Takishita, S; Yoshihara, F | 1 |
| Gardon, ML; Gelband, CH; Goldberg, DS; Katovich, MJ; Keene, K; Raizada, MK; Reaves, PY; Wang, H | 1 |
| Aoki, H; Izumo, S; Sadoshima, J | 1 |
| De Windt, LJ; Lim, HW; Molkentin, JD; Taigen, T | 1 |
| Aoki, H; Izumo, S; Richmond, M; Sadoshima, J | 1 |
| Parsons, JT; Rovin, JD; Taylor, JM | 1 |
| Clerk, A; Sugden, PH | 2 |
| Babu, GJ; Lalli, MJ; Periasamy, M; Sadoshima, J; Sussman, MA | 1 |
| Gu, JL; Kreutz, R; Lee, JC; Maleeff, B; Mirabile, RC; Ohlstein, EH; Parsons, AA; Reith, AD; Wang, C; Wang, Y; Yue, TL | 1 |
| Alessandrini, A; Choukroun, G; Force, T; Hajjar, R; Haq, S; Kang, ZB; Matsui, T; Michael, A; Molkentin, JD; Ranu, H; Rosenzweig, A; Woodgett, J | 1 |
| Harpf, AE; Keller, RS; Loftus, JC; Pham, CG; Ross, RS; Shai, SY; Vu, HT | 1 |
| Bueno, OF; De Windt, LJ; Kimball, TR; Lim, HW; Molkentin, JD; Tymitz, KM; Witt, SA | 1 |
| Chalothorn, D; Daly, CJ; Deighan, C; Gaivin, RJ; Hellard, D; McGee, A; McGrath, JC; Morehead, AJ; Perez, DM; Piascik, MT; Plow, EF; Ross, SA; Thomas, JD; Waugh, DJ; Zuscik, MJ | 1 |
| Han, J; Lim, HW; Molkentin, JD; New, L | 1 |
| DiDonato, JA; Lin, A; Mercurio, F; Purcell, NH; Tang, G; Yu, C | 1 |
| Autelitano, DJ; Ridings, R; Tang, F | 1 |
| Iaccarino, G; Keys, JR; Koch, WJ; Lefkowitz, RJ; Rapacciuolo, A; Rockman, HA; Shotwell, KF | 1 |
| Dickens, M; Finn, SG; Fuller, SJ | 1 |
| Asimakopoulos, P; Carageorgiou, H; Cokkinos, DD; Cokkinos, DV; Giannakakis, S; Malliopoulou, V; Mourouzis, I; Pantos, CI; Tzeis, SM; Tzilalis, V; Varonos, DD | 1 |
| Berrebi-Bertrand, I; Bril, A; Laville, MP; Livi, GP; Robert, P; Sarau, HM; Tsui, P | 1 |
| Aoyagi, T; Baxter, JD; Bristow, MR; Camacho, SA; Eto, Y; Kinugawa, K; Long, CS; Ribeiro, RC; Simpson, PC; Yonekura, K | 1 |
| Ikeda, U; Lee, RT; Ohki, R; Shimada, K; Yamamoto, K | 1 |
| Bedell, KA; Dalshaug, GB; Scholz, TD; Segar, JL; Smith, OM | 1 |
| Eskelinen, S; Luodonpää, M; Ruskoaho, H; Vuolteenaho, O | 1 |
| Asakura, M; Asanuma, H; Beppu, S; Higashiyama, S; Hori, M; Ishiguro, H; Ishikura, F; Kitakaze, M; Liao, Y; Matsumura, Y; Node, K; Ohmoto, H; Sanada, S; Tada, M; Takashima, S; Takeda, H; Yoshinaka, T; Yoshino, K | 1 |
| Iwao, H; Kim, S; Nakamura, Y; Omura, T; Takeuchi, K; Yoshida, K; Yoshikawa, J; Yoshiyama, M | 1 |
| Piper, M; Ruf, S; Schlüter, KD | 1 |
| Force, T; Haq, S; Kilter, H; Michael, A | 1 |
| Higuchi, Y; Hirotani, S; Hori, M; Mano, T; Matsumura, Y; Morita, T; Nakayama, H; Nishida, K; Otsu, K; Tada, M; Ueno, H; Yamaguchi, O | 1 |
| Eskelinen, S; Kerkelä, R; Majalahti-Palviainen, T; Pikkarainen, S; Pöntinen, J; Ruskoaho, H; Tokola, H; Vuolteenaho, O | 1 |
| Agabiti-Rosei, E; Cotecchia, S; Frati, G; Fratta, L; Guelfi, D; Lembo, G; Mulvany, MJ; Notte, A; Porteri, E; Poulet, R; Rizzoni, D; Trimarco, B; Trimarco, V; Vecchione, C | 1 |
| Inchiosa, MA; Pagano, VT | 1 |
| Bhatnagar, RK; Lund, DD; McNamara, RF; Schmid, PG; Schmidt, JA | 1 |
| Horwitz, LD; Leshin, SJ; Mitchell, JH | 1 |
| Franklin, D; Kemper, WS; McKown, D; Ross, J; Sasayama, S | 1 |
| Brown, L; Fletcher, P; Newling, R; Sernia, C | 1 |
| Anversa, P; Gewitz, M; Hintze, TH; Loud, AV; Ochoa, M; Patel, MB; Stewart, JM; Wang, J | 1 |
| Foster, KA; Hock, CE; Reibel, DK | 1 |
| Anversa, P; Fiegel, L; Hintze, TH; Loud, AV; Patel, MB; Stewart, JM; Wang, J | 1 |
| Beuckelmann, D; Böhm, M; Diet, F; Erdmann, E; Feiler, G; Lohse, MJ | 1 |
| Condorelli, M; Cuocolo, A; De Luca, N; De Simone, A; Mele, AF; Ricciardelli, B; Trimarco, B; Volpe, M | 1 |
| Fouad, FM; Hanna, MM; Khairallah, PA; Shimamatsu, K; Tarazi, RC | 1 |
| Böhm, M; Mende, U; Schmitz, W; Scholz, H | 1 |
| Braunwald, E; Eckberg, DL; Higgins, CB; Vatner, SF | 1 |
| Amari, J; Gupta, S; Lauterstein, J; Oran, E; Piccone, VA; Potter, R; Yeo, B | 1 |
3 review(s) available for phenylephrine and Cardiomegaly
| Article | Year |
|---|---|
PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes.
Topics: Arachidonic Acid; Cardiomegaly; Cardiotonic Agents; Enzyme Activation; Gene Expression; Humans; Isoproterenol; Mitochondria, Heart; Muscle Proteins; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Phenylephrine; Protein Kinase C-epsilon; Sarcomeres; Substrate Specificity | 2016 |
Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists.
Topics: Adrenergic alpha-Agonists; Cardiomegaly; Endothelin-1; GTP-Binding Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Myocardium; Phenylephrine; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcription, Genetic | 1999 |
Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists.
Topics: Adrenergic alpha-Agonists; Animals; Cardiomegaly; Endothelin-1; Heart; Humans; Monomeric GTP-Binding Proteins; Myocardium; Phenylephrine; Protein Binding; ras Proteins; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 2000 |
303 other study(ies) available for phenylephrine and Cardiomegaly
| Article | Year |
|---|---|
Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice.
Topics: Adenosine Triphosphate; Animals; Anthelmintics; Cardiomegaly; Cell Line; Collagen; Disease Models, Animal; Enalapril; Fibroblasts; Heart Failure; Humans; Interleukin-6; Macrophages; Male; Mice; Mitochondria; Myocytes, Cardiac; Niclosamide; Phenylephrine; Proto-Oncogene Proteins c-bcl-2; Rats; STAT3 Transcription Factor; Survivin | 2021 |
JNK signaling-dependent regulation of histone acetylation are involved in anacardic acid alleviates cardiomyocyte hypertrophy induced by phenylephrine.
Topics: Acetylation; Anacardic Acids; Animals; Anthracenes; Cardiomegaly; China; Disease Models, Animal; Female; Histone Acetyltransferases; Histones; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; p300-CBP Transcription Factors; Phenylephrine; Primary Cell Culture; Signal Transduction | 2021 |
Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway.
Topics: Acrolein; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; MAP Kinase Signaling System; Mice; Myocytes, Cardiac; Phenylephrine; Rats; Ryanodine Receptor Calcium Release Channel | 2022 |
The Regulatory Mechanism and Effect of Receptor-Interacting Protein Kinase 3 on Phenylephrine-Induced Cardiomyocyte Hypertrophy.
Topics: Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Humans; Myocytes, Cardiac; Phenylephrine; Reactive Oxygen Species | 2022 |
Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Cycloheximide; Limonins; Mice; Myocytes, Cardiac; Phenylephrine; Rats; RNA, Small Interfering; Sirtuins; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases | 2022 |
Can Blebbistatin block the hypertrophy status in the zebrafish ex vivo cardiac model?
Topics: Animals; Cardiomegaly; Heterocyclic Compounds, 4 or More Rings; Humans; Pericardium; Phenylephrine; Zebrafish | 2022 |
Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.
Topics: AMP-Activated Protein Kinases; Animals; Cardiomegaly; Carrier Proteins; Endoplasmic Reticulum; Male; Mice; Mice, Inbred C57BL; Mitochondria; Myocytes, Cardiac; Phenylephrine; TRPV Cation Channels | 2022 |
LincRNA RMRP Regulates Phenylephrine-induced Cardiomyocyte Hypertrophy by Means of Targeting miR-1.
Topics: Cardiomegaly; Cardiotonic Agents; Humans; Luciferases; MicroRNAs; Myocytes, Cardiac; Phenylephrine; RNA, Long Noncoding | 2022 |
Auraptene, a citrus peel-derived natural product, prevents myocardial infarction-induced heart failure by activating PPARα in rats.
Topics: Animals; Atrial Natriuretic Factor; Biological Products; Cardiomegaly; Citrus; Coumarins; Endothelin-1; Fibrosis; Heart Failure; Myocardial Infarction; Peroxisome Proliferators; Phenylephrine; PPAR alpha; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2022 |
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.
Topics: Animals; Cardiomegaly; Female; Fibrosis; Hypertension; Male; Mice; Myocytes, Cardiac; Phenylephrine; Proto-Oncogene Proteins B-raf; Tamoxifen | 2022 |
Dose-dependent Effects of PRC2 and HDAC Inhibitors on Cardiomyocyte Hypertrophy Induced by Phenylephrine.
Topics: Animals; Cardiomegaly; Histone Deacetylase Inhibitors; Histones; Myocytes, Cardiac; Natriuretic Peptides; Phenylephrine; Rats | 2023 |
CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling.
Topics: Angiotensin II; Animals; Cardiomegaly; Chemokines; Gene Knockout Techniques; Heart; MARVEL Domain-Containing Proteins; Mice; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Rats; Up-Regulation | 2023 |
Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Topics: Animals; Animals, Newborn; Cardiomegaly; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Phenylephrine; Proto-Oncogene Proteins c-akt; Rats; Tripartite Motif Proteins | 2023 |
DEF6(differentially exprehomolog) exacerbates pathological cardiac hypertrophy via RAC1.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Heart Failure; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phenylephrine; Signal Transduction | 2023 |
TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway.
Topics: Animals; Cardiomegaly; Heart Failure; Mice; Phenylephrine; Proto-Oncogene Proteins c-akt; Rats; TNF Receptor-Associated Factor 4 | 2023 |
Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction.
Topics: Animals; Cardiomegaly; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; Microtubules; Mitochondria, Heart; Mitochondrial Proteins; Myocytes, Cardiac; Phenylephrine; Proteolysis; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2019 |
High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3.
Topics: Acetylation; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Isoflavones; Isoproterenol; Male; Mice, Inbred C57BL; Mitochondria, Heart; Myocytes, Cardiac; Phenylephrine; Rats; Sirtuin 3 | 2020 |
SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity.
Topics: Acetylation; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cardiotonic Agents; Cell Line; Isoproterenol; Male; Mitochondria; Myocytes, Cardiac; Natriuretic Peptide, Brain; Phenylephrine; Poly (ADP-Ribose) Polymerase-1; Rats; Rats, Sprague-Dawley; Sirtuin 3 | 2020 |
Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Cardiomegaly; Gene Expression Regulation; Heart Ventricles; Mitochondrial Dynamics; Mitochondrial Proteins; Myocytes, Cardiac; Phenylephrine; Rats, Sprague-Dawley; rho GTP-Binding Proteins; RNA, Messenger | 2020 |
Are microRNAs responsible for cardiac hypertrophy in fish and mammals? What we can learn in the activation process in a zebrafish ex vivo model.
Topics: Animals; Cardiomegaly; Disease Models, Animal; HSP70 Heat-Shock Proteins; Hypertrophy; Mammals; MicroRNAs; Pericardium; Phenylephrine; Zebrafish | 2020 |
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Topics: Angiotensin II; Animals; Animals, Newborn; Aortic Valve Stenosis; Cardiomegaly; CRISPR-Cas Systems; Disease Models, Animal; Endopeptidases; Fibrosis; Inflammation; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phenylephrine; Pressure; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Ubiquitin-Protein Ligases; Ventricular Remodeling | 2020 |
G6PD, bond by miR-24, regulates mitochondrial dysfunction and oxidative stress in phenylephrine-induced hypertrophic cardiomyocytes.
Topics: Cardiomegaly; Cardiotonic Agents; Glucosephosphate Dehydrogenase; Humans; Membrane Potential, Mitochondrial; MicroRNAs; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Phenylephrine | 2020 |
6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway.
Topics: Animals; Anti-Inflammatory Agents; Cardiomegaly; Cardiotonic Agents; Catechols; Fatty Alcohols; Fibroblasts; Fibrosis; Inflammation; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Rats, Sprague-Dawley; Transforming Growth Factor beta; Ventricular Remodeling | 2021 |
Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling.
Topics: Angiotensins; Animals; Aorta; Cardiomegaly; Carrier Proteins; Cells, Cultured; Constriction; Extracellular Matrix Proteins; Female; Glycoproteins; Humans; Integrins; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Paracrine Communication; Phenylephrine; Rats; Stress, Physiological; Transforming Growth Factor beta; Ventricular Remodeling | 2021 |
Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF-κB signaling in pressure overload-induced rats.
Topics: Animals; Animals, Newborn; Aorta, Abdominal; Cardiomegaly; Constriction, Pathologic; Disease Models, Animal; Fibrosis; Inflammation; Isoproterenol; Lignans; Male; Myocytes, Cardiac; NF-kappa B; Phenylephrine; Pressure; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases; Ventricular Remodeling | 2021 |
Metabolic Interventions to Prevent Hypertrophy-Induced Alterations in Contractile Properties In Vitro.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Energy Metabolism; Glucose; Muscle Contraction; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Rats; Signal Transduction | 2021 |
Mitochondrial Disruption Is Involved in the Effect of Nuclear Factor of Activated T cells, Cytoplasmic 4 on Aggravating Cardiomyocyte Hypertrophy.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Acetylation; Adrenergic alpha-1 Receptor Agonists; Animals; Cardiomegaly; Cell Line; Gene Expression Regulation; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; Nerve Tissue Proteins; NFATC Transcription Factors; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenylephrine; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2021 |
Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Aorta; Cardiomegaly; Cell Survival; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Organ Size; Phenylephrine; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction | 2022 |
PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Gene Knockdown Techniques; Humans; Male; MAP Kinase Signaling System; Myocytes, Cardiac; Oxidation-Reduction; Peroxisome-Targeting Signal 1 Receptor; Phenylephrine; Primary Cell Culture; Rats; Reactive Oxygen Species; STAT3 Transcription Factor | 2021 |
Interactions between the ERK1/2 signaling pathway and PCAF play a key role in PE‑induced cardiomyocyte hypertrophy.
Topics: Acetylation; Anacardic Acids; Animals; Butadienes; Cardiomegaly; Cell Survival; Disease Models, Animal; Female; Histone Acetyltransferases; Histones; Male; MAP Kinase Signaling System; MEF2 Transcription Factors; Mice; Myocytes, Cardiac; Nitriles; p300-CBP Transcription Factors; Phenylephrine; Signal Transduction | 2021 |
Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes.
Topics: Acetylation; Adrenergic alpha-1 Receptor Agonists; Animals; Cardiomegaly; Cells, Cultured; E1A-Associated p300 Protein; Heart Failure; Histone Acetyltransferases; Metformin; Myocytes, Cardiac; Phenylephrine; Rats, Sprague-Dawley | 2021 |
Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors.
Topics: Animals; Animals, Newborn; Cardiomegaly; Endothelin-1; Gene Expression Regulation; HEK293 Cells; Humans; Male; Myocytes, Cardiac; Phenylephrine; Protein Kinase Inhibitors; Rats, Wistar; Receptor, Endothelin A; RNA, Messenger; Signal Transduction; Transcription, Genetic; Up-Regulation | 2017 |
Caffeic acid phenethyl ester attenuates pathological cardiac hypertrophy by regulation of MEK/ERK signaling pathway in vivo and vitro.
Topics: Animals; Blotting, Western; Caffeic Acids; Cardiomegaly; Cell Line; Disease Models, Animal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Phenylephrine; Phenylethyl Alcohol; Polymerase Chain Reaction; Rats; Resveratrol; Smad Proteins; Stilbenes; Transforming Growth Factor beta | 2017 |
Sestrin 2 attenuates neonatal rat cardiomyocyte hypertrophy induced by phenylephrine via inhibiting ERK1/2.
Topics: Animals; Animals, Newborn; Cardiomegaly; MAP Kinase Signaling System; Myocytes, Cardiac; Nuclear Proteins; Phenylephrine; Rats; Rats, Sprague-Dawley | 2017 |
Nobiletin, a Polymethoxy Flavonoid, Protects Against Cardiac Hypertrophy Induced by Pressure-Overload via Inhibition of NAPDH Oxidases and Endoplasmic Reticulum Stress.
Topics: Animals; Antioxidants; Aorta; Body Weight; Cardiomegaly; Cardiotonic Agents; Disease Progression; Drug Administration Schedule; Endoplasmic Reticulum Stress; Flavones; Gene Expression; Heart; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Organ Size; Oxidative Stress; Phenylephrine; Primary Cell Culture | 2017 |
Upregulation of α-enolase protects cardiomyocytes from phenylephrine-induced hypertrophy.
Topics: Animals; Animals, Newborn; Aorta, Abdominal; Biocatalysis; Cardiomegaly; Constriction, Pathologic; Cytoprotection; GATA4 Transcription Factor; Gene Knockdown Techniques; Gene Silencing; Male; Myocytes, Cardiac; Phenylephrine; Phosphopyruvate Hydratase; Rats, Sprague-Dawley; Up-Regulation | 2018 |
DJ-1 activates autophagy in the repression of cardiac hypertrophy.
Topics: Animals; Autophagy; Cardiomegaly; Gene Expression Regulation; Lung; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiprotein Complexes; Myocardium; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Primary Cell Culture; Protein Deglycase DJ-1; Pulmonary Edema; Rats, Sprague-Dawley; Severity of Illness Index; TOR Serine-Threonine Kinases; Vasoconstrictor Agents | 2017 |
Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure.
Topics: Animals; Apoptosis; Calcineurin; Cardiomegaly; Cell Line; Cyclic AMP-Dependent Protein Kinases; Growth Hormone-Releasing Hormone; Heart; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Phenylephrine; Phospholipase C beta; Protein Kinase C; Rats; Signal Transduction | 2017 |
SOX2-mediated inhibition of miR-223 contributes to STIM1 activation in phenylephrine-induced hypertrophic cardiomyocytes.
Topics: Animals; Cardiomegaly; Cells, Cultured; MicroRNAs; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; SOXB1 Transcription Factors; Stromal Interaction Molecule 1 | 2018 |
Upregulation of eIF6 inhibits cardiac hypertrophy induced by phenylephrine.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cell Size; Cells, Cultured; Eukaryotic Initiation Factors; Muscle Cells; Phenylephrine; Rats; Up-Regulation | 2018 |
Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway.
Topics: Angiotensin II; Animals; Aorta; Cardiomegaly; Constriction, Pathologic; Gene Knockdown Techniques; Male; Myocytes, Cardiac; NF-kappa B; Phenylephrine; Phosphorylation; Pressure; Protein Kinase C; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor RelA; Transcription, Genetic; Triterpenes | 2018 |
Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.
Topics: Animals; Aorta; Cardiomegaly; Cells, Cultured; Constriction, Pathologic; Electrocardiography; Hemodynamics; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lysophospholipids; Male; Mice, Inbred C57BL; Models, Biological; Phenylephrine; Rats; Receptors, Lysosphingolipid; RNA, Small Interfering; Sphingosine; Up-Regulation | 2018 |
The role of angiopoietin-like protein 4 in phenylephrine-induced cardiomyocyte hypertrophy.
Topics: Angiopoietin-1; Angiopoietin-Like Protein 4; Animals; Animals, Newborn; Cardiomegaly; Disease Models, Animal; Fatty Acids; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase 8; Myocytes, Cardiac; Oxidation-Reduction; Phenylephrine; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Surface Properties | 2019 |
The Involvement of Cytochrome c Oxidase in Mitochondrial Fusion in Primary Cultures of Neonatal Rat Cardiomyocytes.
Topics: Animals; Cardiomegaly; Cation Transport Proteins; Cells, Cultured; Copper Sulfate; Copper Transport Proteins; Electron Transport Complex IV; Mitochondria, Heart; Mitochondrial Dynamics; Myocytes, Cardiac; Phenylephrine; Primary Cell Culture; Rats, Sprague-Dawley; Signal Transduction | 2018 |
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
Topics: Animals; Cardiomegaly; Cell Nucleus; Gene Expression Regulation; Janus Kinase 2; Male; Myocardium; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Pressure; Protein Binding; Rats, Sprague-Dawley; STAT3 Transcription Factor; Transcription, Genetic | 2018 |
Engineering an in vitro organotypic model for studying cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium; Cardiomegaly; Connectin; Gene Expression; Heart; Models, Biological; Myocytes, Cardiac; Phenylephrine; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Rats, Wistar; Silicon; Surface Properties; Tissue Engineering; Tissue Scaffolds; Ultraviolet Rays | 2018 |
PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy
Topics: Animals; Animals, Newborn; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; G-Protein-Coupled Receptor Kinase 5; Gene Expression Regulation; In Vitro Techniques; Myocytes, Cardiac; Phenylephrine; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley | 2018 |
N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Cardiomegaly; Energy Metabolism; Lipid Droplets; Mitochondria, Heart; Myocytes, Cardiac; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenylephrine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2018 |
PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
Topics: Active Transport, Cell Nucleus; Angiotensin II; Animals; Cardiomegaly; Cell Nucleus; HMGB1 Protein; Isoproterenol; Male; Myocytes, Cardiac; Phenylephrine; Poly (ADP-Ribose) Polymerase-1; Rats, Sprague-Dawley | 2019 |
Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Benzamides; Cardiomegaly; Fibronectins; Heart Failure; Humans; Mice; Mice, Transgenic; Myocytes, Cardiac; Phenylephrine; Pressure; Pyrimidines; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro.
Topics: AMP-Activated Protein Kinases; Animals; Cardiomegaly; Epimedium; Flavonoids; Hypertrophy; Mechanistic Target of Rapamycin Complex 1; Myocytes, Cardiac; Phenylephrine; Rats, Sprague-Dawley; Signal Transduction; Ventricular Remodeling | 2018 |
The long noncoding RNA XIST protects cardiomyocyte hypertrophy by targeting miR-330-3p.
Topics: Animals; Cardiomegaly; Disease Progression; Mice; MicroRNAs; Myocytes, Cardiac; Phenylephrine; Protective Agents; RNA, Long Noncoding; S100 Calcium Binding Protein beta Subunit | 2018 |
Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress.
Topics: Acetylcysteine; Animals; Cardiomegaly; Drug Synergism; Enzymes; Flavonoids; Flavonols; Gene Expression Regulation; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Phenylephrine; TOR Serine-Threonine Kinases | 2018 |
Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium Signaling; Cardiomegaly; Cardiotonic Agents; Feedback, Physiological; Mice; Mice, Knockout; Myocardial Contraction; Neoplasm Proteins; NFATC Transcription Factors; Phenylephrine; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Ubiquitination | 2018 |
Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
Topics: Angiotensin II; Animals; Biological Transport; Calmodulin; Cardiomegaly; Cell Nucleus; Cells, Cultured; Dantrolene; Histone Deacetylases; Mice; Nuclear Localization Signals; Phenylephrine; Receptors, G-Protein-Coupled; Ryanodine Receptor Calcium Release Channel; Suramin | 2018 |
Inhibition of cardiac hypertrophy by aromadendrin through down-regulating NFAT and MAPKs pathways.
Topics: Animals; Antioxidants; Cardiomegaly; Cardiotonic Agents; Down-Regulation; Fibrosis; Flavonoids; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Pressure; Protein Biosynthesis | 2018 |
Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress.
Topics: Animals; Antioxidant Response Elements; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Lycopene; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Phenylephrine; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reactive Oxygen Species | 2019 |
C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress.
Topics: Adipokines; Animals; Animals, Newborn; Aorta; Cardiomegaly; Constriction, Pathologic; Cyclic AMP Response Element-Binding Protein; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fibrosis; Male; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Rats, Sprague-Dawley; Signal Transduction; Up-Regulation | 2019 |
Zingerone attenuates aortic banding-induced cardiac remodelling via activating the eNOS/Nrf2 pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Cardiomegaly; Cells, Cultured; Fibrosis; Guaiacol; Heart Failure; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocytes, Cardiac; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; Oxidative Stress; Phenylephrine; Rats; Signal Transduction; Ventricular Remodeling | 2019 |
LncRNA PEG10 aggravates cardiac hypertrophy through regulating HOXA9.
Topics: Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Homeodomain Proteins; Mice; Myocytes, Cardiac; Phenylephrine; Primary Cell Culture; RNA, Long Noncoding; Up-Regulation | 2019 |
A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Cardiomegaly; Cells, Cultured; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; GRB2 Adaptor Protein; MAP Kinase Kinase 1; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; MicroRNAs; Mitogen-Activated Protein Kinase 3; Muscle Proteins; Phenylephrine; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Rats, Sprague-Dawley | 2013 |
p90(RSK)s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes.
Topics: Animals; Cardiomegaly; Chromatin Immunoprecipitation; Male; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Ribosomal; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Fibroblast growth factor 21 protects against cardiac hypertrophy in mice.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cardiotonic Agents; Fetus; Fibroblast Growth Factors; Gene Expression Regulation; Inflammation; Inflammation Mediators; Isoproterenol; Mice; Myocardium; Myocytes, Cardiac; Phenylephrine; Rats; RNA, Messenger; Ultrasonography | 2013 |
Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Cells, Cultured; Dynamins; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oxygen Consumption; Phenylephrine; Phosphorylation; Proteomics; Rats; Signal Transduction | 2013 |
Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy.
Topics: Angiotensin II; Animals; Animals, Newborn; Apoptosis; Bronchodilator Agents; Cardiomegaly; Caspase 3; Caspase 9; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelin-1; Enzyme Activation; Fluorescent Antibody Technique; Hypertrophy; In Vitro Techniques; Isoproterenol; Membrane Potential, Mitochondrial; Myocardium; Myocytes, Cardiac; Oligopeptides; Phenylephrine; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasoconstrictor Agents | 2013 |
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
Topics: A Kinase Anchor Proteins; Angiotensin II; Animals; Aorta; Apoptosis; Cardiomegaly; Collagen; Female; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Heart Failure; Histone Deacetylases; Male; Mice; Mice, Transgenic; Minor Histocompatibility Antigens; Myocardium; Phenylephrine; Protein Kinase C; Protein Structure, Tertiary; Signal Transduction | 2014 |
AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cardiomegaly; Cells, Cultured; Gene Expression Regulation; Myocytes, Cardiac; Nuclear Proteins; Oncogene Protein v-akt; Phenylephrine; Phosphorylation; Rats; RNA, Messenger; Signal Transduction; Transcription, Genetic | 2013 |
Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Cardiomegaly; Cell Death; Cells, Cultured; Dehydroepiandrosterone; Disease Models, Animal; Enzyme Inhibitors; Female; Glucosephosphate Dehydrogenase; Hexokinase; Isoproterenol; Male; Mice; Mice, Transgenic; Myocytes, Cardiac; Oxidative Stress; Pentose Phosphate Pathway; Phenylephrine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA Interference; Time Factors; Transfection | 2013 |
B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy.
Topics: Animals; Calcium-Binding Proteins; Cardiomegaly; Cells, Cultured; Humans; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Proto-Oncogene Proteins B-raf; Rats, Wistar; Signal Transduction | 2014 |
The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cell Size; Cells, Cultured; Cyclic AMP; Eukaryotic Initiation Factor-2B; Gene Expression; Inositol Phosphates; Isoproterenol; Myocytes, Cardiac; Phenylephrine; Protein Biosynthesis; Protein Interaction Domains and Motifs; Rats; Receptors, G-Protein-Coupled; RGS Proteins; Second Messenger Systems | 2014 |
CD73-TNAP crosstalk regulates the hypertrophic response and cardiomyocyte calcification due to α1 adrenoceptor activation.
Topics: 5'-Nucleotidase; Adenosine; Adrenergic alpha-1 Receptor Agonists; Alkaline Phosphatase; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; GPI-Linked Proteins; Myocytes, Cardiac; Phenylephrine; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Signal Transduction; Time Factors; Vascular Calcification | 2014 |
Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription.
Topics: Animals; Animals, Newborn; Cardiomegaly; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Mice; Models, Biological; Myocytes, Cardiac; NF-kappa B; Phenylephrine; Promoter Regions, Genetic; Protein Binding; Rats; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Transcription, Genetic | 2014 |
Polydatin attenuates cardiac hypertrophy through modulation of cardiac Ca2+ handling and calcineurin-NFAT signaling pathway.
Topics: Active Transport, Cell Nucleus; Animals; Atrial Natriuretic Factor; Calcineurin; Calcium; Calcium Signaling; Cardiomegaly; Cell Nucleus; Cells, Cultured; Glucosides; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Myosin Heavy Chains; NFATC Transcription Factors; Phenylephrine; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Stilbenes; Ventricular Remodeling | 2014 |
The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy.
Topics: Animals; Apoptosis; Cardiomegaly; Cell Proliferation; Humans; In Situ Nick-End Labeling; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Phenylephrine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Serine-Threonine Kinase 3; Stress, Physiological | 2014 |
Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Animals, Newborn; Aorta, Abdominal; Cardiomegaly; Cell Membrane; Imidazoles; Isoproterenol; Male; MAP Kinase Signaling System; Myocardium; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Plasmids; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Tumor Suppressor Proteins | 2014 |
Polydatin prevents hypertrophy in phenylephrine induced neonatal mouse cardiomyocytes and pressure-overload mouse models.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cardiotonic Agents; Cell Size; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Glucosides; Heart Failure; Heart Ventricles; Male; Mice, Inbred C57BL; Oxidative Stress; Phenylephrine; Rats; rho-Associated Kinases; Stilbenes; Ventricular Remodeling | 2015 |
REDD1 attenuates cardiac hypertrophy via enhancing autophagy.
Topics: Animals; Autophagy; Cardiomegaly; Cell Enlargement; Cells, Cultured; Gene Knockdown Techniques; MAP Kinase Signaling System; Myocytes, Cardiac; Phenylephrine; Rats; Repressor Proteins; Sirolimus; Transcription Factors | 2014 |
Alpha-lipoic acid attenuates cardiac hypertrophy via inhibition of C/EBPβ activation.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Cardiomegaly; CCAAT-Enhancer-Binding Protein-beta; Down-Regulation; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; Thioctic Acid; Vitamin B Complex | 2015 |
Omentin functions to attenuate cardiac hypertrophic response.
Topics: Adiposity; AMP-Activated Protein Kinases; Animals; Aorta; Cardiomegaly; Constriction, Pathologic; Cytokines; GPI-Linked Proteins; Humans; Lectins; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Phenylephrine; Rats; Signal Transduction | 2015 |
Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy.
Topics: Animals; Aorta, Abdominal; Cardiomegaly; Cell Line; Cyclin D1; Cyclin D2; Cyclins; Disease Models, Animal; Enzyme Activation; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Retinoblastoma Protein; STAT3 Transcription Factor | 2015 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Acids; Fenofibrate; Flavonoids; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Myocytes, Cardiac; Oxazoles; Phenylephrine; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2015 |
Phytochemical and in vitro and in vivo biological investigation on the antihypertensive activity of mango leaves (Mangifera indica L.).
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antioxidants; Baroreflex; Cardiomegaly; Chromatography, Liquid; Enalapril; Hypertension; Mangifera; Nitroprusside; Phenylephrine; Plant Extracts; Plant Leaves; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tandem Mass Spectrometry | 2015 |
Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress.
Topics: Animals; Animals, Newborn; Blood Pressure; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Acids; Fenofibrate; Heart; Heart Ventricles; Insulin-Like Growth Factor I; Myocytes, Cardiac; Organ Size; Oxidation-Reduction; Phenylephrine; PPAR alpha; Rats, Inbred SHR; Rats, Wistar; RNA Interference; RNA, Messenger; RNA, Small Interfering; Substrate Specificity; Systole; Time Factors; Ultrasonography | 2015 |
Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy.
Topics: Animals; Cardiomegaly; Cells, Cultured; GATA4 Transcription Factor; MAP Kinase Signaling System; Mice; Mice, Knockout; Muscle Proteins; Nuclear Proteins; Phenylephrine; Phosphorylation; Repressor Proteins; Signal Transduction | 2015 |
Endothelin A receptor antagonist, atrasentan, attenuates renal and cardiac dysfunction in Dahl salt-hypertensive rats in a blood pressure independent manner.
Topics: Animals; Atrasentan; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Endothelin A Receptor Antagonists; Gene Expression; Heart Diseases; Hemodynamics; Hypertension; Hypertrophy; Kidney Function Tests; Male; Myocytes, Cardiac; Phenylephrine; Pyrrolidines; Rats; Receptor, Endothelin A; Renal Insufficiency, Chronic | 2015 |
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
Topics: Acetylation; Adenosine Triphosphatases; Animals; Biphenyl Compounds; Cardiomegaly; Cardiotonic Agents; Carrier Proteins; Cell Differentiation; Cell Proliferation; Enzyme Activation; Fibroblasts; Gene Expression Regulation; Isoproterenol; Lignans; Membrane Proteins; Mice; Mitochondria; Mitochondrial Proton-Translocating ATPases; Myocardium; Myocytes, Cardiac; Myofibroblasts; Phenylephrine; Primary Cell Culture; Reactive Oxygen Species; Signal Transduction; Sirtuin 3; Superoxide Dismutase | 2015 |
Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Female; Humans; Hypertrophy; Male; Mice; Mice, Knockout; Mice, Transgenic; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TNF Receptor-Associated Factor 3; Up-Regulation | 2015 |
Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy.
Topics: Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Gene Expression Regulation; Heart; Humans; Mitogen-Activated Protein Kinase 3; Myoblasts, Cardiac; Nitriles; Phenylephrine; Phosphorylation; Rats | 2015 |
Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Cardiomegaly; Cells, Cultured; Endothelin-1; GATA4 Transcription Factor; Gene Expression; Gene Expression Regulation; Heart Ventricles; Isoproterenol; Myocytes, Cardiac; NFATC Transcription Factors; Nuclear Receptor Subfamily 4, Group A, Member 1; Phenylephrine; Rats, Sprague-Dawley | 2015 |
Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.
Topics: Calcium; Calcium Channels; Cardiomegaly; Cell Differentiation; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Heart Failure; Human Embryonic Stem Cells; Humans; Myocytes, Cardiac; Nitric Oxide; ORAI1 Protein; Phenylephrine; Phosphorylation; Signal Transduction | 2015 |
Adenosine A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1 -adrenoceptor stimulation in vivo.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adrenergic alpha-1 Receptor Agonists; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cell Culture Techniques; Dose-Response Relationship, Drug; Fibrosis; Insulin-Like Growth Factor I; Male; Matrix Metalloproteinase 2; Mice; Myocytes, Cardiac; Oxidative Stress; Phenylephrine; Rats; Receptor, Adenosine A1; Up-Regulation | 2016 |
BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Angiotensin II; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type I; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Inhibitor of Differentiation Protein 1; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Phosphorylation; Pyrazoles; Pyrimidines; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Smad Proteins; Time Factors; Transfection | 2016 |
Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.
Topics: Animals; Cardiomegaly; Drosophila melanogaster; Endothelin-1; Heart Failure; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Myofibrils; Phenylephrine; Profilins; Sarcomeres | 2016 |
Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy.
Topics: Animals; Cardiomegaly; Gene Expression Regulation; Gene Knockdown Techniques; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocytes, Cardiac; Phenylephrine; RNA, Long Noncoding | 2016 |
SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.
Topics: Animals; Cardiomegaly; Cells, Cultured; E1A-Associated p300 Protein; Myocytes, Cardiac; NF-kappa B; Phenylephrine; Rats, Sprague-Dawley; RNA, Small Interfering; Sirtuins | 2016 |
PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy.
Topics: Animals; Cardiomegaly; Cells, Cultured; Green Fluorescent Proteins; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Plasmids; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; STAT3 Transcription Factor | 2016 |
Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cell Respiration; Cells, Cultured; Disease Models, Animal; Electron Transport Complex I; Electron Transport Complex II; Gene Expression Profiling; Gene Expression Regulation; Insulin-Like Growth Factor I; Kinesins; Male; Mitochondria, Heart; Myocytes, Cardiac; Organelle Biogenesis; Phenylephrine; Rats | 2016 |
Qiliqiangxin Attenuates Phenylephrine-Induced Cardiac Hypertrophy through Downregulation of MiR-199a-5p.
Topics: Actinin; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardial Infarction; Myocytes, Cardiac; Myosin Heavy Chains; Natriuretic Peptide, Brain; Oligonucleotides, Antisense; Phenylephrine; Rats; Rats, Sprague-Dawley | 2016 |
Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ.
Topics: Acetylation; Actins; Amino Acid Sequence; Animals; Animals, Newborn; CapZ Actin Capping Protein; Cardiomegaly; Cell Size; Heart Ventricles; Histone Deacetylase Inhibitors; Histone Deacetylases; Models, Biological; Myocytes, Cardiac; Myofibrils; Phenylephrine; Phosphorylation; Protein Kinase C-epsilon; Protein Processing, Post-Translational; Rats, Sprague-Dawley; Sarcomeres | 2016 |
Tyrosine phosphorylation of RACK1 triggers cardiomyocyte hypertrophy by regulating the interaction between p300 and GATA4.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Cell Enlargement; Cells, Cultured; Disease Models, Animal; E1A-Associated p300 Protein; GATA4 Transcription Factor; Gene Knockdown Techniques; HEK293 Cells; Humans; Male; Myocytes, Cardiac; Neoplasm Proteins; Phenylephrine; Phosphorylation; Protein Binding; Rats; Rats, Inbred Dahl; Receptors for Activated C Kinase; Tetrazoles; Transcription, Genetic; Tyrosine | 2016 |
Efficacy of nobiletin, a citrus flavonoid, in the treatment of the cardiovascular dysfunction of diabetes in rats.
Topics: Acetylcholine; Animals; Antioxidants; Biomarkers; Cardiomegaly; Citrus; Diabetes Mellitus, Experimental; Flavones; Flavonoids; Hemodynamics; Hyperglycemia; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oxidative Stress; Phenylephrine; Rats; Rats, Wistar | 2016 |
Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice.
Topics: Animals; Calcium Channels, L-Type; Calcium Signaling; Cardiomegaly; Gene Expression Regulation; Mesenteric Arteries; Mice; Mice, Knockout; Myocardium; Phenylephrine; TRPC Cation Channels; Vasoconstriction | 2016 |
Lactobacillus rhamnosus GR-1 Attenuates Induction of Hypertrophy in Cardiomyocytes but Not through Secreted Protein MSP-1 (p75).
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Bacterial Proteins; Cardiomegaly; Disease Models, Animal; Heart Failure; Lacticaseibacillus rhamnosus; Myocytes, Cardiac; Phenylephrine; Probiotics; Rats; Rats, Sprague-Dawley | 2017 |
Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Autophagy; Cardiomegaly; Cell Cycle Proteins; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Phenylephrine; Phosphorylation; Protein Kinases; Rats; Signal Transduction | 2017 |
Phenylephrine-induced cardiac hypertrophy is attenuated by a histone acetylase inhibitor anacardic acid in mice.
Topics: Acetylation; Anacardic Acids; Animals; Cardiomegaly; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Heart Function Tests; Histone Acetyltransferases; Histones; Male; MEF2 Transcription Factors; Mice; Myocardium; Phenylephrine; Protein Binding; Transcription, Genetic | 2017 |
Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.
Topics: Active Transport, Cell Nucleus; Angiotensin II; Aniline Compounds; Animals; Atrial Remodeling; Calcium; Cardiomegaly; Cytoplasm; Disease Models, Animal; Endothelin-1; Fluorescent Dyes; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Humans; Membrane Proteins; Muscular Dystrophy, Emery-Dreifuss; Myocardium; Myocytes, Cardiac; Nuclear Envelope; Nuclear Proteins; Phenylephrine; Primary Cell Culture; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Ventricular Remodeling; Xanthenes | 2017 |
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Mice; Multienzyme Complexes; Myocytes, Cardiac; Peptide Elongation Factor 2; Phenylephrine; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Resveratrol; Ribosomal Protein S6 Kinases, 70-kDa; Stilbenes; Transcription, Genetic | 2008 |
Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes.
Topics: Adenoviridae; Animals; Anti-Bacterial Agents; Atrial Natriuretic Factor; Biomarkers; Cardiomegaly; Cardiotonic Agents; Cell Proliferation; Cell Size; Cells, Cultured; Genetic Vectors; Heart Ventricles; Male; Monomeric GTP-Binding Proteins; Myocytes, Cardiac; Natriuretic Peptide, Brain; Neuropeptides; Phenylephrine; Protein Biosynthesis; Protein Kinases; Ras Homolog Enriched in Brain Protein; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2008 |
[Inhibition of cardiac hypertrophy by mitofusin 2 in neonatal rat cardiomyocytes].
Topics: Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; GTP Phosphohydrolases; Membrane Proteins; Mice; Mitochondrial Proteins; Myocytes, Cardiac; Phenylephrine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transfection | 2008 |
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.
Topics: 14-3-3 Proteins; A Kinase Anchor Proteins; Active Transport, Cell Nucleus; Animals; Cardiomegaly; Cell Line; Chlorocebus aethiops; COS Cells; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Heart Ventricles; Histone Deacetylases; Humans; MEF2 Transcription Factors; Minor Histocompatibility Antigens; Models, Biological; Myocytes, Cardiac; Myogenic Regulatory Factors; Phenylephrine; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Rats; RNA Interference; Signal Transduction | 2008 |
Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy.
Topics: Animals; Cardiomegaly; Cell Enlargement; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Proto-Oncogene Proteins c-jun; Rats; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; Up-Regulation | 2009 |
Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes.
Topics: Animals; Binding Sites; Cardiomegaly; Carrier Proteins; Cell Enlargement; Cells, Cultured; Cycloheximide; Eukaryotic Initiation Factor-4F; Eukaryotic Initiation Factor-4G; Intracellular Signaling Peptides and Proteins; Male; Mutation; Myocytes, Cardiac; Phenylephrine; Phosphoproteins; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sirolimus; Transcription Factors | 2009 |
Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy.
Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Estrogens; Female; Fluoresceins; Fluorescent Dyes; Heart Ventricles; Hydrogen-Ion Concentration; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Time Factors | 2009 |
Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Calcineurin; Calcium Signaling; Cardiomegaly; Cardiotonic Agents; Cell Division; Cells, Cultured; Cytosol; Enzyme Inhibitors; Gene Expression; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Protein Kinase C; Rats; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Sodium-Calcium Exchanger; Thapsigargin; TRPC Cation Channels | 2009 |
CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms.
Topics: Actin Cytoskeleton; Animals; Benzophenanthridines; CapZ Actin Capping Protein; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Endothelin-1; Fluorescence Recovery After Photobleaching; Green Fluorescent Proteins; Myocytes, Cardiac; Neomycin; Phenylephrine; Phosphatidylinositol 4,5-Diphosphate; Protein Binding; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sarcomeres | 2009 |
Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Atrial Natriuretic Factor; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Corticosterone; Disease Progression; Gene Expression; Glucocorticoids; Heart Failure; Male; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Myosin Heavy Chains; Phenylephrine; Rats; Rats, Inbred Dahl; Steroids | 2009 |
DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy.
Topics: Animals; Base Sequence; Calcineurin; Calcium Signaling; Cardiomegaly; Cell Enlargement; Cells, Cultured; Dyrk Kinases; Endothelin-1; Gene Expression; Harmine; MicroRNAs; Models, Cardiovascular; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; RNA, Messenger | 2009 |
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Topics: Acute Disease; ADAM Proteins; ADAM12 Protein; Adrenergic alpha-Agonists; Animals; Cardiomegaly; Disease Models, Animal; Hypertension; Matrix Metalloproteinase 7; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Norepinephrine; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; RNA Interference; Signal Transduction | 2009 |
Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes.
Topics: Animals; Atrial Natriuretic Factor; Cardiac Myosins; Cardiomegaly; Cardiotonic Agents; Cell Movement; Cells, Cultured; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Myocytes, Cardiac; Myosin Light Chains; Phenylephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Transfection | 2009 |
Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes.
Topics: Actinin; Animals; Animals, Newborn; Cardiomegaly; Cytoskeletal Proteins; Cytoskeleton; Disease Models, Animal; DNA-Binding Proteins; Fetus; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Heart Failure; Heart Ventricles; LIM Domain Proteins; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Paxillin; Phenylephrine; Protein Transport; Rats; Reproducibility of Results; RNA, Small Interfering; Transfection | 2009 |
Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway.
Topics: Animals; Cardiomegaly; Cells, Cultured; Copper; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Acute and chronic adrenergic stimulation of submandibular salivary glands. Effects on the endocrine function of epidermal growth factor in mice.
Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; Epidermal Growth Factor; Heart; Isoproterenol; Male; Mice; Myocardium; Organ Size; Phenylephrine; Submandibular Gland | 2009 |
Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.
Topics: Adenoviridae; Animals; Apoptosis; Cardiomegaly; Cell Line; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Down-Regulation; Heart Failure; Humans; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phenylephrine; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Suppressor Proteins; Vasoconstrictor Agents | 2009 |
Interaction between renin-angiotensin and sympathetic nervous systems in a rat model of pressure overload cardiac hypertrophy.
Topics: Angiotensin II; Animals; Aortic Valve Stenosis; Blood Pressure; Cardiomegaly; Electrocardiography; Male; Methoxamine; Norepinephrine; Phenylephrine; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sympathetic Nervous System | 2009 |
beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes.
Topics: Animals; Atrial Natriuretic Factor; beta Catenin; Cardiomegaly; Gene Expression Regulation; Gene Knockdown Techniques; Lymphoid Enhancer-Binding Factor 1; Myocytes, Cardiac; Phenylephrine; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; TCF Transcription Factors; Transcription, Genetic; Up-Regulation | 2009 |
Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
Topics: Adenosine; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Heart Ventricles; Myocytes, Cardiac; Nucleoside Transport Proteins; Phenylephrine; Prazosin; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Up-Regulation | 2010 |
Scutellarin exerts its anti-hypertrophic effects via suppressing the Ca2+-mediated calcineurin and CaMKII signaling pathways.
Topics: Animals; Animals, Newborn; Apigenin; Calcineurin; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Size; Cells, Cultured; Drugs, Chinese Herbal; Glucuronates; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Wistar; Signal Transduction; Vasodilator Agents | 2010 |
The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Carbazoles; Cardiomegaly; Cell Nucleus; Endothelin-1; Genes, jun; Heart; Hypertrophy; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Natriuretic Peptide, Brain; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor AP-1; Transcription Factors | 2010 |
Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.
Topics: Animals; Aorta; Calreticulin; Cardiomegaly; Constriction, Pathologic; Embryo, Mammalian; Endothelin-1; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Organ Size; Phenylephrine; Pressure; Signal Transduction; Solubility; src-Family Kinases | 2010 |
Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cardiotonic Agents; Cardiovascular Agents; Cell Size; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribonucleotides | 2010 |
The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis.
Topics: Animals; Cardiomegaly; Cells, Cultured; Connective Tissue Growth Factor; Fibrosis; Heart Failure; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Phenylephrine; Pressure; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2010 |
MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes.
Topics: Adrenergic alpha-Agonists; Animals; Cardiomegaly; Cell Size; Down-Regulation; Gene Deletion; Humans; Male; MicroRNAs; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; Up-Regulation | 2010 |
Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Cardiomegaly; Computational Biology; Cytoskeleton; Gene Expression Profiling; Humans; Mice; Microarray Analysis; Microfilament Proteins; MicroRNAs; Myocytes, Cardiac; NIH 3T3 Cells; Phenylephrine; Protein Binding; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Transgenes | 2010 |
Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cardiomegaly; Cells, Cultured; Enzyme Activation; Forkhead Transcription Factors; Gene Silencing; Muscle Proteins; Myocytes, Cardiac; Nerve Tissue Proteins; Phenylephrine; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Ribonucleotides; RNA, Small Interfering; Signal Transduction; Transfection; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2010 |
Cytochrome c oxidase is essential for copper-induced regression of cardiomyocyte hypertrophy.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Cardiomegaly; Cell Size; Cells, Cultured; Copper; Cyclooxygenase 1; Diet; Electron Transport Complex IV; Flow Cytometry; Gene Silencing; Immunohistochemistry; Male; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Vascular Endothelial Growth Factor A | 2010 |
GATA4 regulates ANF expression synergistically with Sp1 in a cardiac hypertrophy model.
Topics: Animals; Atrial Natriuretic Factor; Base Sequence; Binding Sites; Cardiomegaly; Disease Models, Animal; GATA4 Transcription Factor; Gene Expression Regulation; HeLa Cells; Humans; Molecular Sequence Data; Phenylephrine; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Rats; Rats, Sprague-Dawley; Sp1 Transcription Factor; Sp3 Transcription Factor; Transcription, Genetic | 2011 |
Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy?
Topics: Angiotensin II; Cardiomegaly; Cell Cycle; Cell Differentiation; Cell Line; Cell Proliferation; Cell Size; Cells, Cultured; Embryonic Stem Cells; Gene Expression Regulation; Humans; MAP Kinase Kinase 3; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Protein Kinase Inhibitors; Signal Transduction; Vasoconstrictor Agents | 2011 |
Phospholipase Cbeta1b associates with a Shank3 complex at the cardiac sarcolemma.
Topics: Adaptor Proteins, Signal Transducing; Alternative Splicing; Animals; Cardiomegaly; Cardiotonic Agents; Carrier Proteins; Cells, Cultured; HEK293 Cells; Humans; Membrane Microdomains; Microfilament Proteins; Myocardium; Myocytes, Cardiac; Nerve Tissue Proteins; Phenylephrine; Phospholipase C beta; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sarcolemma; Signal Transduction; src Homology Domains | 2011 |
Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo.
Topics: Animals; Calcineurin; Cardiomegaly; Cells, Cultured; Dyrk Kinases; Female; Gene Knockdown Techniques; Male; Mice; Mice, Transgenic; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Pregnancy; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Signal Transduction | 2011 |
Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy.
Topics: Acetylation; Animals; Autophagy; Cardiomegaly; Histone Deacetylase Inhibitors; Phenylephrine; Rats; Rats, Sprague-Dawley | 2011 |
Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts.
Topics: Adrenergic alpha-1 Receptor Agonists; AMP-Activated Protein Kinase Kinases; Animals; Cardiomegaly; Cell Line; Cell Survival; Cytoprotection; Gene Knockdown Techniques; Myoblasts, Cardiac; Phenylephrine; Protein Biosynthesis; Protein Kinases; Rats; Sirtuin 1; Stress, Physiological; Up-Regulation | 2011 |
Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy.
Topics: Angiotensin II; Animals; Base Sequence; Cardiomegaly; Cell Enlargement; Cells, Cultured; DNA Primers; MicroRNAs; Models, Cardiovascular; Myocytes, Cardiac; Phenylephrine; PTEN Phosphohydrolase; Rats; Up-Regulation | 2012 |
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.
Topics: Amino Acid Substitution; Animals; Cardiomegaly; GATA4 Transcription Factor; Gene Expression; Gene Knock-In Techniques; MAP Kinase Signaling System; Mice; Mice, Mutant Strains; Mice, Transgenic; Mutagenesis, Site-Directed; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Serine; Stress, Physiological | 2011 |
Transactivated EGFR mediates α₁-AR-induced STAT3 activation and cardiac hypertrophy.
Topics: Active Transport, Cell Nucleus; ADAM Proteins; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Male; Mice; Mice, Inbred C57BL; Myocardium; Phenylephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Adrenergic, alpha-1; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Time Factors; Tyrosine | 2011 |
Identification of proteins responding to adrenergic receptor subtype-specific hypertrophy in cardiomyocytes by proteomic approaches.
Topics: Acetylcysteine; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Isoproterenol; Myocytes, Cardiac; Oxidative Stress; Phenylephrine; Phosphorylation; Proteins; Proteomics; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Cardiomegaly; Cell Adhesion; Cell Enlargement; Cell Shape; Cell Size; Cells, Cultured; Image Processing, Computer-Assisted; Insulin-Like Growth Factor I; Isoproterenol; Myocytes, Cardiac; Phenotype; Phenylephrine; Rats; Rats, Sprague-Dawley; Sarcomeres; Signal Transduction; Single-Cell Analysis; Tumor Necrosis Factor-alpha | 2012 |
DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated by adrenergic stimulation and in heart failure.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Biopsy; Cardiomegaly; Disease Models, Animal; Down-Regulation; Endothelin-1; Gene Expression Regulation, Enzymologic; Heart Failure; Humans; Mice; Myocytes, Cardiac; Oxidoreductases; Phenylephrine; Rats; RNA, Messenger; Sarcoplasmic Reticulum; Sympathetic Nervous System | 2012 |
O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy.
Topics: Acetylglucosamine; Animals; Cardiomegaly; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription, Genetic | 2012 |
A novel player in cellular hypertrophy: Giβγ/PI3K-dependent activation of the RacGEF TIAM-1 is required for α₁-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes.
Topics: Adrenergic alpha-1 Receptor Agonists; Aminoquinolines; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; GTP-Binding Protein alpha Subunits, Gi-Go; Guanine Nucleotide Exchange Factors; Immunoblotting; Myocytes, Cardiac; Neoplasm Proteins; p21-Activated Kinases; Phenylephrine; Phosphatidylinositol 3-Kinases; Pyrimidines; rac1 GTP-Binding Protein; Rats; Receptors, Adrenergic, alpha-1; Signal Transduction; T-Lymphoma Invasion and Metastasis-inducing Protein 1 | 2012 |
Automated imaging reveals a concentration dependent delay in reversibility of cardiac myocyte hypertrophy.
Topics: Adrenergic Agonists; Animals; Cardiomegaly; Computational Biology; Microscopy; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley | 2012 |
Non-neuronal cholinergic machinery present in cardiomyocytes offsets hypertrophic signals.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Cardiomegaly; Cell Movement; Cells, Cultured; Isoproterenol; Mice; Muscarinic Antagonists; Myocytes, Cardiac; Nitrogen Oxides; Phenylephrine; Rats; RNA, Small Interfering | 2012 |
Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cardiomegaly; Cyclin-Dependent Kinases; E2F Transcription Factors; Energy Metabolism; Glucose; Heart Failure; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidation-Reduction; Phenylephrine; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, alpha; Retinoblastoma Protein; Signal Transduction; Stroke Volume; Time Factors; Ultrasonography; Ventricular Function | 2012 |
Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms.
Topics: Animals; Antioxidants; Cardiomegaly; Carrier Proteins; Cell Line; Cell Survival; DNA Fragmentation; Heart; Hydrogen Peroxide; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phenylephrine; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Rhodamines; Signal Transduction; Silybin; Silybum marianum; Silymarin; Up-Regulation | 2013 |
Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Chronic Disease; Disease Models, Animal; Female; G-Protein-Coupled Receptor Kinase 5; Gene Expression Regulation, Enzymologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phenylephrine; Ventricular Pressure | 2012 |
Baroreflex control of renal sympathetic nerve activity in mice with cardiac hypertrophy.
Topics: Animals; Arterial Pressure; Baroreflex; Cardiomegaly; Disease Models, Animal; Isoproterenol; Kidney; Male; Mice; Nitroprusside; Phenylephrine; Sympathetic Nervous System | 2012 |
Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiomegaly; Cells, Cultured; Coculture Techniques; Connexin 43; Fibroblasts; Fibrosis; Gap Junctions; Kinetics; Myocytes, Cardiac; Patch-Clamp Techniques; Phenylephrine; Rats; Shal Potassium Channels; Voltage-Sensitive Dye Imaging | 2013 |
Carbonic anhydrase II promotes cardiomyocyte hypertrophy.
Topics: Animals; Carbonic Anhydrase II; Cardiomegaly; Chloride-Bicarbonate Antiporters; Gene Expression; Gene Transfer Techniques; Heart Ventricles; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phenylephrine; Rats; Sodium-Hydrogen Exchangers | 2012 |
Cardiac ankyrin repeat protein attenuates cardiac hypertrophy by inhibition of ERK1/2 and TGF-β signaling pathways.
Topics: Animals; Apoptosis; Blotting, Western; Cardiomegaly; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Microscopy, Confocal; Muscle Proteins; Nuclear Proteins; Phenylephrine; Phosphorylation; Real-Time Polymerase Chain Reaction; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transforming Growth Factor beta | 2012 |
Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.
Topics: Animals; Aortic Valve Stenosis; Cardiomegaly; Cell Nucleus; Cell Size; Cysteine; Enzyme Activation; Enzyme Induction; Histone Deacetylases; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Mice, Transgenic; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Nuclear Envelope; Oxidation-Reduction; Oxidative Stress; Phenylephrine; Protein Transport; Rats; Reactive Oxygen Species; Recombinant Fusion Proteins | 2013 |
Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiomegaly; Cardiomyopathies; Down-Regulation; Dystrophin; E1A-Associated p300 Protein; Echocardiography; Male; Mice; Mice, Inbred C57BL; Models, Biological; Phenylephrine; Proteasome Endopeptidase Complex; Resveratrol; Sirtuin 1; Stilbenes; Ubiquitin | 2013 |
A novel Ca2+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension.
Topics: Acetylcholine; Animals; Benzodioxoles; Calcium Channel Blockers; Calcium Chloride; Cardiomegaly; Familial Primary Pulmonary Hypertension; Hydrazones; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Phenylephrine; Pulmonary Artery; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents | 2013 |
Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy.
Topics: Actins; Adenoviridae; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; Culture Media, Serum-Free; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Heart; Myocardium; Phenylephrine; Proto-Oncogene Proteins; ras Proteins; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins | 2002 |
Lovastatin inhibits phenylephrine-induced ERK activation and growth of cardiac.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Blotting, Western; Cardiomegaly; Cells, Cultured; Coloring Agents; Enzyme Activation; Heart; Lovastatin; Mitogen-Activated Protein Kinases; Myocardium; Phenylephrine; Phosphorylation; Pravastatin; Propidium; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles | 2001 |
Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes.
Topics: Action Potentials; Animals; Animals, Newborn; Biomarkers; Calcineurin; Calcium; Calcium Signaling; Cardiac Myosins; Cardiac Pacing, Artificial; Cardiomegaly; Cell Size; Cells, Cultured; DNA; DNA-Binding Proteins; Genes, Reporter; Heart; In Vitro Techniques; Myocardium; NFATC Transcription Factors; Phenylephrine; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; RNA, Messenger; Shal Potassium Channels; Transcription Factors; Transfection | 2002 |
Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes.
Topics: Adrenergic alpha-Agonists; Animals; Cardiomegaly; Carrier Proteins; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; Heart; Heterotrimeric GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Phenylephrine; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; ras Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2002 |
Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature.
Topics: Angiotensin II; Animals; Cardiomegaly; Catecholamines; Cells, Cultured; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gq-G11; Heart; Hemodynamics; Heterotrimeric GTP-Binding Proteins; Infusion Pumps, Implantable; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Mitogen-Activated Protein Kinases; Muscle Proteins; Muscle, Smooth, Vascular; Peptide Fragments; Phenylephrine; Receptors, Cell Surface; Serotonin; Signal Transduction; Time; Vasoconstrictor Agents | 2002 |
The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity.
Topics: Acetyltransferases; Animals; Animals, Newborn; Cardiomegaly; Cardiotonic Agents; Cell Separation; CREB-Binding Protein; Culture Media, Serum-Free; E1A-Associated p300 Protein; Flow Cytometry; Genes, Dominant; Genes, Reporter; Green Fluorescent Proteins; Histone Acetyltransferases; Hypertrophy; Luciferases; Luminescent Proteins; Microscopy, Fluorescence; Myocardium; Nuclear Proteins; Oligonucleotides, Antisense; Phenylephrine; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae Proteins; Signal Transduction; Time Factors; Trans-Activators; Transcriptional Activation; Transfection | 2003 |
Effects of tanshinone VI on the hypertrophy of cardiac myocytes and fibrosis of cardiac fibroblasts of neonatal rats.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Collagen; Endothelin-1; Female; Fibroblasts; Fibrosis; Insulin-Like Growth Factor I; Leucine; Male; Myocytes, Cardiac; Paracrine Communication; Phenanthrenes; Phenylephrine; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Salvia miltiorrhiza; Tritium | 2002 |
Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload.
Topics: Angiotensin II; Animals; Aortic Coarctation; Biomechanical Phenomena; Cardiac Output, Low; Cardiomegaly; Carrier Proteins; Cytoskeletal Proteins; Echocardiography; Female; Gene Silencing; Heart Ventricles; Hemodynamics; Integrin beta1; Male; Mice; Mice, Knockout; Muscle Proteins; Muscle, Skeletal; Myocardium; Phenylephrine; Signal Transduction; Stress, Mechanical; Vasoconstrictor Agents; Ventricular Function | 2003 |
Chronic activation of extracellular-signal-regulated protein kinases by phenylephrine is required to elicit a hypertrophic response in cardiac myocytes.
Topics: Adrenergic alpha-Antagonists; Animals; Atrial Natriuretic Factor; Benzamides; Butadienes; Cardiomegaly; Cell Size; Cells, Cultured; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Luciferases; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Nitriles; Phenylephrine; Prazosin; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Time Factors | 2003 |
Cellular localization of integrin isoforms in phenylephrine-induced hypertrophic cardiac myocytes.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Collagen; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Integrins; Myocytes, Cardiac; Okadaic Acid; Phenylephrine; Protein Isoforms; Rats | 2003 |
Multiprotein bridging factor 1 cooperates with c-Jun and is necessary for cardiac hypertrophy in vitro.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Animals, Newborn; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Calmodulin-Binding Proteins; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Humans; Mice; Molecular Sequence Data; Myocytes, Cardiac; Oligonucleotides, Antisense; Phenylephrine; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Recombinant Fusion Proteins; Sequence Alignment; Trans-Activators | 2003 |
Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation.
Topics: Adenoviridae; Adrenergic beta-Agonists; Animals; Animals, Newborn; Apoptosis; Cardiomegaly; Cell Size; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element Modulator; DNA-Binding Proteins; Endothelin-1; Feedback, Physiological; Gene Expression Regulation; Genetic Vectors; Immunohistochemistry; Isoproterenol; Male; Myocytes, Cardiac; Phenylephrine; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Repressor Proteins; RNA, Messenger; Transfection | 2003 |
A20 is dynamically regulated in the heart and inhibits the hypertrophic response.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Apoptosis; Cardiomegaly; Cells, Cultured; Cysteine Endopeptidases; Endothelin-1; Feedback, Physiological; I-kappa B Proteins; Intracellular Signaling Peptides and Proteins; Mice; Myocardium; Myocytes, Cardiac; NF-kappa B; NF-KappaB Inhibitor alpha; Nuclear Proteins; Phenylephrine; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stress, Mechanical; Transfection; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
[ACETYLCHOLINE INPAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA].
Topics: Acetylcholine; Bundle-Branch Block; Cardiac Conduction System Disease; Cardiomegaly; Geriatrics; Heart Block; Heart Valve Diseases; Hypertension; Mitral Valve Insufficiency; Myocardial Infarction; Phenylephrine; Procainamide; Tachycardia; Tachycardia, Paroxysmal; Tachycardia, Supraventricular | 1963 |
Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes.
Topics: Acrylates; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calpain; Cardiomegaly; Cells, Cultured; Cysteine Proteinase Inhibitors; Glycoproteins; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Rats; Time Factors; Ventricular Function, Left | 2003 |
Mepivacaine alters vascular responsiveness to vasoconstrictors in aortic rings from normal and aortic-banded rats.
Topics: Anesthetics, Local; Animals; Aorta; Cardiomegaly; Constriction; Endothelium, Vascular; Male; Mepivacaine; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Vasoconstrictor Agents | 2003 |
Transcription activator protein 1 mediates alpha- but not beta-adrenergic hypertrophic growth responses in adult cardiomyocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Cardiomegaly; Cell Division; Cells, Cultured; Genes, Immediate-Early; Isoproterenol; Male; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; RNA, Messenger; Transcription Factor AP-1 | 2004 |
Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity.
Topics: Angiotensin II; Animals; Aortic Diseases; Cardiomegaly; Carrier Proteins; Cell Cycle Proteins; Cell Size; Cells, Cultured; Constriction, Pathologic; Disease Models, Animal; Genetic Vectors; Heart; Ligation; Male; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Phenylephrine; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Single-Blind Method; Stress, Mechanical; Thioredoxins; Transcriptional Activation | 2004 |
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.
Topics: Animals; Calcium; Cardiomegaly; Cells, Cultured; Endothelin-1; Enzyme Activation; Focal Adhesion Kinase 2; Mutation; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Receptors, G-Protein-Coupled; Signal Transduction; Transfection | 2004 |
Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid.
Topics: Animals; Blotting, Western; Cardiomegaly; Docosahexaenoic Acids; Immunohistochemistry; Phenylephrine; Phosphorylation; Protein Kinases; Rats; Rats, Wistar | 2004 |
Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Celiprolol; Cells, Cultured; Disease Progression; Drug Evaluation, Preclinical; Enzyme Induction; Fibrosis; Gene Expression Regulation; Heart Failure; Hypertrophy; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phenylephrine; Pressure; Rats; RNA, Messenger; Transcription, Genetic; Vasodilator Agents | 2004 |
Effects of alpha1-adrenergic stimulation on normal and hypertrophied mouse hearts. Relation to caveolin-3 expression.
Topics: Action Potentials; Adrenergic alpha-Agonists; Alkaloids; Animals; Benzophenanthridines; Calcium Channels, L-Type; Cardiomegaly; Caveolin 3; Caveolins; Female; Immunoblotting; Male; Mice; Mice, Transgenic; Myocardial Contraction; Myocardium; Perfusion; Phenanthridines; Phenylephrine; Protein Kinase C; Signal Transduction; Staurosporine; Stimulation, Chemical | 2004 |
Decreased baroreflex sensitivity in isoproterenol-treated mice with cardiac hypertrophy.
Topics: Animals; Baroreflex; Blood Pressure; Body Weight; Bronchodilator Agents; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Heart; Heart Rate; Isoproterenol; Male; Mice; Nitroprusside; Organ Size; Phenylephrine; Vasoconstrictor Agents | 2004 |
Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways.
Topics: Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Immunoprecipitation; Indoles; Isoquinolines; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; Signal Transduction; Sulfonamides; Trans-Activators | 2004 |
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cardiomegaly; Cell Size; Cells, Cultured; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; Hypertrophy; Mitochondria; Myocardium; Myocytes, Cardiac; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Rats | 2004 |
Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.
Topics: Animals; Binding Sites; Calcineurin; Calcium; Cardiomegaly; Cells, Cultured; Cricetinae; Dogs; Female; Heart; Humans; Ion Transport; Male; Mutation; Myocytes, Cardiac; Phenylephrine; Protein Binding; Rats; Sodium; Sodium-Calcium Exchanger; Tacrolimus; Tetradecanoylphorbol Acetate | 2005 |
Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy.
Topics: Animals; Cardiomegaly; Cell Size; Chlorocebus aethiops; COS Cells; Focal Adhesions; Muscle Proteins; Myocytes, Cardiac; Peptides; Phenylephrine; Protein Kinase C; Protein Kinase C-epsilon; Rats; Receptors for Activated C Kinase; Signal Transduction; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2004 |
Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes.
Topics: Acetates; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Chemokine CCL2; Gene Expression Regulation; Ligands; Lipid Metabolism; Lipopolysaccharides; Myocytes, Cardiac; NF-kappa B; Phenols; Phenoxyacetates; Phenylephrine; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley | 2005 |
Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats.
Topics: Anabolic Agents; Animals; Baroreflex; Blood Pressure; Body Weight; Bradycardia; Cardiac Output; Cardiomegaly; Cardiotonic Agents; Cardiovascular System; Consciousness; Drug Administration Schedule; Ganglionic Blockers; Hexamethonium; Injections, Subcutaneous; Male; Nitroprusside; Organ Size; Phenylephrine; Rats; Rats, Wistar; Stanozolol; Sympathetic Nervous System; Tachycardia; Testosterone; Vascular Resistance; Vasodilator Agents | 2005 |
Role of alpha1-adrenoreceptors in cocaine-induced NADPH oxidase expression and cardiac dysfunction.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Cardiomyopathies; Cocaine; Male; Myocardium; NADPH Oxidases; Phenylephrine; Prazosin; Random Allocation; Rats; Rats, Wistar; Vasoconstrictor Agents; Ventricular Dysfunction, Left | 2005 |
Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice.
Topics: Angiotensin II; Animals; Cardiomegaly; Diacylglycerol Kinase; Diglycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Phenylephrine; Promoter Regions, Genetic; Protein Kinase C; Rats; RNA, Messenger; Signal Transduction; Ventricular Myosins | 2006 |
Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Cardiomegaly; Cells, Cultured; GATA4 Transcription Factor; Mice; Mice, Transgenic; Myocytes, Cardiac; Phenylephrine; Protein Binding; Repressor Proteins; Transcription Factors | 2006 |
JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity.
Topics: Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; DNA; Electrophoretic Mobility Shift Assay; Myocytes, Cardiac; Phenylephrine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; RNA, Messenger; Stimulation, Chemical; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2006 |
Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy.
Topics: Adenoviridae; AMP-Activated Protein Kinase Kinases; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Heart; Humans; Mice; Mice, Transgenic; Muscle Cells; Phenylephrine; Plasmids; Protein Serine-Threonine Kinases; Rats; Recombinant Proteins; Transfection | 2007 |
Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy.
Topics: Age Factors; Angiotensin II; Animals; Atrial Natriuretic Factor; Calcium; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cardiomegaly; Cardiotonic Agents; Cation Transport Proteins; Cells, Cultured; Chloride-Bicarbonate Antiporters; Ethoxzolamide; Gene Expression; Humans; Kidney; Membrane Potentials; Membrane Transport Proteins; Mice; Myocytes, Cardiac; Phenylephrine; Rats; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfate Transporters; Transfection; Vasoconstrictor Agents | 2007 |
Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca2+ signaling in neonatal rat cardiac myocytes.
Topics: Animals; Animals, Newborn; Calcium Signaling; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Silencing; Myocytes, Cardiac; Phenylephrine; Rats; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; Time Factors | 2007 |
Gene profiling during regression of pressure overload-induced cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Line; Cells, Cultured; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Humans; Myocytes, Cardiac; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phenylephrine; Pressure; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cell Shape; Echocardiography; In Vitro Techniques; Isometric Contraction; Male; Myocardial Contraction; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Wistar; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Thyroxine; Time Factors; Triiodothyronine; Ventricular Remodeling | 2007 |
Neostigmine and pilocarpine attenuated tumour necrosis factor alpha expression and cardiac hypertrophy in the heart with pressure overload.
Topics: Animals; Animals, Newborn; Body Weight; Cardiomegaly; Cells, Cultured; Constriction, Pathologic; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Heart; Interleukin-10; Male; Neostigmine; Organ Size; Parasympathomimetics; Phenylephrine; Pilocarpine; Pressure; Rats; Rats, Sprague-Dawley; Sympathomimetics; Tumor Necrosis Factor-alpha; Ventricular Function | 2008 |
Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.
Topics: Angiotensin II; Animals; Calcineurin; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cells, Cultured; Endothelin-1; Immunohistochemistry; Indazoles; Phenylephrine; Phosphorylation; Rats; Rats, Wistar | 2007 |
Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes.
Topics: Acetylation; Active Transport, Cell Nucleus; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cardiotonic Agents; Cell Nucleus; Cells, Cultured; E1A-Associated p300 Protein; Endothelin-1; GATA4 Transcription Factor; GATA6 Transcription Factor; Mutation; Myocytes, Cardiac; Phenylephrine; Protein Processing, Post-Translational; Rats; Transcription, Genetic | 2008 |
PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Binding, Competitive; Calcineurin; Cardiomegaly; Cardiotonic Agents; Cell Size; Cells, Cultured; LIM Domain Proteins; Mechanotransduction, Cellular; Mice; Mice, Transgenic; Muscle Proteins; Myocytes, Cardiac; Nerve Tissue Proteins; NFATC Transcription Factors; NIH 3T3 Cells; Phenylephrine; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Signal Transduction; Thioredoxins; Transduction, Genetic | 2008 |
PICOT: a multidomain scaffolding inhibitor of hypertrophic signal transduction.
Topics: Active Transport, Cell Nucleus; Animals; Binding, Competitive; Calcineurin; Cardiomegaly; Cell Size; LIM Domain Proteins; Mechanotransduction, Cellular; Muscle Proteins; Myocytes, Cardiac; Nerve Tissue Proteins; NFATC Transcription Factors; Phenylephrine; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Signal Transduction; Thioredoxins | 2008 |
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cardiomegaly; Diacylglycerol Kinase; Diglycerides; Disease Models, Animal; Disease Progression; Fetal Proteins; Fibrosis; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Failure; Isoenzymes; Ligation; Mice; Mice, Transgenic; Myocardium; Organ Size; Phenylephrine; Protein Kinase C; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; TRPC Cation Channels; TRPC6 Cation Channel; Ventricular Function, Left | 2008 |
Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size.
Topics: Animals; Antidotes; Apoptosis; Biomarkers; Cardiomegaly; Cardiotonic Agents; Cell Size; Cells, Cultured; Copper Sulfate; Dose-Response Relationship, Drug; Mice; Myocytes, Cardiac; Phenylephrine; Rats; Rats, Sprague-Dawley; Time Factors; Vascular Endothelial Growth Factor A | 2008 |
Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy.
Topics: Angiopoietin-1; Animals; Base Sequence; Cardiomegaly; Cell Line; DNA Primers; Endothelial Cells; Integrins; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Quaternary; Receptor, TIE-2; Recombinant Proteins; RNA, Messenger; Ventricular Remodeling | 2008 |
Effects of the adrenergic nervous system on training-induced cardiac enlargement, and on the intrinsic rate and phenylephrine sensitivity of isolated rat atria.
Topics: Adaptation, Physiological; Animals; Cardiomegaly; Cold Temperature; Heart Atria; Heart Rate; In Vitro Techniques; Male; Norepinephrine; Phenylephrine; Physical Exertion; Rats; Running; Swimming; Sympathetic Nervous System | 1982 |
Myocardial oxygen consumption in left ventricular hypertrophy and its relation to left ventricular mechanics.
Topics: Adult; Aged; Cardiomegaly; Coronary Circulation; Female; Heart Ventricles; Humans; Male; Middle Aged; Myocardial Contraction; Myocardium; Nitroglycerin; Oxygen Consumption; Phenylephrine; Stroke Volume | 1983 |
Matching of myocardial oxygen consumption to mechanical load in human left ventricular hypertrophy and dysfunction.
Topics: Adult; Aged; Cardiac Catheterization; Cardiomegaly; Coronary Circulation; Echocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Contraction; Myocardium; Nitroglycerin; Oxygen Consumption; Phenylephrine; Stress, Mechanical; Stroke Volume | 1984 |
Applications and limitations of end-systolic measures of ventricular performance.
Topics: Animals; Cardiomegaly; Chronic Disease; Dogs; Heart Diseases; Heart Function Tests; Heart Ventricles; Humans; Isoproterenol; Mitral Valve Insufficiency; Myocardial Contraction; Phenylephrine; Stimulation, Chemical; Stroke Volume; Systole | 1984 |
An unusual case of Bjork-Shiley mitral valve dysfunction corrected nonsurgically.
Topics: Aspirin; Cardiomegaly; Dipyridamole; Echocardiography; Female; Furosemide; Heart Murmurs; Heart Valve Prosthesis; Humans; Hypotension; Middle Aged; Mitral Valve Prolapse; Phenylephrine; Prothrombin Time; Warfarin | 1981 |
Beta-adrenergic stimulation of cardiac non-myocytes augments the growth-promoting activity of non-myocyte conditioned medium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Betaxolol; Cardiomegaly; Cell Division; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; DNA; Growth Substances; Heart; Isoproterenol; Myocardium; Phenylephrine; Propranolol; Rats; Receptors, Adrenergic, beta; RNA, Messenger; Transforming Growth Factor beta | 1993 |
Retinoid-dependent pathways suppress myocardial cell hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Endothelins; Genetic Markers; Heart; Humans; In Vitro Techniques; Myocardium; Phenylephrine; Rats; Receptors, Adrenergic, alpha; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Transcription Factors; Transcriptional Activation; Transfection; Tretinoin | 1995 |
Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Base Sequence; Cardiomegaly; Cells, Cultured; Chromatography, Gel; Chromatography, High Pressure Liquid; DNA Primers; Endothelins; Enzyme Activation; Gene Expression Regulation; Heart Ventricles; Kinetics; Molecular Sequence Data; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Phenylephrine; Protein Kinase C; Radioimmunoassay; Rats; Rats, Wistar; Restriction Mapping; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1995 |
Effect of alpha adrenergic stimulation and carnitine palmitoyl transferase I inhibition on hypertrophying adult rat cardiomyocytes in culture.
Topics: Animals; Atrial Natriuretic Factor; Base Sequence; Cardiomegaly; Cell Division; Cells, Cultured; DNA; Epoxy Compounds; Gene Expression; Glucose; Molecular Sequence Data; Myocardium; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Phenylalanine; Phenylephrine; Protein Biosynthesis; Rats; Sodium Channels | 1995 |
Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes.
Topics: Age Factors; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Dactinomycin; Epidermal Growth Factor; Heart; Heart Ventricles; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Myocardium; Phenylephrine; Physical Stimulation; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Gene Expression; Heart Ventricles; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Myocardium; Myosins; Phenylephrine; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Recombinant Proteins; Transcription, Genetic; Transfection | 1994 |
The tyrosine kinase inhibitor, genistein, prevents alpha-adrenergic-induced cardiac muscle cell hypertrophy by inhibiting activation of the Ras-MAP kinase signaling pathway.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Gene Expression; Genistein; Isoflavones; Mitogen-Activated Protein Kinase 1; Myocardium; Myosin-Light-Chain Kinase; Phenylephrine; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Rats; Receptors, Adrenergic, alpha; Signal Transduction | 1994 |
Differential response of hypertrophied rat hearts to various alpha 1-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Aortic Valve Stenosis; Blood Pressure; Cardiomegaly; Cardiotonic Agents; Heart Rate; Imidazoles; Male; Methoxamine; Organ Size; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity | 1993 |
An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes.
Topics: Animals; Animals, Newborn; Base Sequence; Binding Sites; Cardiomegaly; Cells, Cultured; Enhancer Elements, Genetic; Enzyme Activation; Humans; Isoenzymes; Mice; Molecular Sequence Data; Myocardium; Myosins; Nuclear Proteins; Oligodeoxyribonucleotides; Phenylephrine; Promoter Regions, Genetic; Protein Kinase C; Rabbits; Rats; Receptors, Adrenergic, alpha-1; Sequence Homology, Nucleic Acid; Transfection | 1994 |
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heart Ventricles; Hydrolysis; Luciferases; Microinjections; Myocardium; Oncogene Protein p21(ras); Phenylephrine; Phosphatidylinositols; Rats; Receptors, Adrenergic, alpha-1 | 1994 |
Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Chromatography, Liquid; Disease Models, Animal; Endothelins; Enzyme Activation; Glycogen Synthase Kinase 3; Molecular Sequence Data; Myocardium; Phenylephrine; Phosphoprotein Phosphatases; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1993 |
HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cell Division; Cells, Cultured; Gene Expression; Genes, fos; Genes, ras; Genetic Markers; Heart Ventricles; Myocardium; Phenylephrine; Rats; Transfection | 1993 |
Hypertrophic effects of calcitonin gene-related peptide (CGRP) and amylin on adult mammalian ventricular cardiomyocytes.
Topics: Age Factors; Amyloid; Animals; Calcitonin Gene-Related Peptide; Cardiomegaly; Cells, Cultured; Creatine Kinase; Cytosol; Heart Ventricles; Islet Amyloid Polypeptide; L-Lactate Dehydrogenase; Male; Phenylephrine; Protein Biosynthesis; Protein Kinase C; Proteins; Rats; Rats, Wistar | 1995 |
Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes.
Topics: Actin Cytoskeleton; Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cardiomegaly; Endothelins; Enzyme Activation; Flavonoids; Gene Expression; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; Myosin-Light-Chain Kinase; Phenylephrine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; Receptors, Cell Surface | 1996 |
Extracellular ATP inhibits adrenergic agonist-induced hypertrophy of neonatal cardiac myocytes.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic Antagonists; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Cardiomegaly; Cell Size; Cells, Cultured; Chromatography, High Pressure Liquid; Extracellular Space; Gene Expression; Genes, fos; Heart Ventricles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Probes; Molecular Sequence Data; Myocardium; Phenylalanine; Phenylephrine; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar | 1996 |
Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in rat cardiac myocytes.
Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Down-Regulation; Molecular Sequence Data; Oligonucleotides, Antisense; Phenylephrine; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley | 1996 |
Overexpression of the transcription factor UBF1 is sufficient to increase ribosomal DNA transcription in neonatal cardiomyocytes: implications for cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Base Sequence; Cardiomegaly; Cells, Cultured; DNA Primers; DNA-Binding Proteins; DNA, Ribosomal; Gene Expression Regulation; Molecular Sequence Data; Myocardial Contraction; Phenylephrine; Pol1 Transcription Initiation Complex Proteins; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA, Ribosomal; Transcription Factors; Transcription, Genetic; Transfection | 1996 |
Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo.
Topics: Aging; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Dinoprost; Heart; Male; Myocardial Infarction; Myocardium; Phenylephrine; Prostaglandins; Prostaglandins F, Synthetic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1996 |
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-1 Receptor Antagonists; Amino Acids; Animals; Animals, Newborn; Biological Transport; Bucladesine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Heart; Kinetics; Myocardium; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Sarcolemma | 1997 |
MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells.
Topics: 3T3 Cells; Actins; ADP Ribose Transferases; Animals; Atrial Natriuretic Factor; Botulinum Toxins; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Cycle Proteins; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; GTP Phosphohydrolases; Immediate-Early Proteins; Luminescent Proteins; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphoprotein Phosphatases; Protein Kinases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rho Factor; Signal Transduction; Transcription Factor AP-1 | 1997 |
Cross-talk between receptor-mediated phospholipase C-beta and D via protein kinase C as intracellular signal possibly leading to hypertrophy in serum-free cultured cardiomyocytes.
Topics: Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Culture Media, Serum-Free; Down-Regulation; Endothelin-1; Histones; Immunoblotting; Isoenzymes; Myocardium; Phenylephrine; Phospholipase C beta; Phospholipase D; Protein Biosynthesis; Protein Kinase C; Proteins; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Division; Cell Size; Cells, Cultured; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Pyridines; Rats; Sarcomeres | 1997 |
Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Bradykinin; Bradykinin Receptor Antagonists; Cardiomegaly; Cells, Cultured; Heart; Indoles; Myocardium; Nitrates; Nitric Oxide; Nitrites; Nitroarginine; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Regression Analysis | 1997 |
Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo.
Topics: Actins; Aldosterone; Animals; Aorta, Thoracic; Carbachol; Cardiomegaly; Cell Cycle; DNA; Heart; Hypertension; In Vitro Techniques; Isometric Contraction; Muscle, Skeletal; Muscle, Smooth, Vascular; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Polyploidy; Rats; Rats, Inbred WKY; Renin-Angiotensin System; RNA, Messenger; Transcription, Genetic | 1998 |
Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy.
Topics: Acetylcholine; Animals; Animals, Newborn; Blood Pressure; Cardiomegaly; Coronary Vessels; DNA, Antisense; Fibrosis; Genetic Therapy; Genetic Vectors; Heart; Heart Ventricles; Humans; Hypertension; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Artery; Retroviridae | 1998 |
An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy.
Topics: Amino Acid Sequence; Animals; Cardiomegaly; Cells, Cultured; Databases, Factual; Electrophoresis, Gel, Two-Dimensional; Humans; Image Processing, Computer-Assisted; Molecular Sequence Data; Myocardium; Peptide Mapping; Phenylephrine; Proteins; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1998 |
Differential expression and localization of annexin V in cardiac myocytes during growth and hypertrophy.
Topics: Animals; Annexin A5; Cardiomegaly; Cardiotonic Agents; Cell Differentiation; Female; Heart; Male; Myocardium; Phenylephrine; Pregnancy; Rats; Rats, Inbred Lew; Rats, Inbred WKY | 1998 |
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
Topics: Angiotensin II; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcineurin; Cardiomegaly; Cell Nucleus; DNA-Binding Proteins; GATA4 Transcription Factor; Immunosuppressive Agents; Mice; Mice, Transgenic; Myocardium; Natriuretic Peptide, Brain; NFATC Transcription Factors; Nuclear Proteins; Phenylephrine; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Zinc Fingers | 1998 |
Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cardiotonic Agents; Endothelin-1; Enzyme Inhibitors; Growth Inhibitors; Heart; Imidazoles; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Leukemia Inhibitory Factor; Lymphokines; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats | 1998 |
Influence of pHi and creatine phosphate on alpha-adrenoceptor-mediated cardiac hypertrophy.
Topics: Adrenergic alpha-Agonists; Animals; Cardiomegaly; Cell Division; Cells, Cultured; Guanidines; Heart Ventricles; Hydrogen-Ion Concentration; Male; Myocardium; Phenylephrine; Phosphocreatine; Propionates; Protein Biosynthesis; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; RNA; Sodium-Hydrogen Exchangers; Sulfones | 1998 |
Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes.
Topics: Adenoviridae; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Extracellular Matrix; Gene Expression Regulation, Viral; Heart Ventricles; Integrin beta1; Isomerism; Myocardium; Phenylephrine; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Signal Transduction; Transfection | 1998 |
Crosstalk between alpha-1A and alpha-1B adrenoceptors in neonatal rat myocardium: implications in cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channels; Cardiomegaly; Heart; Imidazoles; Isoenzymes; Myocardial Contraction; Phenylephrine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Tetrahydronaphthalenes | 1998 |
Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Size; Cell Survival; Cells, Cultured; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Heart Ventricles; Hypertrophy; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Receptors, Cell Surface; Virulence Factors, Bordetella | 1998 |
Electrophysiological properties of neonatal rat ventricular myocytes with alpha1-adrenergic-induced hypertrophy.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Analysis of Variance; Animals; Animals, Newborn; Barium; Calcium Channels; Calcium Channels, L-Type; Cardiomegaly; Cells, Cultured; Heart; Heart Ventricles; Myocardium; Patch-Clamp Techniques; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Sodium Channels | 1998 |
Regulation of Kv4.2 and Kv1.4 K+ channel expression by myocardial hypertrophic factors in cultured newborn rat ventricular cells.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Culture Media, Conditioned; Endothelin-1; Heart Ventricles; Insulin-Like Growth Factor I; Kv1.4 Potassium Channel; Molecular Sequence Data; Myocardium; Phenylephrine; Potassium Channels; Potassium Channels, Voltage-Gated; Rabbits; Rats; Rats, Wistar; Shal Potassium Channels; Triiodothyronine | 1998 |
A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.
Topics: Adenoviridae; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Size; Cells, Cultured; Fluorescent Antibody Technique; Gene Expression Regulation; Gene Transfer Techniques; GTP Phosphohydrolases; GTP-Binding Proteins; Myocardium; Phenylephrine; Protein Biosynthesis; Proto-Oncogene Proteins c-raf; rac GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Sarcomeres; Signal Transduction | 1998 |
A Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy.
Topics: Adenoviridae; Animals; Cardiomegaly; Cells, Cultured; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Gene Expression Regulation; Genes, ras; GTPase-Activating Proteins; Immunohistochemistry; Myocardium; Phenylephrine; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proteins; ras GTPase-Activating Proteins; Rats; Rats, Sprague-Dawley; RNA; RNA Polymerase II; Signal Transduction; Transcriptional Activation; Transfection | 1998 |
Phenylephrine, endothelin, prostaglandin F2alpha' and leukemia inhibitory factor induce different cardiac hypertrophy phenotypes in vitro.
Topics: Actins; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; Dinoprost; Endothelins; Growth Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Myocardium; Phenylephrine; Rats; RNA, Messenger | 1998 |
Role of phosphatidylinositol 3-kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Androstadienes; Animals; Cardiomegaly; Cells, Cultured; Chromatography, Thin Layer; Chromones; DNA; Enzyme Activation; Enzyme Inhibitors; Isoproterenol; Male; Morpholines; Myocardium; Phenylalanine; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Biosynthesis; Rats; Rats, Wistar; RNA; Signal Transduction; Stimulation, Chemical; Time Factors; Uridine; Wortmannin | 1998 |
RGS4 inhibits G-protein signaling in cardiomyocytes.
Topics: Actin Cytoskeleton; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; Endothelin-1; Fibroblast Growth Factor 2; Gene Expression Regulation, Enzymologic; Genes, Reporter; GTP-Binding Proteins; Luciferases; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Point Mutation; Proteins; Rats; Rats, Sprague-Dawley; RGS Proteins; Signal Transduction; Subcellular Fractions; Sympathomimetics; Transcriptional Activation; Transfection | 1999 |
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; beta-Adrenergic Receptor Kinases; Body Weight; Cardiomegaly; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Heart; Heart Ventricles; Infusion Pumps; Isoproterenol; Mice; Mice, Inbred C57BL; Myocardium; Organ Size; Phenylephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Signal Transduction | 1999 |
Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists.
Topics: Animals; Cardiomegaly; Cell Cycle Proteins; Cells, Cultured; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 6; Flavonoids; Gene Expression Regulation; Genes, ras; Genes, Reporter; Glucose Transporter Type 1; Glucose Transporter Type 4; Heart Ventricles; Immediate-Early Proteins; Microscopy, Fluorescence; Monosaccharide Transport Proteins; Muscle Proteins; Phenylephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 1999 |
Alpha1-adrenergic stimulation induced hypertrophy in protein kinase C down-regulated cultured cardiac myocytes.
Topics: Adrenergic alpha-Agonists; Animals; Cardiomegaly; Cell Size; Cells, Cultured; Down-Regulation; Hypertrophy; Myocardium; Phenylephrine; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate | 1999 |
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcinogens; Cardiomegaly; Cells, Cultured; Chromones; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Heart Ventricles; Indoles; Isoenzymes; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Wortmannin | 1999 |
Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Cyclic GMP; Enzyme Activation; Fluorescent Antibody Technique; Mitogen-Activated Protein Kinase Kinases; Myocardium; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley | 1999 |
Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Cardiomegaly; DNA-Binding Proteins; GATA4 Transcription Factor; Gene Expression Regulation; Genes, Immediate-Early; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myosin Heavy Chains; Phenylephrine; Receptors, Adrenergic; Transcription Factors; Xenopus Proteins | 1999 |
Inhibitory regulation of hypertrophy by endogenous atrial natriuretic peptide in cultured cardiac myocytes.
Topics: Actins; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; Gene Expression; Mice; Myocardium; Myosin Heavy Chains; Natriuretic Peptide, Brain; Phenylephrine; Polysaccharides; Protein Biosynthesis; Rats; RNA, Messenger | 2000 |
Angiotensin I-converting enzyme antisense gene therapy causes permanent antihypertensive effects in the SHR.
Topics: Acetylcholine; Angiotensins; Animals; Blood Pressure; Bradykinin; Cardiomegaly; Cell Line; Coronary Circulation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Genetic Therapy; Hypertension; Male; Oligonucleotides, Antisense; Peptidyl-Dipeptidase A; Phenotype; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Retroviridae; Transgenes; Vascular Resistance; Vasodilator Agents | 2000 |
Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro.
Topics: Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Myosin-Light-Chain Kinase; Phenotype; Phenylephrine; Phosphorylation; Rats; Rats, Wistar; Sarcomeres | 2000 |
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.
Topics: Adenoviridae; Angiotensin II; Animals; Apoptosis Regulatory Proteins; Atrial Natriuretic Factor; Calcineurin; Calcineurin Inhibitors; Cardiomegaly; Carrier Proteins; Cattle; Cells, Cultured; DNA-Binding Proteins; Fetal Blood; Gene Expression Regulation; Genes; Genetic Therapy; Genetic Vectors; Hypertrophy; Myocardium; NFATC Transcription Factors; Nuclear Proteins; Phenylephrine; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transfection | 2000 |
Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice.
Topics: Actins; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression; Genes, fos; Genes, jun; Immediate-Early Proteins; Isoproterenol; Male; Mice; Mice, Mutant Strains; Myosin Heavy Chains; Neoplasm Proteins; Phenylephrine; Receptors, Adrenergic; Repressor Proteins; Sp1 Transcription Factor; Transcription Factors | 2000 |
Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro.
Topics: Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Heart; Heart Ventricles; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Cardiovascular; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Recombinant Proteins; Signal Transduction; Transfection | 2000 |
A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes.
Topics: Animals; Animals, Newborn; Cardiomegaly; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Heart Ventricles; Immunohistochemistry; Phenylephrine; Phosphorylation; Protein-Tyrosine Kinases; Rats; Tyrosine | 2000 |
Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Nucleus; Cells, Cultured; Cytosol; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Genes, Reporter; Imidazoles; MAP Kinase Kinase 1; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Nuclear Proteins; Phenylephrine; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Serum Response Factor; Time Factors; Transcription Factors; Transfection | 2000 |
Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy.
Topics: Animals; Base Sequence; Butadienes; Cardiomegaly; DNA Primers; Endothelin-1; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Phenylephrine; Rats; Rats, Sprague-Dawley | 2000 |
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy.
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; DNA-Binding Proteins; Endothelin-1; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Mutation; Myocardium; NFATC Transcription Factors; Nuclear Proteins; Phenylephrine; Phosphatidylinositol 3-Kinases; Rats; Signal Transduction; Transcription Factors | 2000 |
Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Antibodies; Atrial Natriuretic Factor; Cardiomegaly; Cardiotonic Agents; Cell Size; Cytoplasm; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Genes, Reporter; Heart Ventricles; Integrin beta1; Molecular Sequence Data; Muscle Fibers, Skeletal; Muscle, Skeletal; Myocardium; Phenylephrine; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction | 2000 |
The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo.
Topics: Adenoviridae; Animals; Animals, Newborn; Atrial Natriuretic Factor; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Catecholamines; Cells, Cultured; DNA, Recombinant; Endothelin-1; Female; Gene Expression; Gene Transfer Techniques; Genetic Vectors; Mice; Mice, Transgenic; Myocardium; Phenylephrine; Phosphorylation; Protein Tyrosine Phosphatases; Rats; RNA, Messenger | 2001 |
Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor.
Topics: Animals; Blood Pressure; Body Weight; Bradycardia; Cardiomegaly; Dose-Response Relationship, Drug; Echocardiography; Epinephrine; Femoral Artery; Heart Rate; Heart Septum; Humans; Hydrocortisone; Hypotension; Inositol 1,4,5-Trisphosphate; Kidney; Male; Mice; Mice, Knockout; Mice, Transgenic; Norepinephrine; Organ Culture Techniques; Organ Size; Phenotype; Phenylephrine; Promoter Regions, Genetic; Receptors, Adrenergic, alpha-1; Time Factors | 2001 |
Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.
Topics: Animals; Animals, Newborn; Calcimycin; Calcineurin; Cardiomegaly; Cell Cycle Proteins; Cell Line; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cyclosporine; Dual Specificity Phosphatase 1; Fibroblasts; Gene Expression Regulation, Enzymologic; Heart; Immediate-Early Proteins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transfection | 2001 |
Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; DNA-Binding Proteins; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phenylephrine; Rats; Rats, Sprague-Dawley | 2001 |
Adrenomedullin is a regulated modulator of neonatal cardiomyocyte hypertrophy in vitro.
Topics: Adenylyl Cyclases; Adrenomedullin; Analysis of Variance; Animals; Atrial Natriuretic Factor; Calcium; Cardiomegaly; Cells, Cultured; Colforsin; Endothelin-1; Enzyme Activation; Gene Expression Regulation; Myocardium; Peptides; Phenylephrine; Protein Kinase C; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2001 |
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Animals; beta-Adrenergic Receptor Kinases; Body Weight; Cardiomegaly; Cardiomyopathy, Dilated; Cyclic AMP-Dependent Protein Kinases; Mice; Mice, Transgenic; Muscle Proteins; Myocardium; Neuropeptide Y; Organ Size; Phenylephrine; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; RNA, Messenger; Signal Transduction | 2001 |
c-Jun N-terminal kinase-interacting protein 1 inhibits gene expression in response to hypertrophic agonists in neonatal rat ventricular myocytes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Cardiomegaly; Carrier Proteins; Cell Size; Cells, Cultured; Endothelin-1; Genes, Immediate-Early; Heart Ventricles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Transfection | 2001 |
Phenylephrine induced aortic vasoconstriction is attenuated in hyperthyroid rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cardiomegaly; Endothelium, Vascular; Hyperthyroidism; Male; Models, Animal; Muscle, Smooth, Vascular; Myocardial Contraction; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Thyroxine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Heart; Humans; Immediate-Early Proteins; Lysophospholipids; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Peptides; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Structure, Tertiary; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Stress Fibers; Tissue Extracts; Virulence Factors, Bordetella | 2001 |
Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy.
Topics: Animals; Calcium-Transporting ATPases; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Male; Motor Activity; Myocardium; Myosin Heavy Chains; Phenotype; Phenylephrine; Physical Conditioning, Animal; Protein Isoforms; Rats; Rats, Wistar; Receptors, Thyroid Hormone; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Transfection; Triiodothyronine | 2001 |
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Biological Transport; Cardiomegaly; Cells, Cultured; Chromans; Heart; Leucine; Myocardium; Natriuretic Peptide, Brain; NF-kappa B; Phenylephrine; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stress, Mechanical; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Brain; Cardiomegaly; Female; Gestational Age; Heart; Imidazoles; Kidney; Lung; Organ Size; Phenylephrine; Pregnancy; Pulmonary Artery; Pyridines; Receptor, Angiotensin, Type 2; Sheep | 2001 |
Effects of adrenomedullin on hypertrophic responses induced by angiotensin II, endothelin-1 and phenylephrine.
Topics: Adrenomedullin; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cyclic AMP; Cyclic GMP; Drug Interactions; Endothelin-1; Gene Expression; Heart; Heart Ventricles; In Vitro Techniques; Myocardium; Natriuretic Peptide, Brain; Peptides; Phenylephrine; Rats; Sarcomeres | 2001 |
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy.
Topics: ADAM Proteins; ADAM12 Protein; Angiotensin II; Animals; Aorta, Thoracic; Cardiomegaly; Disease Models, Animal; Disintegrins; Epidermal Growth Factor; ErbB Receptors; Glycine; GTP-Binding Proteins; Heart Ventricles; Heparin-binding EGF-like Growth Factor; Hydroxamic Acids; Hypertension; Intercellular Signaling Peptides and Proteins; Male; Membrane Proteins; Metalloendopeptidases; Phenylephrine; Protease Inhibitors; Protein Processing, Post-Translational; Rats; Signal Transduction; Systole; Transcriptional Activation | 2002 |
Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine.
Topics: Adenoviridae; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Size; Cells, Cultured; DNA, Complementary; Endothelin-1; Genes, Dominant; Genes, jun; Heart Ventricles; Lac Operon; Mutation; Myocardium; Natriuretic Peptide, Brain; Phenylephrine; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Transcription Factor AP-1; Transcriptional Activation; Transfection | 2002 |
Specific role for the extracellular signal-regulated kinase pathway in angiotensin II- but not phenylephrine-induced cardiac hypertrophy in vitro.
Topics: Angiotensin II; Animals; Carbon Radioisotopes; Cardiomegaly; Cells, Cultured; Heart Ventricles; In Vitro Techniques; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Myocardium; Phenylalanine; Phenylephrine; Protein Kinase C; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Vasoconstrictor Agents | 2002 |
Apoptosis signal-regulating kinase/nuclear factor-kappaB: a novel signaling pathway regulates cardiomyocyte hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Cytokines; Endothelin-1; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; NF-kappa B; Phenylephrine; Reactive Oxygen Species; Signal Transduction | 2002 |
Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Heterotrimeric GTP-Binding Proteins; I-kappa B Proteins; Kinetics; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; Mutation; Myocardium; NF-kappa B; Phenylephrine; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cell Surface; Sarcomeres | 2002 |
Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Binding Sites; Cardiomegaly; DNA-Binding Proteins; Endothelin-1; GATA4 Transcription Factor; Gene Expression Regulation; Myocardium; Natriuretic Peptide, Brain; Oligodeoxyribonucleotides; Phenylephrine; Promoter Regions, Genetic; Protein Binding; Rats; Transcription Factors | 2002 |
Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.
Topics: Angiotensin II; Animals; Aorta; Arterioles; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Cardiovascular System; Echocardiography; Heart Rate; Heart Ventricles; Hypertension; Male; Mesentery; Mice; Mice, Transgenic; Norepinephrine; Organ Size; Phenylephrine; Receptors, Adrenergic, alpha-1; RNA, Messenger; Vasoconstrictor Agents; Ventricular Remodeling | 2002 |
Cardiomegaly produced by chronic beta-adrenergic stimulation in the rat: comparison with alpha-adrenergic effects.
Topics: Actomyosin; Adenosine Triphosphatases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Dose-Response Relationship, Drug; Isoproterenol; Male; Myocardium; Phenylephrine; Rats | 1977 |
Humoral regulation of vascular resistance after 30 days of pulmonary artery constriction.
Topics: Angiotensin II; Animals; Cardiomegaly; Catecholamines; Dopamine; Epinephrine; Guinea Pigs; Heart Failure; Norepinephrine; Papaverine; Phentolamine; Phenylephrine; Saralasin; Sympathetic Nervous System; Tyrosine 3-Monooxygenase; Vascular Resistance | 1979 |
Dimensional analysis of the left ventricle: effects of acute aortic regurgitation.
Topics: Animals; Aortic Valve Insufficiency; Cardiac Output; Cardiac Volume; Cardiomegaly; Cineradiography; Dogs; Heart Rate; Heart Ventricles; Phenylephrine; Pressure | 1975 |
Dynamic changes in left ventricular wall thickness and their use in analyzing cardiac function in the conscious dog.
Topics: Animals; Aortic Valve Stenosis; Biomechanical Phenomena; Cardiomegaly; Coronary Disease; Dogs; Heart; Heart Rate; Isoproterenol; Myocardial Contraction; Phenylephrine; Propranolol; Ultrasonography; Ventricular Function | 1976 |
Cardiac responses after norepinephrine-induced ventricular hypertrophy in rats.
Topics: Animals; Bucladesine; Calcium Chloride; Cardiomegaly; Colforsin; Heart Rate; Male; Myocardial Contraction; Norepinephrine; Papillary Muscles; Phenylephrine; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1992 |
Chronic elevation of norepinephrine in conscious dogs produces hypertrophy with no loss of LV reserve.
Topics: Animals; Blood Volume; Cardiomegaly; Diastole; Dogs; Hemodynamics; Norepinephrine; Phenylephrine; Reference Values; Stroke Volume; Time Factors; Ventricular Function, Left | 1992 |
Altered responsiveness of hypertrophied rat hearts to alpha- and beta-adrenergic stimulation.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Blood Pressure; Calcium; Cardiomegaly; Colforsin; Isoproterenol; Male; Myocardial Contraction; Myocardium; Organ Size; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1991 |
Altered function and structure of the heart in dogs with chronic elevation in plasma norepinephrine.
Topics: Animals; Cardiomegaly; Dogs; Hemodynamics; Isoproterenol; Microscopy, Electron; Myocardial Contraction; Myocardium; Norepinephrine; Phenylephrine; Ventricular Function, Left | 1991 |
Properties of cardiac alpha- and beta-adrenoceptors in spontaneously hypertensive rats.
Topics: Aging; Animals; Cardiomegaly; Electric Stimulation; Hypertension; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Myocardium; Papillary Muscles; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1988 |
Impaired responsiveness of the ventricular sensory receptor in hypertensive patients with left ventricular hypertrophy.
Topics: Adult; Blood Pressure; Cardiac Output; Cardiomegaly; Central Venous Pressure; Female; Heart Rate; Heart Ventricles; Humans; Hypertension; Male; Phenylephrine; Pressoreceptors; Propranolol; Pulmonary Wedge Pressure; Reflex; Sensory Receptor Cells; Vascular Resistance | 1986 |
Impaired inotropic responses to alpha-adrenergic stimulation in experimental left ventricular hypertrophy.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension, Renal; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phenylephrine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1985 |
Increased sensitivity to alpha-adrenoceptor stimulation but intact purinergic and muscarinergic effects in prehypertensive cardiac hypertrophy of spontaneously hypertensive rats.
Topics: Adenosine; Animals; Carbachol; Cardiomegaly; Hypertension; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Phenylisopropyladenosine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha | 1986 |
Alterations in the baroreceptor reflex in conscious dogs with heart failure.
Topics: Animals; Blood Flow Velocity; Cardiomegaly; Carotid Arteries; Dogs; Heart Failure; Heart Rate; Hypertension; Hypertrophy; Kidney; Mesenteric Arteries; Phenylephrine; Pressoreceptors; Pulmonary Valve Stenosis; Reflex; Tricuspid Valve; Vascular Resistance | 1972 |
Surgical management of coexisting coronary artery disease and idiopathic hypertrophic subaortic stenosis.
Topics: Angina Pectoris; Angiography; Cardiomegaly; Cardiomyopathy, Hypertrophic; Coronary Disease; Diet, Sodium-Restricted; Diuretics; Female; Heart Auscultation; Humans; Hypotension; Middle Aged; Myocardial Revascularization; Phenylephrine; Rest | 1973 |