phenylbutazone has been researched along with Porphyria in 10 studies
Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " But enzyme induction can also lead to acute intermittent porphyrias and distrubances of the phosphorus-calcium metabolism." | 3.65 | [Liver metabolism of drugs (author's transl)]. ( Darnis, F, 1976) |
| " Phenobarbital, which exacerbates acute intermittent porphyria in man, induces drug-oxidizing enzymes in liver." | 3.65 | Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug. ( Alvares, AP; Bickers, DR; Bradlow, HL; Kappas, A, 1977) |
| "Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Day, RS | 1 |
| Blekkenhorst, GH | 1 |
| Eales, L | 1 |
| Darnis, F | 1 |
| Gadzhiev, RG | 1 |
| Davardarova, MM | 1 |
| Kappas, A | 2 |
| Bradlow, HL | 1 |
| Bickers, DR | 1 |
| Alvares, AP | 2 |
| De Matteis, F | 4 |
| Anderson, KE | 1 |
| Sassa, S | 1 |
| Badawy, AA | 1 |
| Evans, M | 1 |
| Gibbs, A | 1 |
1 review available for phenylbutazone and Porphyria
| Article | Year |
|---|---|
The effect of drugs on 5-aminolaevulinate synthetase and other enzymes in the pathway of liver haem biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Animals, Newborn; Cycloheximide; Cytochrome P-450 Enzyme Syst | 1975 |
9 other studies available for phenylbutazone and Porphyria
| Article | Year |
|---|---|
Drug induced acute porphyric episodes in rats.
Topics: Animals; Feces; Female; Hexachlorobenzene; Intestinal Mucosa; Kidney; Kinetics; Liver; Male; Phenylb | 1980 |
[Liver metabolism of drugs (author's transl)].
Topics: Adult; Animals; Anticonvulsants; Biotransformation; Calcium; Child; Cushing Syndrome; Dicumarol; Dru | 1976 |
[Effectiveness of butadione ointment in some dermatoses].
Topics: Acne Vulgaris; Adolescent; Adult; Aged; Child; Dermatitis; Drug Eruptions; Drug Evaluation; Eczema; | 1975 |
Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstenes; Antipyrine; Female; Humans; Ketosteroids; | 1977 |
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane | 1976 |
The effects of drugs on the activities of 5-aminolaevulinate synthetase and other enzymes in the pathway of haem biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarboxylic Acids; Esters; Griseofu | 1972 |
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dicarboxy | 1973 |
Stimulation of liver 5-aminolaevulinate synthetase by drugs and its relevance to drug-induced accumulation of cytochrome P-450. Studies with phenylbutazone and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Topics: 5-Aminolevulinate Synthetase; Animals; Cytochromes; Dicarboxylic Acids; Enzyme Induction; Esters; He | 1972 |
Drugs and porphyria.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Animals; Barbiturates; Chick Embryo; Cytochromes; Griseofu | 1971 |