Page last updated: 2024-11-02

phenylbutazone and Stevens-Johnson Syndrome

phenylbutazone has been researched along with Stevens-Johnson Syndrome in 39 studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

Excerpt	Relevance	Reference
"Those with toxic epidermal necrolysis had 100% mortality."	1.27	Drug eruptions from phenylbutazone in Jamu. ( Giam, YC; Lim, A; Tan, T; Tham, SN, 1986)

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (97.44)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (2.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Haddad, C	1
Chosidow, O	1
Valeyrie-Allanore, L	1
Ghaleh, B	1
Legrand, T	1
Mockenhaupt, M	1
Barau, C	1
Khoudour, N	1
Sekula, P	1
Wolkenstein, P	1
Hulin, A	1
STEEL, SJ	1
MOFFATT, JL	1
VANKOS, J	2
PASTINSZKY, I	1
PASTINSZKY, S	1
BRUNA, F	1
MUSUMECI, V	1
GEORGIEVA, S	1
BOIANOV, L	1
DIMITROVA, II	1
KAPNILOV, S	1
BONCINELLI, U	1
VACCARI, R	1
VAS, CJ	1
ANDERES, W	1
LAMY, P	1
BEUREY, J	1
ANTHOINE, D	1
VADOT, J	1
JACQUIN, B	1
BERTHEAU, JM	1
MANGANOTTI, G	1
SILVESTRI, U	1
STROEM, J	1
DAROCZY, P	1
SZABO, M	1
BURIS, L	1
HELLE, S	1
OVERTON, J	1
Fong, PH	1
Ratnagopal, P	1
Wong, KL	1
Andreeva, GP	1
Krivoshchekova, VG	1
Bazarnaia, NS	1
Pankova, RA	1
Iaroshkevich, TF	1
Volodikhin, VI	1
Zucker, G	1
Stiller, D	1
Giam, YC	1
Tham, SN	1
Tan, T	1
Lim, A	1
Coursin, DB	1
Schulz, KH	1
Stabenow, DL	1
Monnat, A	1
Timperman, J	1
Verbauwhede, W	1
Bruinsma, W	1
Voborová, A	1
Krtková, J	1
Bonnet, J	1
Calas, E	1
Bacconnier, J	1
Alicherif, H	1
Montgomery, PR	1
Jánoska, A	1
Sinka, L	1
Tritsch, H	2
Sprafke, U	1
Omulecki, A	1
Wranicz, A	1
Mazurek, A	1
Carpentier, E	1
Calmettes, L	1
Bazex, A	1
Salvador, R	1
Deodati, F	1
Höfer, W	1
Hönemann, W	1

Reviews

1 review available for phenylbutazone and Stevens-Johnson Syndrome

Article	Year
[CONTRIBUTION TO THE STUDY OF THE LYELL SYNDROME]. Archivio italiano di dermatologia, venereologia, e sessuologia, 1964, Volume: 32 Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Arthritis, Rheumatoid; D	1964

Other Studies

38 other studies available for phenylbutazone and Stevens-Johnson Syndrome

Article	Year
Are Idiopathic Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Related to Drugs in Food? The Example of Phenylbutazone. The Journal of investigative dermatology, 2017, Volume: 137, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Calibration; Ch	2017
Stevens-Johnson syndrome and granulocytopenia after phenylbutazone. British medical journal, 1954, Apr-03, Volume: 1, Issue:4865 Topics: Agranulocytosis; Analgesics; Erythema Multiforme; Humans; Penicillins; Phenylbutazone; Stevens-Johns	1954
[Fatal case of Stevens-Johnson syndrome caused by phenylbutazone]. Orvosi hetilap, 1957, Aug-18, Volume: 98, Issue:33 Topics: Aminopyrine; Erythema Multiforme; Humans; Phenylbutazone; Stevens-Johnson Syndrome	1957
[A fatal case of Stevens-Johnson syndrome due to phenylbutazone]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1957, Jul-15, Volume: 23, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Erythema Multiforme; Humans; Phenylbutazone; Stevens-Johnso	1957
[A fatal case of Stevens-Johnson syndrome due to phenylbutazone; etiopathogenetic observations]. Bollettino d'oculistica, 1958, Volume: 37, Issue:1 Topics: Erythema Multiforme; Humans; Phenylbutazone; Stevens-Johnson Syndrome	1958
[On the Lyell syndrome]. Minerva dermatologica, 1962, Volume: 37 Topics: Drug Eruptions; Penicillins; Phenylbutazone; Stevens-Johnson Syndrome; Streptomycin	1962
[A new superacute drug syndrome (necrolysis epidermalis toxica, Lyell's syndrome)]. Suvremenna meditsina, 1962, Volume: 13(8) Topics: Aminopyrine; Drug Eruptions; Humans; Penicillins; Phenylbutazone; Stevens-Johnson Syndrome; Streptom	1962
[Lyell's syndrome]. Minerva dermatologica, 1963, Volume: 38 Topics: Adrenal Cortex Hormones; Aminopyrine; Anti-Bacterial Agents; Drug Eruptions; Humans; Phenylbutazone;	1963
An unusual complication of phenylbutazone therapy--toxic epidermal necrolysis. Postgraduate medical journal, 1963, Volume: 39 Topics: Drug Eruptions; Humans; Phenylbutazone; Stevens-Johnson Syndrome	1963
[On a case of "toxic epidermal necrolysis" (Lyell) with severe eye complications]. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1963, Volume: 145 Topics: Drug Hypersensitivity; Humans; Keratoconjunctivitis; Phenylbutazone; Skin; Stevens-Johnson Syndrome	1963
[LYELL'S SYNDROME. (APROPOS OF A RECENT CASE)]. Annales medicales de Nancy, 1964, Volume: 3 Topics: Diagnosis, Differential; Drug Eruptions; Penicillins; Phenylbutazone; Stevens-Johnson Syndrome; Toxi	1964
[FEBRILE MUCOCUTANEOUS SYNDROMES (ECTODERMOSIS EROSIVA PLURIORIFICIALIS, STEVENS-JOHNSON SYNDROME, ETC.) CAUSED BY BUTAZOLIDINE]. Svenska lakartidningen, 1964, Nov-11, Volume: 61 Topics: Erythema Multiforme; Exanthema; Humans; Phenylbutazone; Stevens-Johnson Syndrome; Toxicology	1964
[RHEOPYRINE DRAGEE CAUSING LETHAL LYELL'S SYNDROME]. Orvosi hetilap, 1965, Apr-04, Volume: 106 Topics: Aminopyrine; Arthritis; Arthritis, Rheumatoid; Drug Combinations; Drug Therapy; Humans; Phenylbutazo	1965
[LYELL'S TOXIC EPIDERMAL NECROLYSIS]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1964, Nov-15, Volume: 37 Topics: Drug Hypersensitivity; Humans; Phenacetin; Phenylbutazone; Stevens-Johnson Syndrome; Toxicology	1964
Toxic epidermal necrolysis associated phenylbutazone therapy. The British journal of dermatology, 1962, Volume: 74 Topics: Humans; Phenylbutazone; Skin Diseases; Stevens-Johnson Syndrome	1962
Drug induced toxic epidermal necrolysis. Singapore medical journal, 1984, Volume: 25, Issue:3 Topics: Adult; Allopurinol; Burns; Critical Care; Drug Combinations; Emergencies; Female; Humans; Middle Age	1984
[Lyell's syndrome as a consequence of reopirin sensitization]. Sovetskaia meditsina, 1980, Issue:8 Topics: Aminopyrine; Drug Combinations; Drug Hypersensitivity; Female; Humans; Middle Aged; Phenylbutazone;	1980
[Toxic epidermal necrosis as a manifestation of intolerance to butadione and delagyl]. Terapevticheskii arkhiv, 1979, Volume: 51, Issue:6 Topics: Adult; Chloroquine; Female; Humans; Phenylbutazone; Stevens-Johnson Syndrome	1979
[Immunologic in vitro diagnosis of the Lyell syndrome]. Dermatologische Monatschrift, 1978, Volume: 164, Issue:7 Topics: Adult; Cell Migration Inhibition; Codeine; Cytoplasmic Granules; Drug Hypersensitivity; Humans; Lymp	1978
Drug eruptions from phenylbutazone in Jamu. Annals of the Academy of Medicine, Singapore, 1986, Volume: 15, Issue:1 Topics: Adult; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Drug Eruptions; Female; Huma	1986
Stevens-Johnson syndrome: nonspecific parasensitivity reaction? JAMA, 1966, Oct-10, Volume: 198, Issue:2 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Chlorpropamide; Diagnos	1966
[Lymphocyte transformation test in drug hypersensitivity]. Archiv fur dermatologische Forschung, 1972, Volume: 244 Topics: Ampicillin; Drug Hypersensitivity; Exanthema; Humans; Immunologic Techniques; Lymphocyte Activation;	1972
Toxic epidermal necrolysis. Postgraduate medicine, 1972, Volume: 52, Issue:6 Topics: Adult; Age Factors; Child, Preschool; Erythromycin; Humans; Infant; Infant, Newborn; Necrosis; Penic	1972
[Comparative study of Lyell's and Stevens-Johnson syndromes: etiologic role of drugs]. Schweizerische medizinische Wochenschrift, 1972, Dec-23, Volume: 102, Issue:51 Topics: Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Codeine; Female; Humans; Hydant	1972
Toxic epidermal necrolysis (Lyell syndrome) and its medico-legal implications. Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1972, Nov-28, Volume: 71, Issue:2 Topics: Child, Preschool; Diphenhydramine; Female; Forensic Medicine; Humans; Phenylbutazone; Phenylephrine;	1972
Adverse reaction profiles of drug eruptions. Dermatologica, 1972, Volume: 145, Issue:6 Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er	1972
[2 cases of Lyell's syndrome with a severe course]. Ceskoslovenska dermatologie, 1973, Volume: 48, Issue:6 Topics: Arthritis, Rheumatoid; Drug Hypersensitivity; Female; Humans; Middle Aged; Phenylbutazone; Stevens-J	1973
[A case of Lyell's syndrome]. Marseille medical, 1971, Volume: 108, Issue:9 Topics: Adult; Female; Humans; Phenylbutazone; Stevens-Johnson Syndrome	1971
Toxic epidermal necrolysis due to phenylbutazone. The British journal of dermatology, 1970, Volume: 83, Issue:1 Topics: Adult; Female; Fibromyalgia; Humans; Phenylbutazone; Stevens-Johnson Syndrome	1970
[Bullous drug exanthemata with special regard to toxic epidermal necrolysis (Lyell)]. Ceskoslovenska dermatologie, 1969, Volume: 44, Issue:5 Topics: Adult; Aged; Aminopyrine; Blister; Drug-Related Side Effects and Adverse Reactions; Erythema; Female	1969
[Necrolysis as an histopathological phenomenon]. Archiv fur klinische und experimentelle Dermatologie, 1970, Volume: 237, Issue:1 Topics: Exanthema; Humans; Necrosis; Penicillins; Phenylbutazone; Skin Tests; Stevens-Johnson Syndrome	1970
[Acute epidermolysis combustiformis. A case report on Lyell's syndrome]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1967, Aug-15, Volume: 42, Issue:16 Topics: Adult; Aged; Analgesics; Barbiturates; Exanthema; Female; Humans; Male; Middle Aged; Phenylbutazone;	1967
[Histological picture report No. 203. Lyell syndrome]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1968, Apr-15, Volume: 43, Issue:8 Topics: Antipyrine; Child, Preschool; Drug Hypersensitivity; Female; Humans; Infant; Penicillins; Phenolphth	1968
Clinical pathologic conference no. 498. Drug treatment, leukopenia, exfoliative dermatitis. Journal of the Iowa Medical Society, 1968, Volume: 58, Issue:11 Topics: Child; Diagnosis, Differential; Female; Humans; Middle Aged; Phenylbutazone; Stevens-Johnson Syndrom	1968
[A case of Lyell's syndrome (toxic epidermal necrolysis)]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1965, Jun-21, Volume: 20, Issue:25 Topics: Adult; Female; Humans; Penicillins; Phenylbutazone; Stevens-Johnson Syndrome	1965
[A case of Lyell's syndrome]. Archives belges de dermatologie et de syphiligraphie, 1965, Volume: 21, Issue:3 Topics: Humans; Male; Middle Aged; Phenylbutazone; Stevens-Johnson Syndrome	1965
[Oculo-palpebral manifestations of Lyell's disease of toxic origin. (Apropos of a case)]. Bulletin des societes d'ophtalmologie de France, 1966, Volume: 66, Issue:4 Topics: Adult; Eye Manifestations; Eyelids; Female; Humans; Phenylbutazone; Stevens-Johnson Syndrome	1966
[Epidermolysis acuta toxica (Lyell) following phenylbutazone intake, with subsequent keratomalacia]. Das Deutsche Gesundheitswesen, 1966, May-19, Volume: 21, Issue:20 Topics: Adult; Aged; Anti-Bacterial Agents; Cornea; Eye Diseases; Female; Humans; Male; Middle Aged; Phenylb	1966