phenylbutazone has been researched along with Liver Dysfunction in 33 studies
Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy." | 7.65 | Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases. ( Dhar, JK; Ishak, KG; Kirchner, JP, 1977) |
| "A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy." | 3.65 | Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases. ( Dhar, JK; Ishak, KG; Kirchner, JP, 1977) |
| "Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (90.91) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| WEINER, M | 1 |
| CHENKIN, T | 1 |
| BURNS, JJ | 1 |
| CHITI, E | 1 |
| CAPPONI, G | 1 |
| McCOMBS, AP | 1 |
| NETTELBLADT, E | 1 |
| FIOCCA, S | 1 |
| NAVASSA, G | 1 |
| Albengres, E | 1 |
| Urien, S | 1 |
| Kusmierek, J | 1 |
| Tillement, JP | 1 |
| Adithan, C | 1 |
| Shashindran, CH | 1 |
| Gandhi, IS | 1 |
| Singh, DS | 1 |
| Balachandar, J | 1 |
| Andersen, PH | 1 |
| Jarløv, N | 1 |
| Hesselholt, M | 1 |
| Baek, L | 1 |
| Manoukian, AV | 1 |
| Carson, JL | 1 |
| Münst, GJ | 1 |
| Bircher, J | 1 |
| Bond, WS | 1 |
| Ishak, KG | 1 |
| Kirchner, JP | 1 |
| Dhar, JK | 1 |
| González Macías, J | 2 |
| De Castro del Pozo, S | 2 |
| Wallace, S | 1 |
| Brodie, MJ | 1 |
| Herreros Fernández, V | 1 |
| Anderson, KE | 1 |
| Alvares, AP | 1 |
| Sassa, S | 1 |
| Kappas, A | 1 |
| Ellison, RS | 1 |
| Jacobs, RM | 1 |
| Altmann, HW | 1 |
| Kunze, KD | 1 |
| Porst, H | 1 |
| Tschöpel, L | 1 |
| Wouters, JM | 1 |
| van Rijswijk, MH | 1 |
| van de Putte, LB | 1 |
| Levi, AJ | 1 |
| Sherlock, S | 1 |
| Walker, D | 1 |
| Berthelot, P | 1 |
| Black, M | 1 |
| O'Reilly, RA | 2 |
| Kaplinsky, N | 1 |
| Schwartz, J | 1 |
| Frankl, O | 1 |
| Aggeler, PM | 1 |
| Bode, C | 1 |
| Martini, GA | 1 |
| Neumayr, A | 1 |
| Breckenridge, A | 1 |
| Held, H | 1 |
| Kaminski, B | 1 |
| von Oldershausen, HF | 1 |
| Read, AE | 1 |
8 reviews available for phenylbutazone and Liver Dysfunction
| Article | Year |
|---|---|
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injur | 1996 |
[Are dosage adjustments needed in patients with liver diseases? (author's transl)].
Topics: Dose-Response Relationship, Drug; Half-Life; Humans; Liver; Liver Diseases; Oxazepam; Phenylbutazone | 1978 |
Mechanisms and prediction of drug-induced liver disease.
Topics: Adenosine Triphosphate; Age Factors; Animals; Bilirubin; Biotransformation; Carbon Isotopes; Carbon | 1973 |
Liver disease and drug therapy.
Topics: Amobarbital; Azathioprine; Half-Life; Humans; Lidocaine; Liver Cirrhosis; Liver Diseases; Metabolic | 1974 |
Drug interactions involving oral anticoagulants.
Topics: Animals; Anticoagulants; Barbiturates; Blood Coagulation; Blood Coagulation Factors; Cholestyramine | 1974 |
Determinants of the response to oral anticoagulant drugs in man.
Topics: Administration, Oral; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Anticoagulants; Blood | 1970 |
More about isonicotinic acid hydrazide toxicity.
Topics: Adenocarcinoma; Adenofibroma; Adenoma; Animals; Carcinoma; Chemical and Drug Induced Liver Injury; C | 1970 |
[Toxic liver injury].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Cholestyramine Resin; Contraceptives, Oral; Dia | 1970 |
1 trial available for phenylbutazone and Liver Dysfunction
| Article | Year |
|---|---|
Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy.
Topics: Acetylesterase; Acute Disease; Alcoholism; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit | 1968 |
24 other studies available for phenylbutazone and Liver Dysfunction
| Article | Year |
|---|---|
Observations on the metabolic transformation and effects of phenylbutazone in subjects with hepatic disease.
Topics: Analgesics; Humans; Liver Diseases; Phenylbutazone | 1954 |
[Phenylbutazone and liver function; behavior of liver function in relation to treatment with phenylbutazone in normal and in liver disease].
Topics: Analgesics; Humans; Liver; Liver Diseases; Phenylbutazone | 1955 |
Case histories of two patients with toxic symptoms of drug reaction.
Topics: Anemia; Anemia, Aplastic; Humans; Liver Diseases; Phenylbutazone | 1958 |
Rheumatoid arthritis and hepatocellular injury.
Topics: Arthritis; Arthritis, Rheumatoid; Gold; Humans; Liver; Liver Diseases; Phenylbutazone | 1960 |
[CLINICAL AND HISTOPATHOLOGICAL ASPECTS OF INTRAHEPATIC CHOLESTASIS].
Topics: Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diabetes M | 1964 |
Benoxaprofen: plasma binding and binding interactions with some drugs and endogenous compounds.
Topics: Anti-Inflammatory Agents; Anticoagulants; Binding, Competitive; Blood Proteins; Dialysis; Drug Inter | 1982 |
Pharmacokinetics of phenylbutazone in chronic liver disease.
Topics: Adult; Chronic Disease; Female; Humans; Kinetics; Liver Diseases; Male; Phenylbutazone | 1980 |
Studies on in vivo endotoxin plasma disappearance times in cattle.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Clonixin; Endotoxins; Female; Lipidoses; L | 1996 |
Clinical relevance of the effect of hepatic disease on drug disposition.
Topics: Anti-Infective Agents; Antineoplastic Agents; Central Nervous System; Digoxin; Humans; Lidocaine; Li | 1978 |
Clinicopathological Conference. Diagnostic difficulties in a case of polypharmacy. Demonstrated at the Royal College of Physicians of London.
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Vir | 1977 |
Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Cholestasis; Diazepam; Granuloma; Hu | 1977 |
[Metabolism of phenylbutazone in the liver (author's transl)].
Topics: Alcoholism; Cholestasis; Diabetes Mellitus; Enzyme Induction; Epilepsy; Ethanol; Half-Life; Hepatiti | 1976 |
Decreased drug binding in serum from patients with chronic hepatic disease.
Topics: Adult; Aged; Bilirubin; Blood Proteins; Chronic Disease; Female; Humans; Liver Diseases; Male; Middl | 1976 |
[Metabolic capacity of the liver for drugs in hepatobiliary patients].
Topics: Adolescent; Adult; Biliary Tract Diseases; Body Weight; Female; Humans; Injections, Intramuscular; L | 1975 |
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane | 1976 |
The isoelectric focusing properties of serum alkaline phosphatase in disease and following prednisolone and phenylbutazone administration in the horse.
Topics: Alkaline Phosphatase; Animals; Female; Horse Diseases; Horses; Intestinal Diseases; Isoelectric Focu | 1990 |
Morphological changes in the liver due to phenazone and its derivatives.
Topics: Antipyrine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatty Liver; Granulom | 1986 |
[Morphology and pathogenesis of liver injury produced by dihydralazine , propranolol and ketophenylbutazone].
Topics: Chemical and Drug Induced Liver Injury; Dihydralazine; Humans; Hydralazine; Immunity, Cellular; Live | 1985 |
Adult onset Still's disease in the elderly: a report of two cases.
Topics: Aged; Arthritis; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Diagnosis, Differentia | 1985 |
[Löfgren syndrome].
Topics: Adult; Ankle Joint; Arthritis; Erythema Nodosum; Granuloma; Humans; Liver Diseases; Periarthritis; P | 1973 |
[Peptic ulcer].
Topics: Animals; Aspirin; Dogs; Endocrine System Diseases; Gastric Juice; Humans; Hyperparathyroidism; Iatro | 1972 |
Pathophysiological factors influencing drug kinetics.
Topics: Absorption; Age Factors; Antipyrine; Chloral Hydrate; Environmental Exposure; Ethanol; Female; Human | 1971 |
[Influence of liver diseases and kidney function disorders and phenylbutazone, phenprocoumarol and doxycycline on the excretion of glycodiazine].
Topics: Biotransformation; Coumarins; Creatinine; Humans; Hypoglycemic Agents; Kidney Diseases; Liver Diseas | 1970 |
Drugs and liver disease.
Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug | 1969 |