phenylbutazone and Hemorrhage studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Research Excerpts

Excerpt	Relevance	Reference
"Experiments were conducted on 24 mongrel dogs to study the effect of phenylbutazone on acute experimental pancreatitis."	7.67	Effect of phenylbutazone on acute hemorrhagic pancreatitis in dogs. ( Arora, N; Chouhan, I; Mathur, SN; Vanjani, R, 1989)
"Two patients with severe bleeding complications under oral anticoagulant treatment are presented, in one case caused by pharmacokinetic drug interference (phenylbutazone), in the other by genetic predisposition to bleeding induced by coumarin anticoagulants."	3.72	[Clinical problems with oral anticoagulation -- 3 case reports]. ( Lämmle, B, 2003)
"In these Thoroughbreds, phenylbutazone treatment did not modify heart rate or right atrial and pulmonary vascular pressures at rest or during exercise capable of eliciting exercise-induced pulmonary hemorrhage."	3.69	Pulmonary vascular pressures of strenuously exercising thoroughbreds after administration of phenylbutazone. ( Goetz, TE; Griffin, R; Manohar, M; Sullivan, E, 1996)
"Experiments were conducted on 24 mongrel dogs to study the effect of phenylbutazone on acute experimental pancreatitis."	3.67	Effect of phenylbutazone on acute hemorrhagic pancreatitis in dogs. ( Arora, N; Chouhan, I; Mathur, SN; Vanjani, R, 1989)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (90.24)	18.7374
1990's	2 (4.88)	18.2507
2000's	2 (4.88)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Lämmle, B	1
KRAININ, P	1
PERLES, L	1
ZARA, M	1
CHIMENES, H	1
SCHMUTZLER, R	1
STAPLER, N	1
QUIROGA, H	1
SCONFIENZA, G	2
JAVOR, T	1
BENCZE, G	1
RAFFENSPERGER, EC	1
FLORIAN, J	1
KREINDLIN, IuZ	1
NEUMAN, M	1
GELINOV, C	1
TICHOLOV, K	1
EISEN, MJ	1
RIIS, P	1
SOGAARD-ANDERSEN, T	1
ANTHONISEN, P	1
LIBERMTHEN, A	1
MOLLERJENSEN, JE	1
KULEY, M	1
ASANOK, T	1
RAVAULT, PP	1
MAITREPIERRE, J	1
LAMBERT, R	1
BOURRAT, C	1
Tandy, J	1
Thorpe, E	1
Fraumeni, JF	1
Nielsen, HK	1
Husted, SE	1
Krusell, LR	1
Fasting, H	1
Charles, P	1
Hansen, HH	1
Nielsen, BO	1
Petersen, JB	1
Bechgaard, P	1
Manohar, M	1
Goetz, TE	1
Griffin, R	1
Sullivan, E	1
Trumble, TN	1
Ingle-Fehr, J	1
Hendrickson, DA	1
Millard, LG	1
Bull, J	1
Mackinnon, J	1
Mathur, SN	1
Arora, N	1
Chouhan, I	1
Vanjani, R	1
Reinisch, H	1
Maillard, JL	1
Voisin, GA	1
Perlick, E	1
Koller, F	1
Muller, C	1
Ganzoni, AM	1
Vandam, LD	1
Kimura, S	1
Shorota, N	1
Rintelen, F	1
Meyer, JP	1
Jaros, Z	1
Naess, K	1
Brody, BB	1
Kovac, W	1
Mittermayer, K	1
Rudas, B	1
Mayer, GA	1

Article	Year
[Clinical evaluation of anticoagulants]. Der Internist, 1969, Volume: 10, Issue:1 Topics: Angina Pectoris; Anticoagulants; Drug Antagonism; Drug Synergism; Female; Hemorrhage; Humans; Male;	1969
[Acquired aplastic anemia, with special consideration of complications and prognosis]. Schweizerische medizinische Wochenschrift, 1970, Mar-07, Volume: 100, Issue:10 Topics: Adrenal Cortex Hormones; Adult; Aged; Anemia, Aplastic; Blood Cell Count; Carbutamide; Chloramphenic	1970

Article	Year
[Clinical problems with oral anticoagulation -- 3 case reports]. Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:1 Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aortic Valve; B	2003
Gastric ulcer with massive hemorrhage following use of phenylbutazone; report of a case. Journal of the American Medical Association, 1953, May-02, Volume: 152, Issue:1 Topics: Analgesics; Hemorrhage; Peptic Ulcer; Phenylbutazone; Stomach Ulcer	1953
[Digestive complications of phenylbutazone]. Revue du rhumatisme et des maladies osteo-articulaires, 1953, Volume: 20, Issue:5 Topics: Analgesics; Arthritis; Arthritis, Rheumatoid; Gastrointestinal Hemorrhage; Gastrointestinal Tract; H	1953
[Hemorrhagic tendency during irgapyrin therapy]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1954, Mar-01, Volume: 9, Issue:5 Topics: Aminopyrine; Analgesics; Drug Combinations; Gastrointestinal Hemorrhage; Hemorrhage; Phenylbutazone;	1954
[Digestive hemorrhage and icterus due to irgapyrin]. El Dia medico, 1954, May-31, Volume: 26, Issue:35 Topics: Aminopyrine; Analgesics; Drug Combinations; Gastrointestinal Hemorrhage; Gastrointestinal Tract; Hem	1954
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Renal hemorrhage caused by phenylbutazone]. Minerva medica, 1956, Aug-29, Volume: 47, Issue:69 Topics: Hemorrhage; Humans; Kidney; Kidney Diseases; Phenylbutazone	1956
[Rheopyrin causing gastric hemorrhage]. Orvosi hetilap, 1957, Feb-10, Volume: 98, Issue:5-6 Topics: Aminopyrine; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Phenylbutazone; Stomach; Stomach Disea	1957
Postbulbar duodenal ulcer with hemorrhage occurring during butazolidin therapy. Gastroenterology, 1957, Volume: 32, Issue:5 Topics: Duodenal Ulcer; Hemorrhage; Humans; Peptic Ulcer; Phenylbutazone	1957
[Stomach & intestinal hemorrhage after wofapyrin therapy]. Das Deutsche Gesundheitswesen, 1957, Oct-31, Volume: 12, Issue:44 Topics: Aminopyrine; Drug Combinations; Gastrointestinal Hemorrhage; Gastrointestinal Tract; Hemorrhage; Hum	1957
[Side-effects of butadione]. Sovetskaia meditsina, 1959, Volume: 23, Issue:3 Topics: Gastrointestinal Hemorrhage; Gastrointestinal Tract; Hemorrhage; Humans; Phenylbutazone	1959
[RECENT ANALGESICS, ANTIRHEUMATIC AGENTS AND URICOSURIC AGENTS]. Journal de medecine de Bordeaux et du Sud-Ouest, 1963, Volume: 140 Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antirheumatic Agents; Aspirin; Colc	1963
[THERAPY OF PULMONARY HEMORRHAGES IN MITRAL STENOSIS WITH DELTA-BUTAZOLIDINE (WITH DESCRIPTION OF A CASE OF SECONDARY FOCAL PULMONARY HEMOSIDEROSIS)]. Munchener medizinische Wochenschrift (1950), 1964, Jan-24, Volume: 106 Topics: Adrenal Cortex Hormones; Hemoptysis; Hemorrhage; Hemosiderosis; Hemosiderosis, Pulmonary; Humans; Lu	1964
COMBINED EFFECT OF SODIUM WARFARIN AND PHENYLBUTAZONE. JAMA, 1964, Jul-06, Volume: 189 Topics: Arthritis; Coronary Disease; Geriatrics; Hemorrhage; Oxyphenbutazone; Phenylbutazone; Prothrombin Ti	1964
[TREATMENT OF NONSPECIFIC HEMORRHAGIC PROCTOCOLITIS WITH PHENYLBUTAZONE AND PREDNISOLONE SUPPOSITORIES. LIGHT CASES STUDIED WITH THE DOUBLE-BLIND TECHNIC]. Ugeskrift for laeger, 1964, Jun-04, Volume: 126 Topics: Biomedical Research; Colitis; Colitis, Ulcerative; Denmark; Double-Blind Method; Gastrointestinal He	1964
A CASE OF THE BEMUSED MEDIC. The Journal of the Indiana State Medical Association, 1964, Volume: 57 Topics: Aspirin; Colon; Depression; Diagnosis, Differential; Diverticulitis; Diverticulitis, Colonic; Gastro	1964
[SPONTANEOUS GINGIVAL BLEEDING]. Tandlaegebladet, 1965, Volume: 69 Topics: Geriatrics; Gingiva; Gingival Diseases; Gingival Hemorrhage; Hemorrhage; Phenylbutazone; Toxicology	1965
[Allergy to irgapyrin causing hemorrhage & capillaritis]. Turk Tip Cemiyeti mecmuasi, 1955, Volume: 21, Issue:2 Topics: Aminopyrine; Analgesics; Capillaries; Disease; Drug Combinations; Hemorrhage; Humans; Hypersensitivi	1955
[Rectal hemorrhage and hematurias during treatment with phenybutazone]. Lyon medical, 1959, Jul-05, Volume: 91 Topics: Gastrointestinal Hemorrhage; Hematuria; Hemorrhage; Humans; Phenylbutazone; Rectum	1959
A fatal syndrome in a dog following administration of phenylbutazone. The Veterinary record, 1967, Oct-14, Volume: 81, Issue:16 Topics: Animals; Dog Diseases; Dogs; Female; Hemorrhage; Phenylbutazone	1967
Bone marrow depression induced by chloramphenicol or phenylbutazone. Leukemia and other sequelae. JAMA, 1967, Sep-11, Volume: 201, Issue:11 Topics: Anemia, Aplastic; Bone Marrow Diseases; Chloramphenicol; Follow-Up Studies; Hemorrhage; Humans; Infe	1967
Pulmonary vascular pressures of strenuously exercising thoroughbreds after administration of phenylbutazone. American journal of veterinary research, 1996, Volume: 57, Issue:9 Topics: Animals; Blood Pressure; Female; Heart Rate; Hemorrhage; Horse Diseases; Horses; Hypertension, Pulmo	1996
Laparoscopic intra-abdominal ligation of the testicular artery following castration in a horse. Journal of the American Veterinary Medical Association, 2000, May-15, Volume: 216, Issue:10 Topics: Animals; Anti-Infective Agents, Urinary; Anti-Inflammatory Agents, Non-Steroidal; Arteries; Blood Tr	2000
A haemorrhagic bullous eruption of the hands caused by phenylbutazone: a report of 3 cases. Acta dermato-venereologica, 1977, Volume: 57, Issue:1 Topics: Adult; Drug Eruptions; Female; Hand Dermatoses; Hemorrhage; Humans; Male; Middle Aged; Phenylbutazon	1977
Phenylbutazone and anticoagulant control. The Practitioner, 1975, Volume: 215, Issue:1290 Topics: Adult; Aged; Drug Interactions; Female; Hemorrhage; Humans; Male; Middle Aged; Phenylbutazone; Warfa	1975
Effect of phenylbutazone on acute hemorrhagic pancreatitis in dogs. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 1989, Volume: 8, Issue:1 Topics: Animals; Dogs; Female; Hemorrhage; Male; Pancreatic Diseases; Pancreatitis; Phenylbutazone	1989
[Death by sepsis after treatment of butazolidin]. Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1970, Volume: 54 Topics: Adult; Aged; Buttocks; Female; Hematoma; Hemorrhage; Humans; Ileum; Injections, Intramuscular; Intes	1970
Editorial: Drug-induced aplastic anaemia. Lancet (London, England), 1974, Feb-16, Volume: 1, Issue:7851 Topics: Anemia, Aplastic; Anti-Bacterial Agents; Blood Cell Count; Blood Transfusion; Bone Marrow Examinatio	1974
Non-hemorrhagic arthus reaction and its independence from circulating antibodies and complement. International archives of allergy and applied immunology, 1973, Volume: 45, Issue:1 Topics: Animals; Antibodies; Antigen-Antibody Complex; Arthus Reaction; Autacoids; Capillary Permeability; C	1973
[Collagen and thrombocytes]. Folia haematologica (Leipzig, Germany : 1928), 1969, Volume: 92, Issue:4 Topics: Aorta; Arteriosclerosis; Aspirin; Blood Platelets; Collagen; Hemorrhage; Humans; Phenylbutazone; Pla	1969
Gout. British medical journal, 1974, Mar-09, Volume: 1, Issue:5905 Topics: Allopurinol; Blood Cell Count; Cell Movement; Colchicine; Diet; Drug Synergism; Gastrointestinal Dis	1974
Analgetic drugs--the mild analgetics. The New England journal of medicine, 1972, Jan-06, Volume: 286, Issue:1 Topics: Acetaminophen; Acetanilides; Administration, Oral; Analgesics; Aspirin; Codeine; Dextropropoxyphene;	1972
[A case report of massive bleeding from conjunctiva due to drug-induced thrombocytopenia]. Nihon ganka kiyo, 1971, Volume: 22, Issue:11 Topics: Adult; Conjunctiva; Eye Diseases; Eye Injuries; Hemorrhage; Humans; Ketones; Male; Phenylbutazone; T	1971
[Realization of nonocular dangers resulting from general medical therapy in ocular affections]. Klinische Monatsblatter fur Augenheilkunde, 1970, Volume: 156, Issue:2 Topics: Acetazolamide; Aged; Anticoagulants; Diuretics; Drug-Related Side Effects and Adverse Reactions; Ede	1970
[Influence of drugs used in rheumatology on the blood]. Vnitrni lekarstvi, 1971, Volume: 17, Issue:6 Topics: Analgesics; Anti-Inflammatory Agents; Bone Marrow Diseases; Chloroquine; Corticosterone; Gold; Hemat	1971
[Interaction, anticoagulants and the risk of bleeding]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1971, Jun-30, Volume: 91, Issue:18 Topics: Anticoagulants; Drug Synergism; Hemorrhage; Hemorrhagic Disorders; Humans; Phenylbutazone; Warfarin	1971
The effect of drugs on clinical laboratory determinations. Clinical chemistry, 1971, Volume: 17, Issue:5 Topics: 17-Ketosteroids; Chemistry, Clinical; Drug Antagonism; Drug Synergism; Drug Therapy; Hemorrhage; Hum	1971
[Histologic investigation of the influence of anti-inflammatory agents on regenerative granulation tissue in rats]. Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 176, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Capillaries; Connective Tissue; Depression, Chemical; Granulation	1968
A rare complication of coumarin-congener anticoagulant therapy. Canadian Medical Association journal, 1965, Nov-06, Volume: 93, Issue:19 Topics: Blood Coagulation Factors; Coumarins; Hemorrhage; Humans; Phenylbutazone; Prothrombin Time; Purpura,	1965

phenylbutazone and Hemorrhage

Research Excerpts

Research

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