phenylbutazone and Erythema studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.

Research Excerpts

Excerpt	Relevance	Reference
" Anti-edema activities of M-7074 were more potent than those of phenylbutazone in carrageenin, bradykinin and mustard edema tests in rats."	3.66	Anti-inflammatory properties of a newly synthesized compound, 6-chloro-4-oxyimino-1-phenyl-1,2,3,4-tetrahydroquinoline (M-7074). ( Kosuzume, H; Ohkura, M; Ohnishi, H; Satoh, M; Suzuki, Y; Toyonaka, Y; Uohama, M; Yamaguchi, K, 1981)
"Flumizole is a potent anti-inflammatory agent in animal models with an inhibitory activity severalfold that of indomethacin in rat foot edema and prostaglandin synthetase tests."	3.65	Flumizole, a new nonsteroidal anti-inflammatory agent. ( Bettis, JW; McIlhenny, HM; Wiseman, EH, 1975)
" The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid."	1.25	Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	50 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Kaltenbronn, JS	3
Brannigan, LH	1
Hodge, RB	1
Field, L	1
GEYER, G	1
KEIBL, E	1
POZENEL, H	2
CREPAX, P	1
SILVESTRINI, B	1
BRITTAIN, RT	1
SPENCER, PS	1
Winder, CV	1
Birnie, JH	2
Sutton, BM	2
Zuccarello, M	1
Rush, JA	1
Ohnishi, H	1
Kosuzume, H	1
Yamaguchi, K	1
Ohkura, M	1
Satoh, M	1
Uohama, M	1
Toyonaka, Y	1
Suzuki, Y	1
Tolot, F	2
Prost, G	2
Guignot, B	2
Pelletier, M	2
Fox, PK	1
Lewis, AJ	1
Wiseman, EH	2
McIlhenny, HM	1
Bettis, JW	1
Adams, SS	3
McCullough, KF	2
Nicholson, JS	3
Awouters, F	1
Niemegeers, CJ	1
Lenaerts, PM	1
Janssen, PA	1
Valtonen, EJ	1
Hebborn, P	1
Kobayashi, S	1
Takagi, H	1
Julou, L	1
Guyonnet, JC	1
Ducrot, R	1
Bardone, MC	1
Detaille, JY	1
Laffargue, B	1
Lombardino, JG	1
Fujimura, H	2
Tsurumi, K	5
Go, K	1
Hiramatsu, Y	4
Tamura, Y	1
Márquez, M	1
Roberts, DJ	1
Navarro, J	1
Stoliaroff, M	1
Savy, JM	1
Berny, C	1
Brunaud, M	1
Nozaki, M	4
Hayashi, M	4
Yamaguchi, A	2
Rowell, NR	1
Cotterill, JA	1
Gupta, N	1
Levy, L	1
Nakano, K	1
Yamamoto, H	1
Saito, C	1
Inaba, S	1
Awata, H	1
Yamamoto, M	1
Shibuya, T	1
Rhee, TO	1
Mühleisen, H	1
Vörtler, HH	1
Dolbeare, FA	1
Martlage, KA	1
Tanaka, K	1
Iizuka, Y	1
Bianchi, C	1
Lumachi, B	1
Marazzi-Uberti, E	1
Nayyar, KC	1
Pasricha, JS	1
Swingle, KF	2
Harrington, JK	2
Hamilton, RR	2
Kvam, DC	2
Rudas, B	1
Leuschner, F	1
Leuschner, A	1
Jánoska, A	1
Sinka, L	1
Alpermann, HG	1
Lambelin, G	1
Vassart-Thys, D	1
Roba, J	1
Barron, DI	1
Copley, AR	1
Vallance, DK	1
Newbould, BB	1
Jahn, U	1
Adrian, RW	1
Gold, SC	1

Article	Year
Antiinflammatory activity of isomeric phenylnaphthaleneacetic acids. Journal of medicinal chemistry, 1977, Volume: 20, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Erythema; Guinea Pigs; Isomerism; Naphthaleneacetic Acids; Struct	1977
Biologically oriented organic sulfur chemistry. 14. Antiinflammatory properties of some aryl sulfides, sulfoxides, and sulfones. Journal of medicinal chemistry, 1976, Volume: 19, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Edema; Erythema; Female; Male; Mice; Rats; Structure-Activity Rel	1976
[On the effect of phenylbutazone and cortisone on ultraviolet erythema in man]. Zeitschrift fur Rheumaforschung, 1960, Volume: 19 Topics: Cortisone; Erythema; Humans; Male; Phenylbutazone; Ultraviolet Rays	1960
[THE LOCAL EFFECT OF PHENYLBUTAZONE ON ULTRAVIOLET ERYTHEMA IN MAN]. Arzneimittel-Forschung, 1963, Volume: 13 Topics: Biomedical Research; Erythema; Humans; Male; Ointments; Pharmacology; Phenylbutazone; Skin; Ultravio	1963
EXPERIMENTAL EVALUATION IN LABORATORY ANIMALS OF ANTI-INFLAMMATORY ANALGESIC DRUGS. Archives italiennes de biologie, 1963, Oct-05, Volume: 101 Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Animals; Animals, Laboratory; Anti-Inflammatory A	1963
USE OF TIME-RESPONSE RELATIONSHIPS IN ASSESSING PHARMACOLOGICAL ACTIVITY. The Journal of pharmacy and pharmacology, 1965, Volume: 17 Topics: Aminopyrine; Anti-Inflammatory Agents; Antipyrine; Aspirin; Erythema; Guinea Pigs; Oxyphenbutazone;	1965
Experimental observations on flufenamic, mefenamic, and meclofenamic acids. I. Pharmacology. Annals of physical medicine, 1966, Volume: Suppl Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Chemistry, Physical; E	1966
Some anti-inflammatory properties of 8-trifluoromethylphenothiazine-1-carboxylic acid (SK & F 22908). Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1967, Volume: 17, Issue:1 Topics: Animals; Erythema; Flufenamic Acid; Granuloma; Guinea Pigs; Indomethacin; Male; Phenothiazines; Phen	1967
Anti-inflammatory properties of a newly synthesized compound, 6-chloro-4-oxyimino-1-phenyl-1,2,3,4-tetrahydroquinoline (M-7074). Japanese journal of pharmacology, 1981, Volume: 31, Issue:5 Topics: Aminoquinolines; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroi	1981
[Multiple manifestations of intolerance of a combination of anti-inflammatory drugs. Role of phenylbutazone]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1975, Dec-09, Volume: 51, Issue:48 Topics: Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury; Duodenal Ulcer; Erythema;	1975
Production of ultraviolet-light-induced skin erythema in the hairless rat: a comparison with the haired rat in screening for anti-inflammatory drugs. Laboratory animals, 1979, Volume: 13, Issue:4 Topics: Animals; Drug Evaluation, Preclinical; Erythema; Fluocinolone Acetonide; Hair; Male; Phenylbutazone;	1979
Flumizole, a new nonsteroidal anti-inflammatory agent. Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:9 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Biological Availability; Cyclooxygenase Inh	1975
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. Arzneimittel-Forschung, 1975, Volume: 25, Issue:11 Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap	1975
Suprofen, a potent antagonist of ultraviolet-erythema in guinea-pigs. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; E	1975
Studies of the mechanism of ultra-violet erythema formation. 3. A method for biological testing of ultra-violet radiation sources and substances affecting the degree of erythema. Acta dermato-venereologica, 1966, Volume: 46, Issue:4 Topics: Aminopyrine; Animals; Erythema; Methoxsalen; Mice; Phenylbutazone; Skin; Ultraviolet Rays	1966
Some aspects of the pharmacology of ibufenac, a non-steroidal anti-inflammatory agent. The Journal of pharmacy and pharmacology, 1968, Volume: 20, Issue:4 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Bradykinin; Bronchitis; Erythema;	1968
Pharmacological studies of a new antiinflammatory compound, 2-phenyl-6-dimethylamino-6H-cycloheptoxazole. Arzneimittel-Forschung, 1968, Volume: 18, Issue:10 Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Carrageenan; Chloro	1968
[General pharmacological properties of methiazinic acid (16091 RP)]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:8 Topics: Abscess; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Autonomic Nervous Syste	1969
Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles. Journal of medicinal chemistry, 1974, Volume: 17, Issue:11 Topics: Administration, Oral; Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Carrageenan;	1974
[Pharmacological study of phthalazino-(2,3-b)-phthalazine-5 (14H), 12(7H)-dione (L-5418)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1974, Volume: 70, Issue:3 Topics: Analgesia; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Barbiturates; Blood Co	1974
Pharmacological properties of thiazolinobutazone (LAS 11871). I. Anti-inflammatory effects. Arzneimittel-Forschung, 1974, Volume: 24, Issue:11 Topics: Abscess; Administration, Oral; Adrenalectomy; Animals; Bradykinin; Bronchial Spasm; Carrageenan; Ede	1974
[Pharmacologic properties of a new, nonsteroidal anti-inflammatory agent, bucloxic acid (804 CB)]. Arzneimittel-Forschung, 1974, Volume: 24, Issue:9A SUPPL Topics: Administration, Oral; Adrenal Glands; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Cycl	1974
[Pharmacological studies on niflumic acid, with special reference to the comparison with fenametes. 1. Anti-inflammatory and analgesic actions]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:6 Topics: Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability;	1972
Relapsing polychondritis. The British journal of dermatology, 1973, Volume: 88, Issue:4 Topics: Blood Cells; Cartilage; Ear Deformities, Acquired; Erythema; Fever; Hematocrit; Humans; Inflammation	1973
4- and 5-Aryl-l-naphthaleneacetic acids as antiinflammatory agents. Journal of medicinal chemistry, 1973, Volume: 16, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Erythema; Guinea Pigs; Naphthalene	1973
Delayed manifestation of ultraviolet reaction in the guinea-pig caused by anti-inflammatory drugs. British journal of pharmacology, 1973, Volume: 47, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Body Weight; Erythema; Guinea Pigs; Indomethacin; Permea	1973
[Pharmacological studies on N-benzoyl-N'-phenyl-2,6-diaminobenzoic acid (F-1). 1. Anti-inflammatory action]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5 Topics: Adrenal Glands; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Ascorbic Acid; Aspirin; B	1973
Novel quinazoline derivatives. II. A new anti-inflammatory agent, SL-512. Arzneimittel-Forschung, 1973, Volume: 23, Issue:9 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability; Cyclopropanes; Ede	1973
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 1. On acute inflammation]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:2 Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Electrolytes; Eryth	1973
4-(and 5-) (2-Thienyl)-1-naphthaleneacetic acids as antiinflammatory agents. Journal of medicinal chemistry, 1974, Volume: 17, Issue:6 Topics: Acetates; Animals; Anti-Inflammatory Agents; Erythema; Guinea Pigs; Naphthalenes; Phenylbutazone; Sp	1974
Some anti-inflammatory properties of ascorbic acid. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 139, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Arthritis; Ascorbic Acid; Aspirin; Carrageenan; Disease Models, A	1972
[Anti-inflammatory effect of bimetopyrol. I. Suppressive effect on acute inflammation]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyproheptadine; Edema; Erythema; Fever; Flufenamic Acid;	1972
Pharmacological investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 1. Anti-inflammatory, analgesic and antipyretic properties. Arzneimittel-Forschung, 1972, Volume: 22, Issue:1 Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Erythema; F	1972
Fixed drug eruption to oxyphenbutazone and phenylbutazone. Dermatologica, 1972, Volume: 144, Issue:4 Topics: Adult; Drug Hypersensitivity; Erythema; Female; Humans; Oxyphenbutazone; Phenylbutazone; Pruritus; S	1972
Anti-inflammatory activity of N-ethoxycarbonyl-3-benzoyltrifluoromethanesulfonanilide (MBR 4223, triflumidate), a new nonsteroidal compound. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 192, Issue:1 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Arthritis; Benzoates; Benzophenones; Biolog	1971
3-Benzoyldifluoromethanesulfonanilide, sodium salt (diflumidone sodium, MBR 4164-8): a new anti-inflammatory agent. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 189, Issue:1 Topics: Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Benzoates; Car	1971
[Treating of antiphlogistic agents in animal experiment studies]. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1971, Volume: 5, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Cortisone; Disease Models, Animal; Edema; Erythema; Inflammation;	1971
[Percutaneous influencing of experimental swellings and tissue lesions in rats]. Bratislavske lekarske listy, 1971, Volume: 56, Issue:5 Topics: Animals; Disease Models, Animal; Edema; Erythema; Heparin; Phenylbutazone; Promethazine; Rats; Rutin	1971
[Pharmacological studies of calcium-N-n-butylmalonic acid-N,N'-diphenylhydrazide (B-64114-Ca). 1. Anti-inflammatory effects]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1971, Volume: 67, Issue:4 Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Arthritis; Calcium; Capillary Permeability; Carrag	1971
The pharmacological properties of ibuprofen, an anti-inflammatory, analgesic and antipyretic agent. Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 178, Issue:1 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Codeine; Dextropropoxyphene; Eryt	1969
[Bullous drug exanthemata with special regard to toxic epidermal necrolysis (Lyell)]. Ceskoslovenska dermatologie, 1969, Volume: 44, Issue:5 Topics: Adult; Aged; Aminopyrine; Blister; Drug-Related Side Effects and Adverse Reactions; Erythema; Female	1969
[Delay of UV-erythema by thiophencarbonic acid derivatives]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:2 Topics: Acids; Animals; Anti-Inflammatory Agents; Depression, Chemical; Erythema; Flufenamic Acid; Guinea Pi	1970
Pharmacological studies of Bufexamac topically applied on the skin. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 187, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Betamethasone; Carrageenan; Edema; Erythema; Female; Fluocinolone	1970
Anti-inflammatory and related properties of 4-(p-biphenylyl)-3-hydroxybutyric acid. British journal of pharmacology and chemotherapy, 1968, Volume: 33, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Biphenyl Compounds; Blood Pressure; Bronchial	1968
The pharmacology of fenclozic acid (2-(4-chlorophenyl)-thiazol-4-ylacetic acid; I.C.I. 54,450; 'Myalex'); a new compound with anti-inflammatory, analgesic and antipyretic activityl. British journal of pharmacology, 1969, Volume: 35, Issue:3 Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agent	1969
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:1 Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo	1969
Drug eruption. The British journal of dermatology, 1966, Volume: 78, Issue:10 Topics: Adult; Drug Hypersensitivity; Erythema; Female; Humans; Phenylbutazone	1966
Phenothiazine-1-carboxylic acids. Journal of medicinal chemistry, 1966, Volume: 9, Issue:6 Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Chemistry, Organic; Dicarboxylic Acids; Erythema;	1966

phenylbutazone and Erythema

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