phenylbutazone and Fever studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

Excerpt	Relevance	Reference
"The simlutaneous oral administration of benorylate (4-(acetamido) phenyl 2-acetoxybenzoate) with either indomethacin or phenylbutazone to rats suffering from Freund's adjuvant-induced arthritis leads to an anti-inflammatory effect which is significantly greater than the effect of the same drugs administered alone."	3.65	Benorylate interaction with indomethacin and phenylbutazone. ( Khalili-Varasteh, H; Legros, J; Rosner, I, 1976)
" In a rat paw edema test for anti-inflammatory activity naproxen was 55 times more active than aspirin."	3.65	Chemistry and pharmacology of naproxen. ( Dorfman, RI, 1975)
" The efficacy of this drug was not improved by increasing the dosage to two or three times the recommended level."	1.28	The effect of anti-inflammatory agents on the clinical expression of bovine ephemeral fever. ( St George, TD; Uren, MF; Zakrzewski, H, 1989)
"Pericarditis was the most severe manifestation, and in one patient, this required corticosteroid therapy."	1.26	Sialadenitis and systemic reaction associated with phenylbutazone. ( Speed, BR; Spelman, DW, 1982)
" The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid."	1.25	Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (96.08)	18.7374
1990's	1 (1.96)	18.2507
2000's	1 (1.96)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Trongsakul, S	1
Panthong, A	1
Kanjanapothi, D	1
Taesotikul, T	1
ARON, E	1
BERTRAND, J	1
KENEZ, J	2
BRAUN, RN	1
WURTERLE, A	1
HEDRICH, K	1
WIEGANDT, R	1
KAMP, KH	1
WOLLWEBER, A	1
VARTIAINEN, J	1
HURRI, L	1
TEOTINO, UM	1
FRIZ, LP	1
GANDINI, A	1
DELLABELLA, D	1
Glenn, EM	1
Bowman, BJ	1
Kooyers, W	1
Koslowske, T	1
Myers, ML	1
Speed, BR	1
Spelman, DW	1
Mills, PC	1
Ng, JC	1
Hrdlicka, J	1
Auer, DE	1
Khalili-Varasteh, H	1
Rosner, I	1
Legros, J	1
Cashin, CH	2
Dawson, W	1
Kitchen, EA	1
van Duin, CT	1
van Essen, JA	2
van Miert, AS	2
Adams, SS	1
McCullough, KF	1
Nicholson, JS	1
Schwarz, JA	1
Jost, H	1
Dorfman, RI	1
Niemegeers, CJ	1
Lenaerts, FM	1
Janssen, PA	1
Uren, MF	1
St George, TD	1
Zakrzewski, H	1
Haneberg, B	1
Glette, J	1
Sørnes, S	1
Solberg, CO	1
Wouters, JM	1
van Rijswijk, MH	1
van de Putte, LB	1
Littlejohns, DW	1
Assem, ES	1
Kennedy, CT	1
Orozco-Alcala, JJ	1
Baum, J	1
Calabro, JJ	1
Katz, RM	1
Maltz, BA	1
Tubaro, E	1
Banci, F	1
Csaba, B	1
Tóth, S	1
Sobański, H	1
Krupinńska, J	1
Gryglewski, RJ	1
Young, PR	2
Dodge, PW	2
Carter, GW	1
Kimura, ET	2
Schiatti, P	1
Selva, D	1
Arrigoni-Martelli, E	1
Lerner, LJ	1
Diena, A	1
Sardi, A	1
Maffii, G	1
Kuzuna, S	1
Matsumoto, N	1
Kawai, K	1
Tromp, GA	1
Rowell, NR	1
Cotterill, JA	1
Kosersky, DS	1
Dewey, WL	1
Harris, LS	1
Ipatova, NN	1
Martynov, SV	1
Buttinoni, A	1
Cuttica, A	1
Franceschini, J	1
Mandelli, V	1
Orsini, G	1
Passerini, N	1
Turba, C	1
Tommasini, R	1
Riedel, R	1
Schoetensack, W	1
Martel, RR	1
Rochefort, JG	1
Klicius, J	1
Dobson, TA	1
Schmidt, W	1
Rogge, U	1
Lambelin, G	1
Roba, J	1
Gillet, C	1
Buu-Hoï, NP	1
Sweit, LR	1
Tanaka, K	1
Iizuka, Y	1
Bianchi, C	2
Lumachi, B	2
Marazzi-Uberti, E	2
Gaetani, M	1
Coppi, G	1
Kobayashi, S	1
Takagi, H	1
Pflug, E	1
Akimoto, T	1
Tsukada, W	1
Yamasaki, T	1
Kojima, H	1
Kasahara, A	1
Nakanishi, M	1
Imamura, H	1
Maruyama, Y	1
Heading, CE	1
Debelut, J	1

Article	Year
The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz. Journal of ethnopharmacology, 2003, Volume: 85, Issue:2-3 Topics: Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-St	2003
[Action of phenylbutazone on fever in cirrhosis]. Archives des maladies de l'appareil digestif et des maladies de la nutrition, 1955, Volume: 44, Issue:4 Topics: Alcoholism; Analgesics; Fever; Humans; Liver Cirrhosis; Phenylbutazone	1955
[Effect of phenylbutazone derivatives on tuberculotic fever]. Orvosi hetilap, 1956, Oct-14, Volume: 97, Issue:42 Topics: Fever; Phenylbutazone; Tuberculosis	1956
[Effect of phenylbutazone derivatives on tuberculotic fever]. Orvosi hetilap, 1956, Oct-14, Volume: 97, Issue:42 Topics: Fever; Phenylbutazone; Tuberculosis	1956
[Effect of phenylbutazone derivatives on tuberculotic fever]. Orvosi hetilap, 1956, Oct-14, Volume: 97, Issue:42 Topics: Fever; Phenylbutazone; Tuberculosis	1956
[Effect of phenylbutazone derivatives on tuberculotic fever]. Orvosi hetilap, 1956, Oct-14, Volume: 97, Issue:42 Topics: Fever; Phenylbutazone; Tuberculosis	1956
[Severe autonomic paroxysm with a fever aura, prolonged fever sensations and a previously unknown neurotonic reaction during Irgapyrin therapy]. Wiener klinische Wochenschrift, 1958, Feb-07, Volume: 70, Issue:6 Topics: Aminopyrine; Autonomic Nervous System; Autonomic Nervous System Diseases; Drug Combinations; Epileps	1958
[Tests of amidopyrine-butazolidine for therapy of fever in women with genital carcinoma during x-irradiation and in incurable stages]. Zentralblatt fur Gynakologie, 1958, Jan-11, Volume: 80, Issue:2 Topics: Aminopyrine; Carcinoma; Female; Fever; Genitalia; Genitalia, Female; Humans; Neoplasms; Phenylbutazo	1958
[Clinical experiences with a suppository for control of fever in children]. Therapeutische Umschau. Revue therapeutique, 1959, Volume: 16, Issue:4 Topics: Aminopyrine; Barbiturates; Child; Fever; Humans; Infant; Pessaries; Phenylbutazone	1959
[The therapeutic effect of butazolidine and iragapyrine in febrile bacterial infections]. Munchener medizinische Wochenschrift (1950), 1960, Jul-01, Volume: 102 Topics: Bacterial Infections; Fever; Infections; Phenylbutazone	1960
[CLINICAL EXPERIENCES WITH PHENYLBUTAZONE. THERAPEUTIC ACTION AND SIDE-EFFECTS]. Die Medizinische Welt, 1964, Feb-15, Volume: 20 Topics: Arthritis; Arthritis, Rheumatoid; Atrophy; Biomedical Research; Bronchitis; Fever; Gout; Hodgkin Dis	1964
ARTHRITIS DUE TO SALMONELLA TYPHIMURIUM. REPORT OF 12 CASES OF MIGRATORY ARTHRITIS IN ASSOCIATION WITH SALMONELLA TYPHIMURIUM INFECTION. Acta medica Scandinavica, 1964, Volume: 175 Topics: Adolescent; Adrenal Cortex Hormones; Agglutination; Ankle; Antigens; Arthritis; Child; Chloramphenic	1964
THIO DERIVATIVES OF 2,3-DIHYDRO-4H-1,3-BENZOXAZIN-4-ONE. SYNTHESIS AND PHARMACOLOGICAL PROPERTIES. Journal of medicinal chemistry, 1963, Volume: 6 Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Ascites; Aspirin; Chem	1963
The pharmacology of 2,3-bis-(p-methoxyphenyl)-indole (indoxole). The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1 Topics: Adrenalectomy; Anaphylaxis; Animals; Arthritis; Arthritis, Rheumatoid; Aspirin; Barbiturates; Edema;	1967
Sialadenitis and systemic reaction associated with phenylbutazone. Australian and New Zealand journal of medicine, 1982, Volume: 12, Issue:3 Topics: Adult; Drug Eruptions; Female; Fever; Humans; Male; Middle Aged; Pericarditis; Phenylbutazone; Pleur	1982
Disposition and urinary excretion of phenylbutazone in normal and febrile greyhounds. Research in veterinary science, 1995, Volume: 59, Issue:3 Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cy	1995
Benorylate interaction with indomethacin and phenylbutazone. Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 219, Issue:1 Topics: Animals; Arthritis; Aspirin; Drug Interactions; Drug Synergism; Fever; Indomethacin; Male; Phenylbut	1976
The pharmacology of benoxaprofen (2-[4-chlorophenyl]-alpha-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with antiinflammatory activity apparently unrelated to inhibition of prostaglandin synthesis. The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:6 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Arthritis, Experimental; Benzoxazo	1977
Mechanism of the antipyretic action of salicylates and pyrazolone derivates. Zentralblatt fur Veterinarmedizin. Reihe A, 1975, Volume: 22, Issue:6 Topics: Aminopyrine; Animals; Body Temperature; Dipyrone; Disease Models, Animal; Fever; Goats; Phenylbutazo	1975
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. Arzneimittel-Forschung, 1975, Volume: 25, Issue:11 Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap	1975
[Pseudo-LE syndrome after treatment with Venopyronum dragees] (author's transl) Deutsche medizinische Wochenschrift (1946), 1975, Aug-01, Volume: 100, Issue:31 Topics: Adult; Autoantibodies; Autoimmune Diseases; Diagnosis, Differential; Female; Fever; Fluorescent Anti	1975
Chemistry and pharmacology of naproxen. Arzneimittel-Forschung, 1975, Volume: 25, Issue:2A Topics: Administration, Oral; Adrenalectomy; Animals; Aspirin; Carrageenan; Drug Evaluation, Preclinical; Ed	1975
The antipyretic effect of suprofen in rats with yeast-induced fever. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Analgesics; Animals; Aspirin; Body Temperature; Dose-Response Relationship, Drug; Drug Evaluation, P	1975
The effect of anti-inflammatory agents on the clinical expression of bovine ephemeral fever. Veterinary microbiology, 1989, Volume: 19, Issue:2 Topics: Animals; Cattle; Cell Line; Clonixin; Cytopathogenic Effect, Viral; Ephemeral Fever; Fever; Nicotini	1989
Influence of fever temperatures and of some cytoactive drugs on in vitro lysozyme release from monocytes and granulocytes. International journal of immunopharmacology, 1985, Volume: 7, Issue:1 Topics: Body Temperature; Colchicine; Cyclophosphamide; Dose-Response Relationship, Drug; Fever; Granulocyte	1985
Adult onset Still's disease in the elderly: a report of two cases. The Journal of rheumatology, 1985, Volume: 12, Issue:4 Topics: Aged; Arthritis; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Diagnosis, Differentia	1985
Immunological evidence of two forms of allergy to pyrazolone drugs. Rheumatology and rehabilitation, 1973, Volume: 12, Issue:2 Topics: Aged; Drug Eruptions; Drug Hypersensitivity; Female; Fever; Histamine Release; Humans; Immunoglobuli	1973
Pharmacology of a nicotinamido-methylaminopyrazolone (Ra 101). Arzneimittel-Forschung, 1970, Volume: 20, Issue:8 Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Carrageena	1970
The effect of temperature and some mediator antagonists on anaphylactic shock in mice. International archives of allergy and applied immunology, 1971, Volume: 40, Issue:2 Topics: Aminocaproates; Aminopyrine; Anaphylaxis; Animals; Aprotinin; Ascorbic Acid; Bordetella pertussis; D	1971
Carrageenin hyperthermia in rats. Experientia, 1974, Nov-15, Volume: 30, Issue:11 Topics: Animals; Aspirin; Body Temperature; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Fe	1974
Experimental antiinflammatory and analgesic studies with 3-trifluoromethyl-s-triazolo (3,4-a)-isoquinoline. Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 212, Issue:2 Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Digestive System; Edema	1974
Antiinflammatory activity and other pharmacological properties of phthalazino(2,3-b)phthalazine-5,12(7H, 14H)-dione (Diftalone). Arzneimittel-Forschung, 1974, Volume: 24, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Blood Pressure; Diuresis; Drug Ev	1974
Biological activities of metabolites of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284: anti-inflammatory agent). Japanese journal of pharmacology, 1974, Volume: 24, Issue:5 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, Drug; Edema;	1974
The antipyretic effect of pyrazolone derivatives and salicylates on fever induced with leukocytic or bacterial pyrogen. Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 197, Issue:2 Topics: Analgesics; Animals; Antipyrine; Aspirin; Central Nervous System; Drug Antagonism; Escherichia coli;	1972
Relapsing polychondritis. The British journal of dermatology, 1973, Volume: 88, Issue:4 Topics: Blood Cells; Cartilage; Ear Deformities, Acquired; Erythema; Fever; Hematocrit; Humans; Inflammation	1973
Antipyretic, analgesic and anti-inflammatory effects of delta 9-tetrahydrocannabinol in the rat. European journal of pharmacology, 1973, Volume: 24, Issue:1 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Body Temperature; Cannabis; Carrageenan; Dos	1973
[Increasing the effectiveness of treating typhoid fever and other infectious diseases]. Sovetskaia meditsina, 1973, Volume: 36, Issue:5 Topics: Acute Disease; Adolescent; Adult; Chloramphenicol; Chronic Disease; Communicable Diseases; Drug Ther	1973
Pharmacological study on a new analgesic-anti-inflammatory drug: alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionic acid of K 4277. Arzneimittel-Forschung, 1973, Volume: 23, Issue:8 Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Behavi	1973
[Pharmacology of butylmalonic acidmono-(1,2-diphenylhydrazide)-calcium (bumadizone-calcium)]. Arzneimittel-Forschung, 1973, Volume: 23, Issue:9 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Arthritis, Rheumatoid; Blood Pr	1973
Anti-inflammatory properties of furobufen. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:3 Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Benzofurans; Butyrates; Car	1974
[Febrile complications in radium and x-ray therapy of female genital carcinoma]. Zentralblatt fur Gynakologie, 1966, Aug-13, Volume: 88, Issue:33 Topics: Aminopyrine; Anti-Bacterial Agents; Female; Fever; Genital Neoplasms, Female; Humans; Infection Cont	1966
Pharmacology of a new analgesic, antipyretic, and anti-inflammatory agent, 4-allyloxy-3-chlorophenylacetic acid. Arzneimittel-Forschung, 1970, Volume: 20, Issue:5 Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carrageenan; Codeine	1970
Anti-inflammatory and other properties of 2,3-dihydrol-1-H-pyridino-(2,3- b) (1,4)-thiazine-2-one; ABBott-29590. Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 196, Issue:2 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Dogs; Edema; Fever; Gastric Mucos	1972
[Anti-inflammatory effect of bimetopyrol. I. Suppressive effect on acute inflammation]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyproheptadine; Edema; Erythema; Fever; Flufenamic Acid;	1972
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 1. Anti-inflammatory, analgesic and antipyretic properties. Arzneimittel-Forschung, 1972, Volume: 22, Issue:1 Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Erythema; F	1972
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 7. Pharmacological comparison with standard anti-inflammatory drugs. Arzneimittel-Forschung, 1972, Volume: 22, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Edema; Female; Fever; Flufenamic Acid; Indometh	1972
Fever responses to bacterial pyrogens in guinea pigs and application for screening of antipyretic agents. Japanese journal of pharmacology, 1968, Volume: 18, Issue:1 Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Body Temperature; Female; Fever; Flufenami	1968
[Postoperative symptomatic treatment in pediatric surgery]. Therapie der Gegenwart, 1969, Volume: 108, Issue:7 Topics: Adolescent; Aminopyrine; Barbiturates; Child; Child, Preschool; Female; Fever; Humans; Infant; Male;	1969
[Pharmacological studies on 1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (DA-398), a new anti-inflammatory agent]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1969, Jul-20, Volume: 65, Issue:4 Topics: Adrenal Glands; Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Antitussive Agents; Anur	1969
[Studies on anti-inflammatory agents. 3. Effect of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine (Y-3642) on pyretic reaction, vascular permeability and granuloma formation in experimental animals]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1970, Volume: 90, Issue:3 Topics: Adrenalectomy; Aminopyrine; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Fever;	1970
The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins. British journal of pharmacology, 1968, Volume: 34, Issue:1 Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Biological Assay; Body Temperature; Cerebra	1968
[Use of phenylbutazone in postoperative fevers]. Annales de chirurgie, 1968, Volume: 22, Issue:9 Topics: Female; Fever; Humans; Phenylbutazone; Postoperative Complications	1968

phenylbutazone and Fever

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