phenylbutazone and Kidney Diseases studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Research Excerpts

Excerpt	Relevance	Reference
"A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy."	3.65	Aspirin and the kidney. New Zealand Rheumatism Association Study. ( , 1974)
"To evaluate the adverse effects of flunixin, ketoprofen and phenylbutazone when administered I/V to clinically normal miniature donkeys."	2.75	A comparative study on the adverse effects of flunixin, ketoprofen and phenylbutazone in miniature donkeys: haematological, biochemical and pathological findings. ( Alinejad, A; Derakhshanfar, A; Morovati, M; Mozaffari, AA, 2010)
" The goal of this study was to determine the safety of a 10-day dosage regimen of phenylbutazone and firocoxib, both at their standard dosages, in horses."	1.40	Evaluation of the safety of a combination of oral administration of phenylbutazone and firocoxib in horses. ( Kivett, L; Taintor, J; Wright, J, 2014)
" A decrease in total blood neutrophil count occurred in all horses, and was associated with toxic left shift in horses given the 2 larger dosage schedules."	1.27	Effects of large doses of phenylbutazone administration to horses. ( French, TW; MacKay, RJ; Mayhew, IG; Nguyen, HT, 1983)
"Phenobarbital sodium was given in drinking water (0."	1.26	Effects of drugs on mushroom poisoning induced in the rat by Cortinarius speciosissimus. ( Nieminen, L, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (92.31)	18.7374
1990's	1 (1.92)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (5.77)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Kivett, L	1
Taintor, J	1
Wright, J	1
Mozaffari, AA	1
Derakhshanfar, A	1
Alinejad, A	1
Morovati, M	1
Uehara, T	1
Kondo, C	1
Morikawa, Y	1
Hanafusa, H	1
Ueda, S	1
Minowa, Y	1
Nakatsu, N	1
Ono, A	1
Maruyama, T	1
Kato, I	1
Yamate, J	1
Yamada, H	1
Ohno, Y	2
Urushidani, T	1
JOHNSON, BM	1
LARKIN, IM	1
LIPSETT, MB	1
GOLDMAN, R	1
BOLTON, R	1
BARRIE, H	1
LEVY, M	1
SICHERE, RM	1
SCONFIENZA, G	2
LAMPERI, S	1
BIANCHINI, E	1
SCHEITLIN, W	1
JEANNERET, P	1
PRUNIER, P	1
RUFFIE, R	1
FOURNIE, A	1
DIMITRIU, CG	1
TIEGERMAN, T	1
NESTOR, R	1
TREADWELL, B	1
REAH, TG	1
KLENER, P	1
JANOTA, M	1
STEJSKAL, J	1
Clive, DM	1
Stoff, JS	1
Mokhort, NA	1
Nazarenko, NN	1
Kondratiuk, VI	1
MacKay, RJ	1
French, TW	1
Nguyen, HT	1
Mayhew, IG	1
Prescott, LF	1
Critchley, JA	1
Balali-Mood, M	1
Ramirez, S	1
Seahorn, TL	1
Williams, J	1
Kawanishi, T	1
Takahashi, A	1
Omori, Y	1
Boss, GR	1
Seegmiller, JE	1
George, CR	1
Clark, WF	1
Cameron, JS	1
Emmerson, BT	1
Walden, PA	1
Philalithis, PE	1
Joekes, AM	1
Bagshawe, KD	1
Dengler, HJ	1
Eichelbaum, M	1
Schröder, HE	1
Thiele, P	1
Heidelmann, G	2
Tolot, F	1
Prost, G	1
Guignot, B	1
Pelletier, M	1
Nieminen, L	1
Schlegel, SI	1
Paulus, HE	1
van Deventer, SJ	1
Statius van Eps, LW	1
Visintini, E	1
Huriet, C	1
Coppi, G	1
Bonardi, G	1
Gaetani, M	1
Trnavský, K	1
Rovenský, J	1
Kapp, F	1
Baerlocher, C	1
Fahrländer, H	1
Leblanc, A	1
Vernet, A	1
Raab, W	1
Moerth, C	1
Klinenberg, JR	1
Bluestone, R	1
Campion, D	1
Whitehouse, M	1
Gutman, AB	1
Klotz, H	1
Prohaska, E	1
Salmhofer, H	1
Schmid, L	1
Held, H	1
Kaminski, B	1
von Oldershausen, HF	1
Otto, H	1
Enger, E	1
Riccitelli, ML	1
Lawson, AA	1
Maclean, N	1
Bloch-Michel, H	1
Gorins, A	1
Meyerovitch, A	1
Seifert, A	1
Wohlstein, E	1
Horváth, G	1

Article	Year
Renal syndromes associated with nonsteroidal antiinflammatory drugs. The New England journal of medicine, 1984, Mar-01, Volume: 310, Issue:9 Topics: Acute Kidney Injury; Adult; Animals; Anti-Inflammatory Agents; Anuria; Aspirin; Body Water; Electrol	1984
[Pharmacological properties of pyrazolone and pyrazolidine derivatives (review of the literature)]. Vrachebnoe delo, 1984, Issue:3 Topics: Aminopyrine; Anaphylaxis; Animals; Anti-Inflammatory Agents; Dipyrone; Fibrinogen; Humans; Kidney Di	1984
Hyperuricemia and gout. Classification, complications and management. The New England journal of medicine, 1979, Jun-28, Volume: 300, Issue:26 Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Human	1979
The role of platelets in glomerulonephritis. Advances in nephrology from the Necker Hospital, 1975, Volume: 5 Topics: Adenosine; Antidepressive Agents; Aspirin; Blood Platelets; Complement System Proteins; Endothelium;	1975
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone]. Semaine des hopitaux. Therapeutique, 1976, Volume: 52, Issue:3 Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Tolera	1976
Non-steroidal and analgesic therapy in the elderly. Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1 Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen	1986
[Acute kidney function disorders caused by nonsteroidal anti-inflammatory agents]. Nederlands tijdschrift voor geneeskunde, 1986, Apr-19, Volume: 130, Issue:16 Topics: Anti-Inflammatory Agents; Anuria; Diuresis; Humans; Hyperkalemia; Kidney; Kidney Diseases; Natriures	1986

Article	Year
Evaluation of the safety of a combination of oral administration of phenylbutazone and firocoxib in horses. Journal of veterinary pharmacology and therapeutics, 2014, Volume: 37, Issue:4 Topics: 4-Butyrolactone; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Prote	2014
Toxicogenomic biomarkers for renal papillary injury in rats. Toxicology, 2013, Jan-07, Volume: 303 Topics: Animals; Area Under Curve; Down-Regulation; Ethylamines; Gene Expression Profiling; Genetic Markers;	2013
Phenylbutazone and renal function. British medical journal, 1954, Nov-06, Volume: 2, Issue:4896 Topics: Analgesics; Anemia; Humans; Kidney Diseases; Phenylbutazone; Purpura	1954
Phenylbutazone toxicity: report of a case of acute renal failure. Annals of internal medicine, 1954, Volume: 41, Issue:5 Topics: Acute Kidney Injury; Analgesics; Humans; Kidney Diseases; Phenylbutazone	1954
Acute renal failure after phenylbutazone. British medical journal, 1955, Feb-05, Volume: 1, Issue:4909 Topics: Acute Kidney Injury; Analgesics; Arthritis; Humans; Kidney Diseases; Phenylbutazone	1955
[Frequency of renal disorders during phenylbutazone therapy]. Journal d'urologie medicale et chirurgicale, 1955, Volume: 61, Issue:5 Topics: Analgesics; Humans; Kidney; Kidney Diseases; Phenylbutazone	1955
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Electrophoretic research on urinary protein in patients with kidney disease treated with prednisolone & phenylbutazone]. Il Progresso medico, 1957, Mar-15, Volume: 13, Issue:5 Topics: Electrophoresis; Humans; Kidney Diseases; Phenylbutazone; Prednisolone; Proteinuria	1957
[Acute kidney damage in phenylbutazone therapy]. Schweizerische medizinische Wochenschrift, 1957, Jun-29, Volume: 87, Issue:26 Topics: Humans; Kidney; Kidney Diseases; Nephritis; Phenylbutazone	1957
[The treatment of gout crises in patients with renal insufficiency]. Vie medicale (Paris, France : 1920), 1963, Volume: 44 Topics: Colchicine; Gout; Humans; Kidney Diseases; Phenylbutazone; Renal Insufficiency; Salicylates; Uric Ac	1963
[TREATMENT OF GOUT]. Clinique (Paris, France), 1964, Volume: 59 Topics: Abdomen; Abdomen, Acute; Adrenal Cortex Hormones; Colchicine; Gastrointestinal Hemorrhage; Gout; Kid	1964
[RENAL FUNCTIONAL EXPLORATION, A CRITERION FOR INDIVIDUALIZATION OF THE TREATMENT OF RHEUMATOID ARTHRITIS]. Medicina interna, 1964, Volume: 16 Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis; Arthritis, Rheumatoid; Gold; Hematuria; Kidney Di	1964
THE TREATMENT OF GOUT. The New Zealand medical journal, 1964, Volume: 63 Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Colchicine; Diet; Diet Therapy; Dr	1964
GOUT. The Practitioner, 1964, Volume: 193 Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Colchicine; Diagnosis, Differential; Diet; Diet	1964
[RENAL DAMAGE IN PYRABUTOL TREATMENT]. Casopis lekaru ceskych, 1965, Jun-18, Volume: 104 Topics: Drug Therapy; Kidney; Kidney Diseases; Phenylbutazone; Toxicology	1965
Effects of large doses of phenylbutazone administration to horses. American journal of veterinary research, 1983, Volume: 44, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Gastric Mucosa; G	1983
Phenylbutazone overdosage: abnormal metabolism associated with hepatic and renal damage. British medical journal, 1980, Oct-25, Volume: 281, Issue:6248 Topics: Adolescent; Chemical and Drug Induced Liver Injury; Female; Half-Life; Humans; Kidney Diseases; Oxyp	1980
Renal medullary rim sign in 2 adult quarter horses. The Canadian veterinary journal = La revue veterinaire canadienne, 1998, Volume: 39, Issue:10 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Horse Diseases; Horses; Kidney Diseases; Kidney Me	1998
[Biochemical studies of chemically induced renal damage. II) Changes or urinary enzyme activities induced by indomethacin and phenylbutazone (author's transl)]. Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1979, Issue:97 Topics: Acetylglucosaminidase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; gamma-Glutamyltra	1979
Acquired causes of hyperuricaemia. Australian and New Zealand journal of medicine, 1978, Volume: 8 Suppl 1 Topics: Alcohol Drinking; Aspirin; Diet; Energy Intake; Gout; Humans; Kidney Diseases; Phenylbutazone; Uric	1978
Development of a lymphocytic lymphoma during immunosuppressive therapy with azathioprine for systemic lupus erythematosus with renal involvement induced by phenylbutazone. Clinical nephrology, 1977, Volume: 8, Issue:1 Topics: Azathioprine; Female; Humans; Kidney Diseases; Lupus Erythematosus, Systemic; Lymphoma, Non-Hodgkin;	1977
[Polymorphisms and deficient drug metabolism as triggers of toxic reactions (author's transl)]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:96 Topics: Animals; Antipyrine; Cyclacillin; Diazepam; Drug-Related Side Effects and Adverse Reactions; Humans;	1977
[Modern differential-therapeutic aspects of the drug therapy of chronic gout]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1979, Sep-15, Volume: 34, Issue:18 Topics: Allopurinol; Arteriosclerosis; Citrates; Gout; Humans; Hypertension; Kidney Diseases; Obesity; Pheny	1979
Effects of drugs on mushroom poisoning induced in the rat by Cortinarius speciosissimus. Archives of toxicology, 1976, Aug-18, Volume: 35, Issue:4 Topics: Animals; Female; Kidney Diseases; Mushroom Poisoning; Phenobarbital; Phenylbutazone; Rats	1976
[Iatrogenic damage in therapy with phenylbutazone]. Minerva medica, 1971, Feb-24, Volume: 62, Issue:16 Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Drug Eruptions; Endocrine System Di	1971
[Drug-induced nephropathies]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1967, May-08, Volume: 43, Issue:22 Topics: Colistin; Diuretics; Gold; Humans; Kanamycin; Kidney Diseases; Mercury; Methicillin; Nitrofurans; Ph	1967
Experimental gastric ulcers and uropepsinogen excretion in the rat. The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:9 Topics: Animals; Atropine; Carbon Tetrachloride; Endopeptidases; Enzyme Precursors; Female; Hydrochlorothiaz	1971
[Nephrotoxicity of antirheumatic drugs. I. Effect of nonsteroid antirheumatic drugs on urine enzymes]. Fysiatricky a reumatologicky vestnik, 1972, Volume: 50, Issue:4 Topics: Animals; Gold; Kidney; Kidney Diseases; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Phenylbutazo	1972
[Drugs and gastric hemorrhage. Results of 1 year's prospective study]. Zeitschrift fur Gastroenterologie, 1974, Volume: 12, Issue:8 Topics: Alcoholic Beverages; Anticoagulants; Blood Transfusion; Cortisone; Drug Therapy, Combination; Gastro	1974
[Nephrotoxicity of drugs. 3]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Jan-23, Volume: 62, Issue:4 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Catecholamines; Dextrans; Edetic Acid; Humans; Kidney;	1973
[Long-term therapy of gout and hyperuricemia]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1973, Mar-01, Volume: 28, Issue:5 Topics: Allopurinol; Arteriosclerosis; Blood Protein Disorders; Citrates; Colchicine; Diabetes Mellitus; Die	1973
Renal enzyme excretion following administration of analgesic and antirheumatic drugs. Acute and chronic experiments. Helvetica medica acta, 1973, Volume: 37, Issue:1 Topics: Acute Disease; Alkaline Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents; Chronic Disease;	1973
Aspirin and the kidney. New Zealand Rheumatism Association Study. British medical journal, 1974, Mar-30, Volume: 1, Issue:5908 Topics: Acetaminophen; Adult; Arthritis, Rheumatoid; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Hum	1974
The binding of urate to plasma proteins. Advances in experimental medicine and biology, 1974, Volume: 41 Topics: Allopurinol; Aspirin; Binding Sites; Blood Proteins; Colchicine; Dialysis; Evaluation Studies as Top	1974
Medical management of gout. Postgraduate medicine, 1972, Volume: 51, Issue:6 Topics: Adult; Allopurinol; Colchicine; Diet Therapy; Female; Gout; Humans; Kidney Diseases; Male; Middle Ag	1972
[Gout from the view of a special hospital for rheumatic patients]. Wiener klinische Wochenschrift, 1971, Mar-19, Volume: 83, Issue:11 Topics: Acute Disease; Adolescent; Adult; Aged; Austria; Child; Cholesterol; Colchicine; Colic; Diabetes Com	1971
[Influence of liver diseases and kidney function disorders and phenylbutazone, phenprocoumarol and doxycycline on the excretion of glycodiazine]. Diabetologia, 1970, Volume: 6, Issue:4 Topics: Biotransformation; Coumarins; Creatinine; Humans; Hypoglycemic Agents; Kidney Diseases; Liver Diseas	1970
[Kidney findings in polyarthritis under antirheumatic therapy]. Zeitschrift fur Urologie und Nephrologie, 1970, Volume: 63, Issue:5 Topics: Acute Disease; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chronic Disease; Female; Glomerulone	1970
[Drug-induced kidney lesions]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1968, Jan-01, Volume: 88, Issue:1 Topics: Aged; Anti-Bacterial Agents; Contrast Media; Drug Tolerance; Drug-Related Side Effects and Adverse R	1968
Etiology and treatment of gout--modern concepts. Journal of the American Geriatrics Society, 1968, Volume: 16, Issue:6 Topics: Allopurinol; Colchicine; Crystallization; Diagnosis, Differential; Diet Therapy; Gout; Humans; Indom	1968
Renal disease and drug therapy in rheumatoid arthritis. Annals of the rheumatic diseases, 1966, Volume: 25, Issue:5 Topics: Adrenal Cortex Hormones; Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Female; Humans; Kidney Dis	1966
[The renal incidents of phenylbutazone]. La Presse medicale, 1966, Dec-03, Volume: 74, Issue:52 Topics: Adult; Aged; Female; Humans; Kidney Diseases; Male; Middle Aged; Phenylbutazone	1966
[Renal complications following phenylbutazone treatment]. Das Deutsche Gesundheitswesen, 1966, May-19, Volume: 21, Issue:20 Topics: Hematuria; Humans; Kidney Diseases; Phenylbutazone	1966
[Usability of the electrodermatometric technic (Wohlstein) in pyrazolone derivative therapy]. Zeitschrift fur Rheumaforschung, 1966, Volume: 25, Issue:5 Topics: Antimalarials; Balneology; Colchicine; Collagen Diseases; Drug Hypersensitivity; Galvanic Skin Respo	1966

phenylbutazone and Kidney Diseases

Research Excerpts

Research

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