phenylbutazone has been researched along with Porphyrias in 10 studies
Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " But enzyme induction can also lead to acute intermittent porphyrias and distrubances of the phosphorus-calcium metabolism." | 3.65 | [Liver metabolism of drugs (author's transl)]. ( Darnis, F, 1976) |
| " Phenobarbital, which exacerbates acute intermittent porphyria in man, induces drug-oxidizing enzymes in liver." | 3.65 | Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug. ( Alvares, AP; Bickers, DR; Bradlow, HL; Kappas, A, 1977) |
| "Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Day, RS | 1 |
| Blekkenhorst, GH | 1 |
| Eales, L | 1 |
| Darnis, F | 1 |
| Gadzhiev, RG | 1 |
| Davardarova, MM | 1 |
| Kappas, A | 2 |
| Bradlow, HL | 1 |
| Bickers, DR | 1 |
| Alvares, AP | 2 |
| De Matteis, F | 4 |
| Anderson, KE | 1 |
| Sassa, S | 1 |
| Badawy, AA | 1 |
| Evans, M | 1 |
| Gibbs, A | 1 |
1 review available for phenylbutazone and Porphyrias
| Article | Year |
|---|---|
The effect of drugs on 5-aminolaevulinate synthetase and other enzymes in the pathway of liver haem biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Animals, Newborn; Cycloheximide; Cytochrome P-450 Enzyme Syst | 1975 |
9 other studies available for phenylbutazone and Porphyrias
| Article | Year |
|---|---|
Drug induced acute porphyric episodes in rats.
Topics: Animals; Feces; Female; Hexachlorobenzene; Intestinal Mucosa; Kidney; Kinetics; Liver; Male; Phenylb | 1980 |
[Liver metabolism of drugs (author's transl)].
Topics: Adult; Animals; Anticonvulsants; Biotransformation; Calcium; Child; Cushing Syndrome; Dicumarol; Dru | 1976 |
[Effectiveness of butadione ointment in some dermatoses].
Topics: Acne Vulgaris; Adolescent; Adult; Aged; Child; Dermatitis; Drug Eruptions; Drug Evaluation; Eczema; | 1975 |
Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstenes; Antipyrine; Female; Humans; Ketosteroids; | 1977 |
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane | 1976 |
The effects of drugs on the activities of 5-aminolaevulinate synthetase and other enzymes in the pathway of haem biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarboxylic Acids; Esters; Griseofu | 1972 |
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dicarboxy | 1973 |
Stimulation of liver 5-aminolaevulinate synthetase by drugs and its relevance to drug-induced accumulation of cytochrome P-450. Studies with phenylbutazone and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Topics: 5-Aminolevulinate Synthetase; Animals; Cytochromes; Dicarboxylic Acids; Enzyme Induction; Esters; He | 1972 |
Drugs and porphyria.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Animals; Barbiturates; Chick Embryo; Cytochromes; Griseofu | 1971 |